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| 1 | Adapting liposomes for oral drug delivery显示文摘Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract,difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes. | Haisheng He Yi Lu Jianping Qi Quangang Zhu Zhongjian Chen Wei Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 23 |
| 2 | Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, in vitro and in vivo evaluation显示文摘Meloxicam(MLX) is efficient in relieving pain and inflammatory symptoms, which, however, is limited by the poor solubility and gastrointestinal side effects. The objective of this study is to develop a nanocrystal formulation to enhance transdermal delivery of MLX. MLX nanocrystals were successfully prepared by the nanoprecipitation technique based on acidbase neutralization. With poloxamer 407 and Tween 80(80/20, w/w) as mixed stabilizers,MLX nanocrystals with particle size of 175 nm were obtained. The crystalline structure of MLX nanocrystals was confirmed by both differential scanning calorimetry and X-ray powder diffractometry. However, the nanoprecipitation process reduced the crystallinity of MLX.Nanocrystals increased both in vitro and in vivo transdermal permeation of MLX compared with the solution and suspension counterparts. Due to the enhanced apparent solubility and dissolution as well as the facilitated hair follicular penetration, nanocrystals present a high and prolonged plasma MLX concentration. And 2.58-and 4.4-fold increase in AUC0 →2 4 h was achieved by nanocrystals comparing with solution and suspension, respectively. In conclusion, nanocrystal is advantageous for transdermal delivery of MLX. | Qina Yu Xiying Wu Quangang Zhu Wei Wu Zhongjian Chen Ye Li Yi Lu | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 3 | Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route显示文摘Self-microemulsifying drug delivery systems(SMEDDSs)have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of biomacromolecules.However,information on gastrointestinal lipolysis and trans-epithelial transport of SMEDDS is rare.Aggregation-caused quenching(ACQ)fuorescent probes are utilized to visualize the in vivo behaviors of SMEDDSs,because the released probes during lipolysis are quenched upon contacting water.Two SMEDDSs composed of medium chain triglyceride and different ratios of Tween-80 and PEG-400 are set as models,meanwhile Neoral?was used as a control.The SMEDDS droplets reside in the digestive tract for as long as 24 h and obey frst order kinetic law of lipolysis.The increased chain length of the triglyceride decreases the lipolysis of the SMEDDSs.Ex vivo imaging of main tissues and histological examination confrm the trans-epithelial transportation of the SMEDDS droplets.Approximately 2%-4%of the given SMEDDSs are transported via the lymph route following epithelial uptake,while liver is the main termination.Caco-2 cell lines confrm the cellular uptake and trans-epithelial transport.In conclusion,a fraction of SMEDDSs can survive the lipolysis in the gastrointestinal tract,permeate across the epithelia,translocate via the lymph,and accumulate mainly in the liver. | Fei Xia Zhongjian Chen Quangang Zhu Jianping Qi Xiaochun Dong Weili Zhao Wei Wu Yi Lu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 4 |
| 4 | Identification and Fibrinolytic Evaluation of an Isoindolone Derivative Isolated from a Rare Marine Fungus Stachybotrys Iongispora FG216显示文摘isoindolone 衍生物,真菌 fibrinolytic 混合物(R)-2,5-bis((2R,3R)-2-((E)-4,8-dimethylnona-3,7-dien-1-yl)-3,5-dihydroxy-2-methyl-7-oxo-3,4,7,9-tetrahydropyrano[2,3-e]isoindol-8(2H)-yl)pentanoic 酸(FGFC1,真菌 fibrinolytic 化合物 1 ) ,从稀罕海洋的微生物种类 Stachybotrys longispora FG216 被孤立。FGFC1 的结构被 1 H NMR, 13 C NMR,红外,和 MS 数据;而且,它也在 vitro 并且在 vivo 为 fibrinolytic 活动被评估。结果证明 FGFC1 的 0.1-0.4 mmol/L 能刺激胞质素活动的产生(由 2.05-11.44 褶层增加了) 由在 vitro 测量 Glu-plasminogen 和 Lys-plasminogen 激活。荧光黄 isothiocyanate (FITC ) 的实验纤维蛋白原降级显示在 fibrinolytic 活动的 FGFC1 的效果被 plasminogen 和 scuPA 调停。另外, FGFC1 (10 mg/kg ) 能在 vivo 溶解大多数 Wistar 老鼠的肺的血栓。FGFC1 以后是一个潜在的 thrombolytic 代理人,是可能的。 | Ge Wang Wenhui Wu Quangang Zhu Shiqing Fu Xiaoyu Wang Shaotong Hong Ruihua Guo Bin Bao | 2015 | Chinese Journal of Chemistry2015，33，9： | 2 |
| 5 | Hypodermin A, a potential agent for prevention of allogeneic acute rejection显示文摘 | Quangang Chen Renjin Chen Jing Liu Honghua Yuan Peng Liu Ankang Hu Lianlian Wu Liurong Fang Shaobo Xiao Xiaorong Zhu | 2015 | Transplant Immunology2015，，3： | 1 |
| 6 | Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus显示文摘 | Yanfang Li Xiaojian Zhang Quangang Xu Qiang Fu Yinbiao Zhu Sujuan Chen Daxin Peng Xiufan Liu | 2012 | Veterinary Microbiology2012，，： | 1 |
| 7 | Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE 2 production in a human keratinocyte cell line HaCaT显示文摘 | Jin Huang Lei Qiu Li Ding Shaozhan Wang Jing Wang Quangang Zhu Fengyu Song Jinhong Hu | 2010 | International Immunopharmacology2010，，10： | 1 |
| 8 | Pharmacokinetics and tissue distribution of a novel marine fibrinolytic compound in Wistar rat following intravenous administrations显示文摘 | Tongwei Su Wenhui Wu Ting Yan Chaoyan Zhang Quangang Zhu Bin Bao | 2013 | Journal of Chromatography B2013，，： | 1 |
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