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| 1 | Chronic hepatitis B infection in pregnancy显示文摘There are no standard guidelines to follow when a patient with chronic hepatitis B infection becomes pregnant or desires pregnancy. Topics to consider include which patients to treat, when to start treatment, what treatment to use and when to stop treatment. Without any prophylaxis or antiviral therapy, a hepatitis B surface antigen and E antigen positive mother has up to a 90% likelihood of vertical transmission of hepatitis B virus(HBV) to child. Standard of care in the United States to prevent perinatal transmission consists of administration of hepatitis B immune globulin and HBV vaccination to the infant. The two strongest risk factors of mother to child transmission(MTCT) of HBV infection despite immunoprophylaxis are high maternal HBV viral load and high activity of viral replication. The goal is to prevent transmission of HBV at birth by decreasing viral load and/or decreasing activity of the virus. Although it is still somewhat controversial, most evidence shows that starting antivirals in the third trimester is effective in decreasing MTCT without affecting fetal development. There is a growing body of literature supporting the safety and efficacy of antiviral therapies to reduce MTCT of hepatitis B. There are no formal recommendations regarding which agent to choose. Tenofovir, lamivudine and telbivudine have all been proven efficacious in decreasing viral load at birth without known birth defects, but final decision of which antiviral medication to use will have to be determined by physician and patient. The antivirals may be discontinued immediately if patient is breastfeeding, or within first four weeks if infant is being formula fed. | Jennifer R Lamberth Sheila C Reddy Jen-Jung Pan Kevin J Dasher | 2015 | World Journal of Hepatology2015，7，9： | 32 |
| 2 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 3 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 4 | Calcification resistance with aluminium-ethanol treated porcine aortic valve bioprostheses in juvenile sheep显示文摘 | Matthew F Ogle M Sheila J | 2003 | Ann Thorac Surg2003，75，6： | 1 |
| 5 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 6 | Mind- fulness- based stress reduction compared with cognitive behav- ioral therapy for the treatment of insomnia comorbid with canc- er: A randomized, partially blinded, noninferiority trial显示文摘 | Sheila N Garland Linda E Carlson Alisa J Stephens | 2014 | Jour- nal of Clinical Oncology2014，32，5： | 1 |
| 7 | Identification of a point mutation associated with pyrethroid resistance in the para -type sodium channel of Triatoma infestans , a vector of Chagas’ disease显示文摘 | Jésica Fabro Marcos Sterkel Natalia Capriotti Gastón Mougabure-Cueto Mónica Germano Rolando Rivera-Pomar Sheila Ons | 2011 | Infection, Genetics and Evolution2011，，2： | 1 |
| 8 | Consensus Building on Access to Controlled Medicines : A Four-Stage Delphi Consensus Procedure 显示文摘 | Saskia J Sarah B Sheila P | 2013 | J Pain Symptom Manage2013，46，6： | 1 |
| 9 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 10 | A neurovascular niche for neurogenesis after stroke显示文摘 | John J Ohab Sheila Fleming Armin Blesch | 2006 | J Neurosci2006，26，13： | 1 |
| 11 | Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass ,as measured by dual-energy X-ray absorptiometry in ehildren aged 3-19 y显示文摘 | Rachael W T Ianthe E J Sheila M W | 2000 | Am J Clin Nutr2000，72，： | 1 |
| 12 | The effectiveness of the Bobath concept instroke rehabilitation:what is the evidence显示文摘 | Boudesijn J K Sheila L Bernadette L | 2009 | Stroke2009，40，4： | 1 |
| 13 | Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis显示文摘 | Simunovic Nicole Devereaux P J Sprague Sheila Guyatt Gordon H Schemitsch Emil DeBeer Justin Bhandari Mohit | 2010 | Canadian Medical Association. Journal2010，，15： | 1 |
| 14 | Parent-Child Interaction Therapy: New Directions in Research 显示文摘 | Amy D Herschell Esther J Calzada Sheila M Eyberg | 2002 | Cognitive and Behavioral Practice2002，9，1： | 1 |
| 15 | Clinical Issues in Parent-Child Interaction Therapy显示文摘 | Amy D Herschell Esther J Calzada Sheila M Eyberg | 2002 | Cognitive and Behavioral Practice2002，9，1： | 1 |
| 16 | Semantic Web services as behavior-oriented agents显示文摘 | Joanna J Bryson David Martin Sheila A McIlraith | 2002 | IEEE Computer2002，35，11： | 1 |
| 17 | Identification of the Fanconi anemia complementation group I gene, FANCI显示文摘 | Josephine C. Dorsman Marieke Levitus Davy Rockx Martin A. Rooimans Anneke B. Oostra Anneke Haitjema Sietske T. Bakker J?rgen Steltenpool Dezs? Schuler Sheila Mohan Detlev Schindler Fré Arwert Gerard Pals Christopher G. Mathew Quinten Waisfisz Johan P. de | 2007 | Cellular Oncology2007，，3： | 1 |
| 18 | Relationship of plasma amphetamine levels to physiological,subjective,cognitive and biochemical measures in healthy volunteers显示文摘 | Sheila J A Veronique A M I T Glen B B | 2003 | Hum Psychopharmacol Clin Exp2003，18，： | 1 |
| 19 | Single-molecule magnets:jahn-teller isomerism and the origin of two magnetization relaxation processes in Mn12 complexes显示文摘 | Aubin Sheila M J Sun Ziming Eppley Hilary J | 2001 | Inorg Chem2001，40，9： | 1 |
| 20 | Episodic fluid expulsion from geopressured sediments显示文摘 | Sheila J Roberts Jeffrey A Nunn | 1995 | Marine and Petroleum Geology1995，12，： | 1 |
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