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4篇 您的检索式：作者名="Shi Hanzhang"

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		题名	作者	年代	出处	被引量
	1	Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘	Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li	2018	Cell Research2018，28，9：	18
	2	A new ap- proach for Fe( Ⅲ )EDTA reduction in NOx scrubber so- lution using bio-electro reactor 显示文摘	Xu Hongmi Lin Gao Shi Hanzhang	2009	Bioresource Tech- nology2009，100，12：	1
	3	Evaluation of microbial reduction of Fe (Ⅲ) EDTA in a chemical absorption-biological reduction integrated NOx removal system 显示文摘	Wei Li Cheng Zhiwu Shi Hanzhang	2007	Environmental Science and Technology2007，41，2：	1
	4	Parthenolide reveals an allosteric mode to inhibit the delSGylation activity of SARS-CoV-2 papain-like protease显示文摘The coronavirus papain-like protease(PLpro)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for viral polypeptide cleavage and the deISGylation of interferon-stimulated gene 15(ISG15),which enable it to participate in virus replication and host innate immune pathways.Therefore,PLpro is considered an attractive antiviral drug target.Here,we show that parthenolide,a germacrane sesquiterpene lactone,has SARS-CoV-2 PLpro inhibitory activity.Parthenolide covalently binds to Cys-191 or Cys-194 of the PLpro protein,but not the Cys-111 at the PLpro catalytic site.Mutation of Cys-191 or Cys-194 reduces the activity of PLpro.Molecular docking studies show that parthenolide may also form hydrogen bonds with Lys-192,Thr-193,and Gln-231.Furthermore,parthenolide inhibits the deISGylation but not the deubiquitinating activity of PLpro in vitro.These results reveal that parthenolide inhibits PLpro activity by allosteric regulation.	Zhihui Zou Huizhuang Shan Demeng Sun Li Xia Yulong Shi Jiahui Wan Aiwu Zhou Yunzhao Wu Hanzhang Xu Hu Lei Zhijian Xu Yingli Wu	2022	Acta Biochimica et Biophysica Sinica2022，54，8：	0

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