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| 1 | Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinkeshu tablet显示文摘A simple, sensitive and accurate method based on high performance liquid chromatography (HPLC) with diode array detector (DAD) was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu (XKS) tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common peaks to evaluate the similarities among different batches of XKS samples, which were manufactured in a long time span of three years. Additionally, simultaneous quantification of six markers in XKS tablet, including Danshensu, Protocatechuic aldehyde, Puerarin, Daidzin, Salvianolic acid B and Daidzein, was performed. The validation results showed that the developed method was specific, accurate, precise and robust. The preliminary explanation on why a close similarity between fingerprints did not exactly mean similar contents of chemical components in samples was given. The contribution of each chromatographic peak to similarity was also evaluated. The developed method offers an efficient, reliable and practical approach for systematic quality evaluation of XKS tablet. | Pei Wang Lian Li Hailong Yang Shijuan Cheng Yingzi Zeng Lei Nie Hengchang Zang | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 5 |
| 2 | Sedimentation of a Single Charged Elliptic Cylinder in a Newtonian Fluid by Lattice Boltzmann Method显示文摘We simulate the sedimentation of single charged and single uncharged elliptic cylinders in a Newtonian fluid byusing the lattice Boltzmann method. Due to the polarizing effects and non-axial symmetry shape, there are theCoulomb force and corresponding torque exerted on the charged elliptic cylinder during the sedimentation, whichsignificantly change the horizontal translation and rotation of the cylinder. When the dielectric constant of theliquid is smaller than that of the wall, the direction of the Coulomb force is opposite to that of the hydrodynamicforce. Therefore there appears to be a critical linear charge density qc at which the elliptic cylinder will fallvertically off the centreline. | ZHANGChao-Ying SHIJuan TANHui-Li LIUMu-Ren KONGLing-Jiang | 2004 | Chinese Physics Letters2004，21，6： | 4 |
| 3 | 代谢组学在胃肠道微生物研究中的应用(英文)显示文摘On May 13,2016,the American government launched a121-million USD investment for the National Microbiome Initiative(NMI),which aims to provide an in-depth understanding of microbiomes in order to develop new applications in the areas of human health,food security,and environmental restoration[1].NMI also calls for projects to develop platform technologies,reference libraries,and databases for microbiome research in all habitats,including in the human gut.As an important platform technology,metabolomics is able to characterize | Shijuan Yan Jianfeng Huang Zhongjian Chen Zongyong Jiang Xue Li Zhuang Chen | 2016 | Science Bulletin2016，61，15： | 3 |
| 4 | Small RNAs in regulating temperature stress response in plants显示文摘Due to global climate change, temperature stress has become one of the primary causes of crop losses worldwide. Much progress has been made in unraveling the complex stress response mechanisms in plants, particularly in the identification of temperature stress responsive protein-coding genes. Recently discovered micro RNAs(mi RNAs) and endogenous small-interfering RNAs(si RNAs) have also been demonstrated as simportant players in plant temperature stress response.Using high-throughput sequencing, many small RNAs,especially mi RNAs, have been identified to be triggered by cold or heat. Subsequently, several studies have shown an important functional role for these small RNAs in cold or heat tolerance. These findings greatly broaden our understanding of endogenous small RNAs in plant stress response control. Here, we highlight new findings regarding the roles of mi RNAs and si RNAs in plant temperature stress response and acclimation. We also review the current understanding of the regulatory mechanisms of small RNAs in temperature stress response, and explore the outlook for the use of these small RNAs in molecular breeding for improvement of temperature stress tolerance in plants. | Qing Liu Shijuan Yan Tifeng Yang Shaohong Zhang Yue-Qin Chen Bin Liu | 2017 | Journal of Integrative Plant Biology2017，59，11： | 3 |
| 5 | Influenza A virus-induced downregulation of miR-26a contributes to reduced IFNα/β production显示文摘Innate immunity provides immediate defense against viral infection. Influenza A virus(IAV) is able to get past the first line of defense. Elucidation of the molecular interaction between influenza factors and the newly recognized host players in the innate response might help in our understanding of the root causes of virulence and pathogenicity of IAV. In this study, we show that expression of miR-26 a leads to a significant inhibition of IAV replication. miR-26 a does not directly target IAV genome. Instead, miR-26 a activates the type I interferon(IFN) signaling pathway and promotes the production of IFN-stimulated genes, thus suppressing viral replication. Furthermore,ubiquitin-specific protease 3(USP3), a negative regulator of type I IFN pathway, is targeted by miR-26 a upon IAV challenge. However, miR-26 a is significantly downregulated during IAV infection.Thus, downregulation of miR-26 a is a new strategy evolved by IAV to counteract cellular antiviral responses. Our findings indicate that delivery of miR-26 a may be a potential strategy for anti-IAV therapies. | Shijuan Gao Jiandong Li Liping Song Jiaoxiang Wu Wenlin Huang | 2017 | Virologica Sinica2017，32，4： | 3 |
| 6 | A reactive oxygen species burst causes haploid induction in maize显示文摘Haploid induction (HI) is an important tool in crop breeding. Phospholipase A1 (ZmPLA1)/NOT LIKE DAD (NLD)/MATRILINEAL (MTL) is a key gene controlling HI in maize;however, the underlying molecular mechanism remains unclear. In this study, to dissect why loss of ZmPLA1 function could mediate HI we performed a comprehensive multiple omics analysis of zmpla1 mutant anthers by integrating transcriptome, metabolome, quantitative proteome, and protein modification data. Functional classes of significantly enriched or differentially abundant molecular entities were found to be associated with the oxidative stress response, suggesting that a reactive oxygen species (ROS) burst plays a critical role in HI. In support of this, we further discovered that a simple chemical treatment of pollen with ROS reagents could lead to HI. Moreover, we identified ZmPOD65, which encodes a sperm-specific peroxidase, as a new gene controlling HI. Taken together, our study revealed a likely mechanism of HI, discovered a new gene controlling HI, and created a new method for HI in maize, indicating the importance of ROS balance in maintaining normal reproduction and providing a potential route to accelerate crop breeding. | Chenglin Jiang Ju Sun Rui Li Shijuan Yan Wei Chen Liang Guo Guochen Qin Pengcheng Wang Cheng Luo Wenjie Huang Qinghua Zhang Alisdair R.Fernie David Jackson Xiang Li Jianbing Yan | 2022 | Molecular Plant2022，15，6： | 2 |
| 7 | Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex显示文摘 | Feng, Jianrong Fu, Shijuan Cao, Xuan Wu, Hao Lu, Jing Zeng, Ming Liu, Lin Yang, Xue Shen, Yuequan | 2017 | Protein & Cell2017，8，7： | 2 |
| 8 | Influenza A virus‐encoded NS 1 virulence factor protein inhibits innate immune response by targeting IKK显示文摘 | Shijuan Gao Liping Song Jiandong Li Zhenzhu Zhang Haiyan Peng Wei Jiang Qingtao Wang Tiebang Kang Shuai Chen Wenlin Huang | 2012 | Cell Microbiol2012，，12： | 1 |
| 9 | Recent advances in proteomics and metabolomics in plants显示文摘Over the past decade,systems biology and plant-omics have increasingly become the main stream in plant biology research.New developments in mass spectrometry and bioinformatics tools,and methodological schema to inte-grate multi-omics data have leveraged recent advances in proteomics and metabolomics.These progresses are driv-ing a rapid evolution in the field of plant research,greatly facilitating our understanding of the mechanistic aspects of plant metabolisms and the interactions of plants with their external environment.Here,we review the recent progresses in MS-based proteomics and metabolomics tools and workflows with a special focus on their applications to plant biology research using several case studies related to mechanistic understanding of stress response,gene/protein function characterization,metabolic and signaling pathways exploration,and natural product discovery.We also present a projection concerning future perspectives in MS-based proteomics and metabolomics development including their applications to and challenges for system biology.This review is intended to provide readers with an overview of how advanced MS technology,and integrated application of proteomics and metabolomics can be used to advance plant system biology research. | Shijuan Yan Ruchika Bhawal Zhibin Yin Theodore W.Thannhauser Sheng Zhang | 2022 | Molecular Horticulture2022，2，1： | 1 |
| 10 | Targeted minicircle DNA delivery using folate–poly(ethylene glycol)–polyethylenimine as non-viral carrier显示文摘 | Chao Zhang Shijuan Gao Wei Jiang Song Lin Fusheng Du Zichen Li Wenlin Huang | 2010 | Biomaterials2010，，23： | 1 |
| 11 | Lattice Boltzmann Simulation of Sedimentation of a Single Elastic Dumbbell in aNewtonian Fluid显示文摘Based on the lattice Boltzmann method (LBM), the sedimentations of a single elastic dumbbell in a Newtonian fluid under different initial positions and orientations, and also that of the elastic dumbbells with different free lengths of the spring under the same initial conditions have been simulated. All of the numerical results show that the final orientations of the elastic dumbbells are in the same horizontal direction, and the final positions of their centroids are all on the centerline of the tube no matter what the initial positions and orientations of the elastic dumbbell or the free lengths of the spring are. When the elastic dumbbell finally falls down vertically, the two circular cylinders of the elastic dumbbell rotate around their own symmetry-axis respectively, and their angular velocities are equal but opposite to each other. For the sedimentations of the elastic dumbbells with different free lengths of the spring, the shorter of the free length is, the faster the final angular velocity and vertical velocity of the circular cylinder will be. | ZHANGChao-Ying TANHui-Li LIUMu-Ren KONGLing-Jiang SHIJuan | 2004 | Communications in Theoretical Physics2004，42，4X： | 1 |
| 12 | Distributions of surface sediments surrounding the Antarctic Peninsula and its environmental significance显示文摘We analyzed grain size composition to provide information on the types and distributions as well as depositional varieties of marine surface sediments from the area surrounding the Antarctic Peninsula. The samples retrieved from the study area contain gravel, sand, silt and clay. As suggested by bathymetry and morphology, the study area is characterized by neritic, hemipelagic and pelagic deposits. The glacial-marine sediments can be divided into two types, residual paratill and compound paratill, which are primarily transported by glaciers and as ice-rafted debris. Ocean current effects on deposition are more obvious, and the deposit types are distributed consistently with terrain variations. | WANG Chunjuan CHEN Zhihua LI Chunshun DU Dewen YAN Shijuan ZHU Zhiwei | 2014 | Advances in Polar Science2014，25，3： | 1 |
| 13 | Research on MRI Brain Segmentation Algorithm with the Application in Model-based EEG/MEG 显示文摘 | He Shijuan Shen Xueqin Yang Yamei | 2001 | IEEE Trans on Mag2001，37，5： | 1 |
| 14 | Protection of Procambarus clarlat againstwhite spot syndrome virus using recombinant oral vaccineexp ressed in Piclu'a pastoris 显示文摘 | Jha R K Xu Zirong Bal Shijuan | 2007 | Fish & Shellfish Immunology2007，22，： | 1 |
| 15 | Stress analysis of oil and gas pipeline parallel laying when traversing tunnels显示文摘 | Huang Kun Wu Shijuan Chen Liqiong | 2014 | Journal of Chemical and Pharmaceutical Research2014，6，6： | 1 |
| 16 | Rapid and sensitive ultrasonic-assisted derivatisation microextraction (UDME) technique for bitter taste-free amino acids (FAA) study by HPLC–FLD显示文摘 | Guang Chen Jun Li Zhiwei Sun Shijuan Zhang Guoliang Li Cuihua Song Yourui Suo Jinmao You | 2014 | Food Chemistry2014，，： | 1 |
| 17 | Isolation and functional analysis of a strong specific promoter in photosynthetic tissues显示文摘 | Yang Yutao Yang Guodong Liu Shijuan | 2003 | Science in China Series C2003，46，6： | 1 |
| 18 | On the General Hospital to deal with acute infectious diseases countermeasures显示文摘 | Li Shijuan Li Weihua Wang Hui | 2008 | Chinese hosp- ital infection Journal2008，13，11： | 1 |
| 19 | Separation of fine particles from gases in wet flue gas desulfurization system using a cascade of double towers 显示文摘 | Bao Jingjing Yang Linjun Song Shijuan | 2012 | Energy and Fuels2012，26，4： | 1 |
| 20 | Comparative Analysis of FRP and Seamless Steel Pipe on Crude Oil Trans- portation Performance 显示文摘 | Chen Liqiong Wu Shijuan Lu Hongfang | 2014 | Journal of Chemical and Pharma- ceutical Research2014，6，7： | 1 |
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