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| 1 | Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions显示文摘 | Zhen Bian Li-Min Li Rui Tang Dong-Xia Hou Xi Chen Chen-Yu Zhang Ke Zen | 2010 | Cell Research2010，20，9： | 15 |
| 2 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 3 | Therapeutic Effect of Chang'an Ⅰ Recipe(肠安Ⅰ号方) on Irritable Bowel Syndrome with Diarrhea: A Multicenter Randomized Double-Blind Placebo-Controlled Clinical Trial显示文摘Objective: To evaluate the efficacy and safety of Chinese medicine(CM) decoction Chang'an Ⅰ Recipe(肠安Ⅰ号方) in the treatment of irritable bowel syndrome with diarrhea(IBS-D). Method: A multicenter, randomized, double-blind, placebo-controlled clinical trial was designed. Based on the order of inclusion, the IBS-D patients were randomly assigned to the treatment group or the placebo control group, administrated with Chang'an Ⅰ Recipe or placebo, 150 m L/bag, 3 times daily, for 8 weeks. The primary indices of efficacy included the effective rates of IBS symptom severity score(IBS-SSS) and the differences in adequate relief(AR) responder; the secondary indexes of efficacy included the changes in scores of the IBS Quality of Life(IBS-QOL) and Hospital Anxiety and Depression(HAD) scales. The safety indices included adverse events and related laboratory tests. Results: A total of 216 patients were included, with 109 in the treatment group and 107 in the control group, and finally 206 were included in the full analysis set(FAS), 191 were included in the per protocol set(PPS). In FAS, the total effective rate was 67.6% and 40.2% for the treatment and control groups, respectively, with 95% confidence interval(CI) for difference in the effective rates between the two groups of 14.4%–40.2%; while in PPS, the total effective rate was 71.3% and 41.2% for the treatment and control groups, respectively(95% CI 16.6%–43.4%). The consistent conclusions of FAS and PPS showed a better efficacy in the treatment group. Both FAS and PPS showed higher AR responder in the treatment group(FAS: 59.6% vs. 35.5%; PPS: 62.8% vs. 38.1%). As for IBS-QOL, the total score and scores in various dimensions of IBS-QOL were not significantly different between the two groups(P>0.05). Both anxiety and depression scales of HAD were not significantly different between the two groups(P>0.05). No adverse events or laboratory abnormalities were found to be obviously related to the tested drugs or clinically significant. Conclusion: Chang'an Ⅰ Recipe was more effective than placebo in the treatment of IBS-D, with no obvious adverse reactions.(No.ChiC TR-TRC-09000328) | TANG Xu-dong LU Bin LI Zhen-hua WEI Wei MENG Li-na LI Bao-shuang TANG Zhi-peng GAO Rui WANG Feng-yun LU Fang BIAN Li-qun ZHAO Ying-pan WANG Ping ZHANG Yin-qiang | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 6 |
| 4 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 5 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 6 | Regional Differences and Characteristics of Soil Organic Carbon Density Between Dry Land and Paddy Field in China显示文摘Study on the regional characteristics of soil organic carbon (SOC) density in farmland will not only contribute greatly to the technique of soil productivity enhancement, but also give evidences of technique selection and policy making for carbon sequestration in soils. Based on the second national soil survey of China, the situation of SOC density in the plow layer of farmland was analyzed under different land use patterns. Results showed that SOC density in the plow layer was about 3.15 kg m-2 in average ranging from 0.81 to 12.68 kg m-2. The highest density was found in the southeastern region with an average of 3.63 kg m-2, while the lowest occurring in the northwestern region with an average of 3.00 kg m-2. The variation coefficient of SOC density in the plow layer of farmland was 57%, which was 35% lower than that of non-farmland soils. Compared to SOC density in the dry land, SOC density in paddy soils was 13% higher with a lower variation coefficient between different regions. In addition, the relationships between the climatic factors (annual average temperature and precipitation) and SOC density were lower in farmland than those in non-farmland soils, as well as lower in paddy soils than those in dry land of farmland. These results suggest that anthropogenic disturbances have great impacts on SOC density in farmland soils, especially in paddy soils, indicating that Chinese rice cropping may contribute greatly to the SOC stability and sequestration in paddy field. | XU Quan RUI Wen-yi BIAN Xin-min ZHANG Wei-jian | 2007 | Agricultural Sciences in China2007，6，8： | 5 |
| 7 | Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway显示文摘Gallbladder carcinoma (GBC) is the most comm on and aggressive can cer of the biliary tract. Liensinine has been proved to have hypotensive effect. However, the effect of liensinine on GBC is still unknown. The aim of this study is to investigate the effect and mechanism of liensinine in human GBC cells. Cell viability assay and colony formation assay were performed to assess cell growth and proliferation. Flow cytometry analysis was used to investigate cell cycle apoptosis in vitro. Hoechst 33342 staining was also used to evaluate cell apoptosis. Western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis.The effect of liensinine treatment in vivo was experimented with xenografted tumors. We found that liensinine significantly inhibited the growth of GBC cells both in vivo and in vitro. In vitro, cell growth and proliferation were significantly suppressed by liensinine in a dose- and time-dependent manner. In vivo, liensinine inhibited tumor growth. Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins. Liensinine also affected GBC cell cycle progress!on and induced apoptosis by down-regulating phosphorylated protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), phosphatidylinositol 3-kinase (PI3K), and Zinc finger X-chromosomal protein (ZFX) proteins. Liensinine induced G2/M arrest and apoptosis in gallbladder cancer, suggest!ng that liensinine might represent a novel and effective agent against gallbladder cancer. | Yitong Shen Rui Bian Yaxiong Li Yuan Gao Yingbin Liu Yuzhen Xu Xiaoling Song Yijian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 8 | Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening显示文摘 | Hui Wang Lei Wang Zheng Wu Rong Sun Haifeng Jin Jifeng Ma Lili Liu Rui Ling Jun Yi Ling Wang Jiefang Bian Jianghao Chen Nanlin Li Shifang Yuan Jun Yun | 2014 | Medical Oncology2014，，12： | 4 |
| 9 | ADS Injector-I 2 K superfluid helium cryogenic system显示文摘The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in China.High-energy particle accelerators and colliders contain long strings of superconducting devices,superconducting radio frequency cavities,and magnets,which may require cooling by 2 K superfluid helium(HeliumⅡ).2 K superfluid helium cryogenic system has become a research hot spot in the field of superconducting accelerators.In this study,the ADS Injector-I 2 K cryogenic system is examined in detail.The cryogenic system scheme design,key equipment,and technology design,such as the 2 K Joule–Thomson(J–T)heat exchanger and cryomodules CM1+CM2 design,are examined,in addition to the commissioning and operation of the cryogenic system.The ADS Injector-I 2 K cryogenic system is the first 100 W superfluid helium system designed and built independently in China.The ADS proton beam reached 10 Me V at 10 m A in July 2016 and 10 Me V at 2 m A in continuous mode in January 2017 and has been operated reliably for over 15,000 h,proving that the design of ADS Injector-I 2 K cryogenic system,the key equipment,and technology research are reasonable,reliable,and meet the requirements.The research into key technologies provides valuable engineering experience that can be helpful for future projects such as CI-ADS(China Initiative Accelerator-Driven System),SHINE(Shanghai High Repetition Rate XFEL and Extreme Light Facility),PAPS(Platform of Advanced Photon Source Technology),and CEPC(Circular Electron-Positron Collider),thereby developing national expertise in the field of superfluid helium cryogenic systems. | Rui Ge Shao-Peng Li Rui-Xiong Han Miao-Fu Xu Liang-Rui Sun Min-Jing Sang Rui Ye Zhuo Zhang Jie-Hao Zhang Xiang-Zhen Zhang Lin Bian Jian-Qin Zhang Mei Li Chang-Cheng Ma Zheng-Ze Chang Tong-Xian Zhao Yong-Cheng Jiang | 2020 | Nuclear Science and Techniques2020，31，4： | 4 |
| 10 | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2显示文摘Mutations and transient conformational movements of the receptor binding domain(RBD)that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).To mitigate viral escape,we developed a cocktail of neutralizing antibodies(NAbs)targeting epitopes located on different domains of spike(S)protein.Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs,targeting the N-terminal domain(NTD)and RBD domain of S,effective at n M concentrations.Remarkably,a combination of RBD-targeting NAbs and NTD-binding NAbs,FC05,enhanced the neutralization potency in cell-based assays and an animal model.Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM)structures of antigen-binding fragments bound to S unveil determinants of immunogenicity.Combinations of immunogens,identified in the NTD and RBD of S,when immunized in rabbits and macaques,elicited potent protective immune responses against SARS-CoV-2.More importantly,two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge,without observable antibody-dependent enhancement of infection.These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD. | Li Zhang Lei Cao Xing-Su Gao Bin-Yang Zheng Yong-Qiang Deng Jing-Xin Li Rui Feng Qian Bian Xi-Ling Guo Nan Wang Hong-Ying Qiu Lei Wang Zhen Cui Qing Ye Geng Chen Kui-Kui Lu Yin Chen Yu-Tao Chen Hong-Xing Pan Jiaping Yu Wenrong Yao Bao-Li Zhu Jianping Chen Yong Liu Cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu | 2021 | National Science Review2021，8，8： | 4 |
| 11 | IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling显示文摘The epithelial-mesenchymal transition(EMT)process results in fibrosis of renal tubular epithelial cells and is of great importance in the development of acute kidney injury(AKI).Urinary IGF-binding protein-7(IGFBP7)was obviously increased in AKI and is considered to be a biomarker for AKI.However,whether it has an effect on the inhibition of lipopolysaccharide(LPS)-induced EMT in human HK2 cells and on that of cecal ligation and puncture(CLP)-induced EMT in human HK2 cells and in mice remains to be elucidated.Western blot analysis was performed to examine the phosphorylation of ERK1/2 level and expressions of IGFBP7,ERK1/2,EMT markers,such as E-cadherin,α-SMA,and vimentin,and EMT regulatory factors,such as Snail,transforming growth factor-β1(TGF-β1),and connective tissue growth factor(CTGF).The levels of IGFBP7,TGF-β1,and CTGF were detected by enzyme linked immunosorbent assay(ELISA).Concentrations of creatinine(Cr),blood urea nitrogen(BUN),and albumin(ALB)were measured by biochemical analysis.Here,we found that LPS promoted EMT and ERK1/2 activation in HK2 cells,which were inhibited by silencing of IGFBP7.Furthermore,IGFBP7 overexpression significantly increased EMT and ERK1/2 activation in HK2 cells,which were inhibited by ERK1/2 signaling inhibitor PD98059.IGFBP7 knockdown effectively attenuated renal fibrosis,concentrations of Cr,BUN and ALB,and activation of ERK1/2 signaling in CLP-induced mice.These results suggest that inhibiting IGFBP7 can effectively protect the renal tubular epithelial cells from EMT induced by LPS or CLP both in vitro and in vivo,which may be associated with inactivation of ERK1/2 signaling. | Xiaolin Wang Yan Li Zhenzhen Zhao Yan Meng Jinjun Bian Rui Bao Kaimin Zhu Tao Yang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 3 |
| 12 | COVID-19-associated monocytic encephalitis(CAME):histological and proteomic evidence from autopsy显示文摘Severe neurological symptoms are associated with Coronavirus disease 2019(COVID-19).However,the morphologic features,pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection.In this study,neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining,ultrastructural examination under electron microscopy,and an image threshold method,in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals.Differentially expressed proteins were identified by quantitative proteomic assays.Histopathological findings included neurophagocytosis,microglia nodules,satellite phenomena,extensive edema,focal hemorrhage,and infarction,as well as infiltrating mononuclear cells.Immunostaining of COVID-19 brains revealed extensive activation of both microglia and astrocytes,severe damage of the blood-brain barrier(BBB)and various degrees of perivascular infiltration by predominantly CD14+/CD16+/CD141+/CCR7+/CD11c+monocytes and occasionally CD4+/CD8+T lymphocytes.Quantitative proteomic assays combined with bioinformatics analysis identified upregulated proteins predominantly involved in immune responses,autophagy and cellular metabolism in COVID-19 patient brains compared with control brains.Proteins involved in brain development,neuroprotection,and extracellular matrix proteins of the basement membrane were downregulated,potentially caused by the activation of transforming growth factorβreceptor and vascular endothelial growth factor signaling pathways.Thus,our results define histopathological and molecular profiles of COVID-19-associated monocytic encephalitis(CAME)and suggest potential therapeutic targets. | Pei-Pei Zhang Zhi-Cheng He Xiao-Hong Yao Rui Tang Jie Ma Tao Luo Chuhong Zhu Tian-Ran Li Xindong Liu Dingyu Zhang Shuyang Zhang Yi-Fang Ping Ling Leng Xiu-Wu Bian | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 13 | Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial显示文摘Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. | CHENG Chung-wah ZHANG Li ZHAO Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 3 |
| 14 | Expression of BpPIN is associated with IAA levels and the formation of lobed leaves in Betula pendula ’Dalecartica’显示文摘Auxin polar transport genes PIN(PINFORMED)determine the concentration gradient of auxin in plants.To understand the relationship between the development of different tissues in Betula pendula‘Dalecartica’,BpPIN gene expression and indole-3-acetic acid(IAA)content were analyzed using qRT-PCR,ELISA,and GUS staining.Gene expression of BpPIN genes and IAA levels in the leaves,buds,stems,xylem,and roots of B.pendula‘Dalecartica’and B.pendula as a control were measured.BpPIN1,BpPIN5 and BpPIN6 were upregulated during development in both species,suggesting a dominant role in the development of B.pendula‘Dalecartica’leaves.Moreover,BpPIN1 gene expression was positively associated with IAA levels during leaf,vein and petiole development in B.pendula‘Dalecartica’only.The correlation coefficient of the first three leaves was 0.69(P=0.04),while that of the first three petioles was 0.85(P=0.001).In addition,GUS staining of the pro-DR5::GUS transgenic line of cultivar was correlated with the results of BpPIN1 expression.Overall,these findings suggest that BpPIN1 is associated with the formation of lobed leaves in B.pendula‘Dalecartica’. | Chang Qu Xiuyan Bian Rui Han Jing Jiang Qibin Yu Guifeng Liu | 2020 | Journal of Forestry Research2020，31，1： | 3 |
| 15 | 2 K superfluid helium cryogenic vertical test system for superconducting cavity of ADS Injector I显示文摘Purpose The accelerator-driven subcritical system(ADS)is the internationally recognized key technology of nuclear waste problem treatment,of which superconducting proton linac is an important part.With the support of the strategic science and technology pilot project of the Chinese Academy of Sciences,the Institute of High Energy Physics of the Chinese Academy of Sciences took the lead in the research of 325 MHz superconducting proton linac,which is called ADS Injector I.The superconducting accelerator part of ADS Injector I mainly consists of 14 spoke-type superconducting cavities withβ0.12.At the same time,the research work of various cavities with differentβvalues and different frequencies is also carried out to lay the technical and technological foundation for ADS main accelerator.The only way to determine whether the superconducting cavity can reach the design target and whether it can be installed into the cryostat is the vertical test at cryogenic.As the only way to test the microwave performance of the superconducting cavity at low temperature,the vertical test can accurately test the acceleration gradient Eacc and the corresponding quality factor Q0 of the superconducting cavity.The design and construction of the superconducting cavity vertical test facility is based on the practical needs of the pilot project and the long-term development of the superconducting accelerator.Methods This paper mainly introduces the design and construction of the cryogenic vertical test system for the superconducting cavity of ADS Injector I,including the system scheme design,process design,heat load analysis,2 K superfluid helium obtaining method,system commissioning and operation,etc.Results and Conclusion The static heat leakage at 2 K of the 2 K superfluid helium vertical test system of ADS Injector I is 1.624W,which has reached the international advanced level.The 2 K superfluid helium vertical test system of ADS Injector I after constructed not only meets the test requirements of ADS pilot project,but also conducts 4 K and 2 K vertical tests for other different types of superconducting cavities and relevant cryogenic experiments. | Rui Ge Liangrui Sun Miaofu Xu Rui Ye Xiangzhen Zhang Minjing Sang Ruixiong Han Zhuo Zhang Jiehao Zhang Lin Bian Mei Li Changcheng Ma Tongxian Zhao Yongcheng Jiang Zhengze Chang Shaopeng Li | 2020 | Radiation Detection Technology and Methods2020，4，2： | 2 |
| 16 | Review of dynamic performance and control strategy of supercritical CO_(2) Brayton cycle显示文摘In recent years,the supercritical carbon dioxide Brayton cycle(SCBC)has been regarded as a promising next generation power conversation system,owing to its high efficiency,compact components,applicability for various kinds of heat sources and so on.This paper makes a detailed review of the dynamic performance and control strategy of SCBC.The dynamic simulation model of SCBC is overviewed in detail including different modeling methods of the main component models and validation of system model.As the most inevitable approach to evaluate the dynamic performance of SCBC in practice,existing SCBC test benches concerning SCBC are well collected and presented.Based on these,the open loop dynamic system performances by changing different manipulated variables are reviewed and then various control methods for essential state parameters by different manipulated variables are summarized.Finally,various control strategies of load following and startup/shutdown are clearly presented.With the rapid development of artificial intelligence,combining the core mechanism model and key parameters identifi-cation based on experimental data and machine learning to obtain an accurate model within a wide range of working condition is a popular trend in modeling of SCBC.Moreover,deep reinforcement learning will be a potential method for the control strategy in SCBC. | Xuan Wang Rui Wang Xingyan Bian Jinwen Cai Hua Tian Gequn Shu Xinyu Li Zheng Qin | 2021 | Energy and AI2021，5，3： | 2 |
| 17 | Compositions and Pressure-Temperature Conditions of Metamorphic Fluids Overprinting the Talate VMS Pb-Zn Deposit,Southern Altay,China显示文摘Talate Pb-Zn 存款,在扩大泥盆纪 Kelan 的 NW-SE 的东方定位了南部的 Altaides 的暴烈沉积的盆,发生在更低的泥盆纪更低的 Kangbutiebao 形成的上面的秒 lithological 节的变形岩石系列(D 1 k 12) 。Pb-Zn orebodies 由迟了的硫化物石英静脉层状、套印。二个不同矿化作用时期被识别:一个海底的暴烈的沉积呼气时期和一个变形热水的矿化作用时期。变形套印时期能进一步被划分成二个阶段:透镜状的石英静脉在绿泥石片岩和忍受矿石的地平线的 leptite 开发了的床上用品平行描绘的一个早阶段,和一个迟了的阶段由横切绿泥石片岩和 leptite 或巨大的 Pb-Zn 矿石的 pyrite-chalcopyrite-quartz 静脉代表了。在早变形的石英静脉的液体包括主要是公司 2-H2 O-NaCl 并且碳(有次要的水的包括的公司 2±CH4±N2) 包括。公司 2-H2 O-NaCl 包括有 294-368 ° C 的 homogenization 温度, T m,到 -60.5°C, T > h, 7.7 ~ 29.6 °C 的 CO2 ( 一致进液体) ,并且 5.5-7.4 wt% NaCl eqv 的咸度。碳的包括有 T m,到 -58.5°C, 和 T > h,到 20.6 °C 的 -4.2 的 CO2 。在迟了的硫化物石英静脉的液体包括被公司 2-H2 O-NaCl 和公司 2±CH4 包括。公司 2-H2 O-NaCl 包括有 T h, 142 ~ 360 °C 的小孩 , T m,到 -56.6°C, T > h,到 29.4 °C 的 -6.0 的 CO2 ( 一致进液体) 并且 2.4-16.5 wt% NaCl eqv 的咸度。碳的包括有 T m,到 -57.3°C, 和 T > h,到 28.7 °C 的 -27.0 的 CO2 。水的包括(L-V ) 有 T m,到 -1.3°C 和 T > h, 205 ~ 412 °C 的小孩 。套住公司 2-rich 液体包括的条件的磅(100-370 MPa, 250-368 °C ) 是可比较的与迟了 -- 到 regional 以后变态条件。公司 2-rich 液体,可能源于地区性的变态,涉及重做和主要矿石的金属丰富。把结果基于这些, Talate Pb-Zn 存款作为变形液体修改的 VMS 存款被分类。有 banded 和角砾岩结构的巨大的 Pb-Zn 矿石在与 extensional 联系的海底的暴烈的沉积呼气的早时期被开发 subduction 相关的背弧盆,和忍受 polymetallic 硫化物的石英静脉在与二叠三叠纪的大陆人碰撞有关的变形热水的重迭的迟了的时期被形成。 | ZHANG Hui XU Jiuhua CHENG Xihui GUO Xuji LIN Longhua YANG Rui BIAN Chunjing | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 2 |
| 18 | MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin显示文摘 | Jian-Yong Sun Yi Huang Ji-Peng Li Xiang Zhang Lei Wang Yan-Ling Meng Bo Yan Yong-Qian Bian Jing Zhao Wei-Zhong Wang An-Gang Yang Rui Zhang | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 2 |
| 19 | Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm显示文摘Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients. | Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 20 | Influence of clusters in melt on the subsequent glass-formation and crystallization of Fe–Si–B metallic glasses显示文摘The liquid structure of seven representative Fe–Si–B alloys has been investigated by ab initio molecular dynamics simulation focusing on the role of clusters in terms of glass-forming ability(GFA) and crystallization. It is demonstrated that the type of primary phase precipitated from amorphous state under heat treatment is determined by the relative fraction and role of various clusters in melt. The alloy melt shows higher stability and resultantly larger GFA when there is no dominant cluster or several clusters coexist, which explains the different GFAs and crystallization processes at various ratios of Si and B in the Fe–Si–B system. The close correlation among clusters, crystalline phase and GFA is also studied. | Shaoxiong Zhou Bangshao Dong Rui Xiang Guangqiang Zhang Jingyu Qin Xiufang Bian | 2015 | Progress in Natural Science:Materials International2015，25，2： | 1 |
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