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| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | 4 K high frequency pulse tube cryocooler used for terahertz space application显示文摘Terahertz(THz) frequency region, defined from0.1 to 10 THz, is an important frequency band for radio astronomy and atmospheric science. As NbN Superconductor-Insulator-Superconductor(SIS) mixers used for terahertz detection, which are studied by the Purple Mountain Observatory(PMO), Chinese Academy of Sciences(CAS), work at 8–10 K, and require condition of micro vibrations, its astronomical observation in aerospace is limited by suitable refrigeration method. 4 K high frequency pulse tube cryocooler developed by Key Laboratory of Space Energy Conversion Technologies(SECT), Technical Institute of Physics and Chemistry(TIPC), CAS, offers an opportunity for the application of SIS mixers. This article introduces the progress of the two-stage high frequency pulse tube cryocooler researched by TIPC. The cryocooler has reached a no load temperature of 4.5 K which is the lowest temperature for this kind of cryocooler reported so far. The successful coupling between the THz component and the high frequency pulse tube cryocooler lays a solid foundation for space detection in the terahertz band. | Jia Quan Yanjie Liu Dong Liu Kun Zhang Jingtao Liang Jing Li Qijun Yao Shengcai Shi | 2014 | Chinese Science Bulletin2014，59，27： | 12 |
| 3 | Geometric morphometric analysis of Eysarcoris guttiger,E.annamita and E.ventralis(Hemiptera:Pentatomidae)显示文摘The genus Eysarcoris can be easily distinguished from other genera through the two spots in the basal angle of the scutellum.Nevertheless,Eysarcoris species show complex variances.Geometric morphometric methods have been increasingly applied to distinguish species and to define the boundary of genera among insects.In the present study,geometric morphometric approach was firstly employed to evaluate the shape variation of three characters(fore wing,hind wing and pygophore) of E.guttiger,E.annamita and E.ventralis using E.aeneus as outgroup to ascertain whether this approach is a reliable method for the taxonomy of Eysarcoris.Analysis was conducted on the landmarks of the three characters of these species.Multivariate regression of procrustes coordinates against centroid size was conducted to test the presence of allometry.Principal component analysis(PCA),canonical variate analysis(CVA) and cluster analysis were utilized to describe variations in shapes among the studied species.For all of the three characters,though PCA analysis showed some overlap among species,p-values for procrustes distance and mahalanobis distance were all less than 0.0001.The distribution of the three studied species corresponds with their species status.This study demonstrates that the geometric morphometrics of both the fore wing and the hind wing might represent a possible tool for the identification of species within this genus. | Rongrong Li Hufang Zhang Shengcai Li Ming Bai | 2017 | Zoological Systematics2017，42，1： | 6 |
| 4 | Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma显示文摘The aims of the present study were to reveal the prevalence of the TERT C228 T mutation in pediatric papillary thyroid carcinoma(PPTC) and to further investigate the role of the TERT C228 T mutation in PPTC. We also tested another TERT mutation, TERT C250 T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC(41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228 T mutation analysis was performed. Chi-squared analysis,Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228 T mutation presented in 13(27.1%) of the 48 PPTC patients and 10(24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228 T mutation and those without in terms of modified radical neck dissection, multifocality,capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer(AJCC) tumor stage(P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage(P=0.009)and American Thyroid Association(ATA) PPTC stage(P=0.021) between patients with and without the TERT C228 T mutation.These findings indicate that the TERT C228 T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC. | Jiangqiao Geng Yuanhu Liu Yongli Guo Huanmin Wang Jun Tai Yaqiong Jin Jie Zhang Yongbo Yu Shengcai Wang Yingluan Song Xin Ni | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 5 | Improved formulas for thermal behavior of oscillating nanobubbles显示文摘The study of nanobubbles(with sizes of the order of tens to hundreds of nanometers) is currently a hot spot of cavitation and bubble dynamics. In the literature, classical formulas are widely employed for the predictions of the thermal behavior of oscillating macro-bubbles. However, for modelling nanobubbles, the classical formulas may not be adequate due to the effects of the surface tension. In the present paper, a formula with the effects of surface tension fully considered is proposed for the predictions of thermal behavior. The predictions based on the classical formula are also presented for comparisons to show the advantages of the present formula. | 张宇宁 Shengcai LI | 2016 | Journal of Hydrodynamics2016，28，2： | 3 |
| 6 | Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice显示文摘 | Otsuka Motoyuki Zheng Min Hayashi Masaaki Lee Jing-Dwan Yoshino Osamu Lin Shengcai Han Jiahuai | 2008 | Journal of Clinical Investigation2008，，5： | 3 |
| 7 | Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists显示文摘Coronavirus disease 2019(COVID‐19)has become a pandemic disease globally.Although COVID-19 directly invades lungs,it also involves the nervous system.Therefore,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed.They become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐19.It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. | Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li Quanwei He Man Li Ying Su David Wang Longde Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 3 |
| 8 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 9 | Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea显示文摘Obstructive sleep apnea(OSA)is a common sleep-disordered breathing disease that often leads to many comorbidities(e.g.,cognitive dysfunction),which adversely affect the quality of life for patients with OSA.Thus far,the underlying mechanisms of this dysfunction remain unclear.Many studies have focused on OSA-related characteristics,including intermittent hypoxemia and sleep fragmentation.There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction.This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction. | Tingting Ji Xiaodan Li Yue Qiu Lin Mei Xinbei Jia Jun Tai Yongli Guo Jie Zhang Shengcai Wang Xin Ni | 2021 | Pediatric Investigation2021，5，1： | 2 |
| 10 | Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management显示文摘Coronavirus disease-2019(COVID‐19)has become a global pandemic.COVID-19 runs its course in two phases,the initial incubation phase and later clinical symptomatic phase.Patients in the initial incubation phase often have insidious clinical symptoms,but they are still highly contagious.At the later clinical symptomatic phase,the immune system is fully activated and the disease may enter the severe infection stage in this phase.Although many patients are known for their respiratory symptoms,they had neurological symptoms in their first 1-2 days of clinical symptomatic phase,and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase.The key is to prevent a patient from progressing to this severe infection from mild infection.We are sharing our experience on prevention and management of COVID-19. | Yifan Zhou Wei Li David Wang Ling Mao Huijuan Jin Yanan Li Candong Hong Shengcai Chen Jiang Chang Quanwei He Mengdie Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 2 |
| 11 | Extraction of material parameters of a bi-layer structure using Terahertz time-domain spectroscopy显示文摘For a bi-layer structure consisting of a film deposited on a substrate,a new extraction method is proposed using which we can extract both the material parameters of the film and the thickness of the substrate from the measured Terahertz transmission through it,so long as the complex refractive index of the substrate is known beforehand.This method is applicable to a range of refractive indices of the film less than the refractive index of the substrate and a very wide range of layer thicknesses from 20μm to at least 200μm.It is very useful in some cases where the thickness of the substrate cannot be determined using conventional methods such as a Vernier caliper or micrometer screw. | JIN BiaoBing ZHANG CaiHong SHEN XiaoFang MA JinLong CHEN Jian SHI ShengCai WU PeiHeng | 2014 | Science China(Information Sciences)2014，57，8： | 2 |
| 12 | Mutagenesis reveals that the rice OsMPT3 gene is an important osmotic regulatory factor显示文摘Plant mitochondrial phosphate transporters regulate phosphate transport and ATP synthesis. Determining whether they function in abiotic stress response process would shed light on their response to salt stress. We used the CRISPR/Cas9 gene-editing system to mutagenize two mitochondrial phosphate transporters, OsMPT3;1 and OsMPT3;2, to investigate their regulatory roles under salt stress. Two cas9(CRISPR-associated protein9)-free homozygous mutants, mpt33 and mpt30, were confirmed to be stable. Both OsMPT3;1 and OsMPT3;2 were markedly induced by salt stress, and their mutagenesis strongly inhibited growth and development, especially under salt stress. Mutagenesis sharply reduced the accumulation of ATP, phosphate, calcium, soluble sugar, and proline and increased osmotic potential, malondialdehyde, and Na^+ /K^+ ratio under salt stress. Both mutants demonstrate normal growth and development in the presence of ATP, revealing high sensitivity to exogenous ATP under salt stress. The mutants showed lowered rates of Na^+ efflux but also of K^+ and Ca^(2+) influx under salt stress. Mutagenesis of OsMPT3;2 altered the enrichment profiles of differentially expressed genes involved mainly in synthesis of secondary metabolites, metabolism of glycolysis, pyruvate, tricarboxylic acid cycle, in response to salt stress. The mutant displayed significant accumulation differences in 14 metabolites involved in 17 metabolic pathways, and strongly up-regulated the accumulation of glutamine, a precursor in proline synthesis, under salt stress. These findings suggest that the OsMPT3 gene modulates phosphate transport and energy supply for ATP synthesis and triggers changes in accumulation of ions and metabolites participating in osmotic regulation in rice under salt stress, thus increasing rice salt tolerance. This study demonstrates the effective application of CRISPR/Cas9 gene-editing to the investigation of plant functional genes. | Shengcai Huang Shichao Xin Guoqiang Xie Jiao Han Zhonglai Liu Bing Wang Shuqing Zhang Qingyu Wu Xianguo Cheng | 2020 | The Crop Journal2020，8，3： | 2 |
| 13 | Influence of upstream disturbance on the draft-tube flow of Francis turbine under part-load conditions显示文摘Owing to the part-load operations for the enhancement of grid flexibility, the Francis turbine often suffers from severe low-frequency and large-amplitude hydraulic instability, which is mostly pertinent to the highly unsteady swirling vortex rope in the draft tube. The influence of disturbances in the upstream(e.g., large-scale vortex structures in the spiral casing) on the draft-tube vortex flow is not well understood yet. In the present paper, the influence of the upstream disturbances on the vortical flow in the draft tube is studied based on the vortex identification method and the analysis of several important parameters(e.g., the swirl number and the velocity profile). For a small guide vane opening(representing the part-load condition), the vortices triggered in the spiral casing propagate downstream and significantly affect the swirling vortex-rope precession in the draft tube, leading to the changes of the intensity and the processional frequency of the swirling vortex rope. When the guide vane opening approaches the optimum one(representing the full-load condition), the upstream disturbance becomes weaker and thus its influences on the downstream flow are very limited. | 陈婷 郑祥豪 张宇宁 Shengcai Li | 2018 | Journal of Hydrodynamics2018，30，1： | 2 |
| 14 | Mechanical Behaviors and Deformation Properties of Retaining Wall Formed by Grouting Mould-Bag Pile显示文摘The simplified mechanical model and finite element model are established on the basis of the measured results and analysis of the grouting pile deformation monitoring,surface horizontal displacement and vertical displacement monitoring,deep horizontal displacement(inclinometer)monitoring,soil pressure monitoring and seepage pressure monitoring in the lower reaches of Wuan River regulation project in Shishi,Fujian Province.The mechanical behavior and deformation performance of mould-bag pile retaining wall formed after controlled cement grouting in the silty stratum of the test section are analyzed and compared.The results show that the use of controlled cement grouting mould-bag pile technology is to strengthen the soft stratum for sealing water and reinforcement,so that it can rock into a retaining wall,which can both retain soil and seal water with excellent effect.The control of cement grouting technology not only makes the soft soil rock in the range of retaining wall of mould-bag pile,but also makes a wide range of soil around the mould-bag pile squeeze and embed to compaction;and its cohesion and internal friction angle increased,so as to achieve the purpose of reducing soil pressure and improving mechanical and deformation properties of retaining wall. | Shengcai Li Jun Tang Lin Guo | 2019 | Structural Durability & Health Monitoring2019，13，1： | 1 |
| 15 | Cavitation enhancement of silt erosion an envis- aged micro model 显示文摘 | SHENGCAI L | 2006 | Wear2006，260，9： | 1 |
| 16 | Development of superconducting mixers for THz astronomy显示文摘The terahertz(THz)regime,loosely defined as 0.1-10 THz,is the last frequency window to be fully explored in astronomy.In particular,it is a regime in which there are rich molecular rotation lines and atomic fine structure lines.They are very important tracers for studying the dynamics of astronomical objects such as stars and planetary systems.Observing those spectral lines usually makes use of coherent detectors(i.e.,heterodyne mixers).With sensitivity approaching the quantum limit,superconducting mixers have become the coherent detector of choice in THz astronomy.In this paper we mainly introduce the superconducting mixers developed at Purple Mountain Observatory and those for international collaborative projects. | SHI ShengCai | 2012 | Science China(Information Sciences)2012，55，1： | 1 |
| 17 | Experimental hysteretic behavior of in-plane loaded reinforced grouted multi-ribbed aerated concrete blocks masonry walls显示文摘 | Li Shengcai Dong Jianxi Li Lifeng | 2012 | Structural Engineering and Mechanics2012，41，1： | 1 |
| 18 | Cavitation enhancement of silt erosion--an envisaged micro model 显示文摘 | Li Shengcai | 2005 | Wear2005，260，910： | 1 |
| 19 | Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice显示文摘 | Otsuka Motoyuki Zheng Min Hayashi Masaaki Lee Jing-Dwan Yoshino Osamu Lin Shengcai Han Jiahuai | 2008 | Journal of Clinical Investigation2008，，5： | 1 |
| 20 | Study of the seismic damage regularity of ancient masonry pagodas in the 2008 Wenchuan Earthquake 显示文摘 | Yuan Jianli Li Shengcai | 2013 | WIT Transactions on The Built Environment2013，132，8： | 1 |
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