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| 1 | Endothelial PDGF-BB/PDGFR-βsignaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation显示文摘The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis(OA)remain unknown.No pharmacological intervention can currently prevent the progression of osteoarthritis.Accumulating evidence has shown that subchondral bone deterioration is a primary trigger for overlying cartilage degeneration.We previously found that H-type vessels modulate aberrant subchondral bone formation during the pathogenesis of OA.However,the mechanism responsible for the elevation of H-type vessels in OA is still unclear.Here,we found that PDGFR-βexpression,predominantly in the CD31^(hi)Emcn^(hi) endothelium,was substantially elevated in subchondral bones from OA patients and rodent OA models.A mouse model of OA with deletion of PDGFR-βin endothelial cells(ECs)exhibited fewer H-type vessels,ameliorated subchondral bone deterioration and alleviated overlying cartilage degeneration.Endothelial PDGFR-βpromotes angiogenesis through the formation of the PDGFR-β/talin1/FAK complex.Notably,endothelium-specific inhibition of PDGFR-βby local injection of AAV9 in subchondral bone effectively attenuated the pathogenesis of OA compared with that of the vehicle-treated controls.Based on the results from this study,targeting PDGFR-βis a novel and promising approach for the prevention or early treatment of OA. | Zhuang Cui Hangtian Wu Ye Xiao Ting Xu Junjie Jia Hancheng Lin Rongmin Lin Kun Chen Yihuang Lin Kaiqun Li Xiaohu Wu Changjun Li Bin Yu | 2022 | Bone Research2022，10，4： | 4 |
| 2 | Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris显示文摘 | Rongmin Yu Wei Yang Liyan Song Chunyan Yan Zhang Zhang Yu Zhao | 2007 | Carbohydrate Polymers2007，，4： | 2 |
| 3 | Structural elucidation and biological activity of a novel polysaecharide by alkaline extraction from cultured Cordyceps militaris 显示文摘 | YU Rongmin YIN Yin YANG Wei | 2009 | Carbohydrate Polymers2009，75，： | 1 |
| 4 | Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris显示文摘 | Yongshuai Jing Xinlu Cui Zhiyan Chen Lijiao Huang Liyan Song Ting Liu Wenjie Lv Rongmin Yu | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 5 | A new cytotoxic salannin-class limonoid alkaloid from seeds of Azadirachta indica A. Juss显示文摘A new cytotoxic salannin-class limonoid alkaloid, azadiramide A(1),was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 2.70±0.63 μmol/L. | Jianxun Zhu Xiaofeng Lu Xiaona Fan Ruibo Wu Hongjuan Diao Rongmin Yu Hanhong Xu Jiachen Zi | 2018 | Chinese Chemical Letters2018，29，8： | 1 |
| 6 | Structure characterization and antioxidant activity of a novel polysaccharide isolated from Ginkgo biloba显示文摘 | Fei Yuan Rongmin Yu Yin Yin Jianru Shen Quanfeng Dong Ling Zhong Liyan Song | 2010 | International Journal of Biological Macromolecules2010，，4： | 1 |
| 7 | Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris显示文摘 | Rongmin Yu Yin Yin Wei Yang Weili Ma Lin Yang Xiujuan Chen Zhang Zhang Bin Ye Liyan Song | 2008 | Carbohydrate Polymers2008，，1： | 1 |
| 8 | Assembly of a metal-organic framework by sextuple intercatenation of discrete adamantane-like eages显示文摘 | Kuang xiaofei Wu Xiaoyun Yu Rongmin | 2010 | Nat Chem2010，2，6： | 1 |
| 9 | Fingerprint analysis of fruiting bodies of cultured Cordyceps militaris by high-performance liquid chromatograpby-photodiode array detection显示文摘 | Rongmin Yu Bin Ye Chunyan Yan | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，44，： | 1 |
| 10 | Isolation and biological properties of polysacchride CPS - 1 from cultured Cordyceps militaris 显示文摘 | Rongmin Yu Liyan Song | 2004 | Fitoterapia2004，75，4： | 1 |
| 11 | Structural characterization and antitumor activity of a novel heteropolysaccharide isolated from Taxus yunnanensis显示文摘 | Yin Yin Yu Rongmin Yang Wei | 2010 | Carbohydrate Polymers2010，82，3： | 1 |
| 12 | Fingerprint analysis of fruiting bodies of cultured Cordyceps militaris by high-performance liquid chromatography-photodiode array detection显示文摘 | Yu Rongmin Ye Bin Yan Chunyan | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，44，： | 1 |
| 13 | Isolation,purification and identification of polysaccharides from cultured Cordyceps militaris显示文摘 | Rongmin Yu Lei Wang Hui Zhang | 2004 | Fitoterapia2004，75，78： | 1 |
| 14 | Structural characterization and anti-tumor activity of a novel heteropolysaccharide isolated from Taxus yunnanensis显示文摘 | YIN YIN RONGMIN YU WEI YANG | 2010 | Carbohydrate Polymers2010，，82： | 1 |
| 15 | Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris显示文摘 | Rongmin Yu Wei Yang Liyan Song | 2007 | Carbohydrate Polymers2007，70，4： | 1 |
| 16 | Preparation of composited Nano-Ti O2and its application on antimicrobial and selfcleaning coatings显示文摘 | Rongmin Wang Boyun Wang Yu Feng | 2010 | Polymers for Advanced Technologies2010，21，5： | 1 |
| 17 | Purification,characterization and in vitro anti-tumor activity of proteins from Areasubcrenata Lischke显示文摘 | SONG Liyan REN Shengfang YU Rongmin | 2008 | Mar Drugs2008，6，3： | 1 |
| 18 | Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris显示文摘 | YU Rongmin YIN Yin YANG Wei | 2009 | Carbohydrate Polymers2009，75，： | 1 |
| 19 | Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris显示文摘 | Rongmin Yu Wei Yang Liyan Song Chunyan Yan Zhang Zhang Yu Zhao | 2007 | Carbohydrate Polymers2007，，4： | 1 |
| 20 | Purification, characterization and in vitro anti-tumor activity of proteins from Arca subcrenata Lischke显示文摘 | Liyan song shengfang Ren Rongmin Yu | 2008 | Marine Drugs2008，6，： | 1 |
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