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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Liver disease in pregnancy显示文摘 | Deepak Joshi Andra James Alberto Quaglia Rachel H Westbrook Michael A Heneghan | 2010 | The Lancet2010，，9714： | 2 |
| 3 | MicroRNA-144 is a circulating effector of remote ischemic preconditioning显示文摘 | Jing Li Sagar Rohailla Nitai Gelber James Rutka Nesrin Sabah Rachel A. Gladstone Can Wei Pingzhao Hu Rajesh K. Kharbanda Andrew N. Redington | 2014 | Basic Research in Cardiology2014，，5： | 2 |
| 4 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 5 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 6 | Inter-observer agreement for Crohn’s disease sub-phenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study显示文摘 | Krupa Krishnaprasad Jane M. Andrews Ian C. Lawrance Timothy Florin Richard B. Gearry Rupert W.L. Leong Gillian Mahy Peter Bampton Ruth Prosser Peta Leach Laurie Chitti Charles Cock Rachel Grafton Anthony R. Croft Sharon Cooke James D. Doecke Graham L. Rad | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 7 | Differential Cadherin Expression: Potential Markers for Epithelial to Mesenchymal Transformation During Tumor Progression显示文摘 | Georgia Agiostratidou James Hulit Greg R. Phillips Rachel B. Hazan | 2007 | Journal of Mammary Gland Biology and Neoplasia2007，，2： | 1 |
| 8 | Using a Game to Engage Stakeholders in Extreme Event Attribution Science显示文摘The impacts of weather and climate-related disasters are increasing,and climate change can exacerbate many disasters.Effectively communicating climate risk and integrating science into policy requires scientists and stakeholders to work together.But dialogue between scientists and policymakers can be challenging given the inherently multidimensional nature of the issues at stake when managing climate risks.Building on the growing use of serious games to create dialogue between stakeholders,we present a new game for policymakers called Climate Attribution Under Loss and Damage:Risking,Observing,Negotiating(CAULDRON).CAULDRON aims to communicate understanding of the science attributing extreme events to climate change in a memorable and compelling way,and create space for dialogue around policy decisions addressing changing risks and loss and damage from climate change.We describe the process of developing CAULDRON,and draw on observations of players and their feedback to demonstrate its potential to facilitate the interpretation of probabilistic climate information and the understanding of its relevance to informing policy.Scientists looking to engage with stakeholders can learn valuable lessons in adopting similar innovative approaches.The suitability of games depends on the policy context but,if used appropriately,experiential learning can drive coproduced understanding and meaningful dialogue. | Hannah R.Parker Rosalind J.Cornforth Pablo Suarez Myles R.Allen Emily Boyd Rachel James Richard G.Jones Friederike E.L.Otto Peter Walton | 2016 | International Journal of Disaster Risk Science2016，7，4： | 1 |
| 9 | Exposure of the US population to lead in 1991~1994显示文摘 | James L P Rachel B K Debra J B | 1998 | Environ Health Perspect1998，106，： | 1 |
| 10 | Natural history of chronic renal insufficiency after partial and radical nephrectomy显示文摘 | James McKiernan Rachel Simmons Jared Katz Paul Russo | 2002 | Urology2002，，6： | 1 |
| 11 | The impact of taxes and transfer payments on the distribution of income: A parametric comparison显示文摘 | Samuel R. Dastrup Rachel Hartshorn James B. McDonald | 2007 | The Journal of Economic Inequality2007，，3： | 1 |
| 12 | User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability显示文摘 | Paul A. Yushkevich Joseph Piven Heather Cody Hazlett Rachel Gimpel Smith Sean Ho James C. Gee Guido Gerig | 2006 | Neuroimage2006，，： | 1 |
| 13 | Initial Demonstration of in Vivo Tracing of Axonal Projections in the Macaque Brain and Comparison with the Human Brain Using Diffusion Tensor Imaging and Fast Marching Tractography显示文摘 | Geoffrey J.M. Parker Klaas E. Stephan Gareth J. Barker James B. Rowe David G. MacManus Claudia A.M. Wheeler-Kingshott Olga Ciccarelli Richard E. Passingham Rachel L. Spinks Roger N. Lemon Robert Turner | 2002 | Neuroimage2002，，4： | 1 |
| 14 | Clinical implications of discordance between low-density lipoprotein cholesterol and particle number显示文摘 | James D. Otvos Samia Mora Irina Shalaurova Philip Greenland Rachel H. Mackey David C. Goff | 2011 | Journal of Clinical Lipidology2011，，2： | 1 |
| 15 | Stress-induced co-expression of alternative respiratory chain components in Arabidopsis thaliana显示文摘 | Rachel Clifton Ryan Lister Karen L. Parker Pia G. Sappl Dina Elhafez A. Harvey Millar David A. Day James Whelan | 2005 | Plant Molecular Biology2005，，2： | 1 |
| 16 | Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity显示文摘 | Vikrant P. Rachakonda Valerie L. Reeves Jules Aljammal Rachel C. Wills Joy S. Trybula James P. DeLany Petra C. Kienesberger Erin E. Kershaw | 2015 | Obesity2015，，： | 1 |
| 17 | Aldosterone 显示文摘 | Rachell E John P James D | 2002 | Adv Physiol Educ2002，26，1： | 1 |
| 18 | Cognitive function in morbidly obese individuals with and without binge eating disorder显示文摘 | Rachel Galioto Mary Beth Spitznagel Gladys Strain Michael Devlin Ronald Cohen Robert Paul Ross D. Crosby James E. Mitchell John Gunstad | 2012 | Comprehensive Psychiatry2012，，5： | 1 |
| 19 | Why Privacy is Important显示文摘 | James Rachels | 1975 | Philosophy&Public Affairs1975，，4： | 1 |
| 20 | Metabolomics as a diagnostic tool for hepatology: validation in a naturally occurring canine model显示文摘 | Phillip David Whitfield Peter-John Mantyla Noble Hilary Major Robert Jeffrey Beynon Rachel Burrow Alistair Iain Freeman Alexander James German | 2005 | Metabolomics2005，，3： | 1 |
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