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| 1 | FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation显示文摘Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other drugs.We investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia cells.The combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML samples.Venetoclax also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway inhibition.Gilteritinib treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to BCL-2.Venetoclax treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from BCL-2.Treatment with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased apoptosis.These findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM expression.This study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment. | Ruiqi Zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis Amy Duffield Yu Hu Donald Small | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 2 | Minimum Structural Similarity Distortion for Reversible Data Hiding显示文摘Until now, most Reversible data hiding(RDH) techniques have been evaluated by Peak signal-tonoise ratio(PSNR), which based on Mean squared error(MSE). Unfortunately, MSE turns out to be an extremely poor measure when the purpose is to predict perceived signal fidelity or quality. The Structural similarity(SSIM)index has gained widespread popularity as an alternative motivating principle for the design of image quality measures. How to utilize the characterize of SSIM to design RDH algorithm is very critical. We propose an optimal RDH algorithm under structural similarity constraint. We deduce the metric of the structural similarity constraint,and further we prove it does not hold Non-crossing-edges(NCE) property. We construct the rate-distortion function of optimal structural similarity constraint, which is equivalent to minimize the average distortion for a given embedding rate, and then we can obtain the optimal transition probability matrix under the structural similarity constraint. Experiments show that our proposed method can be used to improve the performance of previous RDH schemes evaluated by SSIM. | XU Jiajia ZHANG Weiming JIANG Ruiqi YU Nenghai HU Xiaocheng | 2018 | Chinese Journal of Electronics2018，27，3： | 2 |
| 3 | Sorption of perflunrooctane sulfonate and perfluorooctanoate on activated carbons and resin: kinetic and isotherm study显示文摘 | Yu Qiang Zhang Ruiqi Deng Shubo | 2009 | Water Res2009，43，4： | 1 |
| 4 | Experimental investigation on an adsorption system for producing chilled water显示文摘 | RUIQI ZHU BAOQI HAN YANGZHANG YU | 1992 | Int J Refri1992，15，1： | 1 |
| 5 | SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin显示文摘 | Huifeng Pi Shangcheng Xu Russel J Reiter Pan Guo Lei Zhang Yuming Li Min Li Zhenwang Cao Li Tian Jia Xie Ruiqi Zhang Mindi He Yonghui Lu Chuan Liu Weixia Duan Zhengping Yu Zhou Zhou | 2015 | Autophagy2015，，7： | 1 |
| 6 | TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation显示文摘Dear Editor,The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health(Ding and Schloss,2014).Disorder of microbial community is implicated in the pathogenesis of several human diseases,such as autoimmune disease,allergy,diabetes,obesity,and inflammatory bowel disease(IBD),which is clearly demonstrated to relate to gut dysbiosis in patients and mouse models(Saleh and Elson,2011). | Guotao Yu Fang Wang Menghao You Tiansong Xu Chunlei Shao Yuning Liu Ruiqi Liu Min Deng Zhihong Qi Zhao Wang Jingjing Liu Yingpeng Yao Jingjing Chen Zhen Sun Shanshan Hao Wenhui Guo Tianyan Zhao Zhengquan Yu Qian Zhang Yaofeng Zhao Feng Chen Shuyang Yu | 2020 | Protein & Cell2020，11，5： | 1 |
| 7 | Corrosion fatigue behavior of friction stir processed interstitial free steel显示文摘In this study, interstitial free(IF) steel plates were subjected to double-sided friction stir processing(FSP).The fine-grained structure with an average grain size of about 12 m was obtained in the processed zone(PZ) with a thickness of about 2.5 mm. The yield strength(325 MPa) and ultimate tensile strength(451 MPa) of FSP IF steel were significantly higher than those of base material(BM)(192 and 314 MPa),while the elongation(67.5%) almost remained unchanged compared with the BM(66.2%). The average microhardness value of the PZ was about 130 HV, 1.3 times higher than that of the BM. In addition, the FSP IF steel showed a more positive corrosion potential and lower corrosion current density than the BM,exhibiting lower corrosion tendency and corrosion rates in a 3.5 wt% NaCl solution. Furthermore, FSP IF steel exhibited higher fatigue life than the BM both in air and NaCl solution. Corrosion fatigue fracture surfaces of FSP IF steel mainly exhibited a typical transgranular fracture with fatigue striations, while the BM predominantly presented an intergranular fracture. Enhanced corrosion fatigue performance was mainly attributed to the increased resistance of nucleation and growth of fatigue cracks. The corrosion fatigue mechanism was primarily controlled by anodic dissolution under the combined effect of cyclic stress and corrosive solution. | Wen Wang Ruiqi Xu Yaxin Hao Qiang Wang Liangliang Yu Qianying Che Jun Cai Kuaishe Wang Zongyi Ma | 2018 | Journal of Materials Science & Technology2018，34，1： | 1 |
| 8 | Sorption of perfluorooctane sulfonate and perfluorooctanoate on activated carbon and resin: kinetic and isotherms study显示文摘 | YU Qiang ZHANG Ruiqi DENG Shubo | 2009 | Water Research2009，43，4： | 1 |
| 9 | Overexpression of CD133 enhances chemoresistance to 5-fluorouracil byactivating the PI3K/Akt/p70S6K pathway in gastric cancer cells显示文摘 | Youlong Zhu Jiwei Yu Shoulian Wang Ruiqi Lu Jugang Wu Bojian Jiang | 2014 | Oncology Reports2014，，6： | 1 |
| 10 | Tailoring Defects in Hard Carbon Anode towards Enhanced Na Storage Performance显示文摘Hard carbon(HC)anodes show conspicuously commercialized potential for sodium-ion batteries(SIBs)due to their costeffectiveness and satisfactory performance.However,the development of hard carbon anodes in SIBs is still hindered by low initial Coulombic efficiency(ICE)and insufficient cyclic stability,which are induced by inappropriate defects in the structure.Herein,we introduce a simple but effective method to tailor the defects in HC by the chemically preadsorbed K^(+).The soft Xray absorption spectroscopy at the C K-edges reveals that K^(+)can anchor on the hard carbon via C-O-K bonds,occupying the irreversible reactive sites of Na^(+).Therefore,the irreversible capacity caused by some C-O bonds can be reduced.Moreover,the preadsorbed K^(+)can induce the rearrangement of carbon layers and lead to a high graphitization structure with fewer defects and large interlayer spacing,which not only improves the structural stability and electrical conductivity of the HC anode but also facilitates fast Na^(+)diffusion.Therefore,the as-obtained optimized anode demonstrates a higher ICE with better cyclic stability and superior rate capacities compared with the anode without preadsorbed K^(+).This work indicates that K^(+)preadsorbed into hard carbon is a practicable alternative to enhance the Na storage performances of HC anodes for SIBs. | Ruiqi Dong Feng Wu Ying Bai Qinghao Li Xiqian Yu Yu Li Qiao Ni Chuan Wu | 2022 | Energy Material Advances2022，，1： | 1 |
| 11 | Unveiling the time-temperature dependence of metastability of supercooled liquid using nano-calorimetry显示文摘There is a lack of understanding of both the conversion of an unstable glass into a metastable supercooled liquid(MSL) upon heating and the metastability of MSLs. In this study, we investigated the time-and temperature-dependent metastability of an MSL using an advanced nano-calorimetric technique. The chosen Au-based metallic glass(Au MG) allowed adequate probing of its MSL in a temperature range between 10 and 70 K above the standard glass transition temperature. We found that the survival time of the MSL state is a quadratic function of temperature. Beyond this duration threshold, the sample undergoes fast crystallization even if it is below the crystallization temperature that is measured using differential scanning calorimetry.Employing transmission electron microscopy, we observed the formation of clusters with a partially ordered lattice structure during relaxation in the Au MG sample fabricated using a nano-calorimeter. The atomic ordering within the clusters was enhanced by increasing time and temperature in the MSL region. Once the as-produced glass entered the MSL stage upon heating followed by a quenching stage at a given rate, the mechanical properties of the quenched glass remained the same regardless of its holding temperature and duration within the MSL region. This work provides insights into the glass-MSL-crystal transformation and offers guidance for designing standard metallic glasses for property characterizations. | Yijun Ding Lijian Song Zheng Wang Ruiqi Yu Junqiang Wang Lina Hu Yuanzheng Yue Edgar D.Zanotto | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，3： | 0 |
| 12 | Identification of two pIgR-like molecules in teleost fish with opposite roles in mucosal immunity against bacterial infection显示文摘Polymeric immunoglobulin(Ig)receptor-like(pIgRL)molecules have been identified in teleost fish.However,compared to functional studies of their related genes(e.g.,mammalian CD300 family)in eliminating pathogen invasion while preserving homeostasis,the roles of pIgRL in teleost fish remain unclear.In this study,we demonstrated that a pair of pIgRL molecules in zebrafish,pIgRL3.5 and pIgRL4.2,were highly expressed in the intestine and immune cells.Moreover,we constructed an Edwardsiella piscicida infection model,which induced strong inflammatory responses in the zebrafish intestine.Interestingly,pIgRL3.5 and pIgRL4.2 exhibited opposite inducible expression patterns in response to bacterial infection,suggesting that they perform different roles.More importantly,by conducting overexpression and knockdown experiments,our findings demonstrated that zebrafish pIgRL3.5 played a protective role in host defense against E.piscicida infection by inhibiting excessive inflammatory responses.In contrast,pIgRL4.2 facilitated pathogen growth and dissemination in zebrafish intestine.Collectively,our findings are the first to demonstrate that a pair of pIgRL molecules in teleost fish play opposite roles in mucosal immune response to bacterial infection.Therefore,our results provide crucial insights into the conserved role of pIgRL molecules in immune regulatory functions throughout vertebrate evolution. | Haoyue Xu Zixuan Wang Zhenyu Huang Xiaoyun Chen Ruiqi Lin Yongyao Yu Zhen Xu | 2023 | Water Biology and Security2023，2，4： | 0 |
| 13 | Selective Hydrogenation of Phenylacetylene by Carbon Monoxide and Water显示文摘Catalytic selective hydrogenation of alkynes to the corresponding alkenes is an important process in industrial production.Modulating the selective hydrogenation of alkynes to the alkenes requires ingenuity since alkenes can easily be converted into the corresponding alkanes under reductive conditions.Applying different reductive reagents to prevent the direct usage of H_(2)can avoid difficulties in hydrogen storage and transportation.Herein,we demonstrate a tandem process to hydrogenate phenylacetylene by CO and H_(2)Oviathecouplingof thelow-temperaturewater-gas shift reaction and selective hydrogenation of phenylacetylene utilizing theα-MoC catalyst.The reductive reagent,CO,not only produces H_(2)from H_(2)O to drive the reaction forward,but it also regulates the selectivity of styrene by preventing further hydrogenation. | Xuetao Qin Ruiqi Zhang Ming Xu Yao Xu Lirong Zheng Chengyu Li Shixiang Yu Jie Yan Jinglin Xie Genghuang Wu Junfeng Rong Meng Wang Ding Ma | 2023 | CCS Chemistry2023，5，10： | 0 |
| 14 | Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds显示文摘Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites.In this study,a Janus particle,SEC-Fe@CaT with dual-driven forces,bubble-driving,and magnetic field–(MF–)mediated driving,was prepared via in situ loading of Fe_(3)O_(4) on a sunflower sporopollenin exine capsule(SEC),and followed by growth of flower-shaped CaCO3 clusters.The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration,and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds.During the movement in blood flow,the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells(RBCs)to release procoagulants,thus promoting activation of platelet and rapid hemostasis.Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models,respectively.In contrast,the similar commercial product Celox™required approximately 70 s to stop the bleeding in both bleeding modes.This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds.It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis. | Haoyu Qiu Guangqian Lan Weiwei Ding Xinyu Wang Wenyi Wang Dahua Shou Fei Lu Enling Hu Kun Yu Songmin Shang Ruiqi Xie | 2022 | Research2022，，4： | 0 |
| 15 | CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ显示文摘Dysregulated lineage commitment of mesenchymal stem cells(MSCs)contributes to impaired bone formation and an imbalance between adipogenesis and osteogenesis during skeletal aging and osteoporosis.The intrinsic cellular mechanism that regulates MSC commitment remains unclear.Here,we identified Cullin 4B(CUL4B)as a critical regulator of MSC commitment.CUL4B is expressed in bone marrow MSCs(BMSCs)and downregulated with aging in mice and humans.Conditional knockout of Cul4b in MSCs resulted in impaired postnatal skeletal development with low bone mass and reduced bone formation.Moreover,depletion of CUL4B in MSCs aggravated bone loss and marrow adipose accumulation during natural aging or after ovariectomy.In addition,CUL4B deficiency in MSCs reduced bone strength.Mechanistically,CUL4B promoted osteogenesis and inhibited adipogenesis of MSCs by repressing KLF4 and C/EBPδexpression,respectively.The CUL4B complex directly bound to Klf4 and Cebpd and epigenetically repressed their transcription.Collectively,this study reveals CUL4B-mediated epigenetic regulation of the osteogenic or adipogenic commitment of MSCs,which has therapeutic implications in osteoporosis. | Ruiqi Yu Hong Han Shuxian Chu Yijun Ding Shiqi Jin Yufeng Wang Wei Jiang Yuting Liu Yongxin Zou Molin Wang Qiao Liu Gongping Sun Baichun Jiang Yaoqin Gong | 2023 | Bone Research2023，11，2： | 0 |
| 16 | Microcluster colloidosomes for hemostat delivery into complex wounds:A platform inspired by the attack action of torpedoes显示文摘Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature,thereby causing massive blood loss and significantly increased mortality.Inspired by the attack action of torpedoes,we synthesized microcluster(MC)colloidosomes equipped with magnetic-mediated navigation and“blast”systems to deliver hemostats into the cavity of vase-type wounds.CaCO_(3)/Fe_(2)O_(3)(CF)microparticles functionalized with Arg-Gly-Asp(RGD)modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots(CDs)to form MC colloidosomes,which were loaded with thrombin and protonated tranexamic acid(TXA-NH_(3)^(+)).The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH_(3)^(+).The CO_(2) bubbles generated during disassembly produced a“blast”that propelled thrombin into the wound cavity.Severe bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within~60 s.Furthermore,in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC colloidosomes.This study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis,creating a new paradigm for combating trauma treatment. | Bitao Lu Enling Hu Ruiqi Xie Kun Yu Fei Lu Rong Bao Chenhui Wang Guangqian Lan Fangyin Dai | 2022 | Bioactive Materials2022，7，10： | 0 |
| 17 | Social Network Analysis of Coauthor Networks in Inclusive Finance in China显示文摘The proposal and innovation of inclusive finance provide a very valuable pathway to realize social equity and eliminate poverty,which has attracted extensive attention,especially from developing countries.Based on the papers on inclusive finance published in the Chinese journal database CNKI from 2014 to 2018,we constructed an undirected weighted coauthor network 2154 authors.By employing social network analysis,we found that the number of authors in the field of inclusive finance increased rapidly.Although the cooperation between them was still very low and the cooperation authors were relatively fixed,the scale of cooperation was rapidly expanding.Although no scholar could always be at the center position in the coauthor network,the knowledge transfer path was significantly reduced.Financial universities and some financial institutions were the most important promoters of inclusive finance.Knowledge discovery in this field was promoted alternately by several center authors and cooperation by many scholars 2014-2018.We believe these discoveries are of great significance to promote knowledge sharing and innovation in the academic community of inclusive finance. | Jiamin Yan Fenjing An Ruiqi Wang Ling Chen Xi Yu Mingsen Deng | 2022 | 国际计算机前沿大会会议论文集2022，，1： | 0 |
| 18 | EVs-mediated delivery of CB2 receptor agonist for Alzheimer’s disease therapy显示文摘Alzheimer’s disease(AD)is a typical neurodegenerative disease that leads to irreversible neuronal degeneration,and effective treatment remains elusive due to the unclear mechanism.We utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with the CB2 target medicine AM1241(EVs-AM1241)to protect against neurodegenerative progression and neuronal function in AD model mice.According to the results,EVs-AM1241 were successfully constructed and exhibited better bioavailability and therapeutic effects than bare AM1241.The Morris water maze(MWM)and fear conditioning tests revealed that the learning and memory of EVs-AM1241-treated model mice were significantly improved.In vivo electrophysiological recording of CA1 neurons indicated enhanced response to an auditory conditioned stimulus following fear learning.Immunostaining and Western blot analysis showed that amyloid plaque deposition and amyloidβ(Aβ)-induced neuronal apoptosis were significantly suppressed by EVs-AM1241.Moreover,EVs-AM1241 increased the number of neurons and restored the neuronal cytoskeleton,indicating that they enhanced neuronal regeneration.RNA sequencing revealed that EVs-AM1241 facilitated Aβphagocytosis,promoted neurogenesis and ultimately improved learning and memory through the calcium-Erk signaling pathway.Our study showed that EVs-AM1241 efficiently reversed neurodegenerative pathology and enhanced neurogenesis in modelmice,indicating that they are very promising particles for treating AD. | Yanjing Zhu Ruiqi Huang Deheng Wang Liqun Yu Yuchen Liu Runzhi Huang Shuai Yin Xiaolie He Bairu Chen Zhibo Liu Liming Cheng Rongrong Zhu | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，4： | 0 |
| 19 | Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice显示文摘Nuclear factor erythroid-derived 2-like 2(Nrf2)is the master regulator of antioxidant defenses.High-intensity interval training(HIIT)has been proposed as a time-efficient training program and has become a substantial component of modern training program In the present study,we evaluated the effects of sulforaphane(SFN),a dietary isothiocyanate derived from cruciferous vegetables and a potent Nrf2 activator,on Nrf2-mediated antioxidant defense responses of skeletal muscle induced by exhaustive exercise in HIIT mice.Male C57 BL/6 J mice were randomly allocated into control group,HIIT group,and HIIT pretreated with SFN(HIIT+SFN)group.On the third day after completion of a 6-weeks HIIT protocol,an exhaustive treadmill test was conducted in all mice.Mice were intraperitoneally injected with SFN(HIIT+SFN group)or PBS(HIIT and control mice)4 times in 3 days prior to the exhaustive treadmill test.The results indicated that the 6-weeks HIIT protocol did not increase the antioxidative capacity of skeletal muscle during exhaustive exercise.Importantly,SFN treatment improved anti oxidative capacity of skeletal muscle in response to the acute exhaustive exercise by increasing mRNA and nucleoprotein expression of Nrf2 and these genes involved in antioxidant generation and decreasing blood creatine kinase(CK)and 4-hydroxy-2-nonenal(4-HNE)-modified protein levels in the HIIT mice. | Yangwenjie Wang Yang Xiang Ruiqi Wang Xiangning Li Jianxiong Wang Siwang Yu Ying Zhang | 2022 | Food Science and Human Wellness2022，11，5： | 0 |
| 20 | Identification, biogenesis, function, and mechanism of action of circular RNAs in plants显示文摘CircularRNAs(circRNAs)are a class of single-stranded,closedRNAmolecules with unique functions that are ubiquitously expressed in all eukaryotes.The biogenesis of circRNAs is regulated by specific cis-acting elements and trans-acting factors in humans and animals.circRNAs mainly exert their biological functions by acting as microRNA sponges,forming R-loops,interacting with RNA-binding proteins,or being translated into polypeptides or proteins in human and animal cells.Genome-wide identification of circRNAs has been performedin multiple plant species,and the results suggest that circRNAs are abundant and ubiquitously expressed in plants.There is emerging compelling evidence to suggest that circRNAs play essential roles during plant growthanddevelopment as well as inthe responses to bioticandabiotic stress.However,compared with recent advances in human and animal systems,the roles of most circRNAs in plants are unclear at present.Here we review the identification,biogenesis,function,and mechanism of action of plant circRNAs,which will provide a fundamental understanding of the characteristics and complexity of circRNAs in plants. | Ruiqi Liu Yu Ma Tao Guo Guanglin Li | 2023 | Plant Communications2023，4，1： | 0 |
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