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| 1 | Acute inflammation stimulates a regenerative response in the neonatal mouse heart显示文摘 | Chunyong Han Yu Nie Hong Lian Rui Liu Feng He Huihui Huang Shengshou Hu | 2015 | Cell Research2015，25，10： | 26 |
| 2 | Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘 | Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou | 2016 | Cell Research2016，26，1： | 12 |
| 3 | Interpretation of Annual Report on Cardiovascular Health and Diseases in China 2019显示文摘The Chinese edition of Annual Report on Cardiovascular Health and Diseases in China 2019 have been published[1],and we present herein an interpretation of the report.Influencing factors on cardiovascular health Tobacco use The smoking prevalence among Chinese residents has shown a downward trend.According to the Chinese Adult Tobacco Survey in 2018,the current smoking prevalence among Chinese residents≥15years of age was 26.6%,which was higher in rural areas(28.9%)than in urban areas(25.1%),and the daily consumption by each smoker was 16.0 cigarettes on average. | The Writing Committee of the Annual Report on Cardiovascular Health and Diseases in China Zengwu Wang Shengshou Hu | 2021 | Cardiology Discovery2021，1，4： | 7 |
| 4 | Interpretation of the Annual Report on Cardiovascular Health and Diseases in China 2020显示文摘The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2020 has been published.[1]We present herein an interpretation of this report.Factors influencing cardiovascular health Tobacco use About 1.9 million avoidable deaths from coronary heart disease(CHD)per year(approximately one-fifth of all CHD deaths globally)are attributable to tobacco use and exposure to secondhand smoke(SHS).An estimated 382,000 people died of CHD attributable to SHS exposure,representing 4.3%of all deaths from CHD. | Zengwu Wang Shengshou Hu | 2022 | Cardiology Discovery2022，2，4： | 4 |
| 5 | SinoSCORE:a logistically derived additive prediction model for post-coronary artery bypass grafting in-hospital mortality in a Chinese population显示文摘This study aims to construct a logistically derived additive score for predicting in-hospital mortality risk in Chinese patients undergoing coronary artery bypass surgery(CABG).Data from 9839 consecutive CABG patients in 43 Chinese centers were collected between 2007 and 2008 from the Chinese Coronary Artery Bypass Grafting Registry.This database was randomly divided into developmental and validation subsets(9:1).The data in the developmental dataset were used to develop the model using logistic regression.Calibration and discrimination characteristics were assessed using the validation dataset.Thresholds were defined for each model to distinguish different risk groups.After excluding 275 patients with incomplete information,the overall mortality rate of the remaining 9564 patients was 2.5%.The SinoSCORE model was constructed based on 11 variables:age,preoperative NYHA stageⅢorⅣ,chronic renal failure,extracardiac arteriopathy,chronic obstructive pulmonary disease,preoperative atrial fibrillation or flutter(within 2 weeks),left ventricular ejection fraction,other elective surgery,combined valve procedures,preoperative critical state,and BMI.In the developmental dataset,calibration using a Hosmer-Lemeshow(HL)test was at P=0.44 and discrimination based on the area under the receiver operating characteristic curve(ROC)was 0.80.In the validation dataset,the HL test was at P=0.34 and the area under the ROC(AUC)was 0.78.A logistically derived additive model for predicting in-hospital mortality among Chinese patients undergoing CABG was developed based on the most up-to-date multi-center data from China. | Zhe Zheng Lu Zhang Xi Li Shengshou Hu behalf of the Chinese CABG Registry Study | 2013 | Frontiers of Medicine2013，7，4： | 4 |
| 6 | Prevalence of Cardiovascular Disease Risk Factor Clustering Among the Adult Population of China: Results From the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia)显示文摘 | Dongfeng Gu Anjali Gupta Paul Muntner Shengshou Hu Xiufang Duan Jichun Chen Robert F. Reynolds Paul K. Whelton Jiang He | 2005 | Circulation2005，，5： | 4 |
| 7 | Transplantation of murine neonatal cardiac macrophage improves adult cardiac repair显示文摘Heart regeneration is a promising strategy to prevent cardiac injury and protect against heart failure.^(1,2,3)Distinguishing from adult mammals,neonatal mouse heart can regenerate completely after cardiac injury,such as apical resection(AR)or myocardial infarction(MI).Our previous study reveals that acute inflammation is essential for initiation of neonatal mouse heart regeneration,4 providing an insight to understand the role of immune system in cardiac repair.Macrophage is a prominent inflammatory cell in injured heart during acute immune response;5 here we revealed that genetically deletion of CD11b-positive macrophages in CD11bDTR mice with diphtheria toxin(DT)administration led the suspense of neonatal heart regeneration after AR injury.We transplanted cardiac macrophages sorted from AR-injured neonatal mouse hearts into MI-injured adult mice and found that transfusion of neonatal mouse cardiac macrophages facilitated cardiac repair and enhanced cardiomyocyte proliferation effectively,which served a potential intervention to improve prognosis of patients suffering cardiac diseases. | Yandong Li Haotong Li Jianqiu Pei Shengshou Hu Yu Nie | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 8 | Micro RNA ‐24 regulates cardiac fibrosis after myocardial infarction显示文摘 | Jue Wang Weicong Huang Ruixia Xu Yu Nie Xiaoqing Cao Jiang Meng Xiuqin Xu Shengshou Hu Zhe Zheng | 2012 | J. Cell. Mol. Med2012，，9： | 2 |
| 9 | Functional isolation,culture and cryopreservation of adult human primary cardiomyocytes显示文摘Cardiovascular diseases are the most common cause of death globally.Accurately modeling cardiac homeostasis,dysfunction,and drug response lies at the heart of cardiac research.Adult human primary cardiomyocytes(hPCMs)are a promising cellular model,but unstable isolation efficiency and quality,rapid cell death in culture,and unknown response to cryopreservation prevent them from becoming a reliable and flexible in vitro cardiac model.Combing the use of a reversible inhibitor of myosinⅡATPase,(-)-blebbistatin(Bleb),and multiple optimization steps of the isolation procedure,we achieved a 2.74-fold increase in cell viability over traditional methods,accompanied by better cellular morphology,minimally perturbed gene expression,intact electrophysiology,and normal neurohormonal signaling.Further optimization of culture conditions established a method that was capable of maintaining optimal cell viability,morphology,and mitochondrial respiration for at least 7 days.Most importantly,we successfully cryopreserved hPCMs,which were structurally,molecularly,and functionally intact after undergoing the freeze-thaw cycle.hPCMs demonstrated greater sensitivity towards a set of cardiotoxic drugs,compared to human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs).Further dissection of cardiomyocyte drug response at both the population and single-cell transcriptomic level revealed that hPCM responses were more pronouncedly enriched in cardiac function,whereas hiPSC-CMs responses reflected cardiac development.Together,we established a full set of methodologies for the efficient isolation and prolonged maintenance of functional primary adult human cardiomyocytes in vitro,unlocking their potential as a cellular model for cardiovascular research,drug discovery,and safety pharmacology. | Bingying Zhou Xun Shi Xiaoli Tang Quanyi Zhao Le Wang Fang Yao Yongfeng Hou Xianqiang Wang Wei Feng Liqing Wang Xiaogang Sun Li Wang Shengshou Hu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 1 |
| 10 | Efficiency of radiofrequency ablation for surgical treatment of chronic atrial fibrillation in rheumatic valvular disease显示文摘 | Xu Wang Xin Wang Yunhu Song Shengshou Hu Wei Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 11 | Ulinastatin as a neuroprotective and anti‐inflammatory agent in infant piglets model undergoing surgery on hypothermic low‐flow cardiopulmonary bypass显示文摘 | Xiaocou Wang Qinghua Xue Fuxia Yan Lihuan Li Jinping Liu Shoujun Li Shengshou Hu | 2013 | Paediatr Anaesth2013，，3： | 1 |
| 12 | Investigation on hydrodynamic lubrication of bearings in a left ventricular assisted device显示文摘Formations of clots were found inside the hydrodynamic bearings of the left ventricular assisted devices (LVADs) and caused tremendous risks to the long-term use of these devices. For the hydrodynamic bearings used in the LVAD, not only the lubrication status but also the motion of the blood cells in the bearing will take great effect on the performance of the device. Based on the analysis of the hydrodynamic pressures distribution and the flowing trajectory of red blood cells in the lubrication film, the bearing is designed in a region where enough hydrodynamic pressure is generated to float the rotor to reduce the wear, and the entrainment of red blood cells in the gap of the bearing can be prevented to avoid the formation of clots. | Xiaobing ZHENG Yongjian LI Haosheng CHEN Shengshou HU Jianye ZHOU | 2020 | Friction2020，8，4： | 1 |
| 13 | Simultaneous Hybrid Revascularization by Peripheral Artery Stenting and Off-Pump Coronary Artery Bypass: The Early Results显示文摘 | Hengchao Wu Hansong Sun Xiongjing Jiang Weiguo Ma Xianqiang Wang Jing Zhang Shengshou Hu | 2011 | The Annals of Thoracic Surgery2011，，3： | 1 |
| 14 | Increasing Long-Term Major Vascular Events and Resource Consumption in Patients Receiving Off-Pump Coronary Artery Bypass: A Single-Center Prospective Observational Study显示文摘 | Shengshou Hu Zhe Zheng Xin Yuan Wei Wang Yunhu Song Hansong Sun Jianping Xu | 2010 | Circulation2010，，16： | 1 |
| 15 | Predictive value of different scoring systems for early postoperative mortality in patients with a second coronary artery bypass grafting显示文摘 | Zhang Benqing Sun Hansong Hu Shengshou Xu Jianping Wang Wei Song Yunhu Lyu Feng Wu Hengchao | 2014 | Chinese Medical Journal2014，，4： | 1 |
| 16 | Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro显示文摘 | Xiaoyan Liu Liukun Meng Qiang Shi Shenghua Liu Chuanjue Cui Shengshou Hu Yingjie Wei | 2012 | Matrix Biology2012，，： | 1 |
| 17 | One-Stop Hybrid Coronary Revascularization versus Coronary Artery Bypass Graft and Percutaneous Coronary Intervention for the Treatment of Multivessel Coronary Artery Disease: Three-Year Follow-up Results from A Single Institution显示文摘 | Liuzhong Shen Shengshou Hu Haoran Wang Hui Xiong Zhe Zheng Lihuan Li Bo Xu Hongbing Yan Runlin Gao | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 18 | A retrospective clinical study of transaortic extended septal myectomy for obstructive hypertrophic cardiomyopathy in China显示文摘 | Shuiyun Wang Mingyao Luo Hongtao Sun Yunhu Song Chaohua Yin Liqing Wang Rutai Hui Shengshou Hu | 2013 | European Journal of Cardio-Thoracic Surgery2013，，3： | 1 |
| 19 | In vivo experimental testing of the FW axial blood pump for left ventricular support in Fu Wai Hospital显示文摘 | ZHANG Yan HU Shengshou ZHOU Jianye | 2009 | ASAIO Journal2009，55，1： | 1 |
| 20 | CRISPR-CasRx knock-in mice for RNA degradation显示文摘The RNA editing tool CRISPR-CasRx has provided a platform for a range of transcriptome analysis tools and therapeutic approaches with its broad efficacy and high specificity.To enable the application of CasRx in vivo,we established a Credependent CasRx knock-in mouse.Using these mice,we specifically knocked down the expression of Meis1 and Hoxb13 in cardiomyocytes,which induced cardiac regeneration after myocardial infarction.We also knocked down the lnc RNA Mhrt in cardiomyocytes with the CasRx knock-in mice,causing hypertrophic cardiomyopathy.In summary,we generated a Credependent CasRx knock-in mouse that can efficiently knock down coding gene and lnc RNA expression in specific somatic cells.This in vivo CRISPR-CasRx system is promising for gene function research and disease modeling. | Jiacheng Li Dekun Zhu Shengshou Hu Yu Nie | 2022 | Science China(Life Sciences)2022，65，11： | 1 |
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