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| 1 | Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review显示文摘Background:The coronavirus disease(COVID-19)has been identified as the cause of an outbreak of respiratory illness in Wuhan,Hubei Province,China beginning in December 2019.As of 31 January 2020,this epidemic had spread to 19 countries with 11791 confirmed cases,including 213 deaths.The World Health Organization has declared it a Public Health Emergency of International Concern.Methods:A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley.In this scoping review,65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology,causes,clinical diagnosis,prevention and control of this virus.The research domains,dates of publication,journal language,authors'affiliations,and methodological characteristics were included in the analysis.All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.Results:Most of the publications were written using the English language(89.2%).The largest proportion of published articles were related to causes(38.5%)and a majority(67.7%)were published by Chinese scholars.Research articles initially focused on causes,but over time there was an increase of the articles related to prevention and control.Studies thus far have shown that the virus7 origination is in connection to a seafood market in Wuhan,but specific animal associations have not been confirmed.Reported symptoms include fever,cough,fatigue,pneumonia,headache,diarrhea,hemoptysis,and dyspnea.Preventive measures such as masks,hand hygiene practices,avoidance of public contact,case detection,contact tracing,and quarantines have been discussed as ways to reduce transmission.To date,no specific antiviral treatment has proven effective;hence,infected people primarily rely on symptomatic treatment and supportive care.Conclusions:There has been a rapid surge in research in response to the outbreak of COVID-19.During this early period,published research primarily explored the epidemiology,causes,clinical manifestation and diagnosis,as well as prevention and control of the novel coronavirus.Although these studies are relevant to control the current public emergency,more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short-and long-term. | Sasmita Poudel Adhikari Sha Meng Yu-Ju Wu Yu-Ping Mao Rui-Xue Ye Qing-Zhi Wang Chang Sun Sean Sylvia Scott Rozelle Hein Raat Huan Zhou | 2020 | Infectious Diseases of Poverty2020，9，2： | 28 |
| 2 | Opposite effects of nitrogen fertilization and plastic film mulching on crop N and P stoichiometry in a temperate agroecosystem显示文摘Aims Crop nitrogen(N)and phosphorus(P)stoichiometry can influence food nutritive quality and many ecosystem processes.However,how and why N and P stoichiometry respond to long-term agricul-tural management practices(e.g.N fertilization and film mulching)are not clearly understood.Methods We collected maize tissues(leaf,stem,root and seed)and soil sam-ples from a temperate cropland under 30-year continuous N fer-tilization and plastic film mulching treatments,measured their C,N and P concentrations(the proportion(%)relative to the sample mass),and used structural equation models to uncover the re-sponding mechanisms for crop N and P contents(the total amount(g/m2)in crop biomass).Important Findings Long-term N fertilization increased N concentrations in all crop tissues but sharply decreased P concentrations in vegetative tis-sues(leaf,stem and root),thereby reducing their C/N ratio and increasing C/P and N/P ratios.The drop in P concentration in vegetative tissues was due to the dilution effect by biomass in-crement and the priority of P supply for seed production.In con-trast,film mulching decreased N concentration but increased P concentrations in most crop tissues,thereby increasing C/N ratio and reducing C/P and N/P ratios.Film mulching increased crop P content by increasing soil temperature and moisture;whereas,mulching showed little effect on crop N content,because a posi-tive effects of soil temperature may have canceled out a negative effect by soil moisture.This indicated a decoupling of P and N uptake by crops under film mulching.In conclusion,N fertiliza-tion and plastic film mulching showed opposite effects of on crop N and P stoichiometry. | Fan Ding Shuangyi Li Xiao-Tao Lü Feike A.Dijkstra Sean Schaeffer Tingting An Jiubo Pei Liangjie Sun Jingkuan Wang | 2019 | Journal of Plant Ecology2019，12，4： | 8 |
| 3 | DESC: enabling secure data exchange based on smart contracts显示文摘Dear editor,As data are one of the most important factors of today’s intelligent systems but are relatively scarce,people try exchanging data with other organizations or public marketplaces.However,data exchange is now lack of a secure execution mecha- | Jiao LIANG Weili HAN Zeqing GUO Yaoliang CHEN Chang CAO Xiaoyang Sean WANG Fenghua LI | 2018 | Science China(Information Sciences)2018，61，4： | 5 |
| 4 | LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2显示文摘(HP1 ) Heterochromatin 蛋白质 1 是染色质结构和功能的一个主要管理者。在动物,与 HP1 交往的蛋白质的网络主要与组成的 heterochromatin 由 H3K9me3 标记被联系。HP1 身体上与 SNF2 染色质 remodeler ATRX 的通常认为的 ortholog ?交往,它在哺乳动物控制 histone 变体 H3.3 的免职。在这研究,我们证明 ATRX 的 Arabidopsis thaliana ortholog ?参予 H3.3 免职并且在植物拥有特定的保存领域。我们发现象 HP1 (LHP1 ) 蛋白质一样的那植物通过在陆地植物明确地演变的领域与 ATRX 交往 ? 祖先。在 Arabidopsis 的 ATRX 功能的损失影响 PRC2 (POLYCOMB 压抑的建筑群 2 ) 控制的基因的一个有限子集的表示,包括 flowering 时间管理者 FLC。在 flowering 时间的规定的 ATRX 的函数要求新奇交往 LHP1 领域和 ATRX SNF2 helicase 域的 ATPase 活动。一起拿,这些结果建议不同进化小径在植物在哺乳动物和它的对应物 LHP1 导致了在 ATRX 和 HP1 之间的相互作用,导致 transcriptional 的不同模式规定。 | Haifeng Wang Danhua Jiang Elin Axelsson Zdravko J. Lorkovic Sean Montgomery Sarah Holec Bas J.G.E. Pieters Abbas H.K. AI Temimi Jasmin Mecinovic Frederic Berger | 2018 | Molecular Plant2018，11，8： | 3 |
| 5 | Development of a mobile powered hole digger for orchard tree cultivation using a slider-crank feed mechanism显示文摘The powered hole digger is one of the most important orchard machines.The power consumption of its drill is an important factor affecting the performance and operation of the device.The drill power consumption of the digger at a constant feed rate is directly proportional to digging depth.This research discusses a newly designed powered hole digger using a slider-crank feed mechanism.The motion characteristics of the powered hole digger feeding mechanism was analysed.Additionally,an experiment was conducted to determine the characteristics of the drill power consumption.It can be concluded that there was a positive correlation between the drill power consumption and the powered hole digger feed rate.It was observed that when digging depth reached 200 mm,the drill power consumption reached the maximum power rating;subsequently the drill power consumption decreased with an increase of digging depth.When the drill reached the bottom of the hole,the power consumption of the new powered hole digger did not exceed the maximum designed power rating,hence the drill motor would not stall. | Zong Wangyuan Wang Jingliang Huang Xiaomao Yu Dong Zhao Yingbiao Sean Graham | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 3 |
| 6 | Ru(bpy)_(3)^(2+)-sensitized{001}facets LiCoO_(2) nanosheets catalyzed CO_(2) reduction reaction with 100% carbonaceous products显示文摘Photosensitized heterogeneous CO_(2) reduction(PHCR)has emerged as a promising means to convert CO_(2) into valuable chemicals,however,challenged by the relatively low carbonaceous product selectivity caused by the competing hydrogen evolution reaction(HER).Here,we report a PHCR system that couples Ru(bpy)32+photosensitizer with{001}faceted LiCoO_(2) nanosheets photocatalyst to simultaneously yield 21.2 and 722μmol·g^(-1)·h^(-1) of CO,and 4.42 and 108μmol·g^(-1)·h^(-1) of CH4 under the visible light and the simulated sunlight irradiations,respectively,with completely suppressed HER.The experimental and theoretical studies reveal that the favored CO_(2) adsorption on the exposed Li sites on{001}faceted LiCoO_(2) surface is responsible for the completely suppressed HER. | Shuaiyu Jiang Junxian Liu Kun Zhao Dandan Cui Porun Liu Huajie Yin Mohammad Al-Mamun Sean ELowe Weiping Zhang Yu Lin Zhong Jun Chen Yun Wang Dan Wang Huijun Zhao | 2022 | Nano Research2022，15，2： | 2 |
| 7 | Nonmetabolic functions of metabolic enzymes in cancer development显示文摘Metabolism is a fundamental biological process composed of a series of reactions catalyzed by metabolic enzymes.Emerging evidence demonstrates that the aberrant signaling in cancer cells induces nonmetabolic functions of meta-bolic enzymes in many instrumental cellular activities,which involve metabolic enzyme-mediated protein post-trans-lational modifications,such as phosphorylation,acetylation,and succinylation.In the most well-researched literatures,metabolic enzymes phosphorylate proteins rather than their metabolites as substrates.Some metabolic enzymes have altered subcellular localization,which allows their metabolic products to directly participate in nonmetabolic activities.This review discusses how these findings have deepened our understanding on enzymes originally classi-fied as metabolic enzymes,by highlighting the nonmetabolic functions of several metabolic enzymes responsible for the development of cancer,and evaluates the potential for targeting these functions in cancer treatment. | Sean Lu Yugang Wang | 2018 | Cancer Communications2018，38，1： | 2 |
| 8 | Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression显示文摘 | Akihisa Fukuda Sam C. Wang John P. Morris Alexandra E. Folias Angela Liou Grace E. Kim Shizuo Akira Kenneth M. Boucher Matthew A. Firpo Sean J. Mulvihill Matthias Hebrok | 2011 | Cancer Cell2011，，： | 2 |
| 9 | TFE3 Break-apart FISH Has a Higher Sensitivity for Xp11.2 Translocation–associated Renal Cell Carcinoma Compared With TFE3 or Cathepsin K Immunohistochemical Staining Alone: Expanding the Morphologic Spectrum显示文摘 | Qiu Rao Sean R. Williamson Shaobo Zhang John N. Eble David J. Grignon Mingsheng Wang Xiao-jun Zhou Wenbin Huang Puay-Hoon Tan Gregory T. MacLennan Liang Cheng | 2013 | The American Journal of Surgical Pathology2013，，6： | 2 |
| 10 | A single-molecule multicolor electrochromic device generated through medium engineering显示文摘Multicolor organic electrochromic materials are important for the generation of full-color devices.However,achieving multiple colors using a single-molecule material has proved challenging.In this study,a multicolor electrochromic prototype device is generated by integrating medium engineering/in situ‘electro base’/laminated electrode technologies with the simple flying fish-shaped methyl ketone TM1.This multicolor electrochromic(green,blue and magenta)device is durable and has a high coloration efficiency(350 cm^(2) C^(-1)),a fast switching time(50 ms)and superior reversibility.This study is a successful attempt to integrate solvatochromism and basochromism in an electronic display.This integration not only introduces a new avenue for color tuning,in addition to the structural design of the colorant,but will also inspire further developments in the tuning of many other properties by this medium engineering approach,such as conductance and the redox property,and thereby accelerate versatile applications in data recording,ultrathin flexible displays,and optical communication and sensing. | Yu-Mo Zhang Xiaojun Wang Weiran Zhang Wen Li Xiaofeng Fang Bing Yang Minjie Li Sean Xiao-An Zhang | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 11 | Levels of circulating follicular helper T cells,T helper 1 cells,and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis显示文摘Background:Excessive drinkers(ED)and patients with alcoholic liver disease(ALD)are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations.Follicular helper T(TFH)cells are essential to select B cells in the germinal center and to produce antibodies.TFH cells express both a membrane-associated and a soluble form of CD40 ligand(sCD40L),in which the latter form is released to circulation upon T cell activation.The effect of alcohol on TFH cells has not been studied.Objectives:The goals of this study are to determine the levels of TFH and T helper 1(Th1)cells in ED and those with alcoholic cirrhosis(AC)when compared to healthy controls and to determine the prognostic significance of sCD40L in a cohort of patients with AC.Methods:Controls,ED,and those with AC were enrolled.Baseline demographic,laboratory tests,and peripheral blood mononuclear cells(PBMCs)were isolated and assessed via flow cytometry for TFH cells.In vitro study was performed to determine the ability of PBMCs to secrete interferon(IFN)-ɣupon stimulation.Serum sCD40L was also determined and its prognostic significance was tested in a cohort of AC patients.Results:The levels of circulating TFH(cTFH)cells were significantly lower in peripheral blood of subjects with ED and AC compared to controls(P<0.05).IFN-ɣsecretion from PBMCs upon stimulation was also lower in ED and those with cirrhosis.Serum sCD40L was significantly lower in ED and AC when compared to that in controls(P<0.0005).Its level was an independent predictor of mortality.Conclusions:Patients with AC had significantly lower level of cTFH and sCD40L.The level of sCD40L was an independent predictor of mortality in these patients. | Kristin Hollister Praveen Kusumanchi Ruth Ann Ross Kristina Chandler AdePeju Oshodi Laura Heathers Sean Teagarden Li Wang Alexander L.Dent Suthat Liangpunsakul | 2018 | Liver Research2018，2，1： | 2 |
| 12 | Microcup electronic paper and the converting processes显示文摘 | Wang Xiaojia Kiluk Sean Chang Chris | 2004 | Journal of the ASID2004，，： | 2 |
| 13 | Complete remission of unresectable hepatocellular carcinoma treated with reduced dose of sorafenib: a case report显示文摘 | Sean Xiang Wang Abigail Byrnes Sadhna Verma John R. Pancoast Olivier Rixe | 2010 | Targeted Oncology2010，，1： | 2 |
| 14 | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models显示文摘 | S. Betty Yan Victoria L. Peek Rose Ajamie Sean G. Buchanan Jeremy R. Graff Steven A. Heidler Yu-Hua Hui Karen L. Huss Bruce W. Konicek Jason R. Manro Chuan Shih Julie A. Stewart Trent R. Stewart Stephanie L. Stout Mark T. Uhlik Suzane L. Um Yong Wang Wenj | 2013 | Investigational New Drugs2013，，4： | 1 |
| 15 | Pulmonary oxidant stress in murine sepsis is due to inflammatory cell nitric oxide显示文摘 | Habib M. Razavi Lefeng Wang Sean Weicker Greg J. Quinlan Sharon Mumby David G. McCormack Sanjay Mehta | 2005 | Critical Care Medicine2005，，6： | 1 |
| 16 | Earnings management: The effect of accounting flexibility on R&D investment choices 显示文摘 | Sean Wang Julina D'souza | 2006 | Johnson School Research Paper Series2006，，1： | 1 |
| 17 | Transcriptional profiling of skeletal muscle tissue from two breeds of cattle显示文摘 | Yong-Hong Wang Keren A. Byrne Antonio Reverter Gregory S. Harper Masaaki Taniguchi Sean M. McWilliam Hideyuki Mannen Kenji Oyama Sigrid A. Lehnert | 2005 | Mammalian Genome2005，，3： | 1 |
| 18 | Hypoxia-Independent Upregulation of Placental Hypoxia Inducible Factor-1α Gene Expression Contributes to the Pathogenesis of Preeclampsia显示文摘 | Takayuki Iriyama Wei Wang Nicholas F. Parchim Anren Song Sean C. Blackwell Baha M. Sibai Rodney E. Kellems Yang Xia | 2015 | Hypertension2015，，： | 1 |
| 19 | Isolated splenic metastasis from carcinoma of the breast: A Case Report显示文摘 | Kari Sufficool Jeff Wang Sean Doherty | 2013 | Diagn. Cytopathol2013，，10： | 1 |
| 20 | Modeling requests among cooperating intrusion detection systems 显示文摘 | Peng Ning X Sean Wang Sushil Jajodia | | Computer Communications0，23，17： | 1 |
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