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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats显示文摘It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects. | Bin Liu Jing Tang Jinxia Zhang Shiying Li Min Yuan Ruimin Wang | 2014 | Neural Regeneration Research2014，9，13： | 25 |
| 3 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 4 | Insights into epigenetic patterns in mammalian early embryos显示文摘Mammalian fertilization begins with the fusion of two specialized gametes,followed by major epigenetic remodeling leading to the formation of a totipotent embryo.During the development of the pre-implantation embryo,precise reprogramming progress is a prerequisite for avoiding developmental defects or embryonic lethality,but the underlying molecular mechanisms remain elusive.For the past few years,unprecedented breakthroughs have been made in mapping the regulatory network of dynamic epigenomes during mammalian early embryo development,taking advantage of multiple advances and innovations in low-input genome-wide chromatin analysis technologies.The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals,including DNA methylation,histone modifications,chromatin accessibility and 3D chromatin organization. | Ruimin Xu Chong Li Xiaoyu Liu Shaorong Gao | 2021 | Protein & Cell2021，12，1： | 13 |
| 5 | Historical Transformation of China's Agriculture" Productivity Changes and Other Key Features显示文摘 | Shouying Liu Ruimin Wang Guang Shi | 2018 | China & World Economy2018，26，1： | 9 |
| 6 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 7 | Consumption Structure of Migrant Worker Families in China显示文摘这研究越过在中国城市化区域的四个学生在候鸟的调查上收 12 个城市并且调查城市的候鸟工人家庭和农村消费的结构。结果证明候鸟工人家庭消费的结构被幸存消费统治了。当在他们的农村自已出生的市镇从事明显的消费时,这些家庭趋于节约地住在城市。候鸟工人家庭消费的结构被他们的收入稳定性和财富层次而非他们的当前的收入水平主要塑造。而且,有打算在城市里永久地安定的高教育的层次和那些的候鸟工人家庭是可能的分配实质的开销到地位和快乐消费并且升级他们的城市的消费结构。 | Guangzhong Cao Kai Li Ruimin Wang Tao Liu | 2017 | China & World Economy2017，25，4： | 4 |
| 8 | Assessment of effects of best management practices on agricultural non-point source pollution in Xiangxi River watershed显示文摘 | Ruimin Liu Peipei Zhang Xiujuan Wang Yaxin Chen Zhenyao Shen | 2013 | Agricultural Water Management2013，，： | 3 |
| 9 | Development and test of the Export Coefficient Model in the Upper Reach of the Yangtze River显示文摘 | Xiaowen Ding Zhenyao Shen Qian Hong Zhifeng Yang Xing Wu Ruimin Liu | 2009 | Journal of Hydrology2009，，3： | 3 |
| 10 | A-π-D-π-A small-molecule donors with different end alkyl chains obtain different morphologies in organic solar cells显示文摘For bulk-heterojunction organic solar cells, the morphology of the blend films highly influence the exciton dissociation and charge transport process. In this work, two novel A-π-D-π-A(A represents the acceptor unit and D represents the donor unit) backbone structure small molecular electron donors based on two dimensional conjugated naphtho[1,2-b:5,6-b']dithiophene(NDT) with different end alkyl chains, named as NDT-3T-EH and NDT-3T-O, have been designed and synthesized. The photovoltaic property of NDT-3T-O-based device is better than that of the NDT-3T-EH and the best efficiency reaches 7.06%, and the photovoltaic property of NDT-3T-EH reaches 6.11%. The difference in the performance should be attributed to the different morphology and phase separation resulted from the different crystallinity and aggregation ability of two donors. The results demonstrate that the optimized end alkyl chains can be used to design A-π-D-π-A backbone structure small molecular electron donors for smallmolecule organic solar cells. | Yanan Shi Chen Yang Huan Li Lixuan Liu Ruimin Zhou Wenjun Zou Zhen Wang Qiong Wu Dan Deng Jianqi Zhang Kun Lu Zhixiang Wei | 2019 | Chinese Chemical Letters2019，30，4： | 3 |
| 11 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 12 | Integrated assessment and changes of ecological environment in the Daning River Watershed显示文摘Based on Remote Sensing(RS),Geographical Information Systems(GIS),and the Spatial Principal Compo-nent Analysis(SPCA)method,the integrated assessment and changes in the ecological environment of Daning River Watershed are studied in this paper.The watershed is located in the Three Gorge Area in China.The result of the integrated assessment showed that level 9 had the biggest proportion in the year 1990,which was about 40%.In the year 2000,however,there were no levels with a proportion significantly bigger than the others.By comparing the assessment results in 1990 and 2000,it is discovered that the ecological environ-ment in Daning River Watershed in 1990 was better than that in 2000. | LIU Ruimin SHEN Zhenyao | 2007 | Frontiers in Biology2007，2，4： | 2 |
| 13 | A Great late Ediacaran ice age显示文摘The emergence of the Ediacara biota soon after the Gaskiers glaciation ca.580 million years ago(Ma)implies a possible glacial fuse for the evolution of animals.However,the timing of Ediacaran glaciation remains controversial because of poor age constraints on the∼30 Ediacaran glacial deposits known worldwide.In addition,paleomagnetic constraints and a lack of convincing Snowball-like cap carbonates indicate that Ediacaran glaciations likely did not occur at low latitudes.Thus,reconciling the global occurrences without global glaciation remains a paradox.Here,we report that the large amplitude,globally synchronous ca.571–562 Ma Shuram carbon isotope excursion occurs below the Ediacaran Hankalchough glacial deposit in Tarim,confirming a post-Shuram glaciation.Leveraging paleomagnetic evidence for a∼90°reorientation of all continents due to true polar wander,and a non-Snowball condition that rules out low-latitude glaciations,we use paleogeographic reconstructions to further constrain glacial ages.Our results depict a‘Great Ediacaran Glaciation’occurring diachronously but continuously from ca.580–560 Ma as different continents migrated through polar–temperate latitudes.The succession of radiation,turnover and extinction of the Ediacara biota strongly reflects glacial–deglacial dynamics. | Ruimin Wang Bing Shen Xianguo Lang Bin Wen Ross N.Mitchell Haoran Ma Zongjun Yin Yongbo Peng Yonggang Liu Chuanming Zhou | 2023 | National Science Review2023，10，8： | 2 |
| 14 | Heavy metals in urban soils with various types of land use in Beijing, China显示文摘 | Xinghui Xia Xi Chen Ruimin Liu Hong Liu | 2011 | Journal of Hazardous Materials2011，，2： | 2 |
| 15 | Temporal variation of heavy metal pollution in urban stormwater runoff显示文摘 | Wen LI Zhenyao SHEN Tian TIAN Ruimin LIU Jiali QIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 2 |
| 16 | Reflec- tion-mode in vivo photoacoustic microscopy with sub- wavelength lateral resolution显示文摘 | SONG WEI ZHENG WEI LIU RUIMIN | 2014 | Biomedical Optics Ex- press2014，5，12： | 1 |
| 17 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 18 | Identifying non - point source criti- cal source areas based on multi - factors at a basin scale with SWAT显示文摘 | Ruimin Liu Fei Xu Peipei Zhang | 2016 | Journal of Hydrology2016，533，： | 1 |
| 19 | Spatial and temporal variations in nitrogen and phosphorous nutrients in the Yangtze River Estuary显示文摘 | CHEN Yaxin LIU Ruimin SUN Chengchun | 2012 | Marine Pollution Bulletin2012，64，10： | 1 |
| 20 | Discretizing Laplace–Beltrami Operator from Differential Quantities显示文摘The Laplace–Beltrami operator(LBO)is the fundamental geometric object associated with manifold surfaces and has been widely used in various tasks in geometric processing.By understanding that the LBO can be computed by differential quantities,we propose an approach for discretizing the LBO on manifolds by estimating differential quantities.For a point on the manifold,we first fit a quadratic surface to this point and its neighborhood by minimizing the least-square energy function.Then we compute the first-and second-order differential quantities by the approximated quadratic surface.Finally the discrete LBO at this point is computed from the estimated differential quantities and thus the Laplacian matrix over the discrete manifold is constructed.Our approach has several advantages:it is simple and efficient and insensitive to noise and boundaries.Experimental results have shown that our approach performs better than most of the current approaches.We also propose a feature-aware scheme for modifying the Laplacian matrix.The modified Laplacian matrix can be used in other feature preserving geometric processing applications. | Ruimin Wang Zhouwang Yang Ligang Liu Qing Chen | 2013 | Communications in Mathematics and Statistics2013，1，3： | 1 |
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