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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2显示文摘 | Yang Zeng Xuebin Qu Hongling Li Shan Huang Shihua Wang Qilin Xu Ruizhu Lin Qin Han Jing Li Robert Chunhua Zhao | 2012 | FEBS Letters2012，，16： | 2 |
| 3 | Development of HEP-XXMF Series Hall Thrusters in BICE显示文摘Hall thruster is a type of electric propulsion thruster which is often regarded as a moderate specific impulse space propulsion technology and is used primarily for station keeping and orbit maintenance tasks. Magnetic field is the most important aspect in Hall thruster's design. Each time the performance improvement of Hall thrusters is accompanied with the regeneration of magnetic field design. Now, all the major space nations treat the magnetic field design as the key technology for Hall thrusters, and many Hall thrusters have emerged in recent years, for example, BPT-4000 and NASA-173 M. In China, based on magnetic focus technology, the Beijing Institute of Control Engineering(BICE) has been developing Hall thrusters ranged from hundreds of watts to 5 kilowatts, including the 1500 W HEP-100 MF and the 5 k W HEP-140 MF Hall thrusters. This paper briefly reviews the development of the HEP-XXMF series Hall thruster. The principle of the Hall thruster, the design methods and the current status of HEP-100 MF and HEP-140 MF are discussed in the paper. | HU Yantin HU Dawei WU Pengan LI Shengjun ZANG Juanwei MAO Wei SHAN Shihua YANG Jian | 2016 | Aerospace China2016，17，2： | 2 |
| 4 | Actuation Spaces Synthesis of Lower-Mobility Parallel Mechanisms Based on Screw Theory显示文摘The lower-mobility parallel mechanism has been widely used in the engineering field due to its numerous excellent characteristics.However,little work has been devoted to the actuator selection and placement that best satisfy the system's functional requirements during concept design.In this study,a unified approach for synthesizing the actuation spaces of both rigid and flexure parallel mechanisms has been presented,and all possible combinations of inputs could be obtained,laying a theoretical foundation for the subsequent optimization of inputs.According to the linear independence of actuation space and constraint space of the lower-mobility parallel mechanism,a general expression of actuation spaces in the format of screw systems is deduced,a unified synthesis process for the lower-mobility parallel mechanism is derived,and the efficiency of the method is validated with two selective examples based on screw theory.This study presents a theoretical framework for the input selection problems of parallel mechanisms,aiming to help designers select and place actuators in a correct and even optimal way after the configuration design. | Shihua Li Yanxia Shan Jingjun Yu Yaxiong Ke | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 1 |
| 5 | Creation and validation of a widely applicable multiple gene transfer vector system for stable transformation in plant显示文摘 | Quanxi Sun Jiang Liu Yaxiao Li Qin Zhang Shihua Shan Xinzheng Li Baoxiu Qi | 2013 | Plant Molecular Biology (-)2013，，4： | 1 |
| 6 | Cloning and functional analysis of the promoter of allergen gene Ara h 1 from peanut显示文摘Peanut seeds are ideal bioreactors for the production of foreign recombinant proteins or secondary metabolites.Seed-specific promoters(SSPs)can direct the expression of genes specifically in seeds to avoid undesirable effects associated with constitutive expression.However,few SSPs have been identified in peanut.Previous studies have shown that some allergen-encoding genes encode seed storage proteins or exhibit seed-specific/preferential expression.In this study,we characterized allergen-encoding genes from across the genomes of Arachis species to explore seed-specific genes.We found that at least 9 out of 16 identified peanut allergen-encoding genes were expressed specifically in the seeds or were preferentially expressed.A 1493-bp promoter fragment of allergen gene Ara h 1(we named it AHSSP6)was isolated from cultivated peanut genome.cis-element analysis showed that three RY repeat elements which usually exsisted in seed or embryo specific promoter sequence were also present in AHSSP6 sequence.Histochemical analysis showed AHSSP6 could drive the expression of aβ-glucuronidase(GUS)reporter gene specifically in the seeds or cotyledon tissue of transgenic Arabidopsis,while not in other tissues.These findings indicated that these promoters of allergen genes were candidate SSPs,and AHSSP6 was a novel SSP which could be potentially utilized in peanut improvement. | Cuiling Yuan Chunjuan Li Caixia Yan Xiaobo Zhao Juan Wang Yifei Mou Zhiwei Wang Quanxi Sun Shihua Shan | 2022 | Oil Crop Science2022，7，1： | 0 |
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