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| 1 | Real-time fault detection method based on belief rule base for aircraft navigation system显示文摘Real-time and accurate fault detection is essential to enhance the aircraft navigation system's reliability and safety. The existent detection methods based on analytical model draws back at simultaneously detecting gradual and sudden faults. On account of this reason, we propose an online detection solution based on non-analytical model. In this article, the navigation system fault detection model is established based on belief rule base (BRB), where the system measuring residual and its changing rate are used as the inputs of BRB model and the fault detection function as the output. To overcome the drawbacks of current parameter optimization algorithms for BRB and achieve online update, a parameter recursive estimation algorithm is presented for online BRB detection model based on expectation maximization (EM) algorithm. Furthermore, the proposed method is verified by navigation experiment. Experimental results show that the proposed method is able to effectively realize online parameter evaluation in navigation system fault detection model. The output of the detection model can track the fault state very well, and the faults can be diagnosed in real time and accurately. In addition, the detection ability, especially in the probability of false detection, is superior to offline optimization method, and thus the system reliability has great improvement. | Zhao Xin Wang Shicheng Zhang Jinsheng Fan Zhiliang Min Haibo | 2013 | Chinese Journal of Aeronautics2013，26，3： | 13 |
| 2 | Evaluating the accuracy of Chinese pasture data in global historical land use datasets显示文摘Global historical land use datasets are widely used in global environmental change studies; however, uncertainties in the included pasture data have not been evaluated. In this study, using trend, relative difference ratio(RDR), and spatial comparisons, we evaluated the accuracy of China pasture data in the HYDE(versions 3.1 and 3.2), SAGE, and PJ datasets using historical document-based reconstructions, including the land use datasets for China covering 1935–1997(hereafter Ge-dataset)and Northeast China covering the 1700 s–2000(hereafter Ye-dataset), and the satellite-based China's Land-Use/cover Datasets(CLUDs) for 1980–2015. Four important results were obtained.(1) China pasture area in the HYDE, SAGE, and PJ datasets and grassland area in the Ge-dataset, Ye-dataset, and CLUDs show both disparate trends and large differences in absolute values.(2)Spatially, 50.9%, 52.8%, and 63.0% pasture/grassland grids in 2000 had RDRs greater than 60% between HYDE3.1, HYDE3.2,and SAGE datasets, and CLUDs, respectively. The percentage of grids with RDRs less than 20% were 24.9%, 26.7%, and 16.0%,respectively.(3) Based on HYDE3.2, the spatial distribution of pasture in Northeast China over the last 300 year has expanded,which is in contrast to the results from the Ye-dataset, which shows the spatial distribution of grassland shrinking because of human reclamation activities.(4) The large contrasts between the global datasets and Chinese native datasets are due to differences in pasture/grassland definitions, land use practices, and spatial reconstruction methods. | Fanneng HE Shicheng LI Fan YANG Meijiao LI | 2018 | Science China Earth Sciences2018，61，11： | 7 |
| 3 | Mulching mode and planting density affect canopy interception loss of rainfall and water use efficiency of dryland maize on the Loess Plateau of China显示文摘High and efficient use of limited rainwater resources is of crucial importance for the crop production in arid and semi-arid areas. To investigate the effects of different soil and crop management practices(i.e., mulching mode treatments: flat cultivation with non-mulching, flat cultivation with straw mulching, plastic-covered ridge with bare furrow and plastic-covered ridge with straw-covered furrow; and planting density treatments: low planting density of 45,000 plants/hm^2, medium planting density of 67,500 plants/hm^2 and high planting density of 90,000 plants/hm^2) on rainfall partitioning by dryland maize canopy, especially the resulted net rainfall input beneath the maize canopy, we measured the gross rainfall, throughfall and stemflow at different growth stages of dryland maize in 2015 and 2016 on the Loess Plateau of China. The canopy interception loss was estimated by the water balance method. Soil water storage, leaf area index, grain yield(as well as it components) and water use efficiency of dryland maize were measured or calculated. Results showed that the cumulative throughfall, cumulative stemflow and cumulative canopy interception loss during the whole growing season accounted for 42.3%–77.5%, 15.1%–36.3% and 7.4%–21.4% of the total gross rainfall under different treatments, respectively. Soil mulching could promote the growth and development of dryland maize and enhance the capability of stemflow production and canopy interception loss, thereby increasing the relative stemflow and relative canopy interception loss and reducing the relative throughfall. The relative stemflow and relative canopy interception loss generally increased with increasing planting density, while the relative throughfall decreased with increasing planting density. During the two experimental years, mulching mode had no significant influence on net rainfall due to the compensation between throughfall and stemflow, whereas planting density significantly affected net rainfall. The highest grain yield and water use efficiency of dryland maize were obtained under the combination of medium planting density of 67,500 plants/hm^2 and mulching mode of plastic-covered ridge with straw-covered furrow. Soil mulching can reduce soil evaporation and retain more soil water for dryland maize without reducing the net rainfall input beneath the maize canopy, which may alleviate the contradiction between high soil water consumption and insufficient rainfall input of the soil. In conclusion, the application of medium planting density(67,500 plants/hm^2) under plastic-covered ridge with bare furrow is recommended for increasing dryland maize production on the Loess Plateau of China. | ZHENG Jing FAN Junliang ZHANG Fucang YAN Shicheng GUO Jinjin CHEN Dongfeng LI Zhijun | 2018 | Journal of Arid Land2018，10，5： | 6 |
| 4 | The pain-related behavior changes correlate with the bone damage in a rat model of rheumatoid arthritis显示文摘Objective: In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histological slices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters. | ZHENG Shicheng WANG Kunzheng FAN Lihong SHI Zhibin CHEN Junchang BAO Hongxiang | 2013 | Journal of Medical Colleges of PLA(China)2013，28，3： | 3 |
| 5 | Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation显示文摘The constitutive androstane receptor(CAR, NR3 I1) belongs to nuclear receptor superfamily.It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein(YAP) is a potent regulator of organ size. The aim of this study is to explore the role of YAP in CAR activation-induced hepatomegaly and liver regeneration.TCPOBOP-induced CAR activation on hepatomegaly and liver regeneration was evaluated in wildtype(WT) mice, liver-specific YAP-deficient mice, and partial hepatectomy(PHx) mice. The results demonstrate that TCPOBOP can increase the liver-to-body weight ratio in wild-type mice and PHx mice.Hepatocytes enlargement around central vein(CV) area was observed, meanwhile hepatocytesproliferation was promoted as evidenced by the increased number of KI67+cells around portal vein(PV)area. The protein levels of YAP and its downstream targets were upregulated in TCPOBOP-treated mice and YAP translocation can be induced by CAR activation. Co-immunoprecipitation results suggested a potential proteineprotein interaction of CAR and YAP. However, CAR activation-induced hepatomegaly can still be observed in liver-specific YAP-deficient(Yape/e) mice. In summary, CAR activation promotes hepatomegaly and liver regeneration partially by inducing YAP translocation and interaction with YAP signaling pathway, which provides new insights to further understand the physiological functions of CAR. | Yue Gao Shicheng Fan Hua Li Yiming Jiang Xinpeng Yao Shuguang Zhu Xiao Yang Ruimin Wang Jianing Tian Frank JGonzalez Min Huang Huichang Bi | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 2 |
| 6 | YAP regulates the liver size during the fasting-refeeding transition in mice显示文摘Liver is the central hub regulating energy metabolism during feeding-fasting transition.Evidence suggests that fasting and refeeding induce dynamic changes in liver size,but the underlying mechanisms remain unclear.Yes-associated protein(YAP)is a key regulator of organ size.This study aims to explore the role of YAP in fasting-and refeeding-induced changes in liver size.Here,fasting significantly reduced liver size,which was recovered to the normal level after refeeding.Moreover,hepatocyte size was decreased and hepatocyte proliferation was inhibited after fasting.Conversely,refeeding promoted hepatocyte enlargement and proliferation compared to fasted state.Mechanistically,fasting or refeeding regulated the expression of YAP and its downstream targets,as well as the proliferation-related protein cyclin D1(CCND1).Furthermore,fasting significantly reduced the liver size in AAV-control mice,which was mitigated in AAV Yap(5SA)mice.Yap overexpression also prevented the effect of fasting on hepatocyte size and proliferation.Besides,the recovery of liver size after refeeding was delayed in AAV Yap shRNA mice.Yap knockdown attenuated refeeding-induced hepatocyte enlargement and proliferation.In summary,this study demonstrated that YAP plays an important role in dynamic changes of liver size during fasting-refeeding transition,which provides new evidence for YAP in regulating liver size under energy stress. | Xuan Li Shicheng Fan Chenghui Cai Yue Gao Xinhui Wang Yifei Zhang Hangfei Liang Huilin Li Jie Yang Min Huang Huichang Bi | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 7 | Puerarin blocks the signaling transmission mediated by P2X 3 in SG and DRG to relieve myocardial ischemic damage显示文摘 | Shuangmei Liu Chunping Zhang Qingming Shi Guilin Li Miaomiao Song Yun Gao Changshui Xu Hong Xu Bo Fan Shicheng Yu Chaoran Zheng Qicheng Zhu Bing Wu Lichao Peng Huangui Xiong Qin Wu Shangdong Liang | 2014 | Brain Research Bulletin2014，，： | 1 |
| 8 | Evaluating the reliability of global historical land use scenarios for forest data in China显示文摘Global historical land use scenarios are widely used to simulate the climatic and ecological effects of changes in land cover;however,reliability evaluation of these scenarios for data on China’s forests is missing.By using a historical document-derived Chinese forest dataset(CHFD)for the years 1700–2000,we evaluated the reliability of data on forests in China over three global scenarios-SAGE(Center for Sustainability and the Global Environment),PJ(Pongratz Julia),and KK10(Kaplan and Krumhardt 2010)-through trend-related,quantitative,and spatial comparisons.The results show the following:(1)Although the area occupied by forests in China in the SAGE,PJ,KK10,and CHFD datasets decreased over the past 300 years,there were large differences between global scenarios and CHFD.The area occupied by forests in China in the SAGE scenario for 1700–1990 was 20%–40%more than that according to CHFD,and that occupied by forests in the KK10 from 1700 to 1850 was 32%–46%greater than that in CHFD.The difference between the PJ and CHFD was lower than 20%for most years.(2)Large differences were detected at the provincial and grid cell scales,where the PJ scenario was closer to CHFD in terms of total forested area.Provinces with large differences in terms of trend and quantity were 84%and 92%of all provinces,respectively.Grid cells with relative differences greater than 70%accounted for 60%–80%of all grids.(3)These global historical land use scenarios do not accurately reveal the spatiotemporal pattern of Chinese forests due to differences in the data sources,methods of reconstruction,and spatial scales. | YANG Fan HE Fanneng LI Meijiao LI Shicheng | 2020 | Journal of Geographical Sciences2020，30，7： | 1 |
| 9 | Experiment on Tissue Culture Technique of Saposhnikovia divaricata(Turcz.) Schischk显示文摘The study aimed to optimize the induction and differentiation medium by exploreing different tissue culture of Saposhnikovia divaricata (Turcz.) Schischk. In tissue culture with the root, stem segments, young leaf, cotyledonary node and axillary bud of Saposhnikovia divaricata (Turcz.) Schischk as explants, a lot of plantleles were obtained and the corresponding plant regeneration-system was established. The results showed that when use MS+1.0 mg · L-1 6-BA +0.2 mg · L-1 NAA as callus induction medium, the cotyledonary node had the highest bourgeon rate, and its callus was better than any others; MS +2 mg · L-1 6-BA +0.4 mg · L-1 NAA was the best adventitious buds induction medium, and the best adventitious buds induced condition was 3% sucrose as carbon source, illumination for 12-14 h · d-1 and pH 5.8. The best rootage medium was 1/2 MS+0.5 mg · L-1 NAA. | TONG Weishuang FAN Ruifeng GUO Shicheng CHANG Ying | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，1： | 1 |
| 10 | Potential herb-drug interactions between anti-COVID-19 drugs and traditional Chinese medicine显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has spread worldwide.Effective treatments against COVID-19 remain urgently in need although vaccination significantly reduces the incidence,hospitalization,and mortality.At present,antiviral drugs including Nirmatrelvir/Ritonavir(Paxlovid^(TM)),Remdesivir,and Molnupiravir have been authorized to treat COVID-19 and become more globally available.On the other hand,traditional Chinese medicine(TCM)has been used for the treatment of epidemic diseases for a long history.Currently,various TCM formulae against COVID-19 such as Qingfei Paidu decoction,Xuanfei Baidu granule,Huashi Baidu granule,Jinhua Qinggan granule,Lianhua Qingwen capsule,and Xuebijing injection have been widely used in clinical practice in China,which may cause potential herb-drug interactions(HDIs)in patients under treatment with antiviral drugs and affect the efficacy and safety of medicines.However,information on potential HDIs between the above anti-COVID-19 drugs and TCM formulae is lacking,and thus this work seeks to summarize and highlight potential HDIs between antiviral drugs and TCM formulae against COVID-19,and especially pharmacokinetic HDIs mediated by metabolizing enzymes and/or transporters.These well-characterized HDIs could provide useful information on clinical concomitant medicine use to maximize clinical outcomes and minimize adverse and toxic effects. | Ling Ye Shicheng Fan Pengfei Zhao Chenghua Wu Menghua Liu Shuang Hu Peng Wang Hongyu Wang Huichang Bi | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 11 | Electrochemical Biorefinery toward Chemicals Synthesis and Bio-Oil Upgrading from Lignin显示文摘Recalcitrance and the inherent heterogeneity of lignin structure are the major bottlenecks to impede the popularization of lignin-based chemicals production processes.Recent works suggested a promising pathway for lignin depolymerization and lignin-derived bio-oil upgrading via an electrochemical biorefinery(a process in which lignin valorization is performed via electrochemical oxidation or reduction).This review presents the progress on chemicals synthesis and bio-oil upgrading from lignin by an electrochemical biorefinery,relating to the lignin biosynthesis pathway,reaction pathway of lignin electrochemical conversion,inner-sphere and outer-sphere electron transfer mechanism,basic kinetics and thermodynamics in electrochemistry,and the recent embodiments analysis with the emphasis on the respective feature and limitation for lignin electrochemical oxidative and reductive conversion.Lastly,the challenge and perspective associated with lignin electrochemical biorefinery are discussed.Present-day results indicate that more work should be performed to promote efficiency,selectivity,and stability in pursuing a lignin electrochemical biorefinery.One of the most promising developing directions appears to be integrating various types of lignin electrochemical conversion strategies and other existing or evolving lignin valorization technologies.This review aims to provide more references and discussion on the development for lignin electrochemical biorefinery. | Rui Hu Yuying Zhao Chen Tang Yan Shi Gang Luo Jiajun Fan James H.Clark Shicheng Zhang | 2023 | Engineering2023，，8： | 0 |
| 12 | Spatially explicit reconstruction of cropland cover for China over the past millennium显示文摘Reconstructing historical land use and land cover change using explicit temporal,quantitative,and spatial information is not only the prerequisite for simulating long-term climate change and ecological effects but is also a scientific basis for comprehensively understanding the process and mechanism of anthropogenic land use alterations.Considering changes in historical borders and administrative divisions,a provincial cropland area dataset for China over the past millennium was created on the basis of existing estimations since the Song Dynasty.Land suitability for cultivation was then assessed by incorporating altitude,slope,soil texture,and the maximum potential productivity of climate.Subsequently,a gridding allocation model for cropland was constructed,and the provincial cropland area for 24 years over the past millennium was allocated into grids with a resolution of 10 km.The cropland area in China increased from 3.71×10^(7)ha in AD 1000 to 12.92×10^(7)ha in AD 1999,with a peak of 13.50×10^(7)ha in AD 1980.The total cropland area in China showed fluctuating increasing trends that can be divided into three phases:fluctuation without notable net change for AD 1000–1290,slow increase for AD 1290–1661,and rapid increase for AD 1661–1999.Spatially,cropland intensified in the middle-lower reaches of the Yellow and Yangtze Rivers and expanded to mountainous and frontier areas over the last millennium.Specifically,over the entire period,the fractional cropland areas(FCAs)in the middle-lower reaches of the Yellow and Yangtze Rivers increased by 1.4 and 0.8 times,respectively.Since the mid-Qing Dynasty,large-scale land reclamation expanded to areas of low reclamation in southwest and northeast China.The FCAs for southwest and northeast China increased from 2.13%and 0.55%in AD 1661 to 18.00%and 26.61%in AD 1999,respectively.For AD 1661–1999,the proportion of cropland increased by 55%in the hills and low mountains and 27%in the middle and high mountains.The comparison with remote sensing cropland data shows that the grid cells with absolute differences of 0–10%accounted for 70.35%of all grid cells,while grids with differences exceeding 60%accounted for only 0.83%.This finding indicates that the reconstruction method is feasible,and the reconstruction results objectively reveal the historical spatiotemporal changes in cropland. | Fanneng HE Fan YANG Caishan ZHAO Shicheng LI Meijiao LI | 2023 | Science China Earth Sciences2023，66，1： | 0 |
| 13 | Protection of a cytidine deaminase gene gainst toxicity of high dose chemotherapy in mice显示文摘探索 transfecting cytidine (CD ) 的可行性的目的基因进老鼠骨髓房间以便观察高剂量 Ara-C 的药抵抗并且改进 myelosuppression 追随者联合化疗的忍耐。方法人的 cytidine 基因是进由制动火箭的老鼠骨髓房间的 transfected 病毒的向量。抵抗形成殖民地的单位 granulocyte 巨噬细胞(CFU 美国通用汽车公司) 试金在 Ara-C 对待的 transfected 老鼠骨髓房间以后被执行。DNA 从老鼠骨髓房间被提取。这药在在 transfection 以后的老鼠骨髓房间的抵抗基因被 PCR 检测。与病毒的制片人房间显示出的制动火箭有教养的施主鼠标的结果骨髓房间这药抵抗殖民地和电阻到 Ara-C,那么确实接受了与 CD 基因移植的鼠标(施主鼠标的 CFU 美国通用汽车公司是 52% , χ
2= 124.62, P <
0.01;接受老鼠是 54% , χ
2= 126.26, P <
0.01,与对比组相比) 。动物幸存率比控制的在基因 transfected 组是显著地更高的(χ
2= 7.42, P <
0.01 ) 。transfected 骨髓房间的 CD 基因被 PCR 证实。结论 CD 基因能高效地是进老鼠的骨髓房间的 transfected 并且增加药抵抗到 Ara-C。 | Bo Chen Caigang Liu Yang Lu Ping Lu Feng Jin Fan Yao Ruishan Zhang Jinlong Liu Shicheng Zhao | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 0 |
| 14 | Enhancement of the polynomial functions response surface model for real-time analyzing ozone sensitivity显示文摘Quantification of the nonlinearities between ambient ozone(O3)and the emissions of nitrogen oxides(NOx)and volatile organic compound(VOC)is a prerequisite for an effective O3 control strategy.An Enhanced polynomial functions Response Surface Model(Epf-RSM)with the capability to analyze O3-NOx-VOC sensitivities in real time was developed by integrating the hill-climbing adaptive method into the optimized Extended Response Surface Model(ERSM)system.The Epf-RSM could single out the best suited polynomial function for each grid cell to quantify the responses of O3 concentrations to precursor emission changes.Several comparisons between Epf-RSM and pf-ERSM(polynomial functions based ERSM)were performed using out-of-sample validation,together with comparisons of the spatial distribution and the Empirical Kinetic Modeling Approach diagrams.The comparison results showed that Epf-RSM effectively addressed the drawbacks of pf-ERSM with respect to overfitting in the margin areas and high biases in the transition areas.The O3 concentrations predicted by Epf-RSM agreed well with Community Multi-scale Air Quality simulation results.The case study results in the Pearl River Delta and the north-western area of the Shandong province indicated that the O3 formations in the central areas of both the regions were more sensitive to anthropogenic VOC in January,April,and October,while more NOx-sensitive in July. | Jiangbo Jin Yun Zhu Jicheng Jang Shuxiao Wang Jia Xing Pen-Chi Chiang Shaojia Fan Shicheng Long | 2021 | Frontiers of Environmental Science & Engineering2021，15，2： | 0 |
| 15 | Urgently reveal longly hidden toxicant in a familiar fabrication process of biomass-derived environment carbon material显示文摘Biomass-derived N-doped carbon(BNC)is an important environmental material and widely used in the fields of water purification and soil remediation.However,the toxicant in the commonly used synthesis process of BNC materials have been largely ignored.Herein,we firstly report the presence of a highly toxic by-product(KCN)in the activation process of BNC materials consequential of the carbothermal reduction reaction.Because this carbothermal reduction reaction also regulates the N-doping and pore development of BNC materials,the KCN content directly relates with the properties of BNC material properties.Accordingly,a high KCN content(-611 mg)can occur in the production process of per g BNC material with high specific surface area(-3600 m^2/g).Because the application performance of BNC material is determined by the surface area and available N doping,therefore,production of a BNC material with high performance entails high risk.Undoubtedly,this study proves a completely new risk recognition on a familiar synthesis process of biomass-based material.And,strict protective device should be taken in fabrication process of biomass-derived carbon material. | Chao Jia Jiewen Luo Jiajun Fan James H.Clark Shicheng Zhang Xiangdong Zhu | 2021 | Journal of Environmental Sciences2021，33，2： | 0 |
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