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| 1 | Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis显示文摘 | Chaoying Hu Liu Qian Yi Miao Qiuyu Huang Ping Miao Ping Wang Qiwen Yu Hong Nie Jiying Zhang Dongyi He Rong Xu Xuehua Chen Bingya Liu Dongqing Zhang | 2012 | Cellular & Molecular Immunology2012，9，3： | 18 |
| 2 | Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs显示文摘Clinical xenotransplantations have been hampered by human preformed antibody-mediated damage of the xenografts.To overcome biological incompatibility between pigs and humans,one strategy is to remove the major antigens[Gal,Neu5 Gc,and Sd(a)]present on pig cells and tissues.Triple gene(GGTAI,CMAH,and β4 GalNT2)knockout(TKO)pigs were produced in our laboratory by CRISPR-Cas9 targeting.To investigate the antigenicity reduction in the TKO pigs,the expression levels of these three xenoantigens in the cornea,heart,liver,spleen,lung,kidney,and pancreas tissues were examined.The level of human IgG/IgM binding to those tissues was also investigated,with wildtype pig tissues as control.The results showed that aGal,Neu5 Gc,and Sd(a)were markedly positive in all the examined tissues in wildtype pigs but barely detected in TKO pigs.Compared to wildtype pigs,the liver,spleen,and pancreas of TKO pigs showed comparable levels of human IgG and IgM binding,whereas corneas,heart,lung,and kidney of TKO pigs exhibited significantly reduced human IgG and IgM binding.These results indicate that the antigenicity of TKO pig is significantly reduced and the remaining xenoantigens on porcine tissues can be eliminated via a gene targeting approach. | Ronggen Wang Miaomiao Ruan Runjie Zhang Lei Chen Xiaoxue Li Bin Fang Chu Li Xueyang Ren Jiying Liu Qiang Xiong Lining Zhang Yong Jin Lin Li Rongfeng Li Ying Wang Haiyuan Yang Yifan Dai | 2019 | The Journal of Biomedical Research2019，33，4： | 3 |
| 3 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 4 | Current advances of transition metal dichalcogenides in electromagnetic wave absorption:A brief review显示文摘Transition metal dichalcogenides(TMDs)show great advantages in electromagnetic wave(EMW)absorption due to their unique structure and electrical properties.Tremendous research works on TMD-based EMW absorbers have been conducted in the last three years,and the comprehensive and systematical summary is still a rarity.Therefore,it is of great significance to elaborate on the interaction among the morphologies,structures,phases,components,and EMW absorption performances of TMD-based absorbers.This review is devoted to analyzing TMD-based absorbers from the following perspectives:the EMW absorption regulation strategies of TMDs and the latest progress of TMD-based hybrids as EMW absorbers.The absorption mechanisms and component-performance dependency of these achievements are also summarized.Finally,a straightforward insight into industrial revolution upgrading in this promising field is proposed. | Shijie Zhang Jiying Li Xiaotian Jin Guanglei Wu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，3： | 3 |
| 5 | A Lectin from Chinese Mistletoe Increases γδ T Cell-mediated Cytotoxicity through Induction of Caspase-dependent Apoptosis显示文摘在这研究,槲寄生凝集素(ML ) 在 cytokine 网络的人的鲸鱼群妈三角洲 T 房间 cytotoxicity, apoptosis 和调整上从中国槲寄生和这 60 kDa 汉语 ML 的效果被净化被学习。 8 个 T 房间的细胞毒素的性质被使用 51Cr 版本测试评估并且采用了排序的激活荧光的房间和 enzyme-linkedimmunosorbent 试金分析确定房间 membranephospholipid 的 translocation , phosphatidylserine 和原子 DNA 破碎在 apoptosis.It 期间被发现那:(i) ML 有效地在剂量刺激了鲸鱼群妈三角洲 T 房间增长--并且时间依赖者举止;( i i ) ML 增加了鲸鱼群妈三角洲 T 房间 cytotoxicity ;( iii ) ML 能由增加以一种 支持inflammatory 方式调制 lipopolysaccharide-inducedcytokine 版本肿瘤坏死因素( TNF ) -alpharelease 并且禁止反煽动性的白介素( IL )的版本以caspase依赖、CD95独立的方式的-10;(iv) ML inducedapoptosis 。结果显示 ML 是到人的鲸鱼群妈三角洲 T 房间 cytotoxicity, apoptosis 和 cytokine 生产的 potentimmunomodulator。 | Fang GONG Yanhui MA Anlun MA Qiwen YU Jiying ZHANG Hong NIE Xuehua CHEN Baihua SHEN Ningli LI Dongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 2 |
| 6 | Comparison of pH Value, TBA Value, Glycogen and Lactic Acid Content in Muscle of Landrace and Yorkshire under Different Storage Time and Conditions显示文摘In order to assess the meat quality under different storage time and conditions,the pH value,TBA value,glycogen and lactic acid content in muscle of Landrace and Yorkshire were measured. The results showed that within 10 h post slaughtering,post slaughtering time had extremely significant influence on pH value and lactic acid content of Landrace,but had no significant influence on glycogen content and TBA value. On the other hand,post slaughtering time had extremely significant influence on pH value of Yorkshire,but had no significant influence on glycogen,lactic acid content and TBA value. The pH values of Yorkshire at 3,5 and 10 h post slaughtering were 5. 21%( P < 0. 01),5. 64%( P < 0. 05) and 5. 59%( P < 0. 05) higher than those of Landrace,respectively; the lactic acid content in muscle of Landrace at 10 h post slaughtering was 56. 04%( P < 0. 05) higher than that of Yorkshire; the TBA value in muscle of Yorkshire at 10 h post slaughtering was 89. 19%( P < 0. 01) higher than that of Landrace; there was no significant difference in glycogen content between Yorkshire and Landrace. When pork stored at 4℃,storage time had no significant influence on pH value and glycogen content in muscle of Landrace,but had significant influence on drip loss,lactic acid content and TBA value; storage time had no significant influence on pH value,glycogen content and TBA value in muscle of Yorkshire,but extremely significant influence on drip loss and significant influence on lactic acid content. The pH value in muscle of Yorkshire at 24 h post storage at 4℃ was 6. 56%( P <0. 05) higher than that of Landrace; the glycogen contents in muscle of Landrace at 24,48,72,96,120 and 144 h post storage at 4℃ were 84. 90%( P <0. 05),78. 40%( P <0. 01),101. 87%( P <0. 05),83. 80%( P < 0. 05),83. 59%( P < 0. 05) and 67. 25%( P < 0. 01) higher than those of Yorkshire,respectively; the drip loss of Landrace at 72 h post storage and TBA value at 144 h post storage were 55. 70%( P < 0. 05) and 141. 33%( P < 0. 01) higher than those of Yorkshire,respectively; there was no significant difference in glycogen content between Yorkshire and Landrace. When pork stored at -20℃,storage time had significant influence on TBA value in muscle of Landrace,but had no significant influence on pH value,thawing water loss rate,glycogen and lactic acid content; storage time had no significant impact on pH value,thawing water loss rate,glycogen content and TBA value in muscle of Yorkshire,and had significant influence on lactic acid content. The pH value in muscle of Yorkshire at 24 h post storage at -20℃ was 5. 43%( P < 0. 05) higher than that of Landrace; the glycogen contents in muscle of Landrace at 24,48,72,96,120 h post storage at -20℃ were 85. 08%( P < 0. 05),108. 66%( P < 0. 01),72. 69%( P < 0. 05),90. 31%( P < 0. 01),70. 38%( P > 0. 05) higher than those of Yorkshire,respectively; the thawing water loss rates of Landrace at 24 and 72 h were 160. 14%( P <0. 05) and 74. 32%( P <0. 05) higher than those of Yorkshire,respectively; there was no significant difference in lactic acid content and TBA value at the same time point between Yorkshire and Landrace. | Zhang Yin Guo Jianfeng Lin Haichao Wang Jiying Wang Cheng Wu Ying | 2017 | Animal Husbandry and Feed Science2017，9，3： | 2 |
| 7 | A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex显示文摘Tuberous sclerosis complex(TSC)is a dominant genetic neurocutaneous syndrome characterized by multiple organ hamartomas.Although rodent models bearing a germline mutation in either TSC1 or TSC2 gene have been generated,they do not develop pathogenic lesions matching those seen in patients with TSC because of the significant differences between mice and humans,highlighting the need for an improved large animal model of TSC.Here,we successfully generate monoallelic TSC1-modified Bama miniature pigs using the CRISPR/Cas9 system along with somatic cell nuclear transfer(SCNT)technology.The expression of phosphorylated target ribosomal protein S6 is significantly enhanced in the piglets,indicating that disruption of a TSC1 allele activate the mechanistic target of rapamycin(mTOR)signaling pathway.Notably,differing from the mouse TSC models reported previously,the TSC1^(+/−)Bama miniature pig developed cardiac rhabdomyoma and subependymal nodules,resembling the major clinical features that occur in patients with TSC.These TSC1^(+/−)Bama miniature pigs could serve as valuable large animal models for further elucidation of the pathogenesis of TSC and the development of therapeutic strategies for TSC disease. | Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai | 2020 | Journal of Genetics and Genomics2020，47，12： | 2 |
| 8 | All-fiber spatiotemporal mode-locking lasers with large modal dispersion显示文摘It is a challenging problem to balance the modal walk-off(modal dispersion) between multiple transverse modes and chromatic dispersion in long step-index multimode fibers(MMFs). By properly designing the oscillator, we have overcome the difficulty and successfully obtained an all-fiber spatiotemporal mode-locked laser based on step-index MMFs with large modal dispersion for the first time, to our knowledge. Various proofs of spatiotemporal mode-locking(STML) such as spatial, spectral, and temporal properties, are measured and characterized.This laser works at a fundamental frequency of 28.7 MHz, and achieves a pulse laser with single pulse energy of 8 nJ, pulse width of 20.1 ps, and signal-to-noise ratio of-70 dB. In addition, we observe a dynamic evolution of the transverse mode energy during the STML establishment process that has never been reported before. | Huaiwei Zhang Yunhong Zhang Jiying Peng Xinyang Su Xiaosheng Xia Dongjian Xu Junhao Chen Tianran Sun Kai Zheng Jianquan Yao Yi Zheng | 2022 | Photonics Research2022，10，2： | 2 |
| 9 | Investigation of Fluid Flow and Steel Cleanliness in the Continuous Casting Strand显示文摘 | LIFENG ZHANG SUBO YANG KAIKE CAI JIYING LI XIAOGUANG WAN BRIAN G. THOMAS | 2007 | Metallurgical and Materials Transactions B2007，，1： | 1 |
| 10 | Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model显示文摘 | Lin Lin Lianxu Chen Haijun Wang Xuelei Wei Xin Fu Jiying Zhang Kangtao Ma Chunyan Zhou Changlong Yu | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 11 | Mathematical Model of Decarburization of Ultra Low Carbon Steel during RH Treatment显示文摘According to the balance of carbon and oxygen, a decarburization model for the RH treatment has been developed. in which the influence of the mass transfer of carbon and oxygen in the liquid steel and the stirring energy (ε) in the vacuum vessel on decarburization rate has been considered. The conclusion that the volumetric coefficients of the mass transfer of carbon is proportional to ε(1.5) is drawn. Industrical experiment proves this model is reliable. The influence of some factors on decarburization rate has been obtained. which can provide directions for RH treatment The decarburization behavior of steel with RH-OB treatment is also studied. The OB-or-not curve, the optimized OB time and OB amount are discussed. | ZHANG Lifeng JING Xuejing LI Jiying XU Thongbo CAI Kaike(Metallurgy Engineering School, USTB, Beijing 100083, China) | 1997 | International Journal of Minerals,Metallurgy and Materials1997，11，4： | 1 |
| 12 | Influence of long-period pesticide force on genetic polymorphism of wolf spider Pardosa pseudoannulata (Lycosidae: Araneae)显示文摘Wolf spiders are predators in large quantities in the fields. How wolf spiders keep their dominant species status under long-period pesticide force? To answer this question, eight geographical populations of Pardosa pseudoannulata were used as materials to test the influence of geographical habitats on their genomic DNA polymorphism. The RAPD pattern showed polymorphic variations among and within different populations. Total 84 bands amplified by 10 random primers, of which 62 (73.81%) are polymorphic, were generated from 55 individuals of eight geographical populations. Meanwhile, Shannon’s index (Ho= 0.5177) showed a rich genetic diversity of P. pseudoannulata, and most of the genetic variation (64.24%) was found within populations. Multiple regression analysis suggested that it is the climatic variation (such as annual average temperature etc.) that results in adaptive eco-geographic differentiation, and it is the long-period pesticide force that speeds up the genetic differentiation of P. pseudoannulata which changed the genetic diversity of the population. | Sun Jiying Fu Xiuqin Peng Guangxu Zhang Zhigang Yan Hengmei | 2007 | Progress in Natural Science:Materials International2007，17，10： | 1 |
| 13 | Electrical and structural properties of p-type ZnO:N thin films prepared by plasma enhanced chemical vapour deposition 显示文摘 | Zhiyan Xiao Yichun Liu Jiying Zhang | 2005 | Semiconductor Science and Technology2005，20，8： | 1 |
| 14 | Numerical simulation of the effect of hydrogen addition fraction on catalytic micro-combustion characteristics of methane-air 显示文摘 | Yan Yunfei Tang Weimin Zhang Li Pan Wenli Yang Zhongqing Chen Yanrong Lin Jiying | 2014 | International Journal of Hydrogen Energy2014，39，： | 1 |
| 15 | Electrochemical synthesis of polyaniline nano-networks on p-aminobenzene sulfonic acid functionalized glassy carbon electrode: Its use for the simultaneous determination of ascorbic acid and uric acid 显示文摘 | ZHANG Lei ZHANG Chunhua LIAN Jiying | 2008 | Biosens Bioelectron2008，24，4： | 1 |
| 16 | Combined Treatment with Electrocauterization,Carbon Dioxide Laser,and Microneedle Fractional Radiofrequency for Facial Angiofibromas in Tuberous Sclerosis Complex:A Case Report and Literature Review显示文摘Tuberous sclerosis complex is a type of genetic multisystem disease that causes hamartomas in various organs.Facial angiofibromas commonly occur in 80%of patients and are prominently distributed over the cheek,chin,and nasolabial folds with severe disfigurement and emotional distress.Recently,photoelectric devices have been identified for the treatment of angiofibromas with great efficacy and fewer side effects.We report a case of a 42-year-old man with facial angiofibromas,who was treated with a combination of high-frequency electrocauterization,Ultrapulse CO_(2) laser,and microneedle fractional radiofrequency with 7 sessions and a 6-month follow-up.The patient showed great improvement in relation to the elevated lesions and nodules.A low recurrence rate was observed.This is the first study to investigate the efficacy of high-frequency electrocauterization and microneedle fractional radiofrequency in angiofibromas.It may provide an optimal approach for clinicians wherein a combined treatment of various lasers and electric devices is effective for complicated,protuberant,and firm angiofibromas of specific patients. | Jiying DONG Shen WANG Min YAN Jing MI Ying ZENG Huyan LIN Yiqiu ZHANG Min YAO | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 1 |
| 17 | Elcctrical and Structural Properties of p-Typc ZnO : N Thin Films Prepared by Plasma Enhanced Chcmical Vapour Deposition 显示文摘 | XIAO Zhiyan LIU Yichun ZHANG Jiying ct al | 2005 | Scmicond Sci Tcchnol2005，20，8： | 1 |
| 18 | Removal of Cesium From Low-level Radioactive Wastew aters Using M agnetic Potassium Titanium Hexacyanoferrate显示文摘 | ZHANG Hengxuan ZHAO Xuan WEI Jiying | 2015 | Chemical Engineering Journal2015，275，26： | 1 |
| 19 | MgNiO-based metal-semiconductor-metal ultraviolet photodetector显示文摘 | Zhao Yanmin Zhang Jiying Jiang Dayong | 2009 | J Phys D:Appl Phys2009，42，09： | 1 |
| 20 | Intraoperative study on anthropometry and gender differences of the proximal tibial plateau at the arthroplasty resection surface显示文摘 | Yang Bo Yu Jiakuo Gong Xi Chen Lianxu Wang Yongjian Wang Jian Wang Haijun Zhang Jiying | 2014 | Chinese Medical Journal2014，，1： | 1 |
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