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| 1 | Constructal entransy dissipation rate minimization for 'disc-to-point' heat conduction显示文摘Based on constructal theory,'disc-to-point' heat conduction is optimized by minimizing the entransy dissipation rate whereby a critical point is determined that distributes the high-conductivity material according to optimized radial or branch patterns.The results show that the critical point is determined by the product of the thermal conductivity ratio of the two materials and the volume fraction of the high-conductivity material allocated to the entire volume.The notion of optimal heat transfer performance can be attributed to the disc based on the entransy dissipation extremum principle.Comparing the results based on EDR minimization (entransy dissipation rate minimization) with those based on MTD minimization (maximum temperature difference minimization),one finds that the performance derived from the two optimization procedures are different.When the product of the thermal conductivity ratio and volume fraction is 30,the critical point of the former procedure is that for which the nondimensional radius of the disc equals 1.75,while that of the latter procedure is that for which this radius of the disc equals 2.18.Comparing heat transfer performances from the two procedures,the mean heat transfer temperature difference is decreased more for the former procedure thereby receiving an improved performance quota. | XIAO QingHua CHEN LinGen SUN FengRui | 2011 | Chinese Science Bulletin2011，56，1： | 31 |
| 2 | Constructal entransy dissipation rate and flow-resistance minimizations for cooling channels显示文摘Based on constructal theory,a construct of a volume that generates heat at every point and is cooled by the coolant in the constant or tapered channel is optimized by minimizing entransy dissipation rate and flow resistance.The optimal constructs of the rectangular elements with dimensionless mean thermal resistance minimization as well as the first-,secondand thirdorder assemblies with dimensionless global flow resistance minimizations are obtained respectively.The results show that both the mean temperature difference and the limiting temperature difference of rectangular elements based on EDR (entransy dissipation rate) and MTD (maximum temperature difference) minimizations respectively are almost equal.Comparing heat transfer performances from the two optimization procedures,the dimensionless global flow resistance is decreased more for the former procedure when the assembly’s order is high.It may create great superiority for constructal optimization to combine the entransy dissipation extreme principle with heat convection. | XIAO QingHua,CHEN LinGen & SUN FengRui Postgraduate School,Naval University of Engineering,Wuhan 430033,China | 2010 | Science China(Technological Sciences)2010，53，9： | 27 |
| 3 | Constructal entransy dissipation rate minimization for umbrella-shaped assembly of cylindrical fins显示文摘Umbrella-shaped assembly of cylindrical fins is optimized by adopting analytical method and taking dimensionless mean thermal resistance (MTR) as performance index. The optimal construct of umbrella-shaped assembly is obtained. The results show that the heat conductance performance of the assembly becomes ever worse with ever greater number of elemental cylindrical fins,the umbrella-shaped assembly reduces to cylindrical fin in some values of design parameters,and the diameters’ dependence on design parameters is weak for the optimized assembly. An equivalent thermal resistance defined based on entransy dissipation rate (EDR) reflects an average heat transfer effect of the assembly. The constructal design corresponding to the minimum EDR (or MTR) should be adopted for designing an assembly of fins in engineering at the limit safe condition. | XIAO QingHua CHEN LinGen SUN FengRui | 2011 | Science China(Technological Sciences)2011，54，1： | 24 |
| 4 | Constructal entransy dissipation rate minimization for heat conduction based on a tapered element显示文摘Based on constructal theory,the structure of a tapered element and high-conductivity link is optimized by taking the minimization of the entransy dissipation rate as the optimization objective.The results show that the mean temperature difference of the heat transfer cannot always decrease when the internal complexity of the control-volume increases.There exists an optimal constructal order leading to the minimum mean temperature difference for heat transfer.The thermal current density in high-conductivity links with variable shapes does not linearly depend on the length.Therefore,the optimized constructs based on the minimization of the entransy dissipation rate are different from those based on the minimization of the maximum temperature difference.Compared with the construct based on the minimization of the maximum temperature difference,the construct based on the minimization of the entransy dissipation rate can reduce the mean temperature difference,and improve the heat transfer performance significantly.Because entransy describes the heat transfer ability more suitably,various constructal problems in heat conduction may be addressed more effectively using this basis. | XIAO QingHua CHEN LinGen SUN FengRui | 2011 | Chinese Science Bulletin2011，56，22： | 17 |
| 5 | Constructal design for a steam generator based on entransy dissipation extremum principle显示文摘Steam generator is optimized by applying entransy dissipation extremum principle and constructal theory and adopting analyti-cal method.The obtained results show that the optimal spacing between adjacent tubes,the mass flow rate of gas and the maximum entransy dissipation rate all depend on the dimensionless diameter of one tube,the dimensionless pressure difference number and the dimensionless length of flow channel of gas.Besides the three dimensionless groups,the optimal numbers of riser tubes and downcomer tubes and their summation all depend on the dimensionless height of one tube.The maximum entransy dissipation rate increases as the pressure difference that drives the gas flowing increases,and as the diameter of one tube and the length of flow channel both decrease.The mean heat flux in the heat transfer process of hot gas grows greatly,and the performance of the system is improved.Compared with the optimal construct with heat transfer rate maximization,the optimal construct with entransy dissipation rate maximization can improved the heat transfer effect of the steam generator more. | XIAO QingHua CHEN LinGen SUN FengRui | 2011 | Science China(Technological Sciences)2011，54，6： | 12 |
| 6 | Constructal entransy dissipation rate minimization for a heat generating volume cooled by forced convection显示文摘The geometry of a heat generating volume cooled by forced convection is optimized by applying the entransy dissipation extremum principle and constructal theory, while the optimal spacing between the adjacent tubes and the optimal diameter of each tube are obtained based on entransy dissipation rate minimization. The results of this work show that the optimal constructs based on entransy dissipation rate minimization and maximum temperature difference minimization, respectively, are clearly different. For the former, the porosity of the volume of channels allocated to the heat generating volume is 1/2; while for the latter, the larger the porosity is, the better the performance will be. The optimal construct of the former greatly decreases the mean thermal resistance and improves the global heat transfer performance of the system compared with the optimal construct of the latter. This is identical to the essential requirement of the entransy dissipation extremum principle that the required heat transfer temperature difference is minimal with the same heat transfer rate (the given amount of heat generated in the heat generating volume) based on the entransy dissipation extremum principle. | XIAO QingHua CHEN LinGen SUN FengRui | 2011 | Chinese Science Bulletin2011，56，27： | 12 |
| 7 | Flexible cobalt phosphide network electrocatalyst for hydrogen evolution at all pH values显示文摘为根本切开 pH 值的水的高效的 electrocatalysts 在持续的氢进化的领域里吸引了可观的兴趣。此处,我们与 nanocrystalline 钴磷化物(警察) 报导有效 electrocatalyst 为在 0-14 的 pH 范围切开的水的网络。新奇灵活 electrocatalyst 从在一条传导性的 Hastelloy 带上种的一个理想的 nanocrystalline 警察网络被导出。这种 self-supported 警察网络直接为氢进化被用作 electrocatalytic 阴极。在有 ~ 的低发作过电位的优异性能的 nanocrystalline 网络结构结果在 0 ~ 14 的一个宽广 pH 范围上的 45 mV 并且负担得起 100 mAH | Jianwen Huang Yanrong Li YufeiXia Juntong Zhu Qinghua Yi Hao Wang Jie Xiong Yinghui Sun Guifu Zou | 2017 | Nano Research2017，10，3： | 8 |
| 8 | STUDY ON MECHANISM OF ARC-EXCITED ULTRASONIC显示文摘0INTRODUCTIONAnelectricalarccanbeidentifiedasadynamicresistanceinanarcweldingcircuit.Itistriedsucesfulyintungsteninertgasarcw... | Wu Minsheng Wang Zhengxian Li Luming Sun Diqing Duan Xiangyang Department of Mechanical Engineering, Qinghua University | 1999 | Chinese Journal of Mechanical Engineering1999，12，1： | 8 |
| 9 | BRIF-Seq: Bisulfite-Converted Randomly Integrated Fragments Sequencing at the Single-Cell Level显示文摘Single-cell bisulfite sequencing (scBS-seq) was developed to assess DNA methylation heterogeneity in human and mouse. However, the reads are under-represented in regions with high DNA methylation, because these regions are usually fragmented into long segments and are seldom sequenced on the lllumina plat. form. To reduce the read distribution bias and maximize the use of these long segments, we developed bisulfite-converted randomly integrated fragments sequencing (BRIF-seq), a method with high rates of read mapping and genome coverage. Single microspore of maize, which has a highly methylated and repetitive genome, was used to perform BRIF.seq. High coverage of the haploid genome was obtained to evaluate the methylation states of CG, CHG, and CHH (H = A, C, or T). Compared with scBS-seq, BRIF-seq produced reads that were distributed more evenly across the genome, including regions with high DNA methylation. Surprisingly, the methylation rates among the four microspores within one tetrad were similar, but differed significantly among tetrads, suggesting that non-simultaneous methylation reprogramming could occur among tetrads. Similar levels of heterogeneity, which often occur in lowcopy regions, were detected in different genetic backgrounds. These results suggest that BRIF-seq can be applied for single-cell methylome analysis of any species with diverse genetic backgrounds. | Xiang Li Lu Chen Qinghua Zhang Yonghao Sun Qing Li Jianbing Yan | 2019 | Molecular Plant2019，12，3： | 7 |
| 10 | Melatonin enhances salt tolerance by promoting MYB108A-mediated ethylene biosynthesis in grapevines显示文摘The signal molecules melatonin and ethylene play key roles in abiotic stress tolerance.The interplay between melatonin and ethylene in regulating salt tolerance and the underlying molecular mechanism of this interplay remain unclear.Here,we found that both melatonin and 1-aminocyclopropane-1-carboxylic acid(ACC,a precursor of ethylene)enhanced the tolerance of grapevine to NaCl;additionally,ethylene participated in melatonin-induced salt tolerance.Further experiments indicated that exogenous treatment and endogenous induction of melatonin increased the ACC content and ethylene production in grapevine and tobacco plants,respectively.The expression of MYB108A and ACS1,which function as a transcription factor and a key gene involved in ethylene production,respectively,was strongly induced by melatonin treatment.Additionally,MYB108A directly bound to the promoter of ACS1 and activated its transcription.MYB108A expression promoted ACC synthesis and ethylene production by activating ACS1 expression in response to melatonin treatment.The suppression of MYB108A expression partially limited the effect of melatonin on the induction of ethylene production and reduced melatonin-induced salt tolerance.Collectively,melatonin promotes ethylene biosynthesis and salt tolerance through the regulation of ACS1 by MYB108A. | Lili Xu Guangqing Xiang Qinghua Sun Yong Ni Zhongxin Jin Shiwei Gao Yuxin Yao | 2019 | Horticulture Research2019，6，1： | 7 |
| 11 | Albedo of Coastal Landfast Sea Ice in Prydz Bay,Antarctica:Observations and Parameterization显示文摘The snow/sea-ice albedo was measured over coastal landfast sea ice in Prydz Bay, East Antarctica(off Zhongshan Station)during the austral spring and summer of 2010 and 2011. The variation of the observed albedo was a combination of a gradual seasonal transition from spring to summer and abrupt changes resulting from synoptic events, including snowfall, blowing snow, and overcast skies. The measured albedo ranged from 0.94 over thick fresh snow to 0.36 over melting sea ice. It was found that snow thickness was the most important factor influencing the albedo variation, while synoptic events and overcast skies could increase the albedo by about 0.18 and 0.06, respectively. The in-situ measured albedo and related physical parameters(e.g., snow thickness, ice thickness, surface temperature, and air temperature) were then used to evaluate four different snow/ice albedo parameterizations used in a variety of climate models. The parameterized albedos showed substantial discrepancies compared to the observed albedo, particularly during the summer melt period, even though more complex parameterizations yielded more realistic variations than simple ones. A modified parameterization was developed,which further considered synoptic events, cloud cover, and the local landfast sea-ice surface characteristics. The resulting parameterized albedo showed very good agreement with the observed albedo. | Qinghua YANG Jiping LIU Matti LEPPRANTA Qizhen SUN Rongbin LI Lin ZHANG Thomas JUNG Ruibo LEI Zhanhai ZHANG Ming LI Jiechen ZHAO Jingjing CHENG | 2016 | Advances in Atmospheric Sciences2016，33，5： | 7 |
| 12 | Research on the Relationship between Molecular Activity of Additives and Lubricating Performance of Aluminum Rolling Oil显示文摘In this paper,an ab initio,local density functional(LDF)method was used to explore the relationship between the molecular properties of additives and the lubricating performance of aluminum rolling oil.The structural properties of butyl stearate,dodecanol,docosanol,and methyl dodecanoate were studied according to the density functional theory.The calculated data showed that the atoms in or around the functional groups might be likely the reacting sites.Because of the different functional groups and structure of ester and alcohol,two types of complex additives,dodecanol and butyl stearate,methyl dodecanoate and butyl stearate,respectively,were chosen for studying their tribological properties and performing aluminum cold rolling experiments.The test results agreed with the calculated results very well.The complex ester,viz.methyl dodecanoate and butyl stearate,had the best lubricating performance with a friction coefficient of 0.084 1 and a permissive-rolling thickness of 0.040 mm as compared with that of dodecanol-butyl stearate-base oil formulation. | Xia Lei Sun Jianlin Zeng Yingfeng Zhang Min Duan Qinghua | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，3： | 6 |
| 13 | Determination of PCDD/Fs and dioxin-like PCBs in food and feed using gas chromatography-triple quadrupole mass spectrometry显示文摘A method was developed on a gas chromatograph coupled to a triple quadrupole mass spectrometer(GC-MS/MS) for trace level determination of polychlorinated dibenzo-p-dioxins/dibenzofurans(PCDD/Fs) and dioxin-like polychlorinated biphenyls(DL-PCBs) in food and feed. The results demonstrated good sensitivity and repeatability for PCDD/Fs and DL-PCBs at an extremely low level(10 pg mL^(-1) for 2,3,7,8-TCDD/F), as well as wide linear response of over 3 or 4 orders of magnitude in concentration ranges; 0.5–200 ng mL^(-1) for PeCDD/F and 0.2–2000 ng mL^(-1) for DL-PCBs. The method detection limits for PCDD/Fs and DL-PCBs were in the range from 0.018–0.17 pg g^(-1) to 0.13–0.36 pg g^(-1), respectively. The performance of the GC-MS/MS for food and feed sample analysis showed high precision and accuracy compared to the high resolution gas chromatograph/high resolution mass spectrometer. The results indicated the feasibility of GC-MS/MS as a confirmatory method for the measurement of PCDD/Fs and DL-PCBs in food and feed as required by European Union legislation. | Huizhong Sun Pu Wang Honghua Li Yingming Li Shucheng Zheng Julius Matsiko Yanfen Hao Weiwei Zhang Dou Wang Qinghua Zhang | 2017 | Science China Chemistry2017，60，5： | 6 |
| 14 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 15 | Development of the National Air Quality Health Index-China,2013−2018显示文摘What is already known about this topic?While the establishment of an air quality health index(AQHI)in some countries yielded positive outcomes in communicating health risks of air pollution,China lagged behind in developing its own AQHI.Several research studies of AQHI were conducted in China,but this scientific research has not yet been applied to standards.What is added by this report?This report introduced the method of calculation of Chinese AQHI to be launched in pilot cities.The index in this report was established on the basis of fully drawing on international experience and considering Chinese characteristics.What are the implications for public health practice?The purpose of this report is to guide unified application of the AQHI throughout China and translate scientific evidence into public services to promote public health.Based on the AQHI construction method in this report,an AQHI real-time computing platform and data transfer interface will be developed.The release of AQHI aims to communicate health risk of air pollution and provide scientific health protective guidance to the general public,accordingly to protect people’s health. | Qinghua Sun Huanhuan Zhu Wanying Shi Yu Zhong Yingjian Zhang Tiantian Li | 2021 | China CDC weekly2021，3，4： | 5 |
| 16 | An improved trust region method for unconstrained optimization显示文摘In this paper,we propose an improved trust region method for solving unconstrained optimization problems.Different with traditional trust region methods,our algorithm does not resolve the subproblem within the trust region centered at the current iteration point,but within an improved one centered at some point located in the direction of the negative gradient,while the current iteration point is on the boundary set.We prove the global convergence properties of the new improved trust region algorithm and give the computational results which demonstrate the effectiveness of our algorithm. | ZHOU QingHua ZHANG YaRui XU FengXia GENG Yan SUN XiaoDian | 2013 | Science China Mathematics2013，56，2： | 5 |
| 17 | Short-term Exposure to Fine Particles and Risk of Cause-Specific Mortality--China,2013-2018显示文摘What is already known about this topic?Short-term exposure to PM2.5 has been associated with population excess death.This issue is of critical concern in China given its high level of exposure to PM2.5 compared to that of the rest of the world.What is added by this report?Existing studies were conducted from 2013-2015 and have failed to capture the full effects of China’s actions towards cleaner air in recent years,such as the first Action Plan for Air Pollution Prevention and Control issued in 2013.This study uses the longest time series data to date from 2013-2018,provides the latest evidence on PM2.5 and cause-specific death nationwide,and identifies regional patterns of PM2.5-related effects as well as PM2.5-related susceptible populations.What are the implications for public health practice?This study suggests that the development of standards and the implementation of actions to clean the air and protect public health should be tailored to PM2.5-related sensitive diseases,susceptible populations,and regional patterns. | Chen Chen Tiantian Li Lijun Wang Jinlei Qi Wangying Shi Mike Z He Qinghua Sun Jiaonan Wang Huanhuan Zhu Xiaoming Shi | 2019 | China CDC weekly2019，1，1： | 5 |
| 18 | A fully automated centrifugal microfluidic system for sample-to-answer viral nucleic acid testing显示文摘The outbreak of virus-induced infectious diseases poses a global public-health challenge.Nucleic acid amplification testing(NAAT)enables early detection of pandemic viruses and plays a vital role in preventing onward transmission.However,the requirement of skilled operators,expensive instrumentation,and biosafety laboratories has hindered the use of NAAT for screening and diagnosis of suspected patients.Here we report development of a fully automated centrifugal microfluidic system with sample-in-answer-out capability for sensitive,specific,and rapid viral nucleic acid testing.The release of nucleic acids and the subsequent reverse transcription loop-mediated isothermal amplification(RT-LAMP)were integrated into the reaction units of a microfluidic disc.The whole processing steps such as injection of reagents,fluid actuation by rotation,heating and temperature control,and detection of fluorescence signals were carried out automatically by a customized instrument.We validate the centrifugal microfluidic system using oropharyngeal swab samples spiked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)armored RNA particles.The estimated limit of detection for armored RNA particles is 2 copies per reaction,the throughput is 21 reactions per disc,and the assay sample-to-answer time is approximately 70 min.This enclosed and automated microfluidic system efficiently avoids viral contamination of aerosol,and can be readily adapted for virus detection outside the diagnostic laboratory. | Fei Tian Chao Liu Jinqi Deng Ziwei Han Lu Zhang Qinghua Chen Jiashu Sun | 2020 | Science China Chemistry2020，63，10： | 4 |
| 19 | Clinical characteristics and outcomes of Chinese patients with KRAS-mutant non-small cell lung cancer after chemotherapy显示文摘Dear Editor,The RAS gene is one of the most frequent oncogenes in human cancers,with significantly different mutation frequencies.The RAS family contains three isoforms:KRAS,HRAS and NRAS,with the KRAS mutations being more common than the other two.The KRAS mutation rate varies in non-small cell lung cancer(NSCLC)patients of different races:27%in Caucasians[1]and approximately 10%in Asians[2,3].Recently,the U.S.Food and Drug Administration(FDA)approved sotorasib(AMG510)and adagrasib(MRTX849)for the treatment of metastatic NSCLC harboring KRAS G12C mutations.In the face of novel treatment choices for KRAS-mutated NSCLC,it is indispensable to learn more about the systemic treatment of these patients.Clinical studies have shown that Caucasian patients with KRAS-mutated NSCLC had poor outcomes following first-line chemotherapy[4,5].However,studies on treatment outcomes of Asian patients with KRAS-mutated NSCLC are lacking.As the overwhelming majority of cases are diagnosed with lung adenocarcinoma,the standard first-line treatment for metastatic disease is pemetrexed-based doublet chemotherapy in combination with bevacizumab and/or immunotherapy in China.Herein,we investigated the clinical characteristics of KRAS mutation subtypes,co-occurring genomic alterations,and efficacy of first-line pemetrexed-platinum chemotherapy in Chinese KRAS-mutated NSCLC patients. | Yawen Zheng Qinghua Lai Hanxi Zhao Xiaolin Li Xiaorong Sun Ligang Xing | 2021 | Cancer Communications2021，41，11： | 4 |
| 20 | Elastohydrodynamic lubrication properties and friction behaviors of several ester base stocks显示文摘This paper reports a series of studies on the lubricant properties,elastohydrodynamic film thickness,and coefficients of friction of several commercially available ester base stocks,i.e.,diisooctyl phthalate(DIOP),diisodecyl phthalate(DIDP),diisotridecyl phthalate(DITDP),diisooctyl sebacate(DOS),diisotridecyl sebacate(DTDS),trihydroxymethylpropyl trioleate(TMPTO),and pentaerythritol tetraoleate(PETO).The results include densities and viscosities from 303 to 398 K,and elastohydrodynamic lubricant film thicknesses and friction in the boundary,mixed and full-film lubrication regimes measured at several temperatures,loads,and speeds.These ester base stocks have different lubrication abilities owing to their chain lengths,geometric configurations,and molecular rigidity.This study provides quantitative insight into the use of ester-based lubricants for low friction through the entire lubrication regime(boundary to full film)by utilization of suitable type and size of the ester base stocks. | Yifeng HE Thomas J.ZOLPER Pinzhi LIU Yuzhen ZHAO Xingliang HE Xuejin SHEN Hongwei SUN Qinghua DUAN Qian WANG | 2015 | Friction2015，3，3： | 3 |
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