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| 1 | 肥胖肿瘤的关联机制-潜在可能的研究方向(英文)显示文摘Recently, obesity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease. There is more and more sufficient evidence that excess body weight is an avoidable cause of excess cancers including gastrointestinal, endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal cancers. The mechanism that obesity association with cancer is remains not well understood. There be some most studied hypothesized mechanisms such as, high levels of insulin and free levels of insulin-like growth factors (IGFs), sex hormones, adipocytokines, inflammatory cytokines, c-Myc (or Myc) oncogenic transcription factor, obesity-induced hypoxia and Warburg effect, and so on. In the future, the potential mechanisms and conclusions in obesity associated with increased risk for developing cancer, and the underlying cellular and molecular mechanisms will be studied. | Chunjun Sheng Ruoxue Li Peng Yang Shen Qu Zheng Cui Kun Lu | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，8： | 2 |
| 2 | 6-7 Dual-windows Coupler R&D in IMP显示文摘IMP hosts the project of high intensity Heavy Ion Accelerator Facility (HIAF). High power input couplers are needed for the SRF cavities. In order to assemble cryo-module easily and run the machine safely, new TTF-III like demountable dual-ceramic coupler is developed. This paper will present some results of the 162.5 MHz coupler for the tapper HWR cavity. | Li Yongming Wang Ruoxu Zhang Shenghu Jiang Tiancai Sun Guozhen Liu Lubei He Yuan Zhao Hongwei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 3 | Path Breakthrough of Medical Humanities Education From the Perspective of“All-Staff,Whole-Process,and All-Round Education”显示文摘Medical education is an important cornerstone for the development of healthcare,and medical humanities education,as an integral part of medical education,plays an irreplaceable role in cultivating people’s health guardians with high medical ethics.We adopted the method of stratified random sampling to select 309 students and 107 faculty members from three independent medical colleges in Sichuan province as the research subjects and distributed questionnaire surveys investigating in three dimensions:overall cognition of medical humanities,evaluation of medical humanistic qualities,and the current situation of medical humanities education,supplemented by an in-depth literature review and interviews with subject matter experts.We found that“tech-centrism”still has a great influence,the self-evaluation of medical students’humanistic quality is generally not high,the educational concept of“emphasizing professional skills over morality”of faculty and staff is still quite prevalent,and there is still the“last mile”phenomenon in medical humanities education.In order to promote the integrated development of“new medicine”and“new liberal arts”and break the barriers of“tech-centrism”and“instrumental rationality,”it is necessary to change the educational concept and strengthen the education of all employees,break through the bottleneck of internships and strengthen the whole process of education,integrate educational resources and strengthen all-round education,improve the incentive mechanisms,strengthen the assessment methods,and provide Chinese wisdom and Chinese solutions for the development of medical humanities education. | Li Ruoxue Zhang Jun Jiang Li Jiang Xianwen | 2023 | Contemporary Social Sciences2023，8，4： | 0 |
| 4 | Mutation inε-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice显示文摘Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutation knock-in(KI)mice,we showed here that both KO and KI mice exerted typical movement defects similar to those of MDS patients.SGCE promoted filopodia development in vitro and inhibited excitatory synapse formation both in vivo and in vitro.Loss of function of SGCE leading to excessive excitatory synapses that may ultimately contribute to MDS pathology.Indeed,using a zebrafish MDS model,we found that among 1700 screened chemical compounds,Vigabatrin was the most potent in readily reversing MDS symptoms of mouse disease models.Our study strengthens the notion that mutations of SGCE lead to MDS and most likely,SGCE functions to brake synaptogenesis in the CNS. | Jiao Li Yiqiong Liu Qin Li Xiaolin Huang Dingxi Zhou Hanjian Xu Feng Zhao Xiaoxiao Mi Ruoxu Wang Fan Jia Fuqiang Xu Jing Yang Dong Liu Xuliang Deng Yan Zhang | 2021 | Neuroscience Bulletin2021，37，3： | 0 |
| 5 | 耦合器测试系统的改进显示文摘The 162.5 MHz HWR010 and HWR015 superconducting cavities have been used in the Chinese ADS 25 MeV demo SRF Linac.Each cavity is feed with RF power by one high power coupler.The maximum design coupler power is 20 kW in traveling mode.Prior to assembly,couplers need to be tested and conditioned at room temperature.And the characteristics of conditioning phenomenon can also be thoroughly studied during the conditioning process.Figure 1 presents the block diagram of the test stand system.However,the previous test system is ineligible because of its sundry problems lying in its LLRF control system and its test stand.To overcome the defects of the previous test system,a series of improvements were performed. | Jiang Tiancai Chen Long Wang Ruoxu Li Chunlong | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 6 | Development of RF Cavities at the Department of RF Cavity in 2019显示文摘The cavity design including RF design and multi-physics analysis of the RFQ for the CAFe(Chinese Accelerator Facility for super-heavy Elements)project have been completed by the end of 2019. | Zhang Zhouli Yue Weiming Li Chenxing Li Chunlong Huang Yulu Wang Ruoxu Xu Xianbo Zhang Shengxue Zhang Shenghu He Tao Yang Lei Xing Chaochao Lin Zeqiang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 7 | 650 MHz Elliptical Cavities Development in IMP for CiADS显示文摘Multicell superconducting radio frequency(SRF)elliptical cavities are proposed for efficient acceleration of proton beam in the Chinese initiative Accelerator Driven Subcritical System(CiADS). | Huang Yulu Wang Ruoxu Liu Lubei Jiang Tiancai Zhang Shengxue Liu Shuhui Tan Teng Guo Hao Li Chunlong Yue Weiming Zhang Zhouli Wang Zhijun Zhang Shenghu He Yuan | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 8 | Design of an RFQ for the CAfe Project at IMP显示文摘An RFQ has been designed for the CAFe(Chinese Accelerator Facility for super-heavy Elements)project at IMP.The RFQ,which works at 162.5 MHz and whose design current is 20 pμA. | Li Chengxing Xu Xianbo Zhang Zhouli Huang Yulu Zhang Shengxue Wang Ruoxu | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 9 | 6-5 Operation of HWRs for C-ADS Injector显示文摘There are two types of HWR cavities have been developed in IMP for C-ADS Injector.HWR010s have been used to accelerate proton from 2.1 MeV to 10 MeV.There are 12 HWR010s assembled in two CMs.The taper type HWR015s have been used to accelerate proton from 10MeV to 18.5 MeV.There are 5 HWRs assembled in the third CM.Proton beam has been accelerated to 26 MeV by HWR010,HWR015 and Spoke021 in June 2017.The beam has been accelerated to 18.5 MeV by HWR010 and HWR015.The CMs in the tunnel are shown in Fig.1. | Yue Weiming Zhang Shenghu Li Yongming Chang Wei Jiang Tiancai Zhang Shengxue Gao Zheng Wang Ruoxue Huang Shichun Pan Feng Chen Long Li Chunlong Song Yukun Guo Hao Xiong Pingran Cong Zhang Tan Teng Wan Yuqin Niu Xiaofei Bai Feng Hu Chuanfei Zhang Peng Liu Lubei Huang Yulu Zhao Yugang Guo Xiaohong You Zhiming Zhang Junhui Huang Guirong He Yuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 10 | 6-10 Evaluation of Power Loss on the NC QWR Cavity of a New Room-temperature Test Stand for Couplers显示文摘Room-temperature test with high power is an essential step before couplers are installed on superconducting cavities.A new room-temperature test stand is being designed at IMP.The new stand will be assembled with a NC(normal-conducting)QWR cavity.The power loss on the cavity when couplers are conditioned in traveling-wave mode has to be thoroughly evaluated.Fig.1 demonstrates the power flow in traveling-wave conditioning mode.Pe1 and Pe2 represent the power that is extracted by couplers.Pf and Pre denote the forward power and reflected power,respectively. | Chen Long Li Yongming Zhang Shenghu Jiang Tiancai Li Chunlong Wang Ruoxu He Yuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 11 | 6-11 SRF Power Input Coupler for HWR010 at IMP显示文摘The high power superconducting radiofrequency(SRF)input coupler is the connecting part between the SRF cavity and the RF transmission line.With the RF power transferred through the coupler,the SRF cavity can built up the electromagnetic field and then accelerate the beams.In addition to this RF transmission function,it also has to serve as a vacuum barrier for the SRF cavity vacuum.The HWR010 coupler which designed by IHEP is a single ceramic window coupler. | Li Yongming Jiang Tiancai Wang Ruoxu Zhang Shenghu Yue Weiming Xiong Pingran Li Chunlong Liu Lubei Zhang Shengxue Song Yukun He Yuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 12 | 6-12 Design of a Double Spoke Cavity for CADS显示文摘Spoke cavities have been developed and have apparent advantages for high current proton accelerator based on Fig.1(color online)The electromagnetic field distribution.superconductivity at low and medium energy region.As the research and the technical reserve,Institute of Modern Physics(IMP)has started the R&D program of a double spoke cavity(operating frequency 325 MHz, 0=0.52),within the framework of China Accelerator Driven System(C-ADS)project.The RF design and mechanical structure design have been finished,and two prototype cavities were manufactured in Harbin. | Jiang Tiancai Zhang Shenghu Li Yongming Yue Weiming Xiong Pingran Li Chunlong Liu Lubei Zhang Shengxue Wang Ruoxu Song Yukun Guo Hao Huang Yulu You Zhiming He Yuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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