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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 3 | Eremophilane Sesquiterpenes from Cacalia Roborowskii显示文摘Four new eremophilane type sesquitopnes were isolated from the roots of Cacalia roborowrkii (Maxim) Ling. Their tricfores were eStablished as 8-oxo-eremophila-6. 9-dien-12-oic acid (1), 3β -acetoxyl- 8-oxo-eremophila-6, 9 -dien- 12 -oic aci (2), 3β-angeloyoxyl-8-oxo- eremophila-6, 9-dien-12-oic acid (3) and 3β -(2 -methylbutyryloxyl )-8-oxo-eremophila-6, 9-dien-12- oic acid (4) by means of iD and 2D NOR spectroscopy. | Zhang, SM Zhao, GL Li, R Lin, GQ | 1998 | Chinese Chemical Letters1998，9，1： | 5 |
| 4 | Ultrapure dialysis fluid slows loss of residual renal function in new dialysis patients.显示文摘 | Schiffl H Lang SM Fischer R | | 0，，： | 3 |
| 5 | Design of a multiplex PCR method for detection of toxigenicpathogenic in Vibrio cholerae显示文摘Objective:To study virulence and regulatory genes(hlyA,ctxB,tcpI) in clinical strains of Vibrio ckolerae(V.cholerae),simultaneously.Methods:Three important genes,tepI,hlyA and ctxB were used for detection of toxigenic and pathogenic V.cholera by chain reaction assay method. Results:According to the results of the PCR,the incidence of hlyA,tcpI,and ctxB genes in clinical isolates was obtained as 94.7%(72 sample),90.8%(69 sample),and 92.1%(70 sample), respectively.Five strains possessed all genes except ctxB,six strains possessed all genes except tcpI,four strains possessed all genes except hlyA,one strain possessed only hlyA and 60 strains contained a combination of three genes.Including hlyA,ctxB and tcpI,Conclusions:Result show that this method could be reliable to detect toxigenic-pathogenic strains of V.cholerae in Iran. | Abbas Ali Imani Fooladi Iman Islamieh D Hosseini Doust R Karami A Marashi SM | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae显示文摘Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims. | Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 2 |
| 8 | Antinociceptive actions of decending dopaminergic tracts on cat and rat dorsal horn somatosensory neurons显示文摘 | Hope PJ Mitchell R | 1988 | J Physiol1988，399，： | 1 |
| 9 | Randomized double-blind placebo-controlled trial of thalidomide in combination with gemcitabine and carboplatin in advanced non-small-cell lung cancer 显示文摘 | Lee SM Rudd R Woll PJ | 2009 | J Clin Oncol2009，27，31： | 1 |
| 10 | Patients with an ultrasonographieeervical length 显示文摘 | Hassan SS Romero R Berry SM | 2000 | Am J Obstet Gynecol2000，18，6： | 1 |
| 11 | Urine detection of survivin is a sensitive marker for the noninvasive diagnosis of bladder cancer显示文摘 | Shariat SF Casella R Khoddami SM | 2004 | J Urol2004，17，21： | 1 |
| 12 | Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage 显示文摘 | Mcgirt MJ Blessing R Nimjee SM | 2004 | Neursurgey2004，54，： | 1 |
| 13 | Feeding and dementia: AsystematiC litera- ture review显示文摘 | Watson R Green SM | 2006 | J Adv Nurs2006，54，1： | 1 |
| 14 | Comparing electron microscopy and a competitive blocking ELISA in the detection of rotaviruses in porcine faeces显示文摘 | ROD(A)K L SM(I)TALOV(A) R (S)M(I)D B | 2009 | Vet J2009，187，2： | 1 |
| 15 | Mechanism of cisplatin ototoxicity:antioxidant system显示文摘 | Ravi R Somani SM Rybak LP | 1995 | Pharmacol Toxicol1995，76，6： | 1 |
| 16 | Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy显示文摘 | Wolk R Cobbe SM Hicks MN | 1999 | Pharmacol Ther1999，84，2： | 1 |
| 17 | Portal vein and its tributaries:evaluation with thin-section three-dimensional contrast-enhanced dynamic fat-suppressed MR imaging显示文摘 | Ito K Blasbalg R Hussain SM | 2000 | Radiology2000，215，2： | 1 |
| 18 | Clinical, genetic,and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability 显示文摘 | Eunson LH Rea R Zuberi SM | 2000 | Ann Neurol2000，48，4： | 1 |
| 19 | Effect of carbamide peroxide bleaching on the shear bond strength of composite to dental bonding agent enhanced enamel显示文摘 | Sung EC Chan SM Mito R | 1999 | J Prosthet Dent1999，82，： | 1 |
| 20 | Erlotinib resistance in lung cancer: current progress and future perspectives 显示文摘 | Tang J Salama R Gadgeel SM | 2013 | Front Pharmaeol2013，4，15： | 1 |
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