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| 1 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Flood-illuminated adaptive optics ophthalmoscope with a single curved relay mirror显示文摘For decreasing light loss and diminishing the aberrations of the optical system,an open-loop adaptive optics(AO)system for retinal imaging in vivo is introduced.Taking advantage of the ability of young human eyes to accommodate,there was only one single curved mirror to make the pupil of the eye conjugate with the wavefront corrector and the wavefront sensor.A liquid crystal spatial light modulator(LC-SLM)was adopted as the wavefront corrector because the LC-SLM can be made in a small size to match the sensor.To reduce a pair of lenses or focusing mirrors,the wavefront corrector and sensor are positioned in the noncommon path.The system adopts open-loop control and the high-precision LC-SLM guarantees the effectiveness of the AO system.The designed field of view is 1°on the retina(about 300μm).The image quality was simulated with different mirror surface types,including circular,parabolic,and hyperbolic.A hyperbolic mirror with conic constant−1.07,which is close to−1,could best eliminate the aberrations.Theoretical analysis showed that the optical throughput of this system was at least 22.4%higher than that of a standard transmission AO system.In a practical experiment,a parabolic mirror was positioned in the optical path.Images of the cone photoreceptors and the capillary vessels were obtained successfully.This system simplifies the optical setup in comparison to the commonly used 4F systems while still guaranteeing the effectiveness of AO to correct the ocular aberrations. | Ruixue Liu Yue Qi Xianliang Zheng Mingliang Xia Li Xuan | 2013 | Photonics Research2013，1，3： | 3 |
| 3 | Microenvironment regulation of M-N-C single-atom catalysts towards oxygen reduction reaction显示文摘The development of cost-effective,robust,and durable electrocatalysts to replace the expensive Pt-based catalysts towards oxygen reduction reaction(ORR)is the trending frontier research topic in renewable energy and electrocatalysis.Particular attention has been paid to metal-nitrogen-carbon(M-N-C)single atom catalysts(SACs)due to their maximized atom utilization efficiency,biomimetic active site,and distinct electronic structure.More importantly,their catalytic properties can be further tailored by rationally regulating the microenvironment of active sites(i.e.,M-N coordination number,heteroatom doping and substitution.Herein,we present a comprehensive summary of the recent advancement in the microenvironment regulation of MN-C SACs towards improved ORR performance.The coordination environment manipulation regarding central metal and coordinated atoms is first discussed,focusing on the structure-function relationship.Apart from the near-range coordination,longrange substrate modulation including heteroatom doping,defect engineering is discussed as well.Besides,the synergy mechanism of nanoparticles and single atom sites to tune the electron cloud density at the active sites is summarized.Finally,we provide the challenges and outlook of the development of M-N-C SACs. | Li Zhang Qinglei Meng Ruixue Zheng Liuqing Wang Wei Xing Weiwei Cai Meiling Xiao | 2023 | Nano Research2023，16，4： | 2 |
| 4 | Cell Transformation and Proteome Alteration in QSG7701 Cells Transfected with Hepatitis C Virus Non-structural Protein 3显示文摘坚持的丙肝病毒(HCV ) 感染能引起肝肝硬化 andhepatocellularcarcinoma。非结构的蛋白质 3 (NS3 ) , HCV 的重要部分,在病毒的生命周期被含有并且与主人交往细胞的蛋白质。在这研究,我们在人的 hepatocyteQSG7701 房间在房间 tranformation 和相关蛋白质改变上调查了 NS3 蛋白质的效果。结果显示在 QSG7701 房间的 NS3 蛋白质的那个稳定的表达式与减少的人口双倍工资,抛锚无关的生长和肿瘤开发劝诱了转变人物。十五表示差别的蛋白质被分开并且鉴别 using2-D 电气泳动和飞行 massspectrometry 的帮助矩阵的激光解吸附作用电离时间。蛋白质印迹分析证实 phospho-p44/42 和 phospho-p38proteins 的增加与转变房间被联系。这些结果支持了 HCV NS3protein 玩的看法一个转变角色和提供的一些阐明的线索 HCV 相关的 hepatocellular 的 carcinogenesis 机制癌。 | Qiongqiong HE Ruixue CHENG Zhuchu CHEN Xuxian XIAO Zhiqiang XIAO Cui LI Bo LI Pengfei ZHANG Hui ZHENG Deyun FENG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 2 |
| 5 | Characterization ofα_(2)Precipitates in Ti–6Al and Ti–8Al Binary Alloys:A Comparative Investigation显示文摘Transmission electron microscopy(TEM)and atom probe tomography(APT)techniques were used to investigate the nanoscale orderedα_(2)(Ti_(3)Al)precipitates in Ti–Al binary alloys.Ti–6Al and Ti–8Al binary alloys were solution treated and aged to obtain Widmanstatten microstructure and promoteα_(2)precipitates.The TEM results displayed strong short-range ordering ofα_(2)precipitates in Ti–8Al alloy,while no evidence of the superlattice reflections ofα_(2)in Ti–6Al alloy.The results acquired from APT showed theα_(2)clusters and atoms distribution at the interface between the matrix andα_(2)precipitates.The size and morphology ofα_(2)particles in Ti–8Al alloy,respectively,obtained by TEM and APT are closely consistent.Meanwhile,the APT results displayed tiny size clusters in Ti–6Al alloy,which supposed to give evidence of the initial ordering process ofα_(2)precipitates in the absence of correlative results from TEM. | Sabry S.Youssef Xiaodong Zheng Yingjie Ma Sensen Huang Min Qi Jianke Qiu Ruixue Zhang Peitao Hua Shijian Zheng Jiafeng Lei Rui Yang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，5： | 1 |
| 6 | A 1.8-V 240-MHz 2.19-mW Four-Stage CMOS OTA with a Segmenting Frequency Compensation Technique显示文摘A four-stage Operational transconductance amplifier(OTA)used in an infrared temperature sensor adopting the proposed Feed-forward Gm-stage and segmenting nested Miller compensation technique is presented.The purpose of the proposed segment compensation is primarily to make more amplifier stages concatenated.The circuit linked several transconductance stages to form a segment,and linked several segments to form a large multistage amplifier.For example,a twostage amplifier linked with a three-stage amplifier can realize a five-stage amplifier,two three-stage amplifiers linked can realize a six-stage amplifier.A four-stage amplifier in the form of 2+2(two stages and two stages)was used as an example to verify this compensation method.The proposed OTA is designed in the 180 nm complementary metal oxide semiconductor process.It consists of two parts which ensure the stability and improve the bandwidth performance.The first part is a feedforward transconductance stage,and the second part is the two-segment transconductance stages with the Miller compensation techniques employed within and between the two segments.Based on the small-signal model,stability analysis and theoretical derivation are performed in theory.On condition of a 2-pF load capacitance,a direct current gain of 109 dB and a gain-bandwidth of 240 MHz with a phase margin of 50°can be achieved.The proposed design consumes 2.19 mW in a 1.8-V supply voltage.The transient simulation indicates that the settling time of the output is 19 ns with the settling error being 1%,and the slew rate is 114 V/μs. | LIANG Yuhua ZHENG Zirui LIU Shubin LI Dengquan DING Ruixue ZHU Zhangming | 2021 | Chinese Journal of Electronics2021，30，5： | 0 |
| 7 | Atomically dispersed Fe sites on hierarchically porous carbon nanoplates for oxygen reduction reaction显示文摘Developing cost-effective,robust and stable non-precious metal catalysts for oxygen reduction reaction(ORR) is of paramount importance for electrochemical energy conversion devices such as fuel cells and metal-air batteries.Although Fe-N-C single atom catalysts(SACs) have been hailed as the most promising candidate due to the optimal binding strength of ORR intermediates on the Fe-N_(4) sites,they suffer from serious mass transport limitations as microporous templates/substrates,i.e.,zeolitic imidazolate frameworks(ZIFs),are usually employed to host the active sites.Motivated by this challenge,we herein develop a hydrogen-bonded organic framework(HOF)-assisted pyrolysis strategy to construct hierarchical micro/mesoporous carbon nanoplates for the deposition of atomically dispersed Fe-N_(4) sites.Such a design is accomplished by employing HOF nanoplates assembled from 2-aminoterephthalic acid(NH_(2)-BDC) and p-phenylenediamine(PDA) as both soft templates and C,N precursors.Benefitting from the structural merits inherited from HOF templates,the optimized catalyst(denoted as Fe-N-C SAC-950) displays outstanding ORR activity with a high half-wave potential of 0.895 V(vs.reversible hydrogen electrode(RHE)) and a small overpotential of 356 mV at 10 mA cm^(-2) for the oxygen evolution reaction(OER).More excitingly,its application potential is further verified by delivering superb rechargeability and cycling stability with a nearly unfading charge-discharge gap of 0.72 V after 160 h.Molecular dynamics(MD) simulations reveal that micro/mesoporous structure is conducive to the rapid mass transfer of O_(2),thus enhancing the ORR performance.In situ Raman results further indicate that the conversion of O_(2) to~*O_(2)-the rate-determining step(RDS) for Fe-N-C SAC-950.This work will provide a versatile strategy to construct single atom catalysts with desirable catalytic properties. | Ruixue Zheng Qinglei Meng Hao Zhang Teng Li Di Yang Li Zhang Xiaolong Jia Changpeng Liu Jianbing Zhu Xiaozheng Duan Meiling Xiao Wei Xing | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 8 | Identification of oleic acid as an endogenous ligand of GPR3显示文摘Although GPR3 plays pivotal roles in both the nervous system and metabolic processes,such as cold-induced thermogenesis,its endogenous ligand remains elusive.Here,by combining structural approach(including cryo-electron microscopy),mass spectrometry analysis,and functional studies,we identify oleic acid(OA)as an endogenous ligand of GPR3.Our study reveals a hydrophobic tunnel within GPR3 that connects the extracellular side of the receptor to the middle of plasma membrane,enabling fatty acids to readily engage the receptor.Functional studies demonstrate that OA triggers downstream Gs signaling,whereas lysophospholipids fail to activate the receptor.Moreover,our research reveals that cold stimulation induces the secretion of OA in mice,subsequently activating Gs/cAMP/PKA signaling in brown adipose tissue.Notably,brown adipose tissues from Gpr3 knockout mice do not respond to OA during cold stimulation,reinforcing the significance of GPR3 in this process.Finally,we propose a“born to be activated and cold to enhance”model for GPR3 activation.Our study provides a starting framework for the understanding of GPR3 signaling in cold-stimulated thermogenesis. | Yangjie Xiong Zhenmei Xu Xinzhi Li Yuqin Wang Jing Zhao Na Wang Yaning Duan Ruixue Xia Zhengbin Han Yu Qian Jiale Liang Anqi Zhang Changyou Guo Asuka Inoue Yu Xia Zheng Chen Yuanzheng He | 2024 | Cell Research2024，34，3： | 0 |
| 9 | Response of MaHMA2 gene expression and stress tolerance to zinc stress in mulberry(Morus alba L.)显示文摘HMA2(heavy metal ATPase 2)plays a crucial role in extracellular and intracellular Zn^(2+)transport across biomembranes,maintaining ion homeostasis,and playing an important role in the normal physiological metabolism,growth,and development of plants.In our study,a novel HMA2 gene,named MaHMA2,was isolated and cloned from white mulberry(Morus alba L.).The gene sequence obtained was 1,342 bp long,with an open reading frame of 1,194 bp,encoding a protein of 397 amino acids,with a predicted molecular mass of 42.852 kD and an isoelectric point of 7.53.This protein belonged to the PIB-type ATPase transport protein family.We analyzed the expression of the MaHMA2 gene by quantitative real-time PCR.The results showed that the level of MaHMA2 gene expression decreased to a Zn concentration of 800 mg/kg.Malondialdehyde and proline levels increased and responded to increasing Zn when the MaHMA2 gene was silenced,whereas the activities of peroxidase and superoxide dismutase tended to increase in response to increasing Zn^(2+)ion stress concentrations but were lower in the gene-silenced plants.These findings suggested that the MaHMA2 gene played an active role in the tolerance response of mulberry to Zn stress. | LEI WANG QIUXIA DU YISU SHI MICHAEL ACKAH PENG GUO DANYAN ZHENG MENGMENG WU XIN JIN PEILAN LI QIAONAN ZHANG RUIXUE LI ZHI YIN MENGDI ZHAO WEIGUO ZHAO | 2022 | BIOCELL2022，46，10： | 0 |
| 10 | Recent Advances in Stability Improvement Strategies of M-N_(x)/C Catalysts Towards Oxygen Reduction Reaction显示文摘Although fuel cells possess advantages of high energy conversion efficiency and zero-carbon emission,their large-scale commercialization is restricted by expensive and scarce platinum(Pt)catalysts.Metal-nitrogen-carbon(M-Nx/C)catalysts are hailed as the most promising candidates to replace Pt due to their considerable oxygen reduction reaction(ORR)activity and low cost.Despite tremendous progress in terms of active site identification and activity improvement being achieved in the past few decades,the M-Nx/C catalysts still suffer from insufficient durability,which drastically limits their practical application.In this regard,understanding degradation mechanisms and customizing stabilization strategies are of significant importance yet challengeable.In this review,we summarize the recent advances in the stability improvement of M-Nx/C catalysts.The stability test protocols of the M-Nx/C are firstly introduced.Subsequently,with the combination of advanced ex situ and in situ characterization techniques and density functional theory calculation,we present a comprehensive overview of the main degradation mechanisms during ORR process.Aiming at these deactivation issues,a variety of novel improvement strategies are developed to enhance the stability of M-Nx/C.Finally,the current challenges and prospects to design highly stable M-Nx/C catalysts are also proposed. | Xiaolong Jia Qinglei Meng Ruixue Zheng Xiaohui Liu Yaling Zhao Changpeng Liu Meiling Xiao Wei Xing | 2023 | Renewables2023，1，6： | 0 |
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