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| 1 | Van der Waals integration of 2D atomic crystals for advanced multifunctional devices显示文摘Semiconductor heterostructures play a key role in the development of solid-state electronic and optoelectronic devices.They are generally realized via traditional epitaxial integration,namely two or more dissimilar materials,with matching crystal lattice,polarity and thermal expansion coefficients,are grown on the surface of each other. | Ruiqing Cheng Lei Yin Feng Wang Zhenxing Wang Jun He | 2019 | Science Bulletin2019，64，15： | 4 |
| 2 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 3 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 4 | Research progress and prospects of coal petrology and coal quality in China显示文摘Clean utilization of coal depends on the quality of raw coal,which depends on the coal-forming parent materials(petrology and chemical composition of coal),the multiple media of the coal-forming environment,and some epigenetic conditions,such as thermal evolution(coalification),magmatic hydrothermal fluid,groundwater.Based on the research results of predecessors and prediction studies of coal resources since the founding of China,the present status of research on coal petrology,coal quality,coal metamorphism,and coal geochemistry in China is discussed in detail,with emphasis on research progress and the general situation of highly efficient and clean utilization of coal in the technical fields of coking,pyrolysis,combustion,gasification,and liquefaction,and the development prospects of coal petrology and coal quality in China are prospected. | Yuegang Tang Ruiqing Li Shaoqing Wang | 2020 | International Journal of Coal Science & Technology2020，7，2： | 3 |
| 5 | Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression显示文摘Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor family pyrin domain containing 6(NLRP6)in hippocampus of stress-stimulated mice,being consistent with high corticosterone level.NLRP6 was found to be abundantly expressed in neural stem cells(NSCs)of DG.Both Nlrp6 knockout(Nlrp6^(-/-))and NSCconditional Nlrp6 knockout(Nlrp6CKO)mice were susceptible to stress,being more likely to develop depressive-like behaviors.Interestingly,NLRP6 was required for NSC proliferation in sustaining hippocampal neurogenesis and reinforcing stress resilience during growing up.Nlrp6 deficiency promoted esophageal cancer-related gene 4(ECRG4)expression and caused mitochondrial dysfunction.Corticosterone as a stress factor significantly down-regulated NLRP6 expression,damaged mitochondrial function and suppressed cell proliferation in NSCs,which were blocked by Nlrp6 overexpression.ECRG4 knockdown reversed corticosterone-induced NSC mitochondrial function and cell proliferation disorders.Pioglitazone,a well-known clinical drug,up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction.In conclusion,this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs,and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression. | Chuanfeng Tang Qiaona Wang Jingyan Shen Congying Wang Hong Ding Shiyu Wen Fan Yang Ruiqing Jiao Xingxin Wu Jianmei Li Lingdong Kong | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 6 | Ecosystem service valuation of bays in East China Sea and its response to sea reclamation activities显示文摘Ecosystem service values(ESVs)of bays and their response to sea reclamation are of great practical importance for forming bay eco-compensation policy and extension of blue economic space.Based on land use information of bays collected during the period of 1990–2015,the spatiotemporal evolution of ESVs of 12 main bays in East China Sea and their response to sea reclamation activities over the past 25 years were quantitatively analyzed.The analysis results indicate that ESVs of bays in East China Sea showed a continuous downward trend and the whole ecosystem was continuously degraded,in which the degradation degree of ESV in the southern bays was higher than that in the northern bays.Spatial zoning of ESVs of bays in East China Sea was remarkable,showing a continuous downward trend from low-value to high-value zone.Spatial variation of ESVs of each bay was also significant,expanding from a city and from inland to the coast,which suggests that human activities,mainly reclamation,have become main agents for ESV evolution of bays in East China Sea.ESVs of bays have a significant response to sea reclamation,manifested as a significant negative correlation between ESV and reclamation intensity.The correlation in the southern bays was stronger than that in the northern bays,which was caused by different effects of sea reclamation modes on ESV evolution of muddy and bedrock bays.A negative effect of sea reclamation activities on bay ecosystem was hysteretic.Therefore,an attention should be paid to dynamic monitoring and early warning of development status in offshore areas,ecosystem-level reclamation control policy,and coastal wetland reserves planning.Moreover,the spatial coupling mechanism study between bay ecosystem service demand and its service supply capacity should be strengthened to realize systematic regulation of bay ecological security pattern. | LIU Ruiqing XU Hao LI Jialin PU Ruiliang SUN Chao CAO Luodan JIANG Yimei TIAN Peng WANG Lijia GONG Hongbo | 2020 | Journal of Geographical Sciences2020，30，7： | 2 |
| 7 | Tea picking point detection and location based on Mask-RCNN显示文摘The accurate identification,detection,and segmentation of tea buds and leaves are important factors for realizing intelligent tea picking.A tea picking point location method based on the region-based convolutional neural network(R-CNN)Mask-RCNN is proposed,and a tea bud and leaf and picking point recognition model is established.First,tea buds and leaf pictures are collected in a complex environment,the Resnet50 residual network and a feature pyramid network(FPN)are used to extract bud and leaf features,and preliminary classification and preselection box regression training-performed on the feature maps through a regional proposal network(RPN).Second,the regional feature aggregation method(RoIAlign)is used to eliminate the quantization error,and the feature map of the preselected region of interest(ROI)is converted into a fixed-size feature map.The output module of the model realizes the functions of classification,regression and segmentation.Finally,through the output mask image and the positioning algorithm the positioning of the picking points of tea buds and leaves is determined.One hundred tea tree bud and leaf pictures in a complex environment are selected for testing.The experimental results show that the average detection accuracy rate reaches 93.95%and that the recall rate reaches 92.48%.The tea picking location method presented in this paper is more versatile and robust in complex environments. | Tao Wang Kunming Zhang Wu Zhang Ruiqing Wang Shengmin Wan Yuan Rao Zhaohui Jiang Lichuan Gu | 2023 | Information Processing in Agriculture2023，10，2： | 2 |
| 8 | Recent developments in CVD growth and applications of 2D transition metal dichalcogenides显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)with fascinating electronic energy band structures,rich valley physical properties and strong spin–orbit coupling have attracted tremendous interest,and show great potential in electronic,optoelectronic,spintronic and valleytronic fields.Stacking 2D TMDs have provided unprecedented opportunities for constructing artificial functional structures.Due to the low cost,high yield and industrial compatibility,chemical vapor deposition(CVD)is regarded as one of the most promising growth strategies to obtain high-quality and large-area 2D TMDs and heterostructures.Here,state-of-the-art strategies for preparing TMDs details of growth control and related heterostructures construction via CVD method are reviewed and discussed,including wafer-scale synthesis,phase transition,doping,alloy and stacking engineering.Meanwhile,recent progress on the application of multi-functional devices is highlighted based on 2D TMDs.Finally,challenges and prospects are proposed for the practical device applications of 2D TMDs. | Hui Zeng Yao Wen Lei Yin Ruiqing Cheng Hao Wang Chuansheng Liu Jun He | 2023 | Frontiers of physics2023，18，5： | 2 |
| 9 | Symptom clustering in chronic gastritis based on spectral clustering显示文摘OBJECTIVE: Apply spectral clustering to analyze the patterns of symptoms in patients with chronic gastritis(CG).METHODS: Based on 919 CG subjects, we applied mutual information feature selection to choose the positively correlated symptoms with each pattern.Then, we used the Shi and Malik spectral clustering algorithm to select the top 20 correlated symptoms.RESULTS: We ascertained the results of six patterns.There were three categories for the pattern of accumulation of damp heat in the spleen-stomach(0.00332). There were six categories for the pattern of dampness obstructing the spleen-stomach(0.02466). There were two categories for the pattern of spleen-stomach Qi deficiency(0.013 89).There were three categories for the pattern of spleen-stomach deficiency cold(0.009 15). There were five categories for the pattern of liver-Qistagnation(0.01910).There were four categories for the pattern of stagnant heat in the liver-stomach(0.00585).CONCLUSION: Most of the spectral clustering results of the symptoms of CG patterns were in accordance with clinical experience and Traditional Chinese Medicine theory. Most categories suggested the nature and/or location of the disease. | Wenhua Zhu Zhaoxiang Fan Guoping Liu Jianjun Yan Tao Zhong Wu Zheng Ruiqing Wang Chunying Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 2 |
| 10 | On the continuity and convexity analysis of the expected value function of a fuzzy mapping 显示文摘 | Wang Cheng Tang Wansheng Zhao Ruiqing | 2007 | Journal of Uncertain Systems2007，1，2： | 1 |
| 11 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘 | XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG | | 0，，08： | 1 |
| 12 | Supplychain coordination by revenue sharing contract with fuzzy demand显示文摘 | WANG Junyan ZHAO Ruiqing TANG Wansheng | 2008 | Journal of Intelligent and Fuzzy Systems2008，19，6： | 1 |
| 13 | A Novel Method of Gene Regulatory Network Structure Inference from Gene Knock-Out Expression Data显示文摘Inferring Gene Regulatory Networks(GRNs) structure from gene expression data has been a challenging problem in systems biology. It is critical to identify complicated regulatory relationships among genes for understanding regulatory mechanisms in cells. Various methods based on information theory have been developed to infer GRNs. However, these methods introduce many redundant regulatory relationships in the network inference process due to external noise in the original data, topology sparseness in the network structure, and non-linear dependency among genes. Especially as the network size increases, the performance of these methods decreases dramatically. In this paper, a novel network structure inference method named Loc-PCA-CMI is proposed that first identifies local overlapped gene clusters, and then infers the local network structure for each cluster by a Path Consistency Algorithm based on Conditional Mutual Information(PCA-CMI). The final structure of the GRN is denoted as dependence among genes by an ensemble of the obtained local network structures. Loc-PCA-CMI was evaluated on DREAM3 knock-out datasets, and its performance was compared to other information theorybased network inference methods including ARACNE, MRNET, PCA-CMI, and PCA-PMI. Experimental results demonstrate our novel method Loc-PCA-CMI outperforms the other four methods in DREAM3 datasets especially in size 50 and 100 networks. | Xiang Chen Min Li Ruiqing Zheng Siyu Zhao Jianxin Wang Fang-Xiang Wu Yaohang Li | 2019 | Tsinghua Science and Technology2019，24，4： | 1 |
| 14 | Supply chain coordination by revenue-sharing contract with fuzzy demand显示文摘 | WANG Junyan ZHAO Ruiqing TANG Wansheng | 2008 | Journal of Intelligent and Fuzzy Systems2008，19，6： | 1 |
| 15 | Supply chain coordination by revenue-sharing contract with fuzzy demand显示文摘 | Junyan Wang* Ruiqing Zhao and Wangsheng Tang | 2008 | Journal of Intelligent & Fuzzy Systems2008，19，2008： | 1 |
| 16 | Revenue-sharing Contracts in As sembly Systems with Fuzzy Demand显示文摘 | Junyan Wang Wansheng Tang Ruiqing Zhao | 2007 | Au tomation and Logistics2007，，： | 1 |
| 17 | GL9 from Oryza glumaepatula controls grain size and chalkiness in rice显示文摘Grain size is a key factor influencing grain yield and appearance quality in rice.We identified twelve quantitative trait loci(QTL)for grain length(GL),nine for grain width(GW),and nine for 1000-kernel weight(TKW)using GLU-SSSLs,which are single-segment substitution lines with Oryza glumaepatula as donor parent and Huajingxian 74(HJX74)as recipient parent.Among the QTL,qGL1-2,qGL1-4,qGL9-2,qGW2-2,qGW9-1 and qTKW9-2 contributed to high grain yield.GL9 was identified as a candidate gene for qGL9-2 by map-based cloning and sequencing,and is a novel allele of GS9.The kernel of NIL-gl9was slenderer and longer than that of HJX74,and the TKW and grain yield per plant of NIL-gl9 were higher than those of HJX74.The proportion of grain chalkiness of NIL-gl9 was much lower than that of HJX74.Thus,gl9 increased grain yield and appearance quality simultaneously.Three pyramid lines,NIL-gs3/gl9,NIL-GW7/gl9 and NIL-gw8/gl9,were developed and the kernel of each was longer than that of the corresponding recipient parent lines.The gl9 allele may be beneficial for breeding rice varieties with high grain yield and good appearance quality. | Shaojun Lin Zupei Liu Kui Zhang Weifeng Yang Penglin Zhan Quanya Tan Yajun Gou Shuaipeng Ma Xin Luan Chubing Huang Zhili Xiao Yuanyuan Liu Bihuang Zhu Ruiqing Liang Wenqi Zhou Haitao Zhu Suhong Bu Guifu Liu Guiquan Zhang Shaokui Wang | 2023 | The Crop Journal2023，11，1： | 1 |
| 18 | Simiao pillameliorates urate underexcretion and renal dysfunction inhyperuricemic mice显示文摘 | HU Qinghua JIAO Ruiqing WANG Xing | 2010 | Journal of Ethnophamiacology2010，128，3： | 1 |
| 19 | Ultrasensitive solar-blind ultraviolet detection and optoelectronic neuromorphic computing using α-In_(2)Se_(3)phototransistors显示文摘Detection of solar-blind ultraviolet(SB-UV)light is important in applications like confidential communication,flame detection,and missile warning system.However,the existing SB-UV photodetectors still show low sensitivities.In this work,we demonstrate the extraordinary SB-UV detection performance of α-In_(2)Se_(3 )phototransistors.Benefiting from the coupled semiconductor and ferroelectricity property,the phototransistor has an ultraweak detectable power of 17.85 fW,an ultrahigh gain of 1.2×10^(6),a responsivity of 2.6×10^(5) A/W,a detectivity of 1.3×10^(16) Jones and an ultralow noise-equivalent-power of 4.2×10^(–20 )W/Hz1/2 for 275 nm light.Its performance exceeds most other UV detectors,even including commercial photomultiplier tubes and avalanche photodiodes.It can be also implemented as an optoelectronic synapse for neuromorphic computing.A 784×300×10 artificial neural network(ANN)based on this optoelectronic synapse is constructed and demonstrated with a high recognition accuracy and good noise-tolerance for the Fashion-MNIST dataset.These extraordinary features endow this phototransistor with the potential for constructing advanced SB-UV detectors and intelligent hardware. | Yuchen Cai Jia Yang Feng Wang Shuhui Li Yanrong Wang Xueying Zhan Fengmei Wang Ruiqing Cheng Zhenxing Wang Jun He | 2023 | Frontiers of physics2023，18，3： | 1 |
| 20 | Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis显示文摘Aging-elevated DNMT3A R882H-driven clonal hematopoiesis(CH)is a risk factor for myeloid malignancies remission and overall survival.Although some studies were conducted to investigate this phenomenon,the exact mechanism is still under debate.In this study,we observed that DNMT3 A R878 H bone marrow cells(human allele:DNMT3 A R882 H)displayed enhanced reconstitution capacity in aged bone marrow milieu and upon inflammatory insult.DNMT3 A R878 H protects hematopoietic stem and progenitor cells from the damage induced by chronic inflammation,especially TNFa insults.Mechanistically,we identified that RIPK1-RIPK3-MLKL-mediated necroptosis signaling was compromised in R878 H cells in response to proliferation stress and TNFa insults.Briefly,we elucidated the molecular mechanism driving DNMT3 A R878 H-based clonal hematopoiesis,which raises clinical value for treating DNMT3 A R882 H-driven clonal hematopoiesis and myeloid malignancies with aging. | Min Liao Ruiqing Chen Yang Yang Hanqing He Liqian Xu Yuxuan Jiang Zhenxing Guo Wei He Hong Jiang Jianwei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
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