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| 1 | Grenvillian orogeny in the Southern Cathaysia Block:Constraints from U-Pb ages and Lu-Hf isotopes in zircon from metamorphic basement显示文摘Metamorphic basement rocks in the Cathaysia Block are composed mainly of meta-sediments with different ages. New zircon U-Pb geochronological results from the meta-sedimentary rocks exposed in the Zengcheng and Hezi areas, southern Cathaysia Block, show that they consist dominantly of early Neoproterozoic (1.0―0.9 Ga) materials with minor Paleo- to Mesoproterozoic and late Neoproterozoic (0.8―0.6 Ga) components, suggesting that the detritus mostly come from a Grenvillian orogen. The youngest detrital zircon ages place a constraint on the deposition time of these sediments in Late Neoproterozoic. Zircon Hf isotopic compositions indicate that the Grenvillian zircons were derived from the reworking of Mesoproterozoic arc magmatic rocks and Paleoproterozoic continental crust, implying an arc-continent collisional setting. Single-peak age spectra and the presence of abundant euhedral Grenvillian zircons suggest that the sedimentary provenance is not far away from the sample location. Thus, the Grenvillian orogen probably preexisted along the southern margin of the Cathaysia Block, or very close to the south. Similarity in the ages of Grenvillian orogeny and the influence of the assembly of Gondwana in South China with India and East Antarctic are discussed, with suggestion that South China was more likely linked with the India-East Antarctica continents in Early Neoproterozoic rather than between western Laurentia and eastern Australia. | WANG LiJuan YU JinHai S.Y. O'REILLY W.L. GRIFFIN SUN Tao WEI ZhenYang JIANG ShaoYong SHU LiangShu | 2008 | Chinese Science Bulletin2008，53，19： | 21 |
| 2 | Effects of overlying water aeration on phosphorus fractions and alkaline phosphatase activity in surface sediment显示文摘Microbial activity may influence phosphorus (P) deposit and release at the water sediment interface.The properties of DO (dissolved oxygen),pH,P fractions (TP,Ca-P,Fe-P,OP,IP),and APA (alkaline phosphatase activity) at the water sediment interface were measured to investigate microbial activity variations in surface sediment under conditions of two-month intermittent aeration in overlying water.Results showed that DO and TP of overlying water increased rapidly in the first week and then decreased gradually after 15 day of intermittent aeration.Microorganism metabolism in surface sediment increased pH and decreased DO and TP in the overlying water.After two-month intermittent aeration,APA and OP from surface sediment (0-2 cm) were both significantly higher than those from bottom sediment (6-8 cm) (p < 0.05),and surface sediment Fe-P was transferred to OP during the course of microorganism reproduction on the surface sediment.These results suggest that microbial activity and microorganism biomass from the surface sediment were higher than those from bottom sediment after two-month intermittent aeration in the overlying water. | Jianjun Chen Shaoyong Lu Yikun Zhao Wei Wang Minsheng Huang | 2011 | Journal of Environmental Sciences2011，23，2： | 20 |
| 3 | Geochemical Characteristics and Genesis of the Luxi-Xianrenzhang Diabase Dikes in Xiazhuang Uranium Orefield, Northern Guangdong Province显示文摘The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment in large ion lithophile elements, slight enrichment in light rare earth elements, depletion in Zr and Hf, and basically no depletion in Nb and Ta and no Eu anomaly. They are similar to intraplate basalt in terms of trace element characteristics. They have high εNd(t) values (3.6–4.9), initial 87Sr/86Sr ratios (0.70530–0.70641) and δ18O values and Dupal anomaly of Pb isotope compositions. Their Sr-Nd, Pb-Sr, Pb-Nd and Pb-Pb isotopes plot between DMM and EMII, with Pb similar to EMII, Nd relatively close to DMM and Sr in between. This profile suggests that the diabase dikes studied were derived from partial melting of a mantle source that had been subjected to metasomatism by fluids originated from a subduction zone under a tectonic environment of crustal extension and lithosphere thinning in the late Yanshanian. | LING Hongfei SHEN Weizhou DENG Ping JIANG Shaoyong JIANG Yaohui YE Haimin PU Wei TAN Zhengzhong | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 13 |
| 4 | Effects of different forms of yeast Saccharomyces cerevisiae on growth performance,intestinal development,and systemic immunity in early-weaned piglets显示文摘The present study was conducted to determine effects of different forms of yeast(Saccharomyces cerevisiae,strain Y200007) on the growth performance,intestinal development,and systemic immunity in early-weaned piglets.A total of 96 piglets(14-d old,initial average body weight of 4.5 kg) were assigned to 4 dietary treatments:(1) basal diet without yeast(Control);(2) basal diet supplemented with 3.00 g/kg live yeast(LY);(3) basal diet supplemented with 2.66 g/kg heat-killed whole yeast(HKY);and(4) basal diet supplemented with 3.00 g/kg superfine yeast powders(SFY).Diets and water were provided ad libitum to the piglets during 3-week experiment.Growth performance of piglets was measured weekly.Samples of blood and small intestine were collected at days 7 and 21 of experiment.Dietary supplementation with LY and SFY improved G:F of piglets at days 1-21 of the experiment(P<0.05) compared to Control group.Serum concentrations of growth hormone(GH),triiodothyronine(T_3),tetraiodothyronine(T_4),and insulin growth factor 1(IGF-1) in piglets at day 21 of the experiment were higher when fed diets supplemented with LY and SFY than those in Control group(P < 0.05).Compared to Control group,contents of serum urea nitrogen of piglets were reduced by the 3 yeast-supplemented diets(P< 0.05).Diets supplemented with LY increased villus height and villus-to-crypt ratio in duodenum and jejunum of piglets(P < 0.05) compared to other two groups at day 7 of the experiment.Feeding diets supplemented with LY and SFY increased(P< 0.05) serum concentrations of IgA,IL-2,and IL-6 levels in piglets compared to Control.The CD4^+/CD8^+ ratio and proliferation of T-lymphocytes in piglets fed diets supplemented with LY were increased compared to that of Control group at day 7 of the experiment(P < 0.05).In conclusion,dietary supplementation with both LY and SFY enhanced feed conversion,small intestinal development,and systemic immunity in early-weaned piglets,with better improvement in feed conversion by dietary supplementation with LY,while dietary supplementation with SFY was more effective in increasing systemic immune functions in early-weaned piglets. | Zongyong Jiang Shaoyong Wei Zhilin Wang Cui Zhu Shenglan Hu Chuntian Zheng Zhuang Chen Youjun Hu Li Wang Xianyong Ma Xuefen Yang | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 13 |
| 5 | Boron Isotopic Fractionation and Trace Element Incorporation in Various Species of Modern Corals in Sanya Bay, South China Sea显示文摘硼同位素 paleo-pH 代理广泛地为理解过去的气候变化由于它的潜力被学习了,并且因为与 biocarbonate 微观结构有关的重要可变性,进一步的刻度为代理的精确应用被考虑。在这个工作,我们学习了在现代海洋的珊瑚和他们的共存的海水之间的同位素的分别在 Sanya 海湾沿着浅区域收集了的硼,华南海。硼的明显的分区系数(K < 潜水艇 class= “ a-plus-plus ” > D ) 从 0.83 湩琠敨 ? | Haizhen Wei Shaoyong Jiang Yingkai Xiao N Gary Hemming | 2014 | Journal of Earth Science2014，25，3： | 3 |
| 6 | Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators显示文摘The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases.However,the mechanism underlying allosteric activation of SIRT6 by the activator MDL-801 remains largely elusive because no major conformational changes are observed upon activator binding.By combining molecular dynamics simulations with biochemical and kinetic analyses of wild-type SIRT6 and its variant M136 A,we show that conformational rotation of 2-methyl-4-fluoro-5-bromo substituent on the right phenyl ring(R-ring)of MDL-801,which uncovers previously unseen hydrophobic interactions,contributes to increased activating deacetylation activity of SIRT6.This hypothesis is further supported by the two newly synthesized MDL-801 derivatives through the removal of the 5-Br atom on the R-ring(MDL-801-D1)or the restraint of the rotation of the R-ring(MDL-801-D2).We further propose that the 5-Br atom serves as an allosteric driver that controls the ligand allosteric efficacy.Our study highlights the effect of allosteric enzyme catalytic activity by activator binding and provides a rational approach for enhancing deacetylation activity. | Shaoyong Lu Yingyi Chen Jiacheng Wei Mingzhu Zhao Duan Ni Xinheng He Jian Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 7 | Mineral Chemistry of Melanite from Calcitic Ijolite, the Oka Carbonatite Complex, Canada: Implications for Multi-Pulse Magma Mixing显示文摘Ti-rich garnet is found within calcitic ijolite from the Oka carbonatite complex in Canada, which is characterized by 58%–73% andradite component(2.12 wt.%–4.18 wt.% TiO_2) and classified as melanite. The garnet displays complex zoning and contains abundant high field strength elements(HFSEs) and rare earth elements(REEs). Three groups(Ⅰ, Ⅱ, Ⅲ) have been identified based on their petrographic nature. Compared to groups Ⅱ and Ⅲ, Group Ⅰ garnet cores contain higher TiO_2, Mg O, HFSE, and REE and lower SiO_2 abundances. The distinct chemical and petrographic signatures of the investigated garnets cannot be attributed to simple closed system crystallization, but they are consistent with the multi-pulse magma mixing. Combined with previously reported U-Pb ages for apatite from the calcitic ijolite, at least three stages of magma evolution and subsequent mixing have been involved in the generation of calcitic ijolite at Oka. The early-formed melt that generated Group I garnet core was later mixed with at least two small-volume, more evolved melts. The intermediate stage melt formed the remaining garnet along with some pyroxene, calcite, nepheline, and apatite at 127±3.6 Ma. The youngest, most evolved melt generated the majority of pyroxene, calcite, nepheline, and apatite within the calcitic ijolite at 115±3.1 Ma. | Wei Chen Weiqi Zhang Antonio Simonetti Shaoyong Jiang | 2016 | Journal of Earth Science2016，27，4： | 2 |
| 8 | Load-Balancing and QoS Based Dynamic Resource Allocation Method for Smart Gird Fiber-Wireless Networks显示文摘Real-time network resource allocation based on virtualization technology is an important method to solve the solidification problem of Fiber-wireless(Fi-Wi)access networks.To increase the resource utilization and meet the specific QoS requirements of smart gird communication services,a Load-balancing and QoS based dynamic resource allocation method(LbQ-DR)is proposed with three sub-mechanisms.A time-window based substrate network resource update mechanism is designed to describe the realtime resource consumption of substrate networks,which can balance the accuracy of resource status and the complexity of the allocation algorithm.A QoS-based Virtual network request(VNR)sorting mechanism is presented to precisely calculate the priority of VNRs and reasonably sort the incoming services.A load-balancing based resource allocation mechanism is designed to avoid unbalanced resource consumption.Especially,the channel interference is considered in the cost of embedding and a collision domain mechanism is introduced to decrease interference.Simulation results demonstrate that the proposed method can provide heterogeneous smart grid businesses with differentiated service,improve the utilization and economic benefits of the network and make the network more balanced. | XU Siya LI Peng QI Feng GUO Shaoyong ZHOU Guiping DENG Wei LI Yueyue | 2019 | Chinese Journal of Electronics2019，28，6： | 1 |
| 9 | Edge Computing-Based Tasks Offloading and Block Caching for Mobile Blockchain显示文摘Internet of Things(IoT)technology is rapidly evolving,but there is no trusted platform to protect user privacy,protect information between different IoT domains,and promote edge processing.Therefore,we integrate the blockchain technology into constructing trusted IoT platforms.However,the application of blockchain in IoT is hampered by the challenges posed by heavy computing processes.To solve the problem,we put forward a blockchain framework based on mobile edge computing,in which the blockchain mining tasks can be offloaded to nearby nodes or the edge computing service providers and the encrypted hashes of blocks can be cached in the edge computing service providers.Moreover,we model the process of offloading and caching to ensure that both edge nodes and edge computing service providers obtain the maximum profit based on game theory and auction theory.Finally,the proposed mechanism is compared with the centralized mode,mode A(all the miners offload their tasks to the edge computing service providers),and mode B(all the miners offload their tasks to a group of neighbor devices).Simulation results show that under our mechanism,mining networks obtain more profits and consume less time on average. | Yong Yan Yao Dai Zhiqiang Zhou Wei Jiang Shaoyong Guo | 2020 | Computers, Materials & Continua2020，，2： | 1 |
| 10 | Highly regioselective Wittig reactions of cyclic ketones with a stabilized phosphorus ylide under controlled microwave heating显示文摘 | Wu Jinlong Wu Huafeng Wei Shaoyong | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 11 | Association study of ACE2 (angiotensin I-converting enzyme2) gene polymorphisms with coronary heart disease and myocardial infarction ina Chinese Han population显示文摘 | Wei YANG Wentao HUANG Shaoyong Su | 2006 | Clinical Science2006，111，： | 1 |
| 12 | Association study of ACE2(angiotesin-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population显示文摘 | Wei Y Wentao H Shaoyong S | 2006 | Clin Sci2006，111，1： | 1 |
| 13 | A QoS-Aware Packet Scheduling Mechanism in Cognitive Radio Networks for Smart Grid Applications显示文摘Cognitive radio sensor network is applied to facilitate network monitoring and management, and achieves high spectrum efficiencies in smart grid. However, the conventional traffic scheduling mechanisms are hard to provide guaranteed quality of service for the secondary users. It is because that they ignore the influence of diverse transition requirements in heterogeneous traffi c. Therefore, a novel Qo S-aware packet scheduling mechanism is proposed to improve transmission quality for secondary users. In this mechanism, a Qo S-based prioritization model is established to address data classification firstly. And then, channel quality and the effect of channel switch are integrated into priority-based packet scheduling mechanism. At last, the simulation is implemented with MATLAB and OPNET. The results show that the proposed scheduling mechanism improves the transmission quality of high-priority secondary users and increase the whole system utilization by 10%. | XU Siya WEI Lei LIU Zhu GUO Shaoyong QIU Xuesong MENG Luoming | 2016 | China Communications2016，13，2： | 1 |
| 14 | ∑HfF_5^- current monitoring with off-axis Faraday cup in AMS measurement of ^(182)Hf at CIAE显示文摘In order to reduce the systematic uncertainties caused by the sequential injection in AMS measurement of ^(182)Hf,a technique for instantaneous monitoring of off-axis∑HfF_5^- current was developed in the AMS laboratory at China Institute of Atomic Energy(CIAE).The stability and reliability of this method have been experimentally verified.As a result,the accuracy for AMS measurement of^(182)Hf was significantly improved. | LI Zhenyu HE Ming DONG Kejun LI Chaoli HE Guozhu HE Xianwen ZHANG Wei HU Hao ZHENG Guowen LI Heng WU Shaoyong JIANG Shan | 2012 | Nuclear Science and Techniques2012，23，4： | 1 |
| 15 | Sc(OTf)_(3)-catalyzed synthesis of polysubstituted furans from acylacetonitriles and renewable acetol显示文摘A[3+2]cyclization reaction of acylacetonitriles and hydroxyacetone was developed by using Sc(OTf)_(3)as a catalyst to synthesize some furan derivatives.Bifunctional C2-based acetals,such asα-bromoacetaldehyde acetal,1,4-dithiane-2,5-diol and glycolaldehyde diethyl acetal,also reacted readily as alternative counterpart reagents to acylacetonitriles.The established reactions can be used to synthesize a well-known fungicide,fenfuram.Antifungal activity investigation against four common plant funguses indicated that some of the obtained furan products furnish general and high biological activities. | Wenbo Huang Fang Liu Kaimei Wang Alexander Sidorenko Maxim Bei Zhigang Zhang Wei Fang Minghao Li Yanlong Gu Shaoyong Ke | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
| 16 | Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells显示文摘SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the selectivity problem caused by the structural similarity of orthosteric sites among deacetylases.Here,developing a reversed allosteric strategy Allo Reverse,we identified a cryptic allosteric site,Pocket Z,which was only induced by the bi-directional allosteric signal triggered upon orthosteric binding of NAD^(+).Based on Pocket Z,we discovered an SIRT6 allosteric inhibitor named JYQ-42.JYQ-42 selectively targets SIRT6 among other histone deacetylases and effectively inhibits SIRT6 deacetylation,with an IC50 of 2.33μmol/L.JYQ-42 significantly suppresses SIRT6-mediated cancer cell migration and pro-inflammatory cytokine production.JYQ-42,to our knowledge,is the most potent and selective allosteric SIRT6 inhibitor.This study provides a novel strategy for allosteric drug design and will help in the challenging development of therapeutic agents that can selectively bind SIRT6. | Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng Wei Li Feng Jun-Cheng Su Yingqing Wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong Xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 17 | Analysis of Recurrence and Influencing Factors of Spontaneous Pneumothorax After Thoracoscopic Surgery显示文摘This study was conducted to explore the factors that are influencing the recurrence of spontaneous pneumothorax after thoracoscopic surgery.Around 110 patients with spontaneous pneumothorax who underwent thoracoscopic bullectomy in Hebei Hospital from May 2017 to May 2021 were included in this study.The patients were divided into the recurrence group(15 cases)and the non-recurrence group(95 cases),and the influences of gender,age,smoking history,height,weight,operation time,the weight of the excised tissue,number of excised pulmonary bullae,postoperative chest tube maintenance time,duration of air leakage,and length of hospital stay on the recurrence of spontaneous pneumothorax after thoracoscopic surgery were investigated.This study found that the height/weight,operation time,duration of air leakage,number of pulmonary bullae removed,weight of the removed tissue,postoperative chest tube maintenance time,and duration of hospital stay in the recurrence group was 3.2±0.4,50.9±1.2,2.1±0.4,1.6±0.2,4.2±1.3,2.4±1.5 and 7.2±1.5,respectively.Meanwhile,the recurrence group was 2.6±0.3,50.8±1.3,1.3±0.2,1.8±0.9,4.4±1.2,4.1±1.7 and 6.9±1.6,respectively.After comparing the relevant factors between the recurrence group and the non-recurrence group,it was found that there was comparability between age,height/weight,duration of air leakage and postoperative chest tube maintenance time,where these factors were shown to affect the recurrence of spontaneous pneumothorax after thoracoscopic surgery,while gender,smoking,operation time,number of resected bullae,weight of resected tissue and length of hospital stay had no effect on recurrence after spontaneous pneumothoracoscopic surgery.In short,thoracoscopic bullectomy is the best clinical treatment for spontaneous pneumothorax,however the occurrence of recurrence of spontaneous pneumothorax after the operation,which is mainly influenced by the patient’s height/weight,postoperative air leakage duration,and chest tube maintenance time.Therefore,it is essential to pay attention to the surgical treatment of the patients,and fully identify the related factors of postoperative recurrence,thereby the follow-up clinical treatment can be carried out effectively. | Duo Zhang Shaoyong Dong Wei Li Hefei Li | 2022 | Journal of Clinical and Nursing Research2022，6，4： | 0 |
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