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| 1 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 2 | Discharge rate consistency of each channel for UAV-based pneumatic granular fertilizer spreader显示文摘Unmanned aerial vehicles(UAVs)are widely being used to spread granular fertilizer in China.Granular fertilizer spreaders equipped with UAVs are mainly centrifugal disc-type and pneumatic.The multichannel pneumatic granular fertilizer spreaders(MPGFSs)have a banded fertilizer deposition distribution pattern,which are more suitable for variable rate fertilization with high precision requirement than the circular deposition distribution pattern of disc-type granular fertilizer spreaders(DGFSs).However,the existing MPGFS has the disadvantage of inconsistent discharge rate of each channel,which affects the uniformity of fertilization.In order to explore the causes of inconsistent discharge rate of each channel,the discrete element method(DEM)and bench test were performed to analysis the discharge process of the fluted roller fertilizing apparatus and distribution of fertilizer in axial direction of fluted roller.The computational fluid dynamics(CFD)was used to simulate the airflow field of pneumatic system to analyze the influence of airflow on the movement of fertilizer particles.The simulation results of the discharge process of the fluted roller fertilizing apparatus showed that the filling velocity at the axial ends of the fluted roller fertilizing apparatus was lower than that of the middle.The reason was that the filling capacity was weak near the wall.The simulated results of the airflow field without partitions showed that the airflow provided by the axial flow fan was rotational,and this caused the particles to move irregularly in the throat,resulting in inconsistency discharge rate of each channel.Based on the analysis of reasons of inconsistent discharge rate of each channel,a MPGFS with partitions in the throat was developed.The discharge rate bench tests were carried out to optimize the partition spacing parameters,and fertilization test was performed to test the performance of the improved MPGFS.The discharge rate test results showed better consistency with partition.The coefficient of variation(CV)of the discharge rate of each channel was 20.16%without the partition and 7.70%with the optimal partition.The fertilizer spreading uniformity bench test results shown that the CV of spreading uniformity of MPGFS without partitions was 15.32%,and that MPGFS with partitions was 8.69%.The partitions design was beneficial to improve the consistency of each channel discharge rate and the uniformity of fertilization.The finding can provide a strong reference to design the MPGFS. | Xunwei Wang Rui Jiang Zhiyan Zhou Cancan Song Xiwen Luo Ruifeng Bao Zichen Lyu Junhao Huang Jianqin Lin | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 1 |
| 3 | Multi-Scale Superhydrophobic Anti-Icing Coating for Wind Turbine Blades显示文摘As a surface functional material,super-hydrophobic coating has great application potential in wind turbine blade anti-icing,self-cleaning and drag reduction.In this study,ZnO and SiO2 multi-scale superhydrophobic coatings with mechanical flexibility were prepared by embedding modified ZnO and SiO2 nanoparticles in PDMS.The prepared coating has a higher static water contact angle(CA is 153°)and a lower rolling angle(SA is 3.3°),showing excellent super-hydrophobicity.Because of its excellent superhydrophobic ability and micro-nano structure,the coating has good anti-icing ability.Under the conditions of−10C and 60%relative humidity,the coating can delay the freezing time by 1511S,which is 10.7 times slower than the normal freezing time.More importantly,due to the mechanical properties provided by SiO2 and the synergistic effect of micro-nano particles,the coating has excellent mechanical durability.After 10 wear tests,the contact angle of the coating is still as high as 141°and the rolling angle is 6.8°.This research provides a theoretical reference for the preparation of a mechanically stable coating with a simple preparation process,as well as a basic research on the anti-icing behavior of the coating. | Jiangyong Bao Jianjun He Biao Chen Kaijun Yang Jun Jie Ruifeng Wang Shihao Zhang | 2021 | Energy Engineering2021，118，4： | 1 |
| 4 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
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