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| 1 | Genetic correction of p-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice显示文摘 | Yixuan Wang Chen-Guang Zheng Yonghua Jiang Jiqin Zhang Jiayu Chen Chao Yao Qingguo Zhao Sheng Liu Ke Chen Juan Du Ze Yang Shaorong Gao | 2012 | Cell Research2012，22，4： | 27 |
| 2 | Epidemiological Characteristics of Newly-Reported HIV Cases Among Youth Aged 15−24 Years-China, 2010−2019显示文摘Summary What is already known about this topic?An estimated 1,400 new cases of human immunodeficiency virus(HIV)occur every day among youths globally.However,HIV distribution among youth aged 15–24 years in China has not been researched extensively. | Hao Zhao Hui Liu Lu Wang Xuan Yang Shaorong Wang Mengjie Han Jian Li | 2020 | China CDC weekly2020，2，48： | 23 |
| 3 | Generation of induced pluripotent stem cells from human β-thalassemia fibroblast cells显示文摘 | Yixuan Wang Yonghua Jiang Sheng Liu Xiaofang Sun Shaorong Gao | 2009 | Cell Research2009，19，9： | 16 |
| 4 | Insights into epigenetic patterns in mammalian early embryos显示文摘Mammalian fertilization begins with the fusion of two specialized gametes,followed by major epigenetic remodeling leading to the formation of a totipotent embryo.During the development of the pre-implantation embryo,precise reprogramming progress is a prerequisite for avoiding developmental defects or embryonic lethality,but the underlying molecular mechanisms remain elusive.For the past few years,unprecedented breakthroughs have been made in mapping the regulatory network of dynamic epigenomes during mammalian early embryo development,taking advantage of multiple advances and innovations in low-input genome-wide chromatin analysis technologies.The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals,including DNA methylation,histone modifications,chromatin accessibility and 3D chromatin organization. | Ruimin Xu Chong Li Xiaoyu Liu Shaorong Gao | 2021 | Protein & Cell2021，12，1： | 13 |
| 5 | Advance in highly efficient hydrogen production by high temperature steam electrolysis显示文摘High Temperature Steam Electrolysis (HTSE) through a solid oxide electrolytic cell (SOEC) has been receiving increasing research and development attention worldwide because of its high conversion efficiency (about 45%-59%) and its potential usage for large-scale production of hydrogen. The mechanism, composition, structure, and developing challenges of SOEC are summarized. Current situation, key materials, and core technologies of SOEC (solid oxide electrolytic cell) in HTSE are re- viewed, and the prospect of HTSE future application in advanced energy fields is proposed. In addition, the recent research achievements and study progress of HTSE in Tsinghua University are also intro- duced and presented. | YU Bo ZHANG WenQiang CHEN Jing XU JingMing WANG ShaoRong | 2008 | Science China Chemistry2008，51，4： | 10 |
| 6 | Histone methyltransferase G9a contributes to H3K27 methylation in vivo显示文摘 | Hui Wu Xiuzhen Chen Jun Xiong Yingfeng Li Hong Li Xiaojun Ding Sheng Liu She Chen Shaorong Gao Bing Zhu | 2011 | Cell Research2011，21，2： | 8 |
| 7 | Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis显示文摘Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 8 |
| 8 | Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation显示文摘 | Lan Kang Tong Wu Yu Zao Ye Yuan Jing He Yu Zhang Tong Luo Zhaohui Kou Shaorong Gao | 2011 | Cell Research2011，21，3： | 5 |
| 9 | Induced pluripotent stem cells(iPSCs)——a new era of reprogramming显示文摘Embryonic stem cells (ESCs) derived from the early embryos possess two important characteristics:self-renewal and pluripotency,which make ESCs ideal seed cells that could be potentially utilized for curing a number of degenerative and genetic diseases clinically.However,ethical concerns and immune rejection after cell transplantation limited the clinical application of ESCs.Fortunately,the recent advances in induced pluripotent stem cell (iPSC) research have clearly shown that differentiated somatic cells from various species could be reprogrammed into pluripotent state by ectopically expressing a combination of several transcription factors,which are highly enriched in ESCs.This ground-breaking achievement could circumvent most of the limitations that ESCs faced.However,it remains challenging if the iPS cell lines,especially the human iPSCs lines,available are fully pluripotent.Therefore,it is prerequisite to establish a molecular standard to distinguish the better quality iPSCs from the inferior ones. | Lan Kang Zhaohui Kou Yu Zhang Shaorong Gao | 2010 | Journal of Genetics and Genomics2010，37，7： | 5 |
| 10 | Precise temporal regulation of Dux is important for embryo development显示文摘Dear Editor,Zygotic genome activation(ZGA)following fertilization is accomplished through a process termed the maternal-to-zygotic transition,during which the maternal RNAs and proteins are degraded and zygotic genome is transcriptionally activated.In mice,minor ZGA occurs from S phase of the zygote to G1 phase of the two-cell(2C)embryo,while major ZGA takes place during the middle-to-late 2C stage with a burst of transcription of totipotent cleavage stage-specific genes and retrotransposons. | Mingyue Guo Yanping Zhang Jianfeng Zhou Yan Bi Junqin Xu Ce Xu Xiaochen Kou Yanhong Zhao Yanhe Li Zhifen Tu Kuisheng Liu Jiaming Lin Peng Yang Shaorong Gao Yixuan Wang | 2019 | Cell Research2019，29，11： | 5 |
| 11 | Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats显示文摘Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome.This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back.Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease,and that abnormal behavior of rats was significantly improved following electroacupuncture treatment.These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease.Thus,electroacupuncture may be useful in the treatment of Parkinson's disease. | Shuju Wang Jianqiao Fang Jun Ma Yanchun Wang Shaorong Liang Dan Zhou Guojie Sun | 2013 | Neural Regeneration Research2013，8，6： | 4 |
| 12 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 13 | Recent advances in nanorobotic manipulation inside scanning electron microscopes显示文摘A scanning electron microscope(SEM)provides real-time imaging with nanometer resolution and a large scanning area,which enables the development and integration of robotic nanomanipulation systems inside a vacuum chamber to realize simultaneous imaging and direct interactions with nanoscaled samples.Emerging techniques for nanorobotic manipulation during SEM imaging enable the characterization of nanomaterials and nanostructures and the prototyping/assembly of nanodevices.This paper presents a comprehensive survey of recent advances in nanorobotic manipulation,including the development of nanomanipulation platforms,tools,changeable toolboxes,sensing units,control strategies,electron beam-induced deposition approaches,automation techniques,and nanomanipulation-enabled applications and discoveries.The limitations of the existing technologies and prospects for new technologies are also discussed. | Chaoyang Shi Devin K Luu Qinmin Yang Jun Liu Jun Chen Changhai Ru Shaorong Xie Jun Luo Ji Ge Yu Sun | 2016 | Microsystems & Nanoengineering2016，2，1： | 4 |
| 14 | In situ localization of calmodulin mRNA in the developing tobacco anthers显示文摘The temporal and spatial expression patterns of calmodulin mRNA in the developing tobacco anthers were investigated by in situ RNA hybridization, using digoxigening-labeled anti-RNA probe. Calmodulin mRNA was distributed in various developmental stages of tobacco anthers, but the expression level had temporal and spatial differences distinctly. During early stage of anther development, the expression level of calmodulin mRNA was significantly high, mainly distributed in epidermis, tapetum and transfusion parenchyma cells and so on. Especially, more mRNA was accumulated in the nuclei and chromosomes of microspore mother cells prior to and during meiosis. With the development of anther,mRNA was decreased gradually in the anther wall and pollen. By mature pollen stage, only a stronger positive reaction still existed in the epidermis of anther wall and transfusion parenchyma cells. The results suggest that the temporal and spatial expression of calmodulin mRNA is closely correlated with cell division, | Shaorong Chen Yingtang Lu Hongyuan Yang | 1999 | Chinese Science Bulletin1999，44，2： | 4 |
| 15 | Spatial Analysis of HIV/AIDS Cases Among Out-of-School Youth Aged 15-24 Years-China,2010-2020显示文摘Summary What is already known about this topic?There are 4,000 new HIV infections every day worldwide,and 31%of which are in adolescents aged 15–24 years old.However,previous study is not aware of the distribution of out-of-school youth among this age group. | Shaorong Wang Junjie Wang Peng Xu Wanting Lyu Mengjie Han | 2021 | China CDC weekly2021，3，48： | 3 |
| 16 | ViWoSG:A distributed scene graph of ultra-massive distributed virtual environments显示文摘An ultra-massive distributed virtual environment generally consists of ultra-massive terrain data and a large quantity of objects and their attribute data, such as 2D/3D geometric models, audio/video, images, vectors, characteristics, etc. In this paper, we propose a novel method for constructing distributed scene graphs with high extensibility. This method can support high concurrent interaction of clients and implement various tasks such as editing, querying, accessing and motion controlling. Some application experiments are performed to demonstrate its efficiency and soundness. | WANG GuoPing, LI Sheng, WANG ShaoRong, LU Bin & LI WenHang Key Lab of Machine Perception and Intelligent, MOE Department of Computer Science, Peking University, Beijing 100871, China | 2009 | Science in China(Series F)2009，52，3： | 3 |
| 17 | CRISPR/Cas9-mediated genome engineering of the ferret显示文摘 | Zhaohui Kou Qian Wu Xiaochen Kou Chonghai Yin Hong Wang Zhentao Zuo Yan Zhuo Antony Chen Shaorong Gao Xiaoqun Wang | 2015 | Cell Research2015，25，12： | 3 |
| 18 | Stiffening of sickle cell trait red blood cells under simulated strenuous exercise conditions显示文摘The higher risk of vaso-occlusion events and sudden death for sickle-cell trait(SCT)athletes has been speculatively ascribed to SCT red blood cell(RBC)stiffening during strenuous exercise.However,the microenvironmental changes that could induce the stiffening of SCT RBCs are unknown.To address this question,we measured the mechanical properties of and changes in SCT RBCs under deoxygenated and acidic environments,which are two typical conditions present in the circulation of athletes undertaking strenuous exercise.The results reveal that SCT RBCs are inherently stiffer than RBCs from non-SCT healthy subjects,and a lower pH further stiffens the SCT cells.Furthermore,at both normal and low pH levels,deoxygenation was found to not be the cause of the stiffness of SCT RBCs.This study confirms that the stiffening of SCT RBCs occurs at a low pH and implies that SCT RBC stiffening could be responsible for vaso-occlusion in SCT athletes during strenuous exercise. | Zhensong Xu Yi Zheng Xian Wang Nadine Shehata Chen Wang Shaorong Xie Yu Sun | 2016 | Microsystems & Nanoengineering2016，2，1： | 2 |
| 19 | Transparent,stretchable,temperature-stable and self-healing ionogel-based triboelectric nanogenerator for biomechanical energy collection显示文摘A flexible and stable power supply is essential to the rapid development of wearable electronic devices.In this work,a transparent,flexible,temperature-stable and ionogel electrode-based self-healing triboelectric nanogenerator(IS-TENG)was developed.The ionogel with excellent stretchability(1,012%),high ionic conductivity(0.3 S·m^(−1))and high-temperature stability(temperature range of−77 to 250℃)was used as the electrode of the IS-TENG.The IS-TENG exhibited excellent transparency(92.1%)and stability.The output performance did not decrease when placed in a 60℃oven for 48 h.In addition,the IS-TENG behaved like a stable output in the range of−20 to 60℃.More importantly,the IS-TENG could also achieve self-healing of electrical performance at temperatures between−20 and 60℃and its output can be restored to its original state after healing.When the single-electrode IS-TENG with an area of 3 cm×3 cm was conducted under the working frequency of 1.5 Hz,the output values for open-circuit voltage,short-circuit current,short-circuit transferred charge,and maximum peak power density were 189 V,6.2μA,57 nC,and 2.17 W·m^(−2),respectively.The IS-TENG enables to harvest biomechanical energy,and drive electronic devices.Furthermore,the application of IS-TENGs as self-driven sensors for detecting human behavior was also demonstrated,showing good application prospects in the field of wearable power technology and self-driven sensing. | Weiqiang Liao Xiukun Liu Yuqi Li Xu Xu Jinxing Jiang Shaorong Lu Dequan Bao Zhen Wen Xuhui Sun | 2022 | Nano Research2022，15，3： | 2 |
| 20 | Feasibility of probing solid state nuclear tracks by thermal analysis method显示文摘The feasibility of probing solid state nuclear tracks by thermal analysis method is discussed both theoretically and experimentally.Comparison is made between the thermal analysis method and the optical microscope method,and it is demonstrated that this thermal analysis method is applicable to probing solid state nuclear tracks. | YANG TongSuo ZHOU Bing YANG xinxin HE ShaoRong HENG ShuYun YUAN SunSheng | 2007 | Chinese Science Bulletin2007，52，8： | 2 |
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