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| 1 | Hybrid QoS-aware semantic web service composition strategies显示文摘Hybrid QoS model which consists of certain and uncertain expressions has strong power of semantic QoS description. For solving the hybrid QoS-aware semantic web service composition problem,this paper presents an Uncertain Multi-attribute decision making based Composition algorithm(UMC) . The UMC includes two parts. First,UMC-Core can be used to synthetically evaluate the hybrid service quality information. Second,UMC-DH(Distributed and Heuristic framework for UMC) aims at enhancing the run-time performance of UMC when the problem space increases. The simulation results show that the UMC has lower execution cost,higher approximation ratio and success ratio than other similar approaches. | YANG FangChun SU Sen LI Zhen | 2008 | Science in China(Series F)2008，51，11： | 19 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 4 | QoS-Aware Semantic Web Service Composition with Uncertainties显示文摘 | LI Zhen YANG Fangchun SU Sen | 2008 | Chinese Journal of Electronics2008，17，4： | 6 |
| 5 | New Hardy Spaces Associated with Some Anisotropic Herz Spaces and Their Applications | Yong Ding Sen Hua Lan Shan Zhen Lu | 2008 | Acta Mathematica Sinica,English Series2008，24，9： | 2 |
| 6 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 7 | The identification of a new actin-binding region in p57显示文摘肌动朊绑定蛋白质 p57 是哺乳动物的象 coronin 一样蛋白质的一个成员。在吞噬细胞的过程的这蛋白质的角色想象得到地与 F 肌动朊取决于它的相互作用。二个区域, p57 (1-34 ) 和 p57 (111-204 ) ,以前被报导是肌动朊绑定地点。在这研究,我们发现 p57 的 C 终端区域, p57 (297-461 ) ,也拥有的 F 肌动朊有约束力的活动。而且,在 p57 (297-461 ) 的 C 终点的白氨酸拉链领域为这项肌动朊绑定活动是必要的。F 肌动朊 cross-linking 试金表明在 p57 (297-461 ) 包含的区域对交叉结合肌动朊细丝足够。我们的结果强烈建议在 p57 的 C 终点有一个新肌动朊绑定区域。 | Chang Zhen Liu Yong Chen Sen Fang Sui | 2006 | Cell Research2006，16，1： | 2 |
| 8 | Effect of Zn^2+ during reactivation and refolding of urea-denatured ereatine kinase 显示文摘 | Li Sen Xu Zhen Zhou Haimeng | 2002 | Biochemistry2002，67，7： | 1 |
| 9 | Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD in a C hinese population显示文摘 | Qing Fan Yang Bai Li Chen Qing Sen Zhang Zhen Hua Zhu Bin Hu Yao He Xiang Gao Yi Ming Wang Pin Jin Hu Min Hu Chen Zhi Rong Zeng | 2015 | Journal of Digestive Diseases2015，，1： | 1 |
| 10 | Occurrence and impact of polychlorinated dibenzo-p-dioxins/dibenzofurans in the air and soil around a municipal solid waste incinerator显示文摘To assess the influence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDD/Fs) on the environment in the vicinity of municipal solid waste incinerators(MSWIs), we determined the levels of PCDD/Fs in air and soil samples collected around a MSWI, which is the largest in China. The International Toxicity Equivalency Quantity(I-TEQ) concentrations of PCDD/Fs in air samples were from 0.0300 to 1.03 pg I-TEQ/m^3(0.445–13.6 pg/m^3), with an average of 0.237 pg I-TEQ/m^3, while in soil samples they ranged from 0.520 to 3.40 pg I-TEQ/g(2.41–88.7 pg/g) with an average of1.49 pg I-TEQ/g. The concentrations of PCDD/Fs in air and soil samples were comparable to other areas, and Pe CDFs were the dominant contributors, which was different from stack gas homologue patterns. Multivariate statistical analysis showed that PCDD/Fs emission from the MSWI did not directly affect the profiles of PCDD/Fs in air and soils, so that vehicles and unidentified emission sources should be considered. The daily inhalation levels of PCDD/Fs for children(0.0110 to 0.392 pg I-TEQ/(kg·day) and adults(0.00600 to 0.221 pg I-TEQ/(kg·day) near the MSWI were lower than the tolerable daily intake of 1.00 to 4.00 pg WHO-TEQ/(kg·day), but in winter the values were higher than in summer. These results can be used as basic data for assessing the risk of PCDD/Fs exposure in residents living around this MSWI, and more monitoring programs and studies should be carried out around MSWIs. | Zhiguang Zhou Yue Ren Jiazhi Chu Nan Li Sen Zhen Hu Zhao Shuang Fan Hui Zhang Pengjun Xu Li Qi Shuting Liang Bin Zhao | 2016 | Journal of Environmental Sciences2016，28，6： | 1 |
| 11 | Ganoderma luc - idum inhibits turnout cell pro liferation and induces tumour cell death显示文摘 | Xie Yi Zhen Li Sen Zhu A lbertYee | 2006 | Enzyme andM icrobial Technol2006，4，： | 1 |
| 12 | A preliminary inquiry into the conformation of the side chains on polyimide film and the mechanism of the vertical alignment of liquid crystals induced by polyimides with side chains显示文摘 | Guo Chun-Ju Sun Zhen Xia Sen Lin | | 0，，06： | 1 |
| 13 | Reflective Optical Fiber Micro-Displacement Sensor显示文摘 | Zhang Sen Liu Menghua Wang Zhen | 2007 | Study on Optical Communications2007，，141： | 1 |
| 14 | Fast start-up of Anammox process with appropriate ferrous iron concentration 显示文摘 | Bi Zhen Qiao Sen Zhou Jiti | 2014 | Bioresource Techno- logy2014，170，5： | 1 |
| 15 | Method of calculating the radiance of point-source target in infrared image 显示文摘 | YANG Yao WU Zhen sen | 2002 | International Journal of Infrared and Millimeter Waves2002，23，9： | 1 |
| 16 | Microstructure observation of multilayers separated from wheat bran显示文摘In order to understand more clearly the morphology of the structural layers of the soft and hard wheat bran to understand the effect of mechanical force on the wheat grain,we observed the microstructure of each layer of the wheat bran from soft and hard mature wheat.Based on the differences in mechanical properties and water permeability of each wheat bran layer,the mature wheat grains were alternately treated under cold and heat conditions and separated by manual dissection.The microstructure of each layer of wheat bran from soft and hard mature wheat was determined by optical and fluorescence microscopy.Seven different structure layers were observed by optical microscopy,named them as epidermis,epicarp,cross cells,tube cells,testa,nucellar layer,and aleurone layer.All the layers of the outer bran of wheat grains were separated,except for the tube cells layer.The autofluorescence imagings of five layers were obtained.It was found that the morphology of the structural layers of the soft and hard wheat bran did not differ much,except for the aleurone layer.The aleurone layer of soft wheat bran was significantly different from that of the hard wheat bran,which is fuller and denser compared to soft wheat.In this study,more aleurone grains were lost in the aleurone layer obtained by the outsidein peeling method.The mastery of the morphology of each structural layer of the bran helps us to quickly quantify the degree of peeling of wheat milling,and to make immediate adjustments to the process.At the same time,we understand that the contents of the aleurone cells have different binding strengths with the nucellar layer and the starchy endosperm.The paper is instructive to deep investigation of wheat milling mechanism and product process refinement. | Xiaoling Tian Zhen Wang Shukai Yang Xiaoxi Wang Li Li Binghua Sun Sen Ma Shiquan Zheng | 2021 | Grain & Oil Science and Technology2021，4，4： | 1 |
| 17 | THE REACTION OF CALCIUM WITH WAZO-1 AND ITS BIOANALYTICAL APPLICATION显示文摘THEREACTIONOFCALCIUMWITHWAZO-1ANDITS￥ZhenHuaCHEN;ZhongYiYU;QuanYIN;LiXU;JiPingHEandRongSenSHEN(Dept.ofChemistry,WuhanUniv.,Wu... | Zhen Hua CHEN Zhong Yi YU Quan YIN Li XU Ji Ping HE and Rong Sen SHEN (Dept. of Chemistry, Wuhan Univ., Wuhan 430072)(Ctr. Of Res. & Analysis of Materials, Wuhan Univ. of Technology, Wuhan 430070)(Dept. of Biological Chemistry and Genetics, The Univ. | 1996 | Chinese Chemical Letters1996，7，5： | 1 |
| 18 | Effects of drug relief hospital-based AIDS educational methods on drug users显示文摘The objective of this study is to explore a potentially effective training method for the hospital professionals to educate drug users and to enhance their knowledge of HIV infection. One hundred and sixty one subjects, who came from 13 different provinces and were admitted in a drug relief hospital in Beijing, were recruited for this study. The average age of these subjects was 35.21±6.24 year old. The average numbers of years for drug addiction were 7 years, and the average numbers of drug relief treatment received in the past was 5.5 times. The level of AIDS knowledge of these subjects, including pathogenic factors, source of infection, route of transmission and preventive measures, were evaluated before and after receiving the AIDS educational training to these drug users. Our results showed that there was a statistically significant increase (P<0.01) in the knowledge of HIV infection and prevention among these subjects. Positive attitude and behavioral tendencies toward HIV prevention were also improved. Therefore, it is imperative for the medical professionals to incorporate AIDS education into drug relief treatment to achieve the maximum effect on the knowledge of AIDS and improvement of positive attitudes and behaviors toward HIV prevention among drug users. | Xiang Ping LI Shun Zhen XIAO Qiao Qin WAN Sen Lin SONG Yan Xia TENG | 2005 | Cell Research2005，15，11： | 1 |
| 19 | Ionic Liquid [bmim][BF_4] as a Green Medium for Passerini Reaction显示文摘The Passerini three-component reaction of carboxylic acid, aromatic aldehyde and isocyanide was carried out smoothly and efficiently in ionic liquid [bmim]BF4. Through this reaction, a series of α-acyloxycarboxamides were obtained in high yields. Advantages of this procedure include a green nature, high efficiency and operational | Xin Ying ZHANG Yah Zhen LI Xue Sen FAN Gui Rong QU Jian Ji WANG Xue Yuan HU | 2006 | Chinese Chemical Letters2006，17，5： | 1 |
| 20 | Essential roles of PI (3) K- p1106 in cell growth, metabolism and tumorigenesis显示文摘 | Shidong Jia Zhenning Liu Sen Zhang | 2008 | Nature2008，454，7： | 1 |
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