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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Study of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d broiler chickens显示文摘To study the influence of different levels of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d Arbor Acres(AA) broilers, a total of 800 one-day-old healthy broilers were randomly divided into 5 groups with 4 replicates per group and 40 broilers per replicate. Broilers were fed a basic diet(group 1) which acted as the control group, and 4 other groups(2 to 5) were fed the basal diet with B. subtilis added at concentrations of 100, 150, 200 and 250 mg/kg, respectively for 42 days. The results showed as follow: the average daily gain(ADG) of group 4 was significantly higher than(P < 0.05) that of group 1, and the average daily feed intake(ADFI) of group 5 was the highest but the differences between groups were not significant(P > 0.05). The feed to gain ratio(F/G) of all the experimental groups was lower than that of the control and the difference was significant in group 4(P < 0.05). In addition, supplementation of B. subtilis increased the apparent metabolism of crude protein(P > 0.05), crude fat(P > 0.05), dry matter(P > 0.05) and organic matter(P < 0.05). B. subtilis decreased the Escherichia coli and Salmonella populations in the cecum. This shows that adding B. subtilis to the broiler diet can improve the growth performance, increase feed efficiency, regulate serum index and reduce harmful bacteria in the intestinal tract. Based on our study, it could be recommended that addition of B. subtilis at 200 mg/kg could improve the growth performance of broilers. | Zhenhua Gao Haohao Wu Lin Shi Xiaohui Zhang Ran Sheng Fuquan Yin Ravi Gooneratne | 2017 | Animal Nutrition2017，，2： | 23 |
| 3 | Highly efficient generation of arbitrary vector beams with tunable polarization, phase, and amplitude显示文摘We propose an efficient and robust method to generate tunable vector beams by employing a single phasetype spatial light modulator(SLM). With this method, a linearly polarized Gaussian beam can be converted into a vector beam with arbitrarily controllable polarization state, phase, and amplitude. The energy loss during the conversion is greatly reduced and depends mainly on the reflectivity of the SLM. We experimentally demonstrate that conversion efficiency of about 47% is achieved by using an SLM with reflectivity of 62%.Several typical vector beams, including cylindrical vector beams, vector beams on higher order Poincaré spheres,and arbitrary vector beams attached with phases and with tunable amplitude, are generated and verified experimentally. This method is also expected to create high-power vector beams and play important roles in optical fabrication and light trapping. | SHENG LIU SHUXIA QI YI ZHANG PENG LI DONGJING WU LEI RAN JIANLIN ZHAO | 2018 | Photonics Research2018，6，4： | 23 |
| 4 | Effects of fluid balance on prognosis of acute respiratory distress syndrome patients secondary to sepsis显示文摘BACKGROUND:Fluid management is crucial to acute respiratory distress syndrome(ARDS)secondary to sepsis.However,choices of fluid resuscitation strategies and fluid input volumes remain a thorny problem.Our study aimed to elucidate the relationship between fluid balance and prognosis of ARDS patients secondary to sepsis.METHODS:Our study included 322 sepsis patients from Ruijin Hospital between 2014 and 2018,and 84 patients were diagnosed as ARDS within 72 hours after onset of sepsis according to Berlin ARDS Defi nition.RESULTS:Among the 322 sepsis patients,84(26.1%)were complicated with ARDS within 72 hours.ARDS patients had a lower oxygenation index(PaO2/FiO2166.4±71.0 vs.255.0±91.2,P<0.05),longer duration of mechanical ventilation(11[6-24]days vs.0[0-0]days,P<0.05)than those without ARDS.Sepsis patients with ARDS showed daily positive net fl uid balance during seven days compared with those without ARDS who showed daily negative net fluid balance since the second day with signifi cant statistical differences.Among the 84 sepsis patients with ARDS,58(69.0%)died.Mean daily fl uid input volumes were much lower in survivors than in non-survivors(43.2±16.7 mL/kg vs.51.0±25.2 mL/kg,P<0.05)while output volumes were much higher in survivors(45.2±19.8 mL/kg vs.40.2±22.7 mL/kg,P<0.05).Using binary logistic regression analysis,we found that the mean daily fl uid balance was independently associated with mortality of sepsis patients complicating with ARDS(P<0.05).CONCLUSIONS:Early negative fluid balance is independently associated with a better prognosis of sepsis patients complicated with ARDS. | Yu-ming Wang Yan-jun Zheng Ying Chen Yun-chuan Huang Wei-wei Chen Ran Ji Li-li Xu Zhi-tao Yang Hui-qiu Sheng Hong-ping Qu En-qiang Mao Er-zhen Chen | 2020 | World Journal of Emergency Medicine2020，11，4： | 11 |
| 5 | Mapping the permafrost stability on the Tibetan Plateau for 2005–2015显示文摘Data scarcity is a major obstacle for high-resolution mapping of permafrost on the Tibetan Plateau(TP).This study produces a new permafrost stability distribution map for the 2010 s(2005–2015)derived from the predicted mean annual ground temperature(MAGT)at a depth of zero annual amplitude(10–25 m)by integrating remotely sensed freezing degree-days and thawing degree-days,snow cover days,leaf area index,soil bulk density,high-accuracy soil moisture data,and in situ MAGT measurements from 237 boreholes on the TP by using an ensemble learning method that employs a support vector regression model based on distance-blocked resampled training data with 200 repetitions.Validation of the new permafrost map indicates that it is probably the most accurate of all currently available maps.This map shows that the total area of permafrost on the TP,excluding glaciers and lakes,is approximately 115.02(105.47–129.59)×10^4 km^2.The areas corresponding to the very stable,stable,semi-stable,transitional,and unstable types are 0.86×10^4,9.62×10^4,38.45×10^4,42.29×10^4,and 23.80×10^4 km^2,respectively.This new map is of fundamental importance for engineering planning and design,ecosystem management,and evaluation of the permafrost change in the future on the TP as a baseline. | Youhua RAN Xin LI Guodong CHENG Zhuotong NAN Jinxing CHE Yu SHENG Qingbai WU Huijun JIN Dongliang LUO Zhiguang TANG Xiaobo WU | 2021 | Science China Earth Sciences2021，64，1： | 11 |
| 6 | AP2γ regulates neural and epidermal development down- stream of the BMP pathway at early stages of ectodermal patterning显示文摘骨头形态基因的蛋白质(BMP ) 禁止神经说明并且在 ectodermal patterning 期间导致表皮的区别。然而,这个过程的机制很好没被理解。这里,我们显示出那 AP2γ,一个抄写因素使活跃之物蛋白质(AP )-2 家庭成员,在 pluripotent 干细胞的神经区别期间是由 BMP4 的 upregulated。AP2γ 击倒;便于老鼠胚胎的干细胞(转换字符) 神经命运决心并且损害表皮的区别,而 AP2γoverexpression 禁止神经变换并且支持表皮的承诺。在早小鸡胚胎, AP2γ在 HH 舞台 3 前在全部 epiblast 被表示,逐渐地,到通常认为的表皮的外胚层的移动在 HH 期间上演 4。在未来神经的板 AP2γ也禁止过多的神经扩大和它在表面外胚层支持表皮的开发。而且, AP2γ在部分救的转换字符和小鸡胚胎击倒神经抑制和表皮的正式就职 BMP4 完成。机械学的研究证明 BMP4 直接调整 AP2γ通过对 AP2γ 有约束力的 Smad1 的表示;倡导者。一起拿,我们在小鸡胚胎在 ectodermal patterning 的早阶段期间建议那, AP2γBMP 小径下游地行动在未来的神经的板中限制早熟的神经扩大并且在未来开始表皮的区别表皮的外胚层。 | Yunbo Qiao Yue Zhu Nengyin Sheng Jun Chen Ran Tao Qingqing Zhu Ting Zhang Cheng Qian Naihe Jing | 2012 | Cell Research2012，22，11： | 4 |
| 7 | Efficacy of glycyrrhizin combined with cyclosporine in the treatment of non-severe aplastic anemia显示文摘 | REN Cui-ai LI Yan-xiang CUI Jing-ying SHENG Zhi-xin RAN Xue-hong WANG Bao-hong ZHANG Mao-hong | 2013 | Chinese Medical Journal2013，，11： | 3 |
| 8 | Two new steroidal alkaloids from Veratrum nigrum var.ussuriense显示文摘二新 steroidal 碱, veraussines A (1 ) 和 B (2 ) 从 Veratrum nigrum var 的根和根茎被孤立。ussuriense。他们的结构作为 N-(ethoxycarbonyl )-1,2,3,15-tetrahydroxy-5-jervanin-12-en-11-one (1 ) 和 N-(methoxycarbonyl ) 被决定由分光镜的分析的 -1,2,3,15-tetrahydroxy-5-jervanin-12-en-11-one (2 ) 。 | Xue Feng Zhou Zhi Gang Gao Xu Ran Han Wei Jie Zhao Shi Sheng Wang | 2010 | Chinese Chemical Letters2010，21，10： | 2 |
| 9 | Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma显示文摘Here,evodiamine(EVO)and the photosensitizer indocyanine green(ICG)were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma(OSCC).EVO,as an active component extracted from traditional Chinese medicine,not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation,thus working as a contrast agent for positron emission tomography/computed tomography(PET/CT)imaging.Moreover,EVO could exhibit peroxidase-like catalytic activity,converting endogenous tumor H2O2 into cytotoxic reactive oxygen species(ROS),enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of EVO.As proven by in vitro and in vivo experiments,guided by optical imaging and PET/CT imaging,we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy. | Zheng Wei Huihui Zou Gongyuan Liu Chuanhui Song Chuanchao Tang Sheng Chen Guorong Zhang Jianchuan Ran Yufeng Wang Xiteng Yin Yu Cai Wei Han | 2021 | Bioactive Materials2021，6，7： | 2 |
| 10 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 11 | Attitude control system design and on-orbit performance analysis of nano-satellite––‘‘Tian Tuo 1’’显示文摘‘‘Tian Tuo 1''(TT-1) nano-satellite is the first single-board nano-satellite that was successfully launched in China. The main objective of TT-1 is technology demonstration and scientific measurements. The satellite carries out the significant exploration of single-board architecture feasibility validation, and it is tailored to the low-cost philosophy by adopting numerous commercialoff-the-shelf(COTS) components. The satellite is featured with three-axis stabilization control capability. A pitch bias momentum wheel and three magnetic coils are adopted as control actuators.The sun sensors, magnetometers and a three-axis gyro are employed as the measurement sensors.The quaternion estimator(QUEST) and unscented Kalman filter(UKF) method are adopted for the nano-satellite attitude determination. On-orbit data received by ground station is conducted to analysis the performance of attitude determination and control system(ADCS). The results show that the design of ADCS for TT-1 is suitable, robust and feasible. | Ran Dechao Sheng Tao Cao Lu Chen Xiaoqian Zhao Yong | 2014 | Chinese Journal of Aeronautics2014，27，3： | 2 |
| 12 | Silk Fibroin‑Based Wearable All‑Fiber Multifunctional Sensor for Smart Clothing显示文摘Wearable sensing technology enables the interaction between the physical world and the digital world,as takes an irreplaceable role in development of the Internet of Things(IoT),and artificial intelligence(AI).However,increasing requirements posed by rapid development of wearable electronic information technology bring about many for wearable sensing technology,such as the demands for ultrahigh flexibility,air permeability,excellent biocompatibility,and multifunctional integration.Herein,we propose a wearable all-fiber multifunctional sensor(AFMS)based on a biocompatible material,i.e.,silk fibroin.A simple two-layer configuration of a silk fiber film and an interdigital Ag nanowires(AgNWs)electrode was designed to construct the AFMS,in which silk fibroin simultaneously serves as a fundamental supporting component and a functional sensing component.Electrospinning and spray coating technologies were introduced to process the silk fiber film and the AgNWs electrode.The all-fiber configuration allows AFMS to possess ultrahigh flexibility and good air permeability,and silk fibroin enables the AFMS to have excellent biocompatibility.More importantly,benefiting from the all-fiber structure and the environmentally sensitive dielectric property of silk fibroin,the AFMS presented multiple sensing characteristics,including pressure sensing,temperature sensing,and humidity sensing.Among them,the pressure sensing function reached a high sensitivity of 2.27 pF/kPa(7.5%/kPa)and a remarkable resolution of~26 Pa in the low pressure range.Additionally,the outstanding mechanical reliability and sensing stability of AFMS were proven by a systematic experiment.In addition,the AFMS was successfully applied for smart mask for breathing monitoring and a smart glove for bending angle recognition of finger joints.Multiple sensing characteristics combined with prominent fundamental features enable the AFMS tremendous potential in the smart sensing field,e.g.,smart clothing. | Dan‑Liang Wen Yu‑Xing Pang Peng Huang Yi‑Lin Wang Xin‑Ran Zhang Hai‑Tao Deng Xiao‑Sheng Zhang | 2022 | Advanced Fiber Materials2022，4，4： | 2 |
| 13 | Persistent organic pollutants in environment of the Pearl River Delta, China: an overview显示文摘 | Jiamo Fu Bixian Mai Guoying Sheng Gan Zhang Xinming Wang Ping’an Peng Xianming Xiao Rong Ran Fanzhong Cheng Xianzhi Peng Zhishi Wang U Wa Tang | 2003 | Chemosphere2003，，9： | 2 |
| 14 | Electroporation-Mediated Immunization of a Candidate DNA Vaccine Expressing Dengue Virus Serotype 4 prM-E Antigen Confers Long-Term Protection in Mice显示文摘Dengue fever, caused by dengue viruses(DENVs), is a widespread mosquito-borne zoonotic disease; however, there is no available anti-dengue vaccine for worldwide use. In the current study, a DNA vaccine candidate(pV-D4 ME) expressing prM-E protein of DENV serotype 4(DENV-4) was constructed, and its immunogenicity and protection were evaluated in immunocompetent BALB/c mice. The pV-D4 ME candidate vaccine induced effective humoral and cellular immunity of mice against DENV-4 in vivo when administered both at 50 μg and 5 μg through electroporation. Two weeks after receiving three immunizations, both doses of pV-D4 ME DNA were shown to confer effective protection against lethal DENV-4 challenge. Notably, at 6 months after the three immunizations, 50 μg, but not 5 μg, of pV-D4 ME could provide stable protection(100% survival rate) against DENV-4 lethal challenge without any obvious clinical signs. These results suggest that immunization with 50 μg pV-D4 ME through electroporation could confer effective and long-term protection against DENV-4, offering a promising approach for development of a novel DNA vaccine against DENVs. | Ziyang Sheng Hui Chen Kaihao Feng Na Gao Ran Wang Peigang Wang Dongying Fan Jing An | 2019 | Virologica Sinica2019，34，1： | 2 |
| 15 | Persistent organic pollutants in environment of the Pearl River Delta, China: an overview显示文摘 | Jiamo Fu Bixian Mai Guoying Sheng Gan Zhang Xinming Wang Ping’an Peng Xianming Xiao Rong Ran Fanzhong Cheng Xianzhi Peng Zhishi Wang U Wa Tang | 2003 | Chemosphere2003，，9： | 2 |
| 16 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 17 | Kerogen in an aquifer mate- rial and its strong sorption for nonionic organic pollutants 显示文摘 | Ran Yong Xiao Bao-hua Huang Wei-lin Peng Ping-am Liu De-han Fu Jia-mo Sheng Guo-ying | 2003 | J Environ Qual2003，32，17： | 1 |
| 18 | Persistent organic pollutants in environment of the Pearl River Delta, China: An overview显示文摘 | Fu Jia-mo Mai Bi-xian Sheng Guo-ying Zhang Gan Wang Xin-ming Peng Ping-an Xiao Xian-ming Ran Yong Cheng Fan-zhong Peng Xian-zhi Wang Zhi-shi Tang U-wa | 2003 | Chemosphere2003，52，9： | 1 |
| 19 | Sorption Kinetics of Organic Contaminants by Sandy Aquifer and Its Kerogen Isolate 显示文摘 | Ran Yong Xing Bao-shaaa Rao P S C Sheng Guo-ying Fu Jia-mo | 2005 | Environ Sci Technol2005，39，16： | 1 |
| 20 | Sorption and desorption of 1,4-dichlorobenzene on peat显示文摘Sorption and desorption of 1,4-dichlorobenzene (DCB) on peat (>92% organic matter) display large-scale hysteresis and nonlinearity. The magnitude of desorption hysteresis decreases in the order: untreated Pahokee peat (P)> acid treated peat (FP)> humin (TP). The desorption percentages are lower than 28% of the sorbed 1, 4-DCB after desorbing for 6 days. The sorption and desorption isotherms are well fitted to Freundlich equation, whose parameter 1/n ranges from 0.055 to 0.527. Moreover, the parameter 1/n of the desorption isotherm is significantly lower than that of the sorption isotherm, but the parameter logK increases on contrary to 1/n. The desorption isotherms are very well fitted to Langmuir equation, whose Qm decreases in the order: TP>FP> P. The apparent partition coefficients (Kp) increase with increasing sorption time or decreasing aqueous equilibrium concentration of DCB. And Kp of P is significantly higher than that of FP or TP. | RAN Yong LIN Zheng WANG Xili MIN Yushun SHENG Guoying FU Jiamo | 2000 | Chinese Science Bulletin2000，45，S1： | 1 |
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