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24篇 您的检索式:作者名="Sadaharu"
    题名 作者 年代 出处 被引量
1Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita 2012Journal of Gastroenterology2012,,5:4
2Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC.Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi 2015World Journal of Gastroenterology2015,21,6:3
3Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita 2012Journal of Gastroenterology2012,,5:1
4Regulated expression and dynamic changes in subnuclear localization of mammalian Rad18 under normal and genotoxic conditions显示文摘Sadaharu Masuyama Satoshi Tateishi Kentaro Yomogida 2005Genes Cells2005,10,8:1
5Effect of side methyl groups of polymer glycol on elongation - induced crystallization behavior of polyurethane elastomers显示文摘KEN K SADAHARU N MUTSUHISA F 2004Pol- ymer2004,45,24:1
6Development of pneumatic rotary soft actuator made of silicone rubber显示文摘Toshiro N Mitsuhiko K Sadaharu Y 2001Journal of Robotics and Mechatronics2001,13,1:1
7Effect of side methyl groups of polymer glycol on elongation-induced crystallization behavior of polyurethane elastomers 显示文摘Ken Kojio Sadaharu Nakamura Mutsuhisa Furukawa 2004:8147-81522004,,:1
8An expert system for collision avoidance and its application to marine traffic simulations under traffic lane regulation 显示文摘Kuniji K Sadaharu K Kazuhiko T 1990The Journal of Japan Institute of Navigation1990,84,:1
9Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin显示文摘Tsugiko Oze Naoki Hiramatsu Changho Song Takayuki Yakushijin Sadaharu Iio Yoshinobu Doi Masahide Oshita Hideki Hagiwara Eiji Mita Toshifumi Ito Yoshiaki Inui Taizo Hijioka Shinji Tamura Harumasa Yoshihara Atsuo Inoue Yasuharu Imai Eijiro Hayashi Michio Ka 2012Journal of Gastroenterology2012,,3:1
10Cellulose dyeing parameters of 18 isomeric phenylazo-H-acid dyes containing two different reactive groups 显示文摘SADAHARU Abeta KINGO Akahori ULRICH Meyer 1991Journal of the Society of Dyers and Colourists1991,107,1:1
11Effect of side methyl groups of polymer glycol on elongation-induced crystallization behavior of polyurethane elastomers显示文摘KOJIO KEN NAKAMURA SADAHARU FURUKAWA MUTSUHISA 2004Polymer2004,45,24:1
12Effect of side methyl groups of polymer glycol on elongation-induced crystallization behavior of poly- urethane elastomers 显示文摘Ken K Sadaharu N Mutsuhisa F 2004Polymer2004,45,24:1
13Acetylacetoin synthase as a marker enzyme for detecting the 2,3 - butanediol cycle 显示文摘Sadaharu Ui Takeshi Hosaka Kimiya Mizutani 2002Journal of Bioscience and Bioengineering2002,93,2:1
14Use of capsule endoscopy in patients with C rohn’s disease in J apan: A multicenter survey显示文摘Motohiro Esaki Takayuki Matsumoto Kenji Watanabe Tetsuo Arakawa Yuji Naito Minoru Matsuura Hiroshi Nakase Toshifumi Hibi Takayuki Matsumoto Sadaharu Nouda Kazuhide Higuchi Naoki Ohmiya Hidemi Goto Sei Kurokawa Satoshi Motoya Mamoru Watanabe 2014J Gastroenterol Hepatol2014,,1:1
15Functional analysis of recombinant human serum albumin domains for pharmaceutical applications显示文摘Sadaharu M Yu I Victor T 2004Pharm Res2004,21,10:1
16Effect of side methyl groups of polymer glycol on elongation-induced crystallization behavior of polyure-thane elastomers 显示文摘Ken Kojio Sadaharu Nakamura Mutsuhisa Furuk-awa 2004Polymer2004,45,24:1
17Recombinant human serum albumin dimer has high blood circulation activity and low vascular permeability in comparison with native human serum albumin显示文摘Sadaharu M Victor T Giam C 2006Pharm Res2006,23,5:1
18Functional analysis of recombinant human serum albumin domains for pharmaceutical applications显示文摘Sadaharu M Yu I Victor T 2004Pharm Res2004,1,10:1
19Surface hydrophilic-hydrophobic property on transparent mesoporous silica thin films containing chromium oxide single-site photocatalyst显示文摘Hiromi Y Yuu H Sadaharu I 2008Catalysis Today2008,132,14:1
20Recombinant human serum albumin dimer has high blood circulation activity and low vascular permeability in comparison with native human serum albumin显示文摘Sadaharu M Victor T Giam C 2006Pharm R2006,23,5:1
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