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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens显示文摘Therapeutic options for the treatment of colorectal cancer(CRC) are diverse but still not always satisfying. Recent success of immune checkpoint inhibition treatment for the subgroup of CRC patients suffering from hypermutated tumors suggests a permanent role of immune therapy in the clinical management of CRC. Substantial improvement in treatment outcome could be achieved by development of efficient patient-individual CRC vaccination strategies. This mini-review summarizes the current knowledge on the two general classes of targets: tumor-associated antigens(TAAs) and tumorspecific antigens. TAAs like carcinoembryonic antigen and melanoma associated antigen are present in and shared by a subgroup of patients and a variety of clinical studies examined the efficacy of different TAA-derived peptide vaccines. Combinations of several TAAs as the next step and the development of personalized TAA-based peptide vaccines are discussed. Improvements of peptidebased vaccines achievable by adjuvants and immunestimulatory chemotherapeutics are highlighted. Finally, we sum up clinical studies using tumor-specific antigens-in CRC almost exclusively neoantigens-which revealed promising results; particularly no severe adverse events were reported so far. Critical progress for clinical outcomes can be expected by individualizing neoantigen-based peptide vaccines and combining them with immunestimulatory chemotherapeutics and immune checkpoint inhibitors. In light of these data and latest developments, truly personalized neoantigen-based peptide vaccines can be expected to fulfill modern precision medicine's requirements and will manifest as treatment pillar for routine clinical management of CRC. | Sandra Wagner Christina S Mullins Michael Linnebacher | 2018 | World Journal of Gastroenterology2018，24，48： | 10 |
| 3 | Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathways显示文摘AIM: To study the effect of gelatinases (especially MMP-9)on migration of tissue inhibitor of metalloproteinase (TIMP-1) overexpressing hepatoma cells.METHODS: Wild type HepG2 cells, cells stably transfected with TIMP-1 and TIMP-1 antagonist (MMP-9-H401A, a catalytically inactive matrix metalloproteinase (MMP) which still binds and neutralizes TIMP-1) were incubated in Boyden chambers either with or without Galardin (a synthetic inhibitor of MMP-1, -2, -3, -8, -9) or a specific inhibitor of gelatinases.RESULTS: Compared to wild type HepG2 cells, the cells overexpressing TIMP-1 showed 115% migration (P<0.05)and the cells overexpressing MMP-9-H401A showed 62% migration (P<0.01). Galardin reduced cell migration dose dependently in all cases. The gelatinase inhibitor reduced migration in TIMP-1 overexpressing cells predominantly.Furthermore, we examined intracellular signal transduction pathways of TIMP-1-dependent HepG2 cells. TIMP-1deactivates cell signaling pathways of MMP-2 and MMP-9involving p38 mitogen-activated protein kinase. Specific blockade of the ERK pathway suppresses gelatinase expression either in the presence or absence of TIMP-1.CONCLUSION: Overexpressing functional TIMP-1-enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9. | Elke Roeb Anja-Katrin Bosserhoff Sabine Hamacher Bettina Jansen Judith Dahmen Sandra Wagner Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，8： | 7 |
| 4 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 5 | A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma显示文摘 | Johannes Haybaeck Nicolas Zeller Monika Julia Wolf Achim Weber Ulrich Wagner Michael Odo Kurrer Juliane Bremer Giandomenica Iezzi Rolf Graf Pierre-Alain Clavien Robert Thimme Hubert Blum Sergei A. Nedospasov Kurt Zatloukal Muhammad Ramzan Sandra Ciesek Th | 2009 | Cancer Cell2009，，4： | 1 |
| 6 | Potent protection of gallic acid against DNA oxidation: Results of human and animal experiments显示文摘 | Franziska Ferk Asima Chakraborty Walter J?ger Michael Kundi Julia Bichler Miroslav Mi?ík Karl-Heinz Wagner Bettina Grasl-Kraupp Sandra Sagmeister Gerald Haidinger Christine Hoelzl Armen Nersesyan Maria Du?inská Tatjana Simi? Siegfried Knasmüller | 2011 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2011，，1： | 1 |
| 7 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 8 | Genenration of cytotoxic responses in mice and human indibiduals agains the matological malignancies using survivin-RNA-Transfected dendritic cells显示文摘 | Matthins Zeis Sandra Siegel Aandreas Wagner | 2003 | The journal of Immunology2003，170，： | 1 |
| 9 | Generation of cytotoxic responses in mice and human individuals against hematological malignancies using survivin-RNA-transfected dendritic cells显示文摘 | Matthias Zeis Sandra Siegel Andreas Wagner | 2003 | The Journal of Immunology2003，170，11： | 1 |
| 10 | Lack of a meaningful effect of anacetrapib on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects显示文摘 | Rajesh Krishna Daria Stypinski Melissa Ali Amit Garg Josee Cote Andrea Maes Bruce DeGroot Yang Liu Susie Li Sandra M. Connolly John A. Wagner S. Aubrey Stoch | 2012 | British Journal of Clinical Pharmacology2012，，1： | 1 |
| 11 | Formation of colloidal particles of hydrous iron by forced hydrolysis显示文摘 | Wagner R M Sandra H P Celso V S | 2000 | Journal of Non-crystalline Solids2000，273，： | 1 |
| 12 | Non-traditional biomarkers of eating disorder symptoms amongfemale college students显示文摘Background:Eating disorders(ED)are often diagnosed at an advanced stage because traditional symptoms related to unhealthy eating habits are poorly recognized.ED may be also associated with non-traditional and objective biomarkers,which could prove an important screening tool to support health care professionals in diagnosing,treating,and ultimately preventing ED.Aim:To investigate the association between non-traditional physiological ED biomarkers and symptoms of ED among female college students.Methods:This study included 113 female college students,aged 18 to 23 years,enrolled in their first semester as a Bachelor of Health Sciences undergrad at public universities in the urban zone of Recife,Brazil.Symptoms of ED were measured by self-report questionnaires.Circulating levels of IL-6,IL-10,leptin,insulin,ghrelin,PYY and adiponectin were assessed using commercial immunoassays.Results:Students with symptoms of an ED exhibited higher values of IL-6(p=0.03)and leptin(p<0.001)compared to those without symptoms.A positive correlation was found between leptin levels and bulimia nervosa(r=0.42;p=0.00),between leptin levels and binge eating(r=0.38;p=0.00),and between IL-6 concentrations and binge eating(r=0.25;p=0.04).Multiple linear regression analysis with anorexia nervosa,bulimia nervosa and binge eating as dependent variables showed that IL-6 and leptin best explained ED symptoms,even when adjusted for body mass index(BMI).Conclusions:These findings suggest that peripheral peptides,namely leptin and IL-6,are associated with symptoms of ED in female college students.Future studies are needed to determine if there is a causal relationship between these biomarkers and the onset of ED.Relevance for patients:If future longitudinal studies demonstrate causality between the biomarkers assessed here and ED symptoms,these serum makers could be used as screening tool for inappropriate eating behavior.This may in turn improve the early diagnosis,treatment,and,ultimately,the prognosis of patients with ED. | Mara Cristina Lofrano-Prado Wagner Luiz do Prado Mauro Virgílio Gomes de Barros Lila Missae Oyama Michelle Cardel Sandra Lopes-de-Souza | 2016 | Journal of Clinical & Translational Research2016，2，4： | 0 |
| 13 | Dietary intake of advanced glycation endproducts(AGEs)and cancer risk across more than 20 anatomical sites:A multinational cohort study显示文摘Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed foods.Byproducts of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing sugar.AGEs production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3]. | Reynalda Córdova Ana-Lucia Mayén Viktoria Knaze Elom Kouassivi Aglago Casper Schalkwijk Karl-Heinz Wagner Kim Overvad Anne Tjønneland Cecilie Kyrø Verena Andrea Katzke Charlotte Le Cornet Matthias Bernd Schulze Anna Birukov Domenico Palli Sara Grioni Fabrizio Pasanisi Alberto Catalano Torkjel Manning Sandanger Inger Torhild Gram Guri Skeie Marta Crous-Bou Esther Molina-Montes Pilar Amiano Sandra Milena Colorado-Yohar Eva Ardanaz Isabel Drake Jonas Manjer Ingegerd Johansson Anders Esberg Aurora Perez-Cornago Elisabete Weiderpass Mazda Jenab Heinz Freisling | 2022 | Cancer Communications2022，42，10： | 0 |
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