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| 1 | Effect of the processing route on the microstructure and mechanical behavior of superlight Mg-9Li-1Zn alloy via friction stir processing显示文摘In this study, the effect of the processing route using a friction stir processing(FSP) method on the microstructure and mechanical behavior of a Mg-9Li-1Zn alloy was systematically investigated. In the FSP method, the odd-numbered(1st and 3rd) process directions and even-numbered(2nd and 4th) passes were alternated to distribute the strain throughout the whole processed zone uniformly. Consequently, the processed zone had a much more uniform microstructure and hardness distribution than the processed zone obtained using the conventional FSP method. Using this method, the grain size of a Mg-9Li-1Zn sheet alloy was refined from ~31 μm to ~0.21 μm with uniformly distributedα and β phases. The processed alloy exhibited a high strength-ductility synergy with an ultimate tensile strength(UTS) of 220.1 MPa and total elongation of 70.0% at a strain rate of 10^(-3)s^(-1), overwhelmingly higher than those of the base metal, 155.6 MPa in UTS and 36.0%in elongation. The in-situ SEM-DIC analysis and TEM observation demonstrated that such an outstanding ductility with moderate strength is caused by grain boundary sliding, the dominant deformation mechanism of the ultra-fine-grained sample after FSP. The processing route with reverse processing direction was proven to be efficient in producing the ultrafine grain size microstructure and improving the mechanical properties of superlight Mg-9Li-1Zn alloy. | Mengran Zhou Zhuoran Zeng Chun Cheng Yoshiaki Morisada Qingyu Shi Jian-Yih Wang Hidetoshi Fujii | 2022 | Journal of Magnesium and Alloys2022，10，11： | 2 |
| 2 | A Red-Emissive Sextuple Hydrogen-Bonding Self-Assembly Molecular Duplex Bearing Perylene Diimide Fluorophores for Warm-White Organic Light-Emitting Diode Application显示文摘一篇小说六倍结合氢(HB ) 自己组装分子的双适用的红射出的 perylene diimide (PDI ) fluorophores,也就是 PDIHB,被综合,并且它的分子的结构被 1 H NMR, 13 C NMR, TOFMS 和 2D NMR。与小分子的参考混合物 PDI 相比, PDIHB 处于稳固的状态(4.1% 对 2.1%) 显示出提高的荧光效率一次。更重要地,在 PDIHB 的笨重 HB oligoamide 海滨的存在能在薄稳固的电影触发在客人和主人 fluorophores 之间的有效空间分离州的、因此低效的精力转移在 2 wt% 发生在蓝射出的主人 2TPhNIHB 和红客人 PDIHB 之间客人 / 主人相配电影。作为结果,有 ITO/PEDOT 的相当简单的设备结构的一根处理答案的器官的轻射出的二极管(OLED ): PSS (40 nm )/PVK (40 nm )/PDIHB (2 wt%) :2TPhNIHB (50 nm )/Al (100 nm ) 能射出的 /LiF (0.8 nm ) 有稳定的委员会共产国际歌 de LEclairage 坐标的偏爱无关的温暖白人的 electroluminescence (0.42, 0.33 ) ,并且最大的亮度和这台设备的当前的效率分别地是 260 cd·m −2 和 0.49 cd·A −1, 。所有这些结果显示了那 HB 自己组装超分子的 fluorophores 能为白 OLED 申请充当未来的材料。 | Hui Zeng Qingyu Huang Jingjing Liu Yan Huang Jie Zhou Suling Zhao Zhiyun Lu | 2016 | Chinese Journal of Chemistry2016，34，4： | 2 |
| 3 | Effects of glass-to-rubber transition of thermosetting resin matrix on the friction and wear properties of friction materials 显示文摘 | Wu Yaoqing Zeng Ming Xu Qingyu | 2012 | Tribology International2012，54，： | 1 |
| 4 | Combining push-pull airflow and top draft hood for local exhaust of tyre vulcanization process显示文摘This paper proposes a push-pull airflow combined with a top draft hood to conduct local exhaust in a rubber workshop.Field measurements are carried out to investigate the characteristics of the emission source,while numerical simulation is performed based on the measurement to test the capture efficiency and to further optimize various parameters including push velocity,hood height and exhaust air rate.Compared with the high-hanging hood,the low-hanging hood can effectively capture the pollutant generated by tyre with lower exhaust air rate.The capture efficiency of the low-hanging hood reaches 98.18%with exhaust air rate of 6000 m^(3)/h and push air velocity of 5m/s.The results indicates that the new ventilation appliance can effectively collect the pollutant at a relatively low exhaust rate. | Kai Liu Shengwei Yang Lingjie Zeng Jun Gao Yumei Hou Changsheng Cao Bo Shi Xiangjin Mo Qingyu Zhang Chun Hou | 2020 | Energy and Built Environment2020，1，3： | 1 |
| 5 | Primary gout inShantou: a clinical and epidemiological study显示文摘 | ZENG Qingyu WANG Qingwen CHEN Ren | 2003 | Chin Med J2003，116，1： | 1 |
| 6 | An Effective Method for the Fabrication of Few‐Layer‐Thick Inorganic Nanosheets显示文摘 | Zhiyuan Zeng Ting Sun Jixin Zhu Xiao Huang Zongyou Yin Gang Lu Zhanxi Fan Qingyu Yan Huey Hoon Hng Hua Zhang | 2012 | Angew. Chem. Int. Ed2012，，36： | 1 |
| 7 | Effects of glass-to- rubber transition of thermoset-ting resin matrix on the friction and wear properties of friction materials显示文摘 | Wu Yaoqing Zeng Ming Xu Qingyu | 2012 | Tribology Interna- tional2012，54，： | 1 |
| 8 | Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274显示文摘 | Bingfa Sun Shunling Guo Qingyu Tang Chen Li Rong Zeng Zhiqi Xiong Chen Zhong Jianping Ding | 2011 | Cell Research2011，21，8： | 1 |
| 9 | Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron显示文摘SARS-CoV-2 variants with adaptive mutations have continued to emerge,causing fresh waves of infection even amongst vaccinated population.The development of broad-spectrum antivirals is thus urgently needed.We previously developed two hetero-bivalent nanobodies(Nbs),aRBD-2-5 and aRBD-2-7,with potent neutralization activity against the wild-type(WT)Wuhan isolated SARS-CoV-2,by fusing aRBD-2 with aRBD-5 and aRBD-7,respectively.Here,we resolved the crystal structures of these Nbs in complex with the receptor-binding domain(RBD)of the spike protein,and found that aRBD-2 contacts with highly conserved RBD residues and retains binding to the RBD of the Alpha,Beta,Gamma,Delta,Delta plus,Kappa,Lambda,Omicron BA.1,and BA.2 variants.In contrast,aRBD-5 and aRBD-7 bind to less conserved RBD epitopes non overlapping with the epitope of aRBD 2,and do not show apparent binding to the RBD of some variants.However,when fused with aRBD-2,they effectively enhance the overal binding affinity.Consistently,aRBD-2-5-Fc and aRBD-2-7 Fc potently neutralized all of the tested authentic or pseudotyped viruses,incuding WT,Alpha,Beta,Gamma,Delta,and Omicron BA.1,BA.1.1 and BA.2.Furthermore,aRBD-2-5-FC provided prophylactic protection against the WT and mouse-adapted SARS CoV-2 in mice,and conferred protection against the Omicron BA.1 variant in hamsters prophylatically and therapeutically,indicating that aRBD-2-5-Fc could potentially beneft the prevention and treatment of COVID-19 caused by the emerging variants of concern.Our strategy provides new solutions in the development of broad-spectrum therapeutic antibodies for COVID-19. | Huan Ma Xinghai Zhang Peiyi Zheng Peter H.Dube Weihong Zeng Shaohong Chen Qingyu Cheng Yunru Yang Yan Wu Junhui Zhou Xiaowen Hu Yan Xiang Huajun Zhang Sandra Chiu Tengchuan Jin | 2022 | Cell Research2022，32，9： | 1 |
| 10 | NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation显示文摘NDFIP1 has been previously reported as a tumor suppressor in multiple solid tumors,but the function of NDFIP1 in NSCLC and the underlying mechanism are still unknown.Besides,the WW domain containing proteins can be recognized by NDFIP1,resulted in the loading of the target proteins into exosomes.However,whether WW domain-containing transcription regulator 1(WWTR1,also known as TAZ)can be packaged into exosomes by NDFIP1 and if so,whether the release of this oncogenic protein via exosomes has an effect on tumor development has not been investigated to any extent.Here,we first found that NDFIP1 was low expressed in NSCLC samples and cell lines,which is associated with shorter OS.Then,we confirmed the interaction between TAZ and NDFIP1,and the existence of TAZ in exosomes,which requires NDFIP1.Critically,knockout of NDFIP1 led to TAZ accumulation with no change in its mRNA level and degradation rate.And the cellular TAZ level could be altered by exosome secretion.Furthermore,NDFIP1 inhibited proliferation in vitro and in vivo,and silencing TAZ eliminated the increase of proliferation caused by NDFIP1 knockout.Moreover,TAZ was negatively correlated with NDFIP1 in subcutaneous xenograft model and clinical samples,and the serum exosomal TAZ level was lower in NSCLC patients.In summary,our data uncover a new tumor suppressor,NDFIP1 in NSCLC,and a new exosome-related regulatory mechanism of TAZ. | Yirui Cheng Xin Lu Fan Li Zhuo Chen Yanshuang Zhang Qing Han Qingyu Zeng Tingyu Wu Ziming Li Shun Lu Cecilia Williams Weiliang Xia | 2023 | Protein & Cell2023，14，2： | 0 |
| 11 | NANOGrav results and dark first order phase transitions显示文摘The recent NANOGrav evidence of a common-source stochastic background provides a hint to gravitational waves(GW)radiation from the Early Universe.We show that this result can be interpreted as a GW spectrum produced from first order phase transitions(FOPTs)around a temperature in the keV-MeV window.Such a class of FOPTs at temperatures much below the electroweak scale can be naturally envisaged in several warm dark matter models such as Majoron dark matter. | Andrea Addazi Yi-Fu Cai Qingyu Gan Antonino Marciano Kaiqiang Zeng | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，9： | 0 |
| 12 | Feasibility Study of Mixing Throat Swab Samples for Severe Acute Respiratory Syndrome Coronavirus-2 Screening显示文摘Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has been declared a pandemic by the World Health Organization(WHO)and has resulted in the worst public health crisis since World War II(Wang et al.2020). | Yang Han Qingyu Yang Ying Liu Ting Shu Li Yue Ting Xiao Qin Zeng Ying Wu Xi Zhou Dingyu Zhang | 2020 | Virologica Sinica2020，35，6： | 0 |
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