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| 1 | Temperature field reconstruction of 3D luminous flames based on light field tomography theory显示文摘Standard plenoptic camera can be used to capture multi-dimensional radiation information of high temperature luminous flame to reconstruct the temperature distribution. In this study, a novel method for reconstructing three-dimensional temperature field is proposed. This method is based on the optical tomography combined with standard plenoptic camera. The flame projection information from different planes is contained in one radiation image. In this model, we introduced the effective concept of the nearest neighbor method in the frequency domain to strip the interference of redundant information in the projection and to realize three-dimensional deconvolution. The flame emission intensity received by the pixels on the charge-coupled device sensor can be obtained according to the optical tomographic model. The temperature distributions of the axisymmetric and nonaxisymmetric flames can be reconstructed by solving the mathematical model with the nearest neighbor method. The numerical results show that three-dimensional temperature fields of high temperature luminous flames can be retrieved, proving the validity of the proposed method. | NIU ZhiTian QI Hong SHI JingWen ZHANG JuQi REN YaTao | 2021 | Science China(Technological Sciences)2021，64，2： | 6 |
| 2 | Three-dimensional temperature reconstruction of diffusion flame from the light-field convolution imaging by the focused plenoptic camera显示文摘The plenoptic imaging technique provides a promising approach to the non-invasive three-dimensional measurement, especially for the high-temperature combustion diagnosis. We establish a light-field convolution imaging model for diffusion flame in this work, considering the radiation transfer process inside the diffusion flame and the light transfer process inside the focused plenoptic camera together. The radiation transfer process is described by the radiation transfer equation and solved by the generalized source multi-flux method. Wave optics theory is adopted to describe the light transfer process, combining Fresnel diffraction and the phase conversion of the lens. The flame light-field image is obtained by the light-field convolution imaging model and adopted as the measurement signal to reconstruct three-dimensional temperature field. The inverse problem of temperature reconstruction is solved by the least square QR decomposition method. The simulative temperature reconstruction work is conducted, including the inverse analysis, the uncertainty analysis, and the measurement noise influence. All the results show that the proposed measurement method is available to reconstruct three-dimensional temperature with satisfactory accuracy and acceptable uncertainty. Both symmetric and asymmetric distributed temperature fields are investigated, and the reconstructed results prove the validity and universality of the measurement method. | SHI JingWen QI Hong YU ZhiQiang AN XiangYang REN YaTao TAN HePing | 2022 | Science China(Technological Sciences)2022，65，2： | 4 |
| 3 | Effects of silver nanoparticles with different dosing regimens and exposure media on artificial ecosystem显示文摘Due to the wide use of silver nanoparticles(AgNPs) in various fields, it is crucial to explore the potential negative impacts on the aquatic environment of AgNPs entering into the environment in different ways. In this study, comparative experiments were conducted to investigate the toxicological impacts of polyvinylpyrrolidone-coated silver nanoparticles(PVP-AgNPs) with two kinds of dosing regimens, continuous and one-time pulsed dosing, in different exposure media(deionized water and XiangJiang River water). There were a number of quite different experimental results(including 100% mortality of zebrafish,decline in the activity of enzymes, and lowest number and length of adventitious roots) in the one-time pulsed dosing regimen at high PVP-AgNP concentration exposure(HOE)compared to the three other treatments. Meanwhile, we determined that the concentration of leached silver ions from PVP-AgNPs was too low to play a role in zebrafish death. Those results showed that HOE led to a range of dramatic ecosystem impacts which were more destructive than those of other treatments. Moreover, compared with the continuous dosing regimen, despite the fact that higher toxicity was observed for HOE, there was little difference in the removal of total silver from the aquatic environment for the different dosing regimens. No obvious differences in ecological impacts were observed between different water columns under low concentration exposure. Overall, this work highlighted the fact that the toxicity of Ag NPs was impacted by different dosing regimens in different exposure media, which may be helpful for assessments of ecological impacts on aquatic environments. | Jingwen Zeng Piao Xu Guiqiu Chen Guangming Zeng Anwei Chen Liang Hu Zhenzhen Huang Kai He Zhi Guo Weiwei Liu Jing Wu Jiangbo Shi | 2019 | Journal of Environmental Sciences2019，31，1： | 2 |
| 4 | Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma显示文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients. | Quanli Zhang Run Shi Yongkang Bai Lijuan Meng Jingwen Hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin | 2021 | Cancer Communications2021，41，6： | 2 |
| 5 | A novel chemotherapy strategy for advanced hepatocellular carcinoma: a multicenter retrospective study显示文摘Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall survival.The Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease stage.Results:From July 2013 to July 2018,111 patients with HCC were included in this study.The median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,respectively.Conclusion:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC. | Juxian Sun Chang Liu Jie Shi Nanya Wang Dafeng Jiang Feifei Mao Jingwen Gu Liping Zhou Li Shen Wan Yee Lau Shuqun Cheng | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 6 | Self-as- sembly of layered double hydroxide nanosheets/Au nanopar- ticles ultrathin films for enzyme-free electrocatalysis of glu- cose显示文摘 | Zhao Jingwen Kong Xianggui Shi Wenying | 2011 | J Mater Chem2011，21，36： | 1 |
| 7 | SHRIMP Zircon U-Pb Dating of the Tongshi Magmatic Complex in Western Shandong and Its Geological Implications显示文摘The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving 206Pb/238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7 ± 3.8 Ma, and the other eight yielded 207Pb/206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518 ± 11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7± 3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle Jurassic, whereas that of 2518 ± 11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period. | HU Huabin MAO Jingwen LIU Dunyi NIU Shuyin WANG Yanbin LI Yongfeng SHI Ruruo | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 1 |
| 8 | Fabrication of aluminum-doped tt-Ni(OH)2 with hierarchical architecture and its largely enhanced electrocatalytic performance显示文摘 | Kong Xianggui Zhao Jingwen Shi Wenying | 2012 | Electrochimica Acta2012，80，2： | 1 |
| 9 | A Survey of kNN Algorithm显示文摘The kNN algorithm is a well-known pattern recognition method,which is one of the best text classifi cation algorithms.It is one of the simplest machine learning algorithms in machine learning classification algorithm.In this paper,we summarize the kNN algorithm and related literature,introduce the idea,principle,implementation steps and implementation code of kNN algorithm in detail,and analyze the advantages and disadvantages of the algorithm and its various improvement schemes.This paper also introduces the development of kNN algorithm,the important published papers.At the end of this paper,the application of kNN algorithm is introduced,and its implementation in text classifi cation is emphasized. | Jingwen Sun Weixing Du Niancai Shi | 2018 | Information Engineering and Applied Computing2018，1，1： | 1 |
| 10 | A novel UPLC- MS/MS method for simultaneous quantification of rhein, emodin,berberine and baicalin in rat plasma and its appli- cation in a pharmacokinetic study 显示文摘 | Huang Ping Gao Jingwen Shi Zhan | 2012 | Bioanalysis2012，4，10： | 1 |
| 11 | Numerical study of heat transfer enhancement of channel via vortexinduced vibration显示文摘 | Shi Junxiang Hu Jingwen Schafer S R | 2014 | Applied Thermal Engineering2014，，70： | 1 |
| 12 | Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation显示文摘Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies for improving the efficiency of germ cell production in vitro.In this study,we developed a coupled screening strategy that took advantage of an arrayed bi-molecular fluorescence complementation(BiFC)platform for protein-protein interaction screens and epiblast-like cell(EpiLC)-induction assays using reporter mouse embryonic stem cells(mESCs).Investigation of candidate interaction partners of core human pluripotent factors OCT4,NANOG,KLF4 and SOX2 in EpiLC differentiation assays identified novel primordial germ cell(PGC)-inducing factors including BEN-domain(BEND/Bend)family members.Through RNA-seq,ChIP-seq,and ATAC-seq analyses,we showed that Bend5 worked together with Bend4 and helped mark chromatin boundaries to promote EpiLC induction in vitro.Our findings suggest that BEND/Bend proteins represent a new family of transcriptional modulators and chromatin boundary factors that participate in gene expression regulation during early germline development. | Guang Shi Yaofu Bai Xiya Zhang Junfeng Su Junjie Pang Quanyuan He Pengguihang Zeng Junjun Ding Yuanyan Xiong Jingran Zhang Jingwen Wang Dan Liu Wenbin Ma Junjiu Huang Zhou Songyang | 2022 | Protein & Cell2022，13，10： | 1 |
| 13 | SPBD:Streamlining Big-Data Processing in Cloud Environments显示文摘Many applications,such as those in genomics,are designed for one machine.This is not problematic if the input data set is small and can fit into the memory of a single powerful machine.However,the application and its algorithms are limited by the capacity and performance of the machine(the application cannot run in parallel).A single machine cannot handle very large data sets.In recent research,cloud computing and MapReduce have been used together to store and process big data.There are three main steps in handling data in the cloud:1) the user uploads the data,2) the data is processed,and 3) results are returned.When the size of the data reaches a certain scale,transmission time becomes the dominant factor;however,most research to date has only been focused on reducing the processing time.Also,it is generally assumed that the data is already stored in the cloud.This assumption does not hold because many organizations now store their data locally.In this paper,we propose SPBD(pronounced'speed') to minimize overall user wait time.We abstract overall processing time as an optimization problem and derive the optimal solution.When evaluated on our private cloud platform,SPBD is shown to reduce user wait time by up to 34% for a traditional WordCount application and up to 31% for a metagenomic application. | Tung Nguyen Jingwen Zhang Weisong Shi | 2013 | ZTE Communications2013，11，2： | 1 |
| 14 | The development of molecular and nano actinide decorporation agents显示文摘Internal contamination of actinides has led to significant health hazards to the public and workers in the context of nuclear power plant accidents,uranium ore mining,and reprocessing of the used fuel.An effective sequestering agent that is able to remove accidentally incorporated actinides in vivo with low toxicity is always in urgent need.The molecular decorporation ligands have been the most widely researched agents for the past few decades,while preliminary studies of functionalized nanoparticles have shown their clear advantages in metal binding selectivity,toxicity,and oxidative stress alleviation.Herein,the state-of-the-art of those two types of decorporation agents is presented with special attention being paid on the correlation between the solution and solid-state chemistry of those agents with actinides and the corresponding decorporation efficacies. | Xiaomei Wang Cen Shi Jingwen Guan Yemeng Chen Yigong Xu Juan Diwu Shuao Wang | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 15 | Two Dawson-type U(Ⅵ)-containing selenotungstates with sandwich structure and its high-efficiency catalysis for pyrazoles显示文摘Two novel uranium-containing selenotungstates Na_(3)[H_(19)(UO_(2))_(2)(μ_(2)-O)(Se_(2)W_(14)O_(52))_(2)]·41 H_(2)O(U_(2))and(NH_(4))_(10)[H_(4)(SeO)_(2)(UO_(2))_(2)(H_(2)O)_(2)(H_(2)Se_(2)W_(14)O_(52))(Se_(2)W_(14)O_(52))]·66 H_(2)O(Se_(2)U_(2))based on the{Se_(2)W_(14)O_(52)}unit were successfully prepared and fully characterized.To our knowledge,the uranium is firstly introduced into the selenotungstates.Moreover,it is notable that U_(2)exhibits excellent Lewis acid-base catalytic activities in the condensation cyclization of sulfonyl hydrazides with diketones to synthesize polysubstituted pyrazoles.All the desired products were obtained in moderate to good yields(up to 99%). | Mengyuan Cheng Yufeng Liu Weixin Du Jingwen Shi Junhua Li Haiying Wang Ke Li Guoping Yang Dongdi Zhang | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 16 | ADVISING score:a reliable grading scale based on injury and response for intracerebral haemorrhage显示文摘Background Intracerebral haemorrhage(ICH)is the most devastating form of stroke causing high morbidity and mortality.We aimed to develop a novel clinical score incorporating multisystem markers to predict functional dependence at 90 days after ICH.Methods We analysed data from Chinese Cerebral Hemorrhage:Mechanism and Intervention study.Multivariable logistic regression analysis was used to identify the factors associated with 90-day functional dependency(the modified Rankin Scale≥3)after ICH and develop the ADVISING scoring system.To test the scoring system,a total of 2111 patients from Hubei province were included as the training cohort,and 733 patients from other three provinces in China were included as an external validation cohort.Results We found nine variables to be significantly associated with functional dependency and included in the ADVISING score system:age,deep location of haematoma,volume of haematoma,National Institutes of Health Stroke Scale,aspartate transaminase,international normalised ratio,neutrophil-lymphocyte ratio,fasting blood glucose and glomerular filtration rate.Individuals were divided into 12 different categories by using these nine potential predictors.The proportion of patients who were functionally dependent increased with higher ADVISING scores,which showed good discrimination and calibration in both the training cohort(C-statistic,0.866;p value of Hosmer-Lemeshow test,0.195)and validation cohort(C-statistic,0.884;p value of Hosmer-Lemeshow test,0.853).The ADVISING score also showed better discriminative performance compared with the other five existing ICH scores(p<0.001).Conclusions ADVISING score is a reliable tool to predict functional dependency at 90 days after ICH. | Yan Wan Hongxiu Guo Shaoli Chen Jiang Chang David Wang Rentang Bi Man Li Ke Shi Zhaowei Wang Daokai Gong Jingwen Xu Quanwei He Bo Hu | 2023 | Stroke & Vascular Neurology2023，8，2： | 0 |
| 17 | A Multi-Agent Spatial Logic for Scenario-Based Decision Modeling and Verification in Platoon Systems显示文摘To cater for the scenario of coordinated transportation of multiple trucks on the highway,a platoon system for autonomous driving has been extensively explored in the industry.Before such a platoon is deployed,it is necessary to ensure the safety of its driving behavior,whereby each vehicle’s behavior is commanded by the decision-making function whose decision is based on the observed driving scenario.However,there is currently a lack of verification methods to ensure the reliability of the scenario-based decision-making process in the platoon system.In this paper,we focus on the platoon driving scenario,whereby the platoon is composed of intelligent heavy trucks driving on cross-sea highways.We propose a formal modeling and verification approach to provide safety assurance for platoon vehicles’cooperative driving behaviors.The existing Multi-Lane Spatial Logic(MLSL)with a dedicated abstract model can express driving scene spatial properties and prove the safety of multi-lane traffic maneuvers under the single-vehicle perspective.To cater for the platoon system’s multi-vehicle perspective,we modify the existing abstract model and propose a Multi-Agent Spatial Logic(MASL)that extends MLSL by relative orientation and multi-agent observation.We then utilize a timed automata type supporting MASL formulas to model vehicles’decision controllers for platoon driving.Taking the behavior of a human-driven vehicle(HDV)joining the platoon as a case study,we have implemented the model and verified safety properties on the UPPAAL tool to illustrate the viability of our framework. | Jingwen Xu Yanhong Huang Jianqi Shi Shengchao Qin | 2021 | Journal of Computer Science & Technology2021，36，6： | 0 |
| 18 | Investigation of Vegetation Resources on City Wall of the Ming Dynasty in Nanjing City and Ecological Evaluation of the City Wall显示文摘Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accounted for the largest ratio.Plants on the city wall are characterized by strong drought resistance and precocity,their seeds can grow out of the wall cracks,and roots secrete acidoid and obtain nutrients from wall bricks.Plants on different wall sections are different,and human interventions influence phyto-groups on the city wall greatly.On this basis,it was concluded that plants had negative influence on city wall,especially plant roots destroyed the wall seriously.Corresponding researches were carried out and prevention suggestions proposed to provide scientific support for the protection of ancient city walls in Nanjing City. | WANG Xiaomei QIN Xiaoying SHI Hao LIU Jingwen QIAN Haili WAN Li LIU Yalan | 2012 | Journal of Landscape Research2012，4，11： | 0 |
| 19 | Incidence Tendency Analysis on Type 2 Diabetes in 4 Asian Countries—China,Malaysia,Singapore,and Thailand,1990–2019显示文摘Summary What is already known about this topic?Roughly 80%of the global disease burden caused by diabetes comes from low-and-middle income countries,and 60%of diabetics are located in Asia;6 of the top 10 countries with the highest prevalence of diabetes are in Asia.What is added by this report?Compared with 1990,the growth rate of the standardized incidence rate of type 2 diabetes in 2019 in China was significantly lower than that of the entire world,while Malaysia,Singapore. | Wenhui Shi Qiqi Wang Jiaojiao Zhang Jingwen Zhang Feng Tan Shicheng Yu | 2021 | China CDC weekly2021，3，52： | 0 |
| 20 | Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system. | Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi Xueqing Wu Junjiu Huang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
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