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51篇 您的检索式:作者名="Dandan Cui"
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1Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD.Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu 2019Biosafety and Health2019,1,1:26
2Pharmacological effects of Chinese herb aconite(Fuzi) on cardiovascular system显示文摘Fuzi(aconite,Radix Aconiti praeparata),a widely used Chinese herb,plays a significant role in the cardiovascular system.This is mainly reflected by Fuzi's cardiotonic effect,its protective effect on myocardial cells,and its effect on heart rate and rhythm,blood pressure,and hemodynamics.In this article,the pharmacological effects and the corresponding mechanisms of Fuzi(aconite) and its active components on cardiovascular system are reviewed.Dandan Zhao Jie Wang Yanjing Cui Xinfang Wu 2012Journal of Traditional Chinese Medicine2012,32,3:19
3Development and application of mechanized maize harvesters显示文摘Maize harvesting is one of the most important filed operations of maize production.As the accelerating development of maize industry,mechanized maize harvesting is widely accepted and used by farmers in the world.According to the harvesting methods,maize harvesters could be classified into two types,one is maize-for-grain harvesters,including pickers and grain harvesters,the other is whole plant harvesters,including forage harvesters and combined grain-stover harvesters.Structure characteristics,appropriate areas and relative technologies of those harvesters are described in this paper,i.e.,pickers are suitable for multi-crop areas,Grain harvesters are mainly for one-crop areas when grain moisture content is lower than 25%,combined grain-stover harvesters are applicable in agro-pastoral ecotone,and forage harvesters are capable in large-scaled animal husbandry farming areas where large amount of silage are required.Meanwhile,the future development trend of the different harvesters is predicted.Big horsepower engines,enhanced working efficiency,automation and intelligence are required by large scaled farms.As maize breeding development,more varieties that are suitable for grain harvesting are put into practice,so grain combine harvesters will be popular in future.Yang Li Cui Tao Qu Zhe Li Kehong Yin Xiaowei Han Dandan Yan Bingxin Zhao Dongyue Zhang Dongxing 2016International Journal of Agricultural and Biological Engineering2016,9,3:13
4Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner显示文摘Angiogenesis,a process by which the preexisting blood vasculature gives rise to new capillary vessels,is associated with a variety of physiologic and pathologic conditions.However,the molecular mechanism underlying this important process remains poorly understood.Here we show that histone deacetylase 6(HDAC6),a microtubule-associated enzyme critical for cell motility,contributes to angiogenesis by regulating the polarization and migration of vascular endothelial cells.Inhibition of HDAC6 activity impairs the formation of new blood vessels in chick embryos and in angioreactors implanted in mice.The requirement for HDAC6 in angiogenesis is corroborated in vitro by analysis of endothelial tube formation and capillary sprouting.Our data further show that HDAC6 stimulates membrane ruffling at the leading edge to promote cell polarization.In addition,microtubule end binding protein 1(EB1)is important for HDAC6 to exert its activity towards the migration of endothelial cells and generation of capillary-like structures.These results thus identify HDAC6 as a novel player in the angiogenic process and offer novel insights into the molecular mechanism governing endothelial cell migration and angiogenesis.Dengwen Li Songbo Xie Yuan Ren Lihong Huo Jinmin Gao Dandan Cui Min Liu Jun Zhou 2011Protein & Cell2011,2,2:13
5Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice显示文摘A neuroinflammatory response is commonly involved in the progression of many neurodegenerative diseases. Potassium 2-(1-hydroxypentyl)-benzoate(PHPB), a novel neuroprotective compound, has shown promising effects in the treatment of ischemic stroke and Alzheimer's disease(AD). In the present study, the anti-inflammatory effects of PHPB were investigated in the plasma and brain of C57BL/6 mice administered a single intraperitoneal(i.p.) injection of lipopolysaccharide(LPS). Levels of i NOS and the cytokines TNFα, IL-1β and IL-10 were elevated in plasma, cerebral cortex and hippocampus after LPS injection and the number of microglia and astrocytes in cortex and hippocampus were increased. LPS also upregulated the expression of heme oxygenase-1(HO-1) in the cortex and hippocampus. PHPB reduced the levels of i NOS and cytokines in the plasma and brain, decreased the number of microglia and astrocytes and further enhanced the upregulation of HO-1. In addition, PHPB inhibited the LPS-induced phosphorylation of ERK, P38 and JNK. These results suggest that PHPB is a potential candidate in the treatment of neurodegenerative diseases through inhibiting neuroinflammation.Chunyang Zhao Weizhen Hou Hui Lei Longjian Huang Shan Wang Dandan Cui Changhong Xing Xiaoliang Wang Ying Peng 2017Acta Pharmaceutica Sinica B2017,7,4:9
6Atomic mobilities and diffusivities in Al alloys显示文摘Knowledge of diffusivity is a prerequisite for understanding many scientific and technological disciplines.In this paper,firstly major experimental methods,which are employed to provide various diffusivity data,are briefly described.Secondly,the fundamentals of various computational methods,including first-principles method,embedded atomic method/molecular dynamic simulation,semi-empirical approaches,and phenomenological DICTRA technique,are demonstrated.Diffusion models recently developed for order/disorder transitions and stoichiometric compounds are also briefly depicted.Thirdly,a newly established diffusivity database for liquid,fcc_A1,L12,bcc_A2,bcc_B2,and intermetallic phases in the multicomponent Al alloys is presented via a few case studies in binary,ternary and quaternary systems.And the integration of various computational techniques and experimental methods is highlighted.The reliability of this diffusivity database is validated by comparing the calculated and measured concentration profiles,diffusion paths,and Kirkendall shifts in various binary,ternary and quaternary diffusion couples.Next,the established diffusivity databases along with thermodynamic and other thermo-physical properties are utilized to simulate the microstructural evolution for Al alloys during solidification,interdiffusion and precipitation.A special discussion is presented on the phase-field simulation of interdiffusion microstructures in a series of Ni-Al diffusion couples composed of γ,γ',and β phases under the effects of both coherent strain and external compressive force.Future orientations in the establishment of next generation of diffusivity database are finally addressed.DU Yong ZHANG LiJun CUI SenLin ZHAO DongDong LIU DanDan ZHANG WeiBin SUN WeiHua JIE WanQi 2012Science China(Technological Sciences)2012,55,2:6
7Design of depth-control planting unit with single-side gauge wheel for no-till maize precision planter显示文摘No-till planters are very popular for maize seeding in fields covered with residue in annual wheat-maize double cropping system in North China Plain.However,there is no suitable depth control mechanism for existing no-till maize planters,and as a result,it is hard to obtain consistent planting depth,uniform emergence,and good passing ability at the same time.For the above reasons,a proper planting unit with a new type of depth-control mechanism was developed in this study.The mechanism consists of a single-side gauge wheel,a parallel four-bar linkage,a pair of double-disc opener,a V-shape press wheel and a depth regulator,which can adjust the planting depth from 30 mm to 90 mm to satisfy the agronomic requirement under different field conditions.Based on analysis and calculation,the width of gauge wheel was set to 50 mm while the length of parallel four-bar linkage was set to 350 mm.Field experiment was conducted and the results indicated that the newly designed planting unit with single-side gauge wheel performed well with regard to planting depth uniformity and anti-blocking ability.The planting depth uniformity and seed spacing quality were 95.45%and 91.90%,respectively,when the average height of stubble was 22.5 cm and residue amount was 0.64 kg/m^(2)in the field.It can satisfy the requirement of no-till maize planting on the cropland with residue and stubble in North China Plain.Zhang Rui Cui Tao Han Dandan Zhang Dongxing Li Kehong Yin Xiaowei Wang Yunxia He Xiantao Yang Li 2016International Journal of Agricultural and Biological Engineering2016,9,6:4
8A new approach to promote astaxanthin accumulation via Na_2WO_4 in Haematococcus pluvialis显示文摘The optimum concentration of Na_2 WO_4 was explored in relation to the cell density and astaxanthin content in Haematococcus pluvialis. Then, the cellular morphology, nitrate reductase(NR) activity, soluble sugar and protein contents, and chlorophyll ?uorescence were measured, and the transcriptional expression of carotenogenic genes was determined by quantitative real-time PCR. The results showed that 3.0 mmol/L of Na_2 WO_4 was the optimum concentration to induce astaxanthin accumulation, with a maximum content of 49.41±0.13 pg/cell reached on the tenth day. The NR activity decreased signi?cantly and continually after Na_2 WO_4 treatment. The soluble sugar content increased gradually during the experimental period and was eventually signi?cantly higher than that in the control. The soluble protein content increased rapidly,reached a maximum in day 0.5 and day 1 and then decreased. The ef fective photochemical effciency of PSII( F v'/F m') and light saturation( E k) ?rst decreased and then tended to stabilize, and NADP +-glyceraldehyde-3-phosphate dehydrogenase(GAPDH) gene expression was correlated with photosynthesis. The transcriptional expression of ipi, psy and bkt was signi?cantly increased compared with that in the control after application of Na_2 WO_4, and the relative expression of ipi reached the highest level on the ?fth day, with a 98.03±1.92-fold increase. Our results describe a new approach to promote the ef fective accumulation of astaxanthin in H. pluvialis by NR inhibitor Na_2 WO_4.LI Yanguo CUI DANDan ZHUO Pinli ZHANG Lin SUN Xue XU Nianjun 2019Journal of Oceanology and Limnology2019,37,1:3
9Efficacy of moxibustion by stimulating acupoints of Danzhong(CV 17) and Ganshu(BL 18) on hyperplasia of mammary gland in rats显示文摘OBJECTIVE: To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong(CV 17) and Ganshu(BL 18) in rats with hyperplasia of mammary gland(HMG) which induced by estrogen and progestogen.METHODS: Thirty female Sprague-Dawley rats were randomly divided into saline control group,HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progesto-gen with moxibustion at the same time. The Changes of nipple diameter and height were measured.The rats' skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas,Danzhong(CV 17) and Ganshu(BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.RESULTS: The diameter and height of the nipples in model group were prominently bigger and higher than that in control group(P < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group(P < 0.01), and there was no significant difference between moxibustion group and control group.Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong(CV 17) and Ganshu(BL 18) decreased prominently in model group(P < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently(P <0.05).CONCLUSION: Treatment with moxibustion can effectively decrease the HMG rats' nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas,Danzhong(CV 17) and Ganshu(BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia.Yang Jiamin Wu Jihui Shen Xiaoyu Zhang Mei Liu Zhenzhen Qi Dandan Zhou Jin Cui Xiao Zhang Lufen Li Yuhang 2018Journal of Traditional Chinese Medicine2018,38,1:3
10Ru(bpy)_(3)^(2+)-sensitized{001}facets LiCoO_(2) nanosheets catalyzed CO_(2) reduction reaction with 100% carbonaceous products显示文摘Photosensitized heterogeneous CO_(2) reduction(PHCR)has emerged as a promising means to convert CO_(2) into valuable chemicals,however,challenged by the relatively low carbonaceous product selectivity caused by the competing hydrogen evolution reaction(HER).Here,we report a PHCR system that couples Ru(bpy)32+photosensitizer with{001}faceted LiCoO_(2) nanosheets photocatalyst to simultaneously yield 21.2 and 722μmol·g^(-1)·h^(-1) of CO,and 4.42 and 108μmol·g^(-1)·h^(-1) of CH4 under the visible light and the simulated sunlight irradiations,respectively,with completely suppressed HER.The experimental and theoretical studies reveal that the favored CO_(2) adsorption on the exposed Li sites on{001}faceted LiCoO_(2) surface is responsible for the completely suppressed HER.Shuaiyu Jiang Junxian Liu Kun Zhao Dandan Cui Porun Liu Huajie Yin Mohammad Al-Mamun Sean ELowe Weiping Zhang Yu Lin Zhong Jun Chen Yun Wang Dan Wang Huijun Zhao 2022Nano Research2022,15,2:2
11Synthesis and performance of Pd/SnO 2 –TiO 2 /MWCNT catalysts for direct formic acid fuel cell application显示文摘Hao An Hao Cui Dandan Zhou Dejing Tao Baojv Li Jianping Zhai Qin Li 2013Electrochimica Acta2013,,:2
12Prediction of Deformation and Footprint of High-speed Rotating Radial Tires显示文摘In this research,the tire deformations due to rotation are divided into three parts:tread,belt and carcass.Tread deformation is obtained by using a rotating hollow cylinder model,belt expansion is calculated according to the laminated composite shell theory,and a formula of dynamic equilibrium profile is built to investigate carcass deformation.Moreover,a simple method is used to predict the footprint changes caused by tire deformation.Results show that a large deformation is occurring at tire shoulder,a smaller one at tread centre,and the shoulder deformations are mostly caused by carcass.Length of footprint side edges increase with tire rolling speed increasing.The predicted tread,belt,carcass deformations and footprint changes are in good agreement with finite element analysis results.The proposed method and the results will offer a helpful guidance to tire and vehicle engineers.CUI Zhibo CHAI Delong LYU Jiafeng HU Kai ZHANG Chunsheng HOU Dandan WANG Youshan 2020橡胶工业2020,67,5:2
13Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research.Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge 2019Chinese Chemical Letters2019,30,3:2
14The prognostic significance of polymorphisms in hMLH1/hMSH2 for colorectal cancer显示文摘Yibaina Wang Guangxiao Li Fulan Hu Haoran Bi Zhiwei Wu Xiaojuan Zhao Ye Li Shuying Li Dandan Li Binbin Cui Xinshu Dong Yashuang Zhao 2014Medical Oncology2014,,6:1
15Environmental Sustainability of Water Footprint in China' Mainland显示文摘Water footprint(WF)measures human appropriation of water resources for consumptive use of surface and ground water(blue WF)and soil water(green WF)and for assimilating polluted water(grey WF).Questions have been often asked about the exact meaning behind the numbers from WF accounting.However,to date environmental sustainability of WF has never been assessed at the sub-national level over time.This study evaluated the environmental sustainability of blue,green and grey WF for China’s 31 mainland provinces in 2002,2007 and 2012,and identified the unsustainable hotspots.Overall,the total WF increased by 30%between 2002 and 2012.The growth can be attributed to the increase of grey WF because the green and blue WF showed only a slight rise.Among all provinces investigated in 2012,eleven showed unsustainable blue WF(sustainability index SI<0),which were mainly located in the North China Plain.There were 12 provinces that displayed unsustainable green WF,and they were distributed in China’s southern and southeastern areas.The grey WF was not sustainable in approximately two third of provinces(19),which were mainly located in China’s middle and northern regions and Guangdong province.More than half of China’s provinces showed trends of improved SI of green and blue WF from 2002 to 2012.However,the SI of grey WF decreased in almost two third of provinces.Poor levels of WF sustainability were due to water scarcity and pollution,which intensify the degradation of local rivers and ecosystems and make restoration more difficult.The results shed light on the policy making needed to improve sustainable water management,and ecological restoration of hotspot regions.Junguo Liu Dandan Zhao Ganquan Mao Wenhui Cui He Chena Hong Yang 2020Geography and Sustainability2020,1,1:1
16Subpixel edge location based on orthogonal Fourier–Mellin moments显示文摘T.J. Bin Ao Lei Cui Jiwen Kang Wenjing Liu Dandan 2007Image and Vision Computing2007,,4:1
17Design and experiment of seed furrow cleaning device based on throwing and sliding for no-till maize seeding显示文摘In order to solve the serious problems of seeds are covered by residual film and overhead by straw during no-till seeding,a seed furrow cleaning device for no-till maize seeding was developed,which adopted a collaborative cleaning method of rotating spring teeth and curved sliding shovel.The movement process and motion trajectory of throwing residual film and straw were constructed.The maximum distance of throwing to one side in horizontal and maximum height in vertical were obtained.The motion trajectory of adjacent spring teeth was analyzed by Matlab,the motion trajectories of adjacent spring teeth at different speeds of 120 r/min,150 r/min and 180 r/min were achieved,the theoretical analysis results showed that the area of omitted area decreased with the increase of rotation speed.Based on theoretical and simulation analysis of critical parameters,the forward speed of machine,rotation speed of spring teeth,and dip angle between spring teeth and rotary disc were selected as the influencing factor.Straw cleaning rate(SCR)and residual film cleaning rate(RFCR)were selected as the response values for three factors and three levels of orthogonal experiment design.The optimal combination of the selected parameters was obtained,and the field test verification was also conducted.The results showed that the rotation speed of spring teeth,forward speed and dip angle of spring teeth significantly affect SCR and RFCR were in decreasing order.The field test results indicated that when forward speed was 6 km/h,rotation speed of spring teeth was 180 r/min and dip angle of spring teeth was 40°,SCR and RFCR were 88.27%and 84.31%,respectively.This study provides a reference for the development of no-till seeder in Xinjiang and the northwestern regions of China.Panpan Yuan Hongwen Li Caiyun Lu Qingjie Wang Jin He Shenghai Huang Dandan Cui 2022International Journal of Agricultural and Biological Engineering2022,15,4:1
18Observation of CO2^++ dication in the dayside Martian upper atmosphere显示文摘Doubly charged positive ions(dications)are an important component of planetary ionospheres because of the large energy required for their formation.Observations of these ions are exceptionally difficult due to their low abundances;until now,only atomic dications have been detected.The Neutral Gas and Ion Mass Spectrometer(NGIMS)measurements made on board the recent Mars Atmosphere and Volatile Evolution mission provide the first opportunity for decisive detection of molecular dications,CO2^++in this case,in a planetary upper atmosphere.The NGIMS data reveal a dayside averaged CO2^++distribution declining steadily from 5.6 cm^−3 at 160 km to below 1 cm^−3 above 200 km.The dominant CO2^++production mechanisms are double photoionization of CO2 below 190 km and single photoionization of CO2^+at higher altitudes;CO2++destruction is dominated by natural dissociation,but reactions with atmospheric CO2 and O become important below 160 km.Simplified photochemical model calculations are carried out and reasonably reproduce the data at low altitudes within a factor of 2 but underestimate the data at high altitudes by a factor of 4.Finally,we report a much stronger solar control of the CO2^++density than of the CO2+density.Hao Gu Jun Cui DanDan Niu LongKang Dai JianPing Huang XiaoShu Wu YongQiang Hao Yong Wei 2020Earth and Planetary Physics2020,4,4:1
19Ethanol-wet bonding may improve root entine bonding performance of hydrophobic adhesive显示文摘Dandan Pei Xueqing Huang Cui Huang 2012Journal of Dentistry2012,40,:1
20Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism显示文摘The pituitary adenylate cyclase-activating polypeptide type I receptor(PAC1R)belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs.Abnormal activation of the receptor mediates trigeminovascular activation and sensitization,which is highly related to migraine,making PAC1R a potential therapeutic target.Elucidation of PAC1R activation mechanism would benefit discovery of therapeutic drugs for neuronal disorders.PAC1R activity is governed by pituitary adenylate cyclase-activating polypeptide(PACAP),known as a major vasodilator neuropeptide,and maxadilan,a native peptide from the sand fly,which is also capable of activating the receptor with similar potency.These peptide ligands have divergent sequences yet initiate convergent PAC1R activity.It is of interest to understand the mechanism of PAC1R ligand recognition and receptor activity regulation through structural biology.Here we report two near-atomic resolution cryo-EM structures of PAC1R activated by PACAP38 or maxadilan,providing structural insights into two distinct ligand binding modes.The structures illustrate flexibility of the extracellular domain(ECD)for ligands with distinct conformations,where ECD accommodates ligands in different orientations while extracellular loop 1(ECU)protrudes to further anchor the ligand bound in the orthosteric site.By structureguided molecular modeling and mutagenesis,we tested residues in the ligand-binding pockets and identified clusters of residues that are critical for receptor activity.The structures reported here for the first time elucidate the mechanism of specificity and flexibility of ligand recognition and binding for PACT R,and provide insights toward the design of therapeutic molecules targeting PAC1R.Jia Wang Xianqiang Song Dandan Zhang Xiaoqing Chen Xun Li Yaping Sun Cui Li Yunpeng Song Yao Ding Ruobing Ren Essa Hu Harrington Liaoyuan AHu Wenge Zhong Cen Xu Xin Huang Hong-Wei Wang Yingli Ma 2020Cell Research2020,30,5:1
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