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| 1 | Characterizing a large outbreak of dengue fever in Guangdong Province, China显示文摘Background:Dengue cases have been reported each year for the past 25 years in Guangdong Province,China with a recorded historical peak in 2014.This study aims to describe the epidemiological characteristics of this large outbreak in order to better understand its epidemic factors and to inform control strategies.Methods:Data for clinically diagnosed and laboratory-confirmed dengue fever cases in 2014 were extracted from the China Notifiable Infectious Disease Reporting System.We analyzed the incidence and characteristics of imported and indigenous cases in terms of population,temporal and spatial distributions.Results:A total of 45224 dengue fever cases and 6 deaths were notified in Guangdong Province in 2014,with an incidence of 47.3 per 100000 people.The elderly(65+years)represented 11.7%of total indigenous cases with the highest incidence(72.3 per 100000).Household workers and the unemployed accounted for 23.1%of indigenous cases.The majority of indigenous cases occurred in the 37th to 44th week of 2014(September and October)and almost all(20 of 21)prefecture-level cities in Guangdong were affected.Compared to the non-Pearl River Delta Region,the Pearl River Delta Region accounted for the majority of dengue cases and reported cases earlier in 2014.Dengue virus serotypes 1(DENV-1),2(DENV-2)and 3(DENV-3)were detected and DENV-1 was predominant(88.4%).Conclusions:Dengue fever is a serious public health problem and is emerging as a continuous threat in Guangdong Province.There is an urgent need to enhance dengue surveillance and control,especially for the high-risk populations in high-risk areas. | Jian-Peng Xiao Jian-Feng He Ai-Ping Deng Hua-Liang Lin Tie Song Zhi-Qiang Peng Xiao-Cheng Wu Tao Liu Zhi-Hao Li Shannon Rutherford Wei-Lin Zeng Xing Li Wen-Jun Ma Yong-Hui Zhang | 2016 | Infectious Diseases of Poverty2016，5，1： | 13 |
| 2 | Signals for activation of the GM-CSF promoter and enhancer in T cells显示文摘 | Shannon MF Coles LS Vadas MA | 1997 | Crit Rev Immunol1997，17，34： | 1 |
| 3 | Mouse ret finger protein (rfp) proto-oncogene is expressed at specific stages of mouse spermatogenesis 显示文摘 | Cao T Shannon M Handel MA | 1996 | Dev Genet1996，19，4： | 1 |
| 4 | First-trimester med- ical abortion with mifepristone 200rag and misoprostol a systematic review显示文摘 | Raymond EG Shannon C Weaver MA | 2013 | Contraception2013，87，1： | 1 |
| 5 | The short-term effect of ambient ozone on mortality is modified by temperature in Guangzhou, China显示文摘 | Tao Liu Tian Tian Li Yong Hui Zhang Yan Jun Xu Xiang Qian Lao Shannon Rutherford Cordia Chu Yuan Luo Qi Zhu Xiao Jun Xu Hui Yan Xie Zhao Rong Liu Wen Jun Ma | 2013 | Atmospheric Environment2013，，： | 1 |
| 6 | Non-neonatal in- fection due to Listeria monocytogenes 显示文摘 | Tim MW Jackson MA Shannon K | 1984 | Pediatr Infect Dis1984，3，3： | 1 |
| 7 | Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21显示文摘 | Byers MA Calloway PA Shannon L | 2008 | J Immunol2008，181，7： | 1 |
| 8 | Current state of biomarker de- ~elopment for clinical application in epithelial ovarian cancer显示文摘 | Richard G Moore A Shannon MA | 2010 | Gyne-cologic Oncology2010，116，： | 1 |
| 9 | Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia显示文摘Despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires resistance.We performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance. | Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 10 | Dilated cardiomypathy associated with simian AIDS in nonhuman primates显示文摘 | Simon MA Mathier MA | 2000 | Circulation2000，101，2： | 1 |
| 11 | Kinetic characteristics of mixed conductive electrodes for lithium ion batteries显示文摘 | Jianxin Ma Chunsheng Wang Shannon Wroblewski | 2007 | Journal of Power Sources2007，164，2： | 1 |
| 12 | Cognitive improvement during continuous sedation in critically ill, awake, and responsive patients: the Acute Neurological ICU Sedation Trial (ANIST) 显示文摘 | Mirski MA Lewin JJ III Shannon LeDroux S | 2010 | Intensive Care Med2010，36，9： | 1 |
| 13 | Kinetic characteristics of mixed conductive electrodes for lithium ion batteries显示文摘 | Jianxin Ma Chunsheng Wang Shannon Wroblewski | 2006 | Journal of Power Sources2006，，2： | 1 |
| 14 | First-trimester medical abortion with mifepristone 200 mg and misoprostol:a systematic review显示文摘 | Raymond EG Shannon C Weaver MA | 2013 | Contraception2013，87，1： | 1 |
| 15 | Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells显示文摘 | Weisheng Lin Yi Xu Chuan-Chin Huang Yinfa Ma Katie B. Shannon Da-Ren Chen Yue-Wern Huang | 2009 | Journal of Nanoparticle Research2009，，1： | 1 |
| 16 | Effeet of thalidomide on apoptosis of lymphoeytes and neutrophils显示文摘 | Aseffa A Dietrich MA Shannon EJ | 1997 | Immunopharmacol Immunotoxieol1997，19，3： | 1 |
| 17 | Restoration of strong grasp and lateral pinch in tetraplegia:a comparision of two methods of thumb control in each patient显示文摘 | House JH Shannon MA | 1985 | J Hand Surg1985，10，： | 1 |
| 18 | Exaggerated cardiovascular effects of cocaine in conscious dogs with pacing-induced dilated cardiomyopathy显示文摘 | Mathier MA Shen YT Shannon RP | 2002 | J Card Fail2002，8，6： | 1 |
| 19 | The short-term effect of ambient ozone on mortality is modified by temperature in Guangzhou, China显示文摘 | Tao Liu Tian Tian Li Yong Hui Zhang Yan Jun Xu Xiang Qian Lao Shannon Rutherford Cordia Chu Yuan Luo Qi Zhu Xiao Jun Xu Hui Yan Xie Zhao Rong Liu Wen Jun Ma | 2013 | Atmospheric Environment2013，，： | 1 |
| 20 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
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