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| 1 | Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis显示文摘 | Chaoying Hu Liu Qian Yi Miao Qiuyu Huang Ping Miao Ping Wang Qiwen Yu Hong Nie Jiying Zhang Dongyi He Rong Xu Xuehua Chen Bingya Liu Dongqing Zhang | 2012 | Cellular & Molecular Immunology2012，9，3： | 18 |
| 2 | 800 Gbit/s transmission over 1 km single-mode fiber using a four-channel silicon photonic transmitter显示文摘We demonstrate the optical transmission of an 800 Gbit/s(4×200 Gbit/s)pulse amplitude modulation-4(PAM-4)signal and a 480 Gbit/s(4×120 Gbit/s)on–off-keying(OOK)signal by using a high-bandwidth(BW)silicon photonic(SiP)transmitter with the aid of digital signal processing(DSP).In this transmitter,a four-channel SiP modulator chip is co-packaged with a four-channel driver chip,with a measured 3 dB BW of 40 GHz.DSP is applied in both the transmitter and receiver sides for pre-/post-compensation and bit error rate(BER)calculation.Back-to-back(B2B)BERs of the PAM-4 signal and OOK signal are first measured for each channel of the transmitter with respect to a variety of data rates.Similar BER performance of four channels shows good uniformity of the transmitter between different channels.The BER penalty of the PAM-4 and OOK signals for 500 m and 1 km standard single-mode fiber(SSMF)transmission is then experimentally tested by using one channel of the transmitter.For a 200 Gbit/s PAM-4 signal,the BER is below the hard-decision forward error correction(HD-FEC)threshold for B2B and below the soft-decision FEC(SD-FEC)threshold after 1 km transmission.For a 120 Gbit/s OOK signal,the BER is below SD-FEC threshold for B2B.After 500 m and 1 km transmission,the data rate of the OOK signal shrinks to 119 Gbit/s and 118 Gbit/s with the SD-FEC threshold,respectively.Finally,the 800 Gbit/s PAM-4 signal with 1 km transmission is achieved with the BER of all four channels below the SD-FEC threshold. | Hongguang Zhang Miaofeng Li Yuguang Zhang Di Zhang Qiwen Liao Jian He Shenglei Hu Bo Zhang Lei Wang Xi Xiao Nan Qi Shaohua Yu | 2020 | Photonics Research2020，8，11： | 5 |
| 3 | Optimizing the grain size and grain boundary morphology of (K,Na) NbO_(3)-based ceramics: Paving the way for ultrahigh energy storage capacitors显示文摘Relaxor dielectric ceramic capacitors are very attractive for high-power energy storage.However,the low breakdown strength severely restricts improvements to the energy storage density and practical application.Here,a strategy of designing small grain sizes and abundant amorphous grain boundaries is proposed to improve the energy storage properties under the guidance of phase field theory.0.925(K_(0.5)Na_(0.5))NbO_(3)-e0.075Bi(Zn_(2/3)(Ta_(0.5)Nb_(0.5))1/3)O_(3)(KNNe-BZTN)relaxor ferroelectric ceramic is taken as an example to verify our strategy.The grain sizes and grain boundaries of the KNNeBZTN ceramics are carefully controlled by the high-energy ball milling method and twoestep sintering strategy.Impedance analysis and diffusion reflectance spectra demonstrate that KNNeBZTN ceramics with a small grain size and abundant amorphous grain boundary exhibit a lower charge carrier concentration and higher band gap.As a consequence,the breakdown electric field of KNNeBZTN ceramics increases from 222 kV/cm to 317 kV/cm when the grain size is decreased from 410 nm to 200 nm,accompanied by a slightly degraded maximum polarization.KNNeBZTN ceramics with an average grain size of~250 nm and abundant amorphous grain boundaries exhibit optimum energy storage properties with a high recoverable energy density of 4.02 J/cm^(3) and a high energy efficiency of 87.4%.This successful local structural design opens up a new paradigm to improve the energy storage performance of other dielectric ceramic capacitors for electrical energy storage. | Xiaozhi Wang Yu Huan Peiyao Zhao Xiaoming Liu Tao Wei Qiwen Zhang Xiaohui Wang | 2021 | Journal of Materiomics2021，7，4： | 3 |
| 4 | A Lectin from Chinese Mistletoe Increases γδ T Cell-mediated Cytotoxicity through Induction of Caspase-dependent Apoptosis显示文摘在这研究,槲寄生凝集素(ML ) 在 cytokine 网络的人的鲸鱼群妈三角洲 T 房间 cytotoxicity, apoptosis 和调整上从中国槲寄生和这 60 kDa 汉语 ML 的效果被净化被学习。 8 个 T 房间的细胞毒素的性质被使用 51Cr 版本测试评估并且采用了排序的激活荧光的房间和 enzyme-linkedimmunosorbent 试金分析确定房间 membranephospholipid 的 translocation , phosphatidylserine 和原子 DNA 破碎在 apoptosis.It 期间被发现那:(i) ML 有效地在剂量刺激了鲸鱼群妈三角洲 T 房间增长--并且时间依赖者举止;( i i ) ML 增加了鲸鱼群妈三角洲 T 房间 cytotoxicity ;( iii ) ML 能由增加以一种 支持inflammatory 方式调制 lipopolysaccharide-inducedcytokine 版本肿瘤坏死因素( TNF ) -alpharelease 并且禁止反煽动性的白介素( IL )的版本以caspase依赖、CD95独立的方式的-10;(iv) ML inducedapoptosis 。结果显示 ML 是到人的鲸鱼群妈三角洲 T 房间 cytotoxicity, apoptosis 和 cytokine 生产的 potentimmunomodulator。 | Fang GONG Yanhui MA Anlun MA Qiwen YU Jiying ZHANG Hong NIE Xuehua CHEN Baihua SHEN Ningli LI Dongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 2 |
| 5 | C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death显示文摘Lysosomes are degradation and signaling centers within the cell,and their dysfunction impairs a wide variety of cellular processes.To understand the cellular effect of lysosome damage,we screened natural smallmolecule compounds that induce iysosomal abnormality using Caenorhabditis elegans (C.elegans)as a model system.A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D)were identified that caused lysosome enlargement in C.elegans macrophage-like cells.Intriguingly,these compounds triggered cell death in the germ line independently of the canonical apoptosis pathway.In mammalian cells, ervachinines A-D induced lysosomal enlargement and damage,leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death.Further analysis revealed that this ervachinine-induced lysosome damage and lysosomal cell death depended on STAT3 signaling,but not RIP1 or RIP3 signaling.These findings suggest that lysosomedamaging compounds are promising reagents for dissecting signaling mechanisms underlying lysosome homeostasis and lysosome-related human disorders. | Yang Li Yu Zhang Qiwen Gan Meng Xu Xiao Ding Guihua Tang Jingjing Liang Kai Liu Xuezhao Liu Xin Wang Lingli Guo Zhiyang Gao Xiaojiang Hao Chonglin Yang | 2018 | Protein & Cell2018，9，12： | 2 |
| 6 | Impact of switching frequencies on the TID response of SiC power MOSFETs显示文摘Different switching frequencies are required when SiC metal-oxide-semiconductor field-effect transistors(MOSFETs)are switching in a space environment.In this study,the total ionizing dose(TID)responses of SiC power MOSFETs are investigated under different switching frequencies from 1 kHz to 10 MHz.A significant shift was observed in the threshold voltage as the frequency increased,which resulted in premature failure of the drain-source breakdown voltage and drain-source leakage current.The degradation is attributed to the high activation and low recovery rates of traps at high frequencies.The results of this study suggest that a targeted TID irradiation test evaluation method can be developed according to the actual switching frequency of SiC power MOSFETs. | Sheng Yang Xiaowen Liang Jiangwei Cui Qiwen Zheng Jing Sun Mohan Liu Dang Zhang Haonan Feng Xuefeng Yu Chuanfeng Xiang Yudong Li Qi Guo | 2021 | Journal of Semiconductors2021，42，8： | 2 |
| 7 | Bottom-up lithium growth guided by Ag concentration gradient in 3D PVDF framework towards stable lithium metal anode显示文摘Three-dimensional(3 D)frameworks have received much attention as an effective modification strategy for next-generation high-energy-density lithium metal batteries.However,the top-growth mode of lithium(Li)on the 3 D framework remains a tough challenge.To achieve a uniform bottom-up Li growth,a scheme involving Ag concentration gradient in 3 D PVDF framework(C-Ag/PVDF)is proposed.Ag nanoparticles with a concentration gradient induce an interface activity gradient in the 3 D framework,and this gradient feature is still maintained during the cycle.As a result,the C-Ag/PVDF framework delivers a long lifespan over 1800 h at a current density of 1 mA cm^(-2) with a capacity of 1 mAh cm^(-2),and shows an ultra-long life(>1300 h)even at a high current density of 4 mA cm^(-2) with a capacity of 4 mAh cm^(-2).The advantage of concentration gradient provides further insights into the optimal design of the 3 D framework for stable Li metal anode. | Yulin Zhao Liping Wang Jian Zou Qiwen Ran Li Li Pengyu Chen Hailong Yu Jian Gao Xiaobin Niu | 2022 | Journal of Energy Chemistry2022，31，2： | 2 |
| 8 | Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy显示文摘Drug delivery systems(DDSs)are of paramount importance to deliver drugs at the intended targets,e.g.,tumor cells or tissue by prolonging blood circulation and optimizing the pharmaceutical profiles.However,the therapeutic efficacy of DDSs is severely impaired by insufficient or non-specific drug release.Dynamic chemical bonds having stimuli-liable prope rties are the refore introduced into DDSs for regulating the drug release kinetics.This review summarizes the recent advances of dynamic covalent chemistry in the DDSs for improving cancer therapy.The review discusses the constitutions of the major classes of dynamic covalent bonds,and the respective applications in the tumor-targe ted DDSs which are based on the different responsive mechanisms,including acid-activatable and reduction-activatable.Furthermore,the review also discusses combination strategies of dual dynamic covale nt bonds which can response to the complex tumor microenvironment much more accurately,and then summarizes and analyzes the prospects for the application of dynamic covalent chemistry in DDSs. | Qiwen Zhu Madiha Saeed Rundi Song Tao Sun Chen Jiang Haijun Yu | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 9 | PIC catalysis based on polyoxometalates promoting 5-HMF oxidation in H_(2)O/MIBK biphase显示文摘Novel polyoxometalate(POM)Pickering interfacial catalyst(PIC)was fabricated through loading(NH_(4))_(5)H_(6)PMo_(4)V_(8)O_(40)(PMo_(4)V_(8))on both alkyl and alkyl-amino groups functionalized silica nanoparticles.PMo_(4)V_(8)/SiO_(2)(C_(8)/C_(8)NH_(2)with molar ratio as 1:1)PIC system provided a new catalytic model for aerobic conversion of 5-hydroxymethylfurfural(5-HMF),as well as its recovery and product separation in H_(2)O/methyl isobutyl ketone(MIBK)biphase reaction.Balancing the ratio of PMo_(4)V_(8),C_(8)and C_(8)NH_(2)gave rise to variety in hydrophilicity and hydrophobicity for PMo_(4)V_(8)/SiO_(2)(C_(8)/C_(8)NH_(2)),which enhanced the transformation of 5-HMF to 2,5-diformylfuran(DFF)in H_(2)O/MIBK with 73.7%yield at 81.8%conversion than in H_(2)O or MIBK single phase. | Qiwen Wang Wenwen Bu Zonghang Li Yu Qi Xiaohong Wang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 10 | Fe_(3)C coupled with Fe-N_(x)supported on N-doped carbon as oxygen reduction catalyst for assembling Zn-air battery to drive water splitting显示文摘Fe-N-C structures have been considered as a candidate to replace noble metal catalysts towards oxygen reduction reaction(ORR)due to their excellent electrocatalytic activity and durability.Herein,a zincmediated synthesis strategy is proposed for N-doped graphitic porous carbon encapsulated uniform dispersed Fe_(3)C nanoparticles coupled with atomically dispersed Fe-Nxmoieties(NPC/Fe-N-C)derived from biomass coconut shell.The introduction of zinc species could be conductive to the dispersion of iron species and formation of porous structures.Density functional theory calculations demonstrate that the N-doped carbon coating structures can weaken the oxygen intermediates adsorption energy barrier of Fe_(3)C.Beside,the graphitic carbon could promote the electron transfer during the electrochemical reaction.These special structures enable NPC/Fe-N-C to have excellent ORR activity with an Eonsetof 1.0 V,which is much better than Pt/C.Furthermore,the zinc-air battery assembled by pairing NPC/Fe-N-C with a high-efficiency oxygen evolution reaction(OER)catalyst can continuously and stably operate a chargedischarge potential gap of 0.8 V at 10 m A/cm^(2)for more than 600 h.More importantly,the assembled batteries could drive overall water splitting device,realizing the effective energy conversion. | Guangying Zhang Xu Liu Peng Yu Di Shen Bowen Liu Qiwen Pan Lei Wang Honggang Fu | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 11 | An innovative rhein-matrine cocrystal: Synthesis, characterization,formation mechanism and pharmacokinetic study显示文摘Rhein(Rhe), an anthraquinone derivative, exhibits excellent anti-inflammatory effects and other pharmacological activities, but its clinical application remains limited due to poor solubility. The present work aims at the improvement of solubility and oral bioavailability of Rhe through cocrystal formation. For this purpose, Rhe and matrine(Mat) were selected as pharmaceutical ingredient(API) and cocrystal former(CCF), respectively, and the Rhe-Mat cocrystal was synthesized and characterized by single crystal X-ray diffraction(SXRD), powder X-ray diffraction(PXRD), thermogravimetric analysis(TGA), differential scanning calorimetry(DSC). The formation mechanism of Rhe-Mat cocrystal was elucidated by molecular surface electrostatic potential(MSEP). It is worth mentioning that the 50-fold increment of dissolution in vitro was observed in pure water in the form of Rhe-Mat cocrystal. Furthermore, the in vivo studies revealed that Rhe-Mat cocrystal indicated the faster absorption rate and the higher peak blood concentration than the pure Rhe. Hence, it can be concluded that current study successfully improved the solubility and oral bioavailability of Rhe. | Hongjuan Wang Dezhi Yang Wen Zhang Junke Song Ningbo Gong Mingchao Yu Shiying Yang Baoxi Zhang Qiwen Liu Guanhua Du Yang Lu | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 12 | Fast ion diffusion alloy layer facilitating 3D mesh substrate for dendrite-free zinc-ion hybrid capacitors显示文摘Although aqueous zinc ion hybrid capacitors have advantageous integration of batteries and supercapacitors,they still suffer from the inherent problems of dendrite growth and interfacial side reactions on Zn anodes.Herein,a universal fast zinc-ion diffusion layer on a three-dimensional(3 D)mesh structure model is demonstrated to effectively improve Zn plating/stripping reversibility.The fast ion diffusion alloy layer accelerates the Zn^(2+)migration in an orderly manner to homogenize Zn^(2+)flux and overcomes the defects of the commercial mesh substrate,effectively avoiding dendrite growth and side reactions.Consequently,the proof-of-concept silver-zinc alloy modified stainless steel mesh delivers superb reversibility with the high coulombic efficiency over 99.4%at 4 mA cm^(-2)after 1600 cycles and excellent reliability of over 830 h at 1 mA cm^(-2),Its feasibility is also evidenced in commercial zinc ion hybrid capacitors with activated carbon as the cathode.This work enriches the fundamental comprehension of fast zinc-ion diffusion layer combined with a 3 D substrate on the Zn deposition and opens a universal approach to design advanced host for Zn electrodes in zinc ion hybrid capacitors. | Huaming Yu Quanyu Li Wen Liu Han Wang Xuyan Ni Qiwen Zhao Weifeng Wei Xiaobo Ji Yuejiao Chen Libao Chen | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 13 | Endocarditis caused by Arcanobacteriumpyogenes显示文摘A21-year-old male farmer was admitted to our hospital on December 28,2011 with intermittent fever and chills of three months duration.Two weeks previously he had developed chest congestion and shortness of breath.His medical history was unremarkable.On physical examination,his temperature was 37.5℃,pulse 115/ min,and respiratory rate 20/min.His blood pressure was 118/49 mmHg.Cardiac auscultation revealed the presence of a systolic ejection murmur at the left sternal border and diastolic murmur at the right sternal border.A transthoracic echocardiogram performed on December 28 revealed left ventricular hypertrophy,an 8 mm ventricular septum,mild aortic valve stenosis,moderate to severe aortic insufficiency,moderate mitral valve insufficiency,vegetation on the aortic valve (measuring 5 mm×5 mm),and trace pericardial effusion.The remaining physical examination was unremarkable.The laboratory test results for this patient are shown in the Table 1. | Zhang Hui Shi Zhongkai Yang Qiwen Chen Yu Xu Yingchun | 2014 | Chinese Medical Journal2014，，19： | 0 |
| 14 | Plasma non-transferrin-bound iron uptake by the small intestine leads to intestinal injury and intestinal flora dysbiosis in an iron overload mouse model and Caco-2 cells显示文摘Iron overload often occurs during blood transfusion and iron supplementation, resulting in the presence of non-transferrin-bound iron(NTBI) in host plasma and damage to multiple organs, but effects on the intestine have rarely been reported. In this study, an iron overload mouse model with plasma NTBI was established by intraperitoneal injection of iron dextran. We found that plasma NTBI damaged intestinal morphology, caused intestinal oxidative stress injury and reactive oxygen species(ROS) accumulation,and induced intestinal epithelial cell apoptosis. In addition, plasma NTBI increased the relative abundance of Ileibacterium and Desulfovibrio in the cecum, while the relative abundance of Faecalibaculum and Romboutsia was reduced. Ileibacterium may be a potential microbial biomarker of plasma NTBI. Based on the function prediction analysis, plasma NTBI led to the weakening of intestinal microbiota function, significantly reducing the function of the extracellular structure. Further investigation into the mechanism of injury showed that iron absorption in the small intestine significantly increased in the iron group. Caco-2 cell monolayers were used as a model of the intestinal epithelium to study the mechanism of iron transport. By adding ferric ammonium citrate(FAC, plasma NTBI in physiological form) to the basolateral side, the apparent permeability coefficient(Papp) values from the basolateral to the apical side were greater than 3×10^(-6)cm s^(-1). Intracellular ferritin level and apical iron concentration significantly increased, and SLC39A8(ZIP8) and SLC39A14(ZIP14) were highly expressed in the FAC group.Short hairpin RNA(sh RNA) was used to knock down ZIP8 and ZIP14 in Caco-2 cells. Transfection with ZIP14-specific sh RNA decreased intracellular ferritin level and inhibited iron uptake. These results revealed that plasma NTBI may cause intestinal injury and intestinal flora dysbiosis due to the uptake of plasma NTBI from the basolateral side into the small intestine, which is probably mediated by ZIP14. | Qian Zhang Haoxuan Ding Xiaonan Yu Qiwen Wang Xuejiao Li Ruiqiang Zhang Jie Feng | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 15 | Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex显示文摘Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020). | Yuxia Wang Lijie Wu Tian Wang Junlin Liu Fei Li Longquan Jiang Zhongbo Fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua Zhi-Jie Liu | 2024 | Protein & Cell2024，15，3： | 0 |
| 16 | N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats显示文摘Lead exposure induces decreased hippocampal N-methyl-D-aspartic acid(NMDA) receptor gene and protein expressions,which influences the molecular mechanisms of learning and memory.However,lead poisoning-induced differences in NMDA subunit expression,and the correlation of lead poisoning with learning and memory,remain poorly understood.The present study measured differences in expression of NMDA receptor subunits NR1,NR2A,and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure.Results demonstrated decreased NR1,NR2A,and NR2B subunit expressions in some memory-related brain areas.The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant,although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure.There was no difference in NR1 expression following exposure to < 4.8 mmol/L lead,although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus.Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory.Therefore,lead toxicity was dependent on NMDA receptor subunit composition,and NR1,NR2A,and NR2B expressions were associated with time and concentration of lead exposure. | Qiwen Zhu Weijian Hou Jianwen Zhao Yu Yang Qi Zhang Li Guo Lihong Shang YinglinCao Chunfu Wu | 2010 | Neural Regeneration Research2010，5，23： | 0 |
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