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| 1 | Multicolor Luminescent Carbon Nanoparticles: Synthesis, Supramolecular Assembly with Porphyrin, Intrinsic Peroxidase-Like Catalytic Activity and Applications显示文摘光碳 nanoparticles (CNP ) 是到 nanomaterials 的世界的新来者并且象因为他们的迷人的光致发光和潜力,是为未来 nanodevices 的有希望的积木为传统的 heavy-metals-based 量点用作无毒的代替一样处于健康和环境应用显示出大影响。此处,荧光灯 CNP 被 refluxing 与 HNO3 从蜡烛煤烟准备了并且随后由单个 centrifugation 分开了。CNP 能被实验公式 C1H0.677O0.586N0.015Na0.069 代表,并且有 20100 nm 的一种尺寸, 3.0 nm 的高度, 7.31 ns 汣癯牥的一生吗? | Xiaohui Wang Konggang Qu Bailu Xu Jinsong Ren Xiaogang Qu | 2011 | Nano Research2011，4，9： | 15 |
| 2 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 3 | Polyoxometalate-based nanozyme: Design of a multifunctional enzyme for multi-faceted treatment of Alzheimer's disease显示文摘 | Nan Gao Kai Dong Andong Zhao Hanjun Sun Ying Wang Jinsong Ren Xiaogang Qu | 2016 | Nano Research2016，9，4： | 7 |
| 4 | Visible-light-driven enhanced antibacterial and biofilm elimination activity of graphitic carbon nitride by embedded Ag nanoparticles显示文摘有 photocatalytic 活动的半导体 nanomaterials 为许多应用有潜力。支持 photocatalytic 活动的一个有效方法在一个半导体上正在扔高贵金属 nanoparticles (NP ) ,自从 NP 作为禁止 photoexcited 电子洞对的快再结合并且从而提高反应的氧种类(ROS ) 的产生的优秀电子领受人扮演的高贵金属。此处,一个高度有效的平台, graphitic 碳氮化物( g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”>有嵌入的 Ag nanoparticles 的 4 ) nanosheets ( Ag/g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 ),被综合由一灵巧的线路。在可见轻照耀下面, Ag/g-C 的 ROS 生产<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanohybrids 极大地与太古的 g-C 相比被改进<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanosheets ,并且而且, nanohybrids 显示出驱散细菌的 biofilms 的提高的抗菌剂功效和能力。我们第一次证明 Ag/g-C < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 是在可见的光下面的有效杀菌代理人照耀,和罐头也为 biofilm 提供一个新方法消除。Ag/g-C 的提高的抗菌剂性质和破坏 biofilm 能力 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 可以为许多提供生物医学的应用。 | Wei Bing Zhaowei Chen Hanjun Sun Peng Shi Nao Gao Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，5： | 7 |
| 5 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 6 | Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing显示文摘Artificial enzymes have provided great antimicrobial activity to combat wound infection.However,the lack of tissue repair capability compromised their treatment effect.Therefore,development of novel artificial enzyme concurrently with the excellent antibacterial activity and the property of promoting wound healing are required.Here,we demonstrated the hydrogel-based artificial enzyme composed of copper and amino acids possessed intrinsic peroxidase-like catalytic activity,which could combat wound pathogen effectively and accelerate wound healing by stimulating angiogenesis and collagen deposition.Furthermore,the system possesses good biocompatibility for practical application.The synergic effect of the hydrogel-based artificial enzyme promises the system as a new paradigm in bacteria-infected wound healing therapy. | Hao Qiu Fang Pu Zhengwei Liu Xuemeng Liu Kai Dong Chaoqun Liu Jinsong Ren Xiaogang Qu | 2020 | Nano Research2020，13，2： | 6 |
| 7 | Prognostic value of clinicopathological characteristics in patients with pancreatic cancer显示文摘Background:The purpose of this study was to analyze me effects of all clinical characteristics on the overall survival time,in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer.Methods:A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital,Shanghai Jiaotong University School of Medicine,between January 2002 and December 2012.There were 68 men and 35 women;the median age was 62 years.Diagnoses of pancreatic cancer in all patients were confirmed by histopathology,cytology,or clinical diagnosis.The Kaplan-Meier method was performed to calculate the overall survival rate.The log-rank method was used to examine the univariate analysis.The Cox regression model was performed for multivariate analysis.Results:The median survival time was 293 days,the 1-,2-,and 3-year survival rates were 27.18%,5.83%,and 1.94%,respectively.Cox regression analysis revealed that age(P=0.015),Karnofsky performance status(PS)(P=0.002),surgical types(P<0.001),and platelet counts(P<0.001) were independent prognostic factors affecting the overall survival of patients with pancreatic cancer.Conclusions:Pancreatic cancer had a poor prognosis,the general physical condition,age,the availability of radical surgery,and platelet counts were factors influencing the overall survival of patients with pancreatic cancer. | Mei Geng Haoping Xu Ruobing Ren Qing Qu Chengfang Shangguan Junwei Wu Jinsong Jiang Hao Li Weiguo Cao | 2015 | Chinese Journal of Cancer Research2015，27，5： | 4 |
| 8 | Chemically exfoliated WS2 nanosheets efficiently inhibit amyloid β-peptide aggregation and can be used for photothermal treatment of Alzheimer's disease显示文摘 | Meng Li Andong Zhao Kai Dong Wen Li Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，10： | 4 |
| 9 | Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation显示文摘淀粉的肽(A) 聚集是在 Alzheimers 疾病(广告) 的致病的关键步。生产的抑制, A 的存在总数和清理的溶解对广告代表有效治疗学的策略。此处,新奇的铂(II ) 协调了 graphitic 碳氮化物(g-C 3 N 4) nanosheet (g-C 3 N 4@Pt) 被设计了 covalently 绑在 A 并且调制肽聚集和毒性。而且, g-C 3 N 4@Pt nanosheets 拥有高 photocatalytic 活动并且能氧化在可见轻照耀之上的 A,显著地 attenuating 聚集力量和 A 的 neurotoxicity。由于它穿过血大脑障碍(BBB ) 和它的好 biocompatibility 的能力, g-C 3 N 4@Pt nanosheet 是聚集的一个有希望的禁止者。这研究可以为为广告的处理使用的新奇多功能的 nanomaterials 的工程担任一个模型。 | Meng Li Yijia Guan Zhaowei Chen Nan Gao Jinsong Ren Kai Dong Xiaogang Qu | 2016 | Nano Research2016，9，8： | 3 |
| 10 | Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dual- functionalized graphene substrate显示文摘这里,我们报导 dual-functionalized 基于在 -cyclodextrin 之间的超分子的相互作用触发癌症房间版本的电气化学的底层(临床的试用 II aptamer AS1411 functionalized graphene 上的 -CD) 和 Fc 站台。一方面,主人客人相互作用能电气化学地是可逆的控制了认识到癌症房间捕获 / 释放,和 1-adamantylamine 绑定能进一步由和 CD 的竞争相互作用放大这个表面变化。在另一方面, AS1411 aptamer 和它的互补 DNA (cDNA ) 能也为房间粘附被用作一个可切换的锚。我们的工作给一个例子为没有标签, multi-functionalized 在修改表面也提供的 graphene 上为房间 catch-and-release 基于 aptamer 和 -CD/graphene-modified 表面和这个多方法触发了房间版本他们的潜在的生物医学的申请。 | Lingyan Feng Wen Li Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，3： | 3 |
| 11 | A pH-switched mesoporous nanoreactor for synergetic therapy显示文摘作为 pH 敏感的药搬运人的一种新类型,锌氧化物 nanoparticles (ZnO NP ) 收到了许多注意。ZnO NP 在生理的 pH 是稳定的,但是能在酸的肿瘤环境快速溶解(pH < 6 ) 产生细胞毒素的锌离子和反应的氧种类(ROS ) 。然而,蛋白质日冕通常引起 ZnO NP 的非特定的降级,它更加限制了他们的申请。此处, pH 敏感的 nanoreactor 的一种新类型(ZnO-DOX@F-mSiO 2-FA), 瞄准了减少 ZnO NP 的非特定的降级,被介绍。在酸的肿瘤环境(pH < 6 ) ,它能释放有效地杀死癌症房间的细胞毒素的锌离子, ROS,和 anticancer 药。另外,从荧光黄 isothiocyanate (FITC ) 射出的荧光标记 mesoporous 为硅石(F-mSiO 2) 和 doxorubicin (纪录影片) 能被用来监视 anticancer 药的版本行为。这份报告提供一个新方法避免 ZnO NP 的非特定的降级,导致由利用导致 NPs 的氧化应力和指向的药释放的 ZnO 的合作治疗。 | Zhengqing Yan Andong Zhao Xinping Liu Jinsong Ren Xiaogang Qu | 2017 | Nano Research2017，10，5： | 2 |
| 12 | Phytochemical-encapsulated nanoplatform for "ondemand" synergistic treatment of multidrug-resistant bacteria显示文摘尽管 phytochemicals 是为与抵抗细菌作斗争的传统的抗菌素的一种有希望的选择,选择的低水溶解度和缺乏严重妨碍他们的普遍应用。此处,我们构造了激活玻尿酸酵素的按需的交货 nanocarrier 为 multidrug 抵抗的细菌的 synergistic 处理包含植物香精油(PEO ) 。PEO 的 bioavailability 和选择被提高,抗菌剂效果被与 nanocarrier 的 photothermal 效果结合显著地改进。这个抗菌剂系统成功地被申请有在老鼠的可以忽略的 cytotoxicity 和 biotoxicity 的愈合的 methicillin 抵抗的葡萄球菌感染 aureus 的创伤。给抗菌素抵抗的增加的风险,我们相信这包含 phytochemical 的 nanoplatform 将提供一个长期的答案并且是为联系皮的细菌的感染的一个新强大的工具。 | Panpan Sun Yan Zhang Xiang Ran Chaoying Liu Zhenzhen Wang Jinsong Ren Xiaogang Qu | 2018 | Nano Research2018，11，7： | 2 |
| 13 | Biomolecule-templated photochemical synthesis of silver nanoparticles: Multiple readouts of localized surface plasmon resonance for pattern recognition显示文摘 | Fang Pu Xiang Ran Meng Guan Yanyan Huang Jinsong Ren Xiaogang Qu | 2018 | Nano Research2018，11，6： | 1 |
| 14 | A grapheme functionalized electrochemical aptasensor for selective label-free detection of cancer cell显示文摘 | Lingyan Feng Yong chen Jinsong Ren | 2011 | Biomaterial2011，32，11： | 1 |
| 15 | Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy显示文摘Nitric oxide(NO)gas therapy,especially,L-arginine(L-Arg)-based NO treatment strategies have attracted extensive attention in the field of oncotherapy.However,current strategies are unable to differentiate well between normal cells and cancer cells,which may lead to unpredictable toxicity.Motivated by the fact that mitochondria of cancer cells can express excessive nitric oxide synthetase(NOS),herein,a nanozyme-based NO generator,cerium oxide(CeO_(2))-AT,is fabricated to specifically catalyze the production of NO in cancer cells for selective tumor treatment.In this system,after being endocytosed into cancer cells,the generator can produce a number of NO under the catalysis of NOS in mitochondria of cancer cells,which can disrupt the mitochondrial respiratory chain of tumor cells and further induce cell apoptosis.In addition,the generator with catalase(CAT)-like activity can catalyze H_(2)O_(2)to produce O_(2),which can promote the generation of NO and improve the performance of NO gas therapy.What is more,our system has no obvious impact on the viability of normal cells owing to the less production of NO.Our work paves a new way for the development of highly selective NO-based treatment particularly useful for the safe and specific cancer therapy. | Mengyu Sun Yanjuan Sang Qingqing Deng Zhengwei Liu Jinsong Ren Xiaogang Qu | 2022 | Nano Research2022，15，6： | 1 |
| 16 | Highly sensitive electroehemiluminescent eytosensing using carbon nanodot@ Ag hybrid material and graphene for dual signal amplification 显示文摘 | WU Li WANG Jiasi REN Jinsong | 2013 | Chem Commun2013，49，50： | 1 |
| 17 | Influences of car body vertical flexibility on ride quality of passenger railway vehicles显示文摘 | ZHOU Jinsong GOODALL R REN Lihui | 2009 | Proceeding of the Institution of Mechanical Engineers Part F: Journal of Rail and Rapid Transit2009，223，5： | 1 |
| 18 | Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer's disease显示文摘Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species (ROS). Although metal chelation is a promising therapeutic strategy for Alzheimer's disease (AD), the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with Aβ plaques from those required by normal metal homeostasis. Furthermore, the multifactorial nature of AD and the current lack of an accepted unitary theory to account for AD neurodegeneration also restrict AD treatment through a single therapeutic strategy. This paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for AD treatment. This electrically responsive drug release platform, based on conducting polymer polypyrrole (PPy) incorporated with graphene-mesoporous silica nanohybrids (GSN) nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. Electrochemical stimulation can treat peripheral nerve injury (PNI) to stimulate neurite outgrowth. This novel system can also effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aβ-related toxicity. The purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for AD treatment. | Li Wu Jiasi Wang Nan Gao Jinsong Ren Andong Zhao Xiaogang Qu | 2015 | Nano Research2015，8，7： | 1 |
| 19 | A cytotoxic amyloid oligomer self-triggered and NIR- enhanced amyloidosis therapeutic system显示文摘We report a new strategy for improving the efficiency of non-specific amyloidosis therapeutic drugs by coating amyloid-responsive lipid bilayers. The approach had drawn inspiration from amyloid oligomer-mediated cell membrane disruption in the pathogenesis of amyloidosis. A graphene-mesoporous silica hybrid (GMS)-supported lipid bilayer (GMS-Lip) system was used as a drug carrier, Drugs were well confined inside the nanocarrier until encountering amyloid oligomers, which could pierce the lipid bilayer coat and cause drug release. To ensure release efficiency, use of a near-infrared (NIR) laser was also introduced to facilitate drug release, taking advantage of the photothermal effect of GMS and thermal sensitivity of lipid bilayers. To facilitate tracking, fluorescent dyes were co-loaded with drugs within GMS-Lip and the NIR laser was used once the oligomer-triggered release had been signaled. Because of the spatially and temporally controllable property of light, the NIR-assisted release could be easily and selectively activated locally by tracking the fluorescence signal. Our design is based on arnyloidosis pathogenesis, the cytotoxic amyloid oligomer self-triggered release via cell membrane disruption, for the controlled release of drug molecules. The results may shed light on the development of pathogenesis- inspired drug delivery systems, | Can Xu Peng Shi Meng Li Jinsong Ren xiaogang Qu | 2015 | Nano Research2015，8，7： | 1 |
| 20 | Nanocomposite incorporating V205 nanowires and gold nanoparticles for mimicking an enzyme cascade reaction and its application in the detection of biomolecules 显示文摘 | Qu Konggang Shi Peng Ren Jinsong | 2014 | Chem Eur J2014，20，24： | 1 |
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