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| 1 | Combining LPJ-GUESS and HASM to simulate the spatial distribution of forest vegetation carbon stock in China显示文摘它在因为他们在陆上的生态系统的碳股票拥有大率,精确地在地区性的规模估计森林碳股票和空间分发是很重要的。然而,在地区性的规模的森林碳存货的当前的评价主要取决于森林库存数据,并且整个过程消费太多劳动,钱和时间。并且同时,它在森林碳存储上有许多否定影响更新。以便弄明白这些问题,基于当模特儿的高精确性表面(HASM ) ,这份报纸建议一个森林植被碳存储模拟方法。这个新方法作为 HASM 的起始的值采用 LPJ 猜测模型的输出并且把库存数据用作 HASM 的样品点在中国模仿森林碳存储的分发。这研究也作为数据来源采用中国的第七森林资源统计产生样品点,并且它也作为模拟精确性测试工作。HASM 模拟证明中国的全部的森林碳存储是 9.2405 Pg,当计算价值基于森林资源统计是 7.8115 Pg 时。森林资源统计基于森林华盖闭合被拿,并且 HASM 的结果对真实森林碳存储更合适。模拟结果也显示西南的山区域和东北森林是在中国的重要森林碳水库,并且他们分别地说明 39.82% 国家和 20.46% 总数森林植被碳存货。与以前的价值(1975-1995 ) 相比,二个区域的碳存储确实清楚地增加,这表明。这研究的结果证明在在中国的最后十年的大规模重新造林达到一个重要的碳水池。 | ZHAO Mingwei YUE Tianxiang ZHAO Na SUN Xiaofang ZHANG Xingying | 2014 | Journal of Geographical Sciences2014，24，2： | 18 |
| 2 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 3 | Generation of induced pluripotent stem cells from human β-thalassemia fibroblast cells显示文摘 | Yixuan Wang Yonghua Jiang Sheng Liu Xiaofang Sun Shaorong Gao | 2009 | Cell Research2009，19，9： | 16 |
| 4 | Calycosin-7-O-β-D-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways显示文摘The iso fl avone calycosin-7-O-β-D-glucopyranoside(CG) is a principal constituent of Astragalus membranaceus(AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this study was to investigate the osteogenic effects of CG and its underlying mechanism in ST2 cells. The results show that exposure of cells to CG in osteogenic differentiation medium increases ALP activity, osteocalcin(Ocal) m RNA expression and the osteoblastic mineralization process. Mechanistically, CG treatment increased the expression of bone morphogenetic protein 2(BMP-2), p-Smad 1/5/8, β-catenin and Runx2, all of which are regulators of the BMP- or wingless-type MMTV integration site family(WNT)/β-catenin-signaling pathways. Moreover, the osteogenic effects of CG were inhibited by Noggin and DKK-1 which are classical inhibitors of the BMP and WNT/β-catenin-signaling pathways, respectively. Taken together, the results indicate that CG promotes the osteoblastic differentiation of ST2 cells through regulating the BMP/WNT signaling pathways. On this basis, CG may be a useful lead compound for improving the treatment of bone-decreasing diseases and enhancing bone regeneration. | Jing Jian Lijuan Sun Xun Cheng Xiaofang Hu Jichao Liang Yong Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 16 |
| 5 | Significantly enhanced piezo-photocatalytic capability in BaTiO_(3) nanowires for degrading organic dye显示文摘Over the last several years,piezo-photocatalytic effect was intensively investigated for a facile,effective and promising protocol to sewage treatment and environmental remediation.The research on the integration of piezocatalytic and photocatalytic process on lead-free ferroelectric materials is highly demanded to further push this field forward.In this work,BaTiO_(3) nanowires(BT NWs)were fabricated by a two-step hydrothermal method.The degradation of organic dye(methyl orange,MO)aqueous solution(5 mg L^(-1))by integrating photocatalysis with the piezoelectric-like effect under UV light radiation and ultrasonic vibration was investigated.The decomposition ratio reaches up to ~98.17%(at 80 min),which is around 1.28 and 2.24 times of the sole piezocatalysis and photocatalysis process,respectively.The intermediate product of hydroxyl radical(·OH)and superoxide radical(·O_(2)^(-))was detected and quantified by radical trapping experiments,to illustrating their key role in degrading MO molecules.In addition,we carried out sequential cycles to evaluate the cycling stability and usage durability of catalysts and a reduction of ~15% in the efficiency was observed after four cycles.This work provides a promising paradigm for the further development of piezo-photocatalytic materials and target applications in environmental field. | Xiaofang Liu Longyin Xiao Yong Zhang Huajun Sun | 2020 | Journal of Materiomics2020，6，2： | 10 |
| 6 | Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds:A large-scale,retrospective study显示文摘Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using ELISAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called'NBNC-HCC')and patients positive for the above indices(called'HBV-HCC and HCV-HCC')were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients. | Dongming Liu Yi Luo Lu Chen Liwei Chen Duo Zuo Yueguo Li Xiaofang Zhang Jing Wu Qing Xi Guangtao Li Lisha Qi Xiaofen Yue Xiehua Zhang Zhuoyu Sun Ning Zhang Tianqiang Song Wei Lu Hua Guo | 2021 | Cancer Biology & Medicine2021，18，1： | 10 |
| 7 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 8 | Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers显示文摘In recent years,the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied.It was reported that all-trans astaxanthin might exist as three stereoisomers,and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products.However,the different biological effects of various all-trans stereoisomers still remain unclear.In the present study,we evaluated the bioactivity of three astaxanthin stereoisomers,(3S,3'S)-trans-,(3R,3'R)-transand meso-trans-astaxanthin,in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells(PECs) systems.After the treatment with three astaxanthin stereoisomers(20 μmol L-1),the lymphocyte proliferation capacity,neutral red phagocytosis of PECs and natural killer(NK) cell cytotoxic activity were comparatively assessed.The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation,phagocytic capacity of PECs,and cytotoxic activity of NK cells.Moreover,the(3S,3'S)-trans-astaxanthin exhibited a much higher response than others. | SUN Weihong XING Lihong LIN Hong LENG Kailiang ZHAI Yuxiu LIU Xiaofang | 2016 | Journal of Ocean University of China2016，15，2： | 7 |
| 9 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 10 | Environmentally Tough and Stretchable MXene Organohydrogel with Exceptionally Enhanced Electromagnetic Interference Shielding Performances显示文摘Conductive hydrogels have potential applications in shielding electromagnetic(EM)radiation interference in deformable and wearable electronic devices,but usually suffer from poor environmental stability and stretching-induced shielding performance degradation.Although organohydrogels can improve the environmental stability of materials,their development is at the expense of reducing electrical conductivity and thus weakening EM interference shielding ability.Here,a MXene organohydrogel is prepared which is composed of MXene network for electron conduction,binary solvent channels for ion conduction,and abundant solvent-polymer-MXene interfaces for EM wave scattering.This organohydrogel possesses excellent anti-drying ability,low-temperature tolerance,stretchability,shape adaptability,adhesion and rapid self-healing ability.Two effective strategies have been proposed to solve the problems of current organohydrogel shielding materials.By reasonably controlling the MXene content and the glycerol-water ratio in the gel,MXene organohydrogel can exhibit exceptionally enhanced EM interference shielding performances compared to MXene hydrogel due to the increased physical cross-linking density of the gel.Moreover,MXene organohydrogel shows attractive stretching-enhanced interference effectiveness,caused by the connection and parallel arrangement of MXene nanosheets.This well-designed MXene organohydrogel has potential applications in shielding EM interference in deformable and wearable electronic devices. | Yuanhang Yu Peng Yi Wenbin Xu Xin Sun Gao Deng Xiaofang Liu Jianglan Shui Ronghai Yu | 2022 | Nano-Micro Letters2022，14，5： | 6 |
| 11 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 12 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 13 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 14 | Braided river and distribution patterns of sand bodies of Jurassic Badaowan formation in Block T13 of Junggar basin显示文摘In order to determine the planar and volume distribution of sand bodies of the Jurassic Badaowan formation in Block T13 of Junggar basin,we used analysis of field outcrop and 3D seismic data,which play an essential role in areas of sparse well coverage.We describe sedimentary facies characteristics,sand body planforms,width and connectivity patterns of sand bodies,and vertical associations and successions by acoustic impedance inversion technology and sedimentological theory.Results of our study show braided fluvial strata deposits in the Jurassic Badaowan formation.Each sand body is approximately lenticular in shape.The width of each sand body falls in the range 100~800 m,with most between 200 and 400 m.The sand bodies vary in thickness from 4 to 13 m,with most below 9 m.The width/thickness ratios lie in the range 20~55.The connectivity of braided fluvial channel sand bodies is controlled by changes of accommodation space.One fining-upward sedimentary cycle of base-level rise is recognized in Badaowan formation,representing an upward rise of base level.The connectivity of sand bodies was found to be greatest in the early stage of base-level rise,becoming progressively worse with increasing base-level rise. | SUN Xiaofang JIN Zhenkui WANG Zhaofeng HUANG Xiaoping GU Junfeng | 2010 | Mining Science and Technology2010，20，3： | 4 |
| 15 | Forest fire smoke recognition based on convolutional neural network显示文摘Traditional fire smoke detection methods mostly rely on manual algorithm extraction and sensor detection;however,these methods are slow and expensive to achieve discrimination.We proposed an improved convolutional neural network(CNN)to achieve fast analysis.The improved CNN can be used to liberate manpower.The network does not require complicated manual feature extraction to identify forest fire smoke.First,to alleviate the computational pressure and speed up the discrimination efficiency,kernel principal component analysis was performed on the experimental data set.To improve the robustness of the CNN and to avoid overfitting,optimization strategies were applied in multi-convolution kernels and batch normalization to improve loss functions.The experimental analysis shows that the CNN proposed in this study can learn the feature information automatically for smoke images in the early stages of fire automatically with a high recognition rate.As a result,the improved CNN enriches the theory of smoke discrimination in the early stages of a forest fire. | Xiaofang Sun Liping Sun Yinglai Huang | 2021 | Journal of Forestry Research2021，32，5： | 3 |
| 16 | Improved bias proportional navigation with multiple constraints for guide ammunition显示文摘According to the infrared guidance ammunition(GA)attacking non-maneuvering targets on the ground or sea level,an improved bias proportional navigation(IBPN) is put forward,which can meet the constraints of the impact angle and the angle of attack(AOA). The motion equations and the collision triangle for the GA and the target are established in the two-dimensional plane. In accordance with the collision triangle, the integral value of the bias term is solved and BPN is designed on the basis of the relative velocity. To ensure the new method can be solved, closedloop equation of the IBPN is deduced. Considering the limitation of the AOA and the seeker angle, a four-phase IBPN is improved by setting different phases of the bias term. At the same time, the guidance law will make the impact angle achieve the desired angle and the normal acceleration also converges to zero. The simulation results show that the improved guidance law can be applied to various flight tasks and has great potential for engineering applications. | Wei Pang Xiaofang Xie Tao Sun | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 3 |
| 17 | Derivation and characterization of human embryonic stem cell lines from poor quality embryos显示文摘Poor quality embryos discarded from in vitro fertilization (IVF) laboratories are good sources for deriving human embryonic stem cell (hESC) lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses (ICMs) could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM at- tachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods (P>0.05). As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories. | Weiqiang Liu, Yifei Yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China | 2009 | Journal of Genetics and Genomics2009，36，4： | 3 |
| 18 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 19 | Effect of phosphate on heterogeneous Fenton oxidation of catechol by nano-Fe_(3)O_(4):Inhibitor or stabilizer?显示文摘The effect of phosphate on adsorption and oxidation of catechol, 1,2-dihydroxybenzene,in a heterogeneous Fenton system was investigated. In situ attenuated total reflectance infrared spectroscopy(ATR-FTIR) was used to monitor the surface speciation at the nano-Fe_3O_4 catalyst surface. The presence of phosphate decreased the removal rate of catechol and the abatement of dissolved organic compounds, as well as the decomposition of H_2O_2. This effect of phosphate was mainly due to its strong reaction with surface sites on the iron oxide catalyst. At neutral and acid pH, phosphate could displace the adsorbed catechol from the surface of catalyst and also could compete for surface sites with H_2O_2. In situ IR spectra indicated the formation of iron phosphate precipitation at the catalyst surface. The iron phosphate surface species may affect the amount of iron atoms taking part in the catalytic decomposition of H_2O_2 and formation of hydroxyl radicals,and inhibit the catalytic ability of Fe_3O_4 catalyst. Therefore, phosphate ions worked as stabilizer and inhibitor in a heterogeneous Fenton reaction at the same time, in effect leading to an increase in oxidation efficiency in this study. However, before use of phosphate as p H buffer or H_2O_2 stabilizer in a heterogeneous Fenton system, the possible inhibitory effect of phosphate on the actual removal of organic pollutants should be fully considered. | Xiaofang Yang Jie He Zhongxi Sun Allan Holmgren Dongsheng Wang | 2016 | Journal of Environmental Sciences2016，28，1： | 2 |
| 20 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
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