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| 1 | Efficient one-pot synthesis of n-butyl levulinate from carbohydrates catalyzed by Fe_2(SO_4)_3显示文摘Butyl levulinate(BL) is a promising new candidate as diesel fuel and fuel additive. In this study, an efficient process for a one-pot synthesis of BL from biomass-derived carbohydrates in butanol medium with the catalysis of metal sulfates was developed. The catalytic activity of a series of metal sulfates for the synthesis of BL from fructose was investigated. Among various metal sulfates, ferric sulfate Fe_2(SO_4)_3 was found to be the most efficient catalyst, which gave a remarkably high BL yield of 62.8 mol% under the conditions of 463 K, 3 h, a catalyst dosage of 5.0 g/L, and fructose concentration of 25 g/L. Different carbohydrates including glucose, cellulose, inulin and sucrose were also used for one-pot synthesis of BL with the catalysis of Fe_2(SO_4)_3, showing the yields of 39.6, 30.5, 56.6 and 50.1 mol%, respectively. In addition,the recycling and reuse of Fe_2(SO_4)_3 was studied by characterizing them using powder X-ray diffraction(XRD), scanning electron microscope(SEM), X-ray photoelectron spectroscopy(XPS). A plausible reaction pathway for the one-pot synthesis of BL from fructose was proposed. This study provides a facile and feasible way for the synthesis of BL from biomass. | Ran An Guizhuan Xu Chun Chang Jing Bai Shuqi Fang | 2017 | Journal of Energy Chemistry2017，26，3： | 8 |
| 2 | The Role of ROS in Hydroquinone-induced Inhibition of K562 Cell Erythroid Differentiation显示文摘The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation was investigated.After K562 cells were treated with hydroquinone for 24 h,and hemin was later added to induce erythroid differentiation for 48 h,hydroquinone inhibited hemin-induced | YU Chun Hong Suriguga LI Yang LI Yi Ran TANG Ke Ya JIANG Liang YI Zong Chun | 2014 | Biomedical and Environmental Sciences2014，27，3： | 5 |
| 3 | The role of ezrin-associated protein network in human sperm capacitation显示文摘在精子房间的膜修正在精子 capacitation 代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin 是 ezrin/radixin/merlin 家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的 cross-linker, ezrin 贡献膜表面结构改变。而且,激活 ezrin 和 Rho 分离禁止者, RhoGDI,通过 Rho 激活支持外皮的 cytoskeleton-polymerized 肌动朊的形成。因此, ezrin,肌动朊, RhoGDI, Rho 和血浆膜蛋白质在 vivo 形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明 ezrin 和 RhoGDI1 在人的睾丸被表示。因此,我们寻求了决定 ezrin 鈥揜h oGDI1 鈥揳c 听鈥搈e mbrane 蛋白质网络是否在人的精子 capacitation 有一个角色。我们由西方的污点的结果显示 ezrin 被 threonine567 残余的 phosphorylation 在 capacitation 期间激活。Co-immunoprecipitation 研究表明在精子 capacitation 期间,在 ezrin 和 RhoGDI1 之间的相互作用增加,并且二维的电气泳动胶化的 phosphostaining 证明 RhoGDI1 是 phosphorylated,建议 RhoGDI1 从 RhoA 分裂并且导致精子头上的肌动朊聚合。我们推测那激活的 ezrin 在 capacitation 以后与 polymerized 肌动朊和 glycosylated 膜蛋白质 cd44 交往。用 ezrin 特定或肌动朊特定的 monoclonal 抗体堵住精子 capacitation 减少他们的 acrosome 反应(AR ) 率,但是没独自在 AR 上有效果。一起拿,我们的结果证明由 ezrin, RhoGDI1, RhoA, F 肌动朊和膜蛋白质组成的一个网络工作影响在人的精子 capacitation 期间发生在精子头的膜上的修正。 | Lei Wang Wen Chen Chun Zhao Ran Huo Xue-Jiang Guo Min Lin Xiao-Yan Huang Yun-Dong Mao Zuo-Min Zhou Jia-Hao Sha | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 4 | Bioremediation of Hexavalent Chromium Pollution by Sporosarcina saromensis M52 Isolated from Offshore Sediments in Xiamen, China显示文摘Objective Cr(VI)removal from industrial effluents and sediments has attracted the attention of environmental researchers.In the present study,we aimed to isolate bacteria for Cr(VI)bioremediation from sediment samples and to optimize parameters of biodegradation.Methods Strains with the ability to tolerate Cr(VI)were obtained by serial dilution and spread plate methods and characterized by morphology,16S r DNA identification,and phylogenetic analysis.Cr(VI)was determined using the 1,5-diphenylcarbazide method,and the optimum p H and temperature for degradation were studied using a multiple-factor mixed experimental design.Statistical analysis methods were used to analyze the results.Results Fifty-five strains were obtained,and one strain(Sporosarcina saromensis M52;patent application number:201410819443.3)having the ability to tolerate 500 mg Cr(VI)/L was selected to optimize the degradation conditions.M52 was found be able to efficiently remove 50-200 mg Cr(VI)/L in24 h,achieving the highest removal efficiency at p H 7.0-8.5 and 35°C.Moreover,M52 could completely degrade 100 mg Cr(VI)/L at p H 8.0 and 35°C in 24 h.The mechanism involved in the reduction of Cr(VI)was considered to be bioreduction rather than absorption.Conclusion The strong degradation ability of S.saromensis M52 and its advantageous functional characteristics support the potential use of this organism for bioremediation of heavy metal pollution. | ZHAO Ran WANG Bi CAI Qing Tao LI Xiao Xia LIU Min HU Dong GUO Dong Bei WANG Juan FAN Chun | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 5 | Tumor Localization for Laparoscopic Colorectal Surgery显示文摘 | Yong Beom Cho Woo Yong Lee Hae Ran Yun Won Suk Lee Seong Hyeon Yun Ho-Kyung Chun | 2007 | World Journal of Surgery2007，，7： | 2 |
| 6 | Glucose Biosensor Based on Carbon/PVC-COOH/Ferrocene Composite with Covalently Immobilized Enzyme显示文摘A carbon/PVC-COOH/ferrocene composite electrode used for the determination of glucose has been prepared. The ferrocene acted as mediator was incorporated into the PVC-COOH polymer and the leakage could be prevented. The presence of carboxyl groups on the electrode surface allowed immobilizing enzyme via EDC and NHS. The ratio of PVC-COOH to graphite powder (w/w) has been studied. Amperometric determination of glucose has been performed at potential of 0.30 V vs SCE. The response time was < 15 s. The linear response range was of 0.1-20 mmol/L with a detection limit of 48 μmol/L. | Chun Xiang LI Yun Long ZENG Chun Ran TANG | 2005 | Chinese Chemical Letters2005，16，10： | 2 |
| 7 | Cu-Catalyzed Selective Oxy-Cyanoalkylation of Allylamines with Cycloketone Oxime Esters and CO2显示文摘Summaryof main observation and conclusion The radical-initiated carboxylativecyclization of allylamines with CO2represents an efficientand highly promising strategy to afford valuable 2-oxazolidinones.However,the radical precursorsand pathways to generate radicals in such processes are still lim-ited.Herein,we report the firstCu-catalyzed selective oxy-cyanoalkylation of allylamines with cycloketone oxime esters and CO2viaC-C bond cleavage.Many cyanoalkyl-substituted 2-oxazolidinones are obtained in moderate togood yields withhigh regio-and chemo-selectivities.The utility ofthis re-dox-neutral and cyanide-free method is demonstrated with mild conditions,broad substrate scope,good functional group tolerance and easy scalability. | Chuan-Kun Ran He Huang Xing-Hui Li Wei Wang Jian-Heng Ye Si-Shun Yan Bi-Qin Wang Chun Feng Da-Gang Yu | 2020 | Chinese Journal of Chemistry2020，38，1： | 2 |
| 8 | In vitro study of the nephrotoxicity of total Dahuang(Radix Et Rhizoma Rhei Palmati) anthraquinones and emodin in monolayer human proximal tubular epithelial cells cultured in a transwell chamber显示文摘OBJECTIVE: To examine changes in the morphology and physiological functions of human proximal tubular epithelial cells (HK-2 cells) caused by total Dahuang (Radix Et Rhizoma Rhei Palmati) anthraquinones (TDA) and emodin. METHODS: HK-2 cells were cultured on polycarbonate (PCF) membranes to form a complete monolayer of cells. A fluorescein isothiocyanate- dextran (FITC) permeability assay was conducted and secretion of γ-glutamyltranspeptidase (GGT), lactate dehydrogenase (LDH), N-acetyl-β-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) was examined. The reabsorption of glucose and the excretion of para-aminohippuric acid (PAH) by HK-2 cells were also examined. The morphology of HK-2 cells was observed using optical microscopy and scanning electron microscopy. The cytoskeleton of HK-2 cells was observed under a fluorescence microscope. RESULTS: Compared with the results for the dimethyl sulfoxide group, treatment of cells with TDA and emodin showed statistically significant differences in the FITC leakage rate, the apical / basolateral ratio of LDH and GGT, and the secretion of GGT, LDH, NAG and KIM-1. At 64 μg/mL, TDA markedly inhibited blood glucose reabsorption and remarkably suppressed PAH excretion by HK-2 cells. Both TDA and emodin caused various degrees of damage to the morphology and cytoskeleton of HK-2 cells with the degree of damage correlating positively with the dosage of the tested substances.CONCLUSION: Both TDA and emodin caused damage to human renal proximal tubular epithelial cells at certain dosages. At the same dosage, TDA caused more severe damage than emodin to the HK-2 cells. | Cao Chunyu Hui Lianqiang Li Chun Yang Yifei Zhang Jiyuan Liu Ting Hao Ran Zhang Yi | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 9 | Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells显示文摘 | Jaemoo Chun Ran Joo Choi Salman Khan Dong-Sung Lee Youn-Chul Kim Young-Joo Nam Dong-Ung Lee Yeong Shik Kim | 2012 | International Immunopharmacology2012，，4： | 1 |
| 10 | Antibacterial Effect of Autologous Platelet-Rich Gel Derived from Subjects with Diabetic Dermal Ulcers In Vitro显示文摘 | Lihong Chen Chun Wang Hengchuan Liu Guanjian Liu Xingwu Ran Weiping Jia | 2013 | Journal of Diabetes Research2013，，： | 1 |
| 11 | Effects of total cholesterol and triglyceride on the percentage difference between the low-density lipop rotein cholesterol concentration measured directly and calculated using the Friedewald formula显示文摘 | Ran Jun K Park H I Chun S | 2008 | Clin Chem Lab Med2008，46，3： | 1 |
| 12 | Association of high-density lipoprotein cholesterol and wound healing in patients with diabetic foot ulcers显示文摘To the Editor:Diabetic foot ulcers(DFUs)are an important cause of morbidity in patients with diabetes mellitus(DM).The prevalence of foot ulcers in patients with diabetes is 4%to 10%,with the lifetime incidence estimated to be between 19%and 34%.[1]DFUs have become a considerable burden on patients and the healthcare service system.However,the mechanism is not fully understood,and DFUs are still difficult to heal.High-density lipoproteins(HDL)are circulating particles composed of phospholipids,cholesterol,and proteins.HDL attracted lots of attention mainly because of its protective effect against the development of atherosclerosis.However,it has been shown that decreased HDL levels are correlated with an increased risk of DM and its complications.The association of HDL with DFUs has also received much attention.Lower levels of HDL cholesterol were associated with increased risk for foot ulceration in patients with diabetes(odds ratio 0.427,95%confidence interval[CI]0.228-0.799,P=0.008).[2]HDL cholesterol levels were also revealed to be an independent risk factor of lower-extremity amputation and wound-related death in patients with DFUs(hazard ratio[HR]0.30,95%CI 0.14-0.63,P=0.002).Therefore,there might be a potential correlation between HDL and wound healing. | Lihong Chen Wanxia Ma Dawei Chen Chun Wang Yun Gao Xingwu Ran | 2022 | Chinese Medical Journal2022，，1： | 1 |
| 13 | The influence of low atmospheric pressure on carbon monoxide of nheptane pool fires 显示文摘 | Fang Jun Chun Yuyu Tu Ran | 2008 | Journal of Hazardous Materials2008，154，123： | 1 |
| 14 | Acaricidal Activity of Boenninghausenia sessilicarpa Against Panonychus citri显示文摘Acaricidal activity of Boenninghausenia sessilicarpa against Panonychus citri was tested in the laboratory. Four solvents were used to prepare crude extracts, petroleum ether, chloroform, ethyl acetate, and ethanol, among which ethanol was the most effective one. The results suggested that ethanol extracts of B. sessilicarpa had eminent acaricidal and ovicidal activities. Concentrated extracts were prepared using petroleum ether, chloroform, ethyl acetate, or distilled water as solvent. Mite mortality rates in the concentrated extracts by petroleum ether, chloroform, or distilled water were significantly lower than those by ethyl acetate. The LC50 values of eggs and female mites were 0.7639 and 1.1033 mg mL-1, respectively. After liquid chromatography and thin layer chromatography, the concentrated extracts were separated into 14 groups of fractions and further tests for their acaricidal and ovicidal activities were conducted. Fraction 2 was found to possess higher acaricidal and ovicidal activities. The mortality of eggs and adult mites were 85.83 and 63.07%, respectively. Moreover, fraction 2 showed moderate oviposition inhibition effect (0.8795) against P. citri when the used dose was higher than 2.5 mg mL-1. | YANG Hui-zhi UU Jun-hua LI Qing LI Hong-jun LIU Hao-qiang YAO Ting-shan RAN Chun LEI Hui-de | 2009 | Agricultural Sciences in China2009，8，9： | 1 |
| 15 | Is rectal MRI beneficial for determining the location of rectal cancer with respect to the peritoneal reflection?显示文摘 | Eun Joo Jung Chun Geun Ryu Gangmi Kim Su Ran Kim Sang Eun Nam Hee Sun Park Young Jun Kim Dae-Yong Hwang | 2012 | Radiology and Oncology2012，，4： | 1 |
| 16 | Acute and 30-day oral toxicity studies of administered carnosic acid显示文摘 | Qun Lu Wang Hao Li Xin Xiang Li Chun Yong Cui Ran Wang Ning Xiao Yu Liang Xue Chen | 2012 | Food and Chemical Toxicology2012，，12： | 1 |
| 17 | An Alternative Pathway in Colorectal Carcinogenesis Based on the Mismatch Repair System and p53 Expression in Korean Patients with Sporadic Colorectal Cancer显示文摘 | Hyoung Ran Kim Hee Cheol Kim Hae-Ran Yun Seok Hyung Kim Cheol Keun Park Yong Beom Cho Seong Hyeon Yun Woo Yong Lee Ho-Kyung Chun | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 18 | The Influence of Low Atmospheric Pressure on Carbon Monoxide of n - heptane Pool Fires 显示文摘 | Fang Jun Chun yu Yu Tu Ran | 2008 | Journal of Hazardous Materials2008，，154： | 1 |
| 19 | Susceptibility and Esterase Activity in Citrus Red Mite Panonychus cirri (McGregor) (Acari: Tetranychidae) After Selection with Phoxim 显示文摘 | CHEN Zhi-yong RAN Chun ZHANG Ling | 2009 | International Journal of Acarology2009，，： | 1 |
| 20 | Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea显示文摘 | Kyung Ran Jun Woochang Lee Mi Sook Jang Sail Chun Gi-Won Song Kwan Tae Park Sung Gyu Lee Duck Jong Han Changwon Kang Dae-Yeon Cho Jin Q. Kim Won-Ki Min | 2009 | Transplantation2009，，8： | 1 |
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