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| 1 | 在结肠和直肠的癌症的淋巴节点收获: 当前的考虑显示文摘 The prognostic significance of identifying lymph node(LN) metastases following surgical resection for colon and rectal cancer is well recognized and is reflected in accurate staging of the disease.An established body of evidence exists,demonstrating an association between a higher total LN count and improved survival,particularly for node negative colon cancer.In node positive disease,however,the lymph node ratios may represent a better prognostic indicator,although the impact of this on clinical treatment has yet to be universally established.By extension,strategies to increase surgical node harvest and/or laboratory methods to increase LN yield seem logical and might improve cancer staging.However,debate prevails as to whether or not these extrapolations are clinically relevant,particularly when very high LN counts are sought.Current guidelines recommend a minimum of 12 nodes harvested as the standard of care,yet the evidence for such is questionable as it is unclear whether an increasing the LN count results in improved survival.Findings from modern treatments,including down-staging in rectal cancer using pre-operative chemoradiotherapy,paradoxically suggest that lower LN count,or indeed complete absence of LNs,are associated with improved survival;implying that using a specific number of LNs harvested as a measure of surgical quality is not always appropriate.The pursuit of a sufficient LN harvest represents good clinical practice;however,recent evidence shows that the exhaustive searching for very high LN yields may be unnecessary and has little in? uence on modern approaches to treatment. | James R McDonald Andrew G Renehan Sarah T O’Dwyer Najib Y Haboubi | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 8 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 4 | Multimodal alarm behavior in urban and rural gray squirrels studied by means of observation and a mechanical robot显示文摘Urbanization of animal habitats has the potential to affect the natural communication systems of any species able tosurvive in the changed environment. Urban animals such as squirrels use multiple signal channels to communicate, but it is unknownhow urbanization has affected these behaviors. Multimodal communication, involving more than one sensory modality,can be studied by use of biomimetic mechanical animal models that are designed to simulate the multimodal signals and be presentedto animal subjects in the field. In this way the responses to the various signal components can be compared and contrastedto determine whether the multimodal signal is made up of redundant or nonredundant components. In this study, we presentedwild gray squirrels in relatively urban and relatively rural habitats in Western Massachusetts with a biomimetic squirrel modelthat produced tail flags and alarm barks in a variety of combinations. We found that the squirrels responded to each unimodalcomponent on its own, the bark and tail flag, but they responded most to the complete multimodal signal, containing both theacoustic and the moving visual components, providing evidence that in this context the signal components are redundant and thattheir combination elicits multimodal enhancement. We expanded on the results of Partan et al. (2009) by providing data on signalingbehavior in the presence and absence of conspecifics, suggesting that alarm signaling is more likely if conspecifics arepresent. We found that the squirrels were more active in the urban habitats and that they responded more to tail flagging in theurban habitats as compared to the rural ones, suggesting the interesting possibility of a multimodal shift from reliance on audio tovisual signals in noisier more crowded urban habitats [Current Zoology 56 (3): 313-326, 2010]. | Sarah R.PARTAN Andrew G FULMER Maya A.M.GOUNARD Jake E.REDMOND | 2010 | Current Zoology2010，56，3： | 4 |
| 5 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties显示文摘 | Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. G?ktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neu | 2013 | Cell2013，，： | 3 |
| 6 | Plasma and nanoparticle shielding during pulsed laser ablation in liquids cause ablation efficiency decrease显示文摘Understanding shielding cross-effects is a prerequisite for maximal power-specific nanosecond laser ablation in liquids(LAL).However,discrimination between cavitation bubble(CB),nanoparticle(NP),and shielding,e.g.,by the plasma or a transient vapor layer,is challenging.Therefore,CB imaging by shadowgraphy is performed to better understand the plasma and laser beam-NP interaction during LAL.By comparing the fluence-dependent CB volume for ablations performed with 1 ns pulses with reports from the literature,we find larger energy-specific CB volumes for 7 ns-ablation.The increased CB for laser ablation with higher ns pulse durations could be a first explanation of the efficiency decrease reported for these laser systems having higher pulse durations.Consequently,1 ns-LAL shows superior ablation efficiency.Moreover,a CB cascade occurs when the focal plane is shifted into the liquid.This effect is enhanced when NPs are present in the fluid.Even minute amounts of NPs trapped in a stationary layer decrease the laser energy significantly,even under liquid flow.However,this local concentration in the sticking film has so far not been considered.It presents an essential obstacle in high-yield LAL,shielding already the second laser pulse that arrives and presenting a source of satellite bubbles.Hence,measures to lower the NP concentration on the target must be investigated in the future. | Sarah Dittrich Stephan Barcikowski Bilal Gökce | 2021 | Opto-Electronic Advances2021，4，1： | 3 |
| 7 | Hospitalized prevalence and 5-year mortality for IBD:Record linkage study显示文摘AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. | Lori A Button Stephen E Roberts Michael J Goldacre Ashley Akbari Sarah E Rodgers John G Williams | 2010 | World Journal of Gastroenterology2010，16，4： | 3 |
| 8 | Low temperature regulation of the Arabidopsis CBF family of AP2 transcriptional activators as an early step in cold induced COR gene expression显示文摘 | Sarah J Gilmour Daniel G | 1998 | The Plant Journal1998，16，： | 1 |
| 9 | Curtis neutralisation of TGF of binding of VLA-4 to fibronectin prevents rat tendon adhesion following transection显示文摘 | Heather G Jorgense N Sarah D | 2005 | Cytokine2005，30，： | 1 |
| 10 | Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus 显示文摘 | CHRISTOPHER G B SARAH F CECILIA M L | 2010 | PLoS One2010，5，14： | 1 |
| 11 | Effect of storage temperature on the in vitro reproduction of Radopholus similis显示文摘 | Fallas G A Sarah J L | | 0，，02： | 1 |
| 12 | Predictors of adolescents academic motiva-tion : Personality, self - efficacy and adolescents' characteristics 显示文摘 | Sarah P Dave P Emma G | 2014 | Personal Indivi Differe2014，，32： | 1 |
| 13 | Development of an immunoassay-based lateral flow dipstick for the rapid detection of aflatoxin B1 in pig feed显示文摘 | BARBARA S D SARAH M D G S LIBERTY S | 2005 | Agric Food Chem2005，53，： | 1 |
| 14 | Extraction and characterisation of lipids from Antarctic krill (Euphausia superba)显示文摘 | JOSEPH C G MATTHEW P D SARAH K B | 2010 | Food Chemistry2010，125，3： | 1 |
| 15 | Multiple roles for FGF-3 during cranial neural development in the chicken显示文摘 | Radma M Paul K Sarah G etc | 1995 | Development1995，121，： | 1 |
| 16 | Lubricating oil and fuel Contributions to particulate matter emissions from light-duty gasoline and heavy-duty diesel vehicles 显示文摘 | Michael J K Sarah G R Michael A R | 2008 | Environmental Science and Technology2008，42，： | 1 |
| 17 | Association between attention-deficit/hyperactivity disorder and epilepsy in pediatric populations 显示文摘 | Hesham MH Daniellc JG Sarah G | 2009 | Expert Rev Neurother2009，9，12： | 1 |
| 18 | Extraction and characterization of lipids from Antarctic krill(Euphausia superba)显示文摘 | Joseph C G Matthew P D Sarah K B | 2011 | Food Chemistry2011，，125： | 1 |
| 19 | Effect of early treatment on stability of occlusion in patients with Class Ⅱ malocclusion显示文摘 | Sarah S Pavlow Susan P McGorray Marie G Taylor | 2008 | Am J Orthod Dentofac Orthod2008，133，： | 1 |
| 20 | A Whole-Genome Scan for Obstructive Sleep Apnea and Obesity显示文摘 | Lyle J Palmer Sarah G Buxbaum | 2003 | Am J Hum Genet2003，72，2： | 1 |
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