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| 1 | Comparison of continuous homogenous azeotropic and pressure-swing distillation for a minimum azeotropic system ethyl acetate/nhexane separation显示文摘Continuous homogenous azeotropic distillation(CHAD) and pressure-swing distillation(PSD) are explored to separate a minimum-boiling azeotropic system of ethyl acetate and n-hexane. The CHAD process with acetone as the entrainer and the PSD process with the pressures of 0.1 MPa and 0.6 MPa in two columns are designed and simulated by Aspen Plus. The operating conditions of the two processes are optimized via a sequential modular approach to obtain the minimum total annual cost(TAC). The computational results show that the partially heat integrated pressure-swing distillation(HIPSD) has reduced in the energy cost and TAC by 40.79% and 35.94%, respectively, than the conventional PSD, and has more greatly reduced the energy cost and TAC by 62.61% and 49.26% respectively compared with the CHAD process. The comparison of CHAD process and partially HIPSD process illustrates that the partially HIPSD has more advantages in averting the product pollution, energy saving, and economy. | Liping Lü Lin Zhu Huimin Liu Hang Li Shirui Sun | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 6 |
| 2 | Extractive distillation: Advances in conceptual design, solvent selection,and separation strategies显示文摘Extractive distillation(ED) is one of the most promising approaches for the separation of the azeotropic or closeboiling mixtures in the chemical industry. The purpose of this paper is to provide a broad overview of the recent development of key aspects in the ED process involving conceptual design, solvent selection, and separation strategies. To obtain the minimum entrainer feed flow rate and reflux ratio for the ED process, the conceptual design of azeotropic mixture separation based on a topological analysis via thermodynamic feasibility insights involving residue curve maps, univolatility lines, and unidistribution curves is presented. The method is applicable to arbitrary multicomponent mixtures and allows direct screening of design alternatives. The determination of a suitable solvent is one of the key steps to ensure an effective and economical ED process. Candidate entrainers can be obtained from heuristics or literature studies while computer aided molecular design(CAMD) has superiority in efficiency and reliability. To achieve optimized extractive distillation systems, a brief review of evaluation method for both entrainer design and selection through CAMD is presented. Extractive distillation can be operated either in continuous extractive distillation(CED) or batch extractive distillation(BED), and both modes have been well-studied depending on the advantages in flexibility and low capital costs. To improve the energy efficiency, several configurations and technological alternatives can be used for both CED and BED depending on strategies and main azeotropic feeds. The challenge and chance of the further ED development involving screening the best potential solvents and exploring the energy-intensive separation strategies are discussed aiming at promoting the industrial application of this environmentally friendly separation technique. | Shirui Sun Liping Lü Ao Yang Shun'an Wei Weifeng Shen | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 6 |
| 3 | Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients显示文摘OBJECTIVE:To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine.METHODS:One hundred migraine patients and 46 healthy subjects were recruited.Patients were randomized into the acupuncture,sham acupuncture,and waiting list groups.Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments.Fractional amplitude of low-frequency fluctuations(f ALFF)calculations were applied to explore the associations between baseline f ALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group.RESULTS:Compared with healthy subjects,migraine patients had lower f ALFF in the left rostral ventromedial medulla,right thalamus,left amygdala,and right angular gyrus.Regression analyses revealed that baseline f ALFF values in the left middle frontal gyrus,left superior temporal gyrus,and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group,while baseline f ALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group.CONCLUSION:The baseline f ALFF values of brain regions associated with cognitive pain modulation,but not migraine severity,may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment. | Li Zhengjie Zhou Jun Cheng Shirui Lan Lei Sun Ruirui Liu Mailan Yang Jie Gao Yujie Guo Taipin Gong Qiyong Zeng Fang Liang Fanrong | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 4 | Effect of formulation variables on in vitro release of a water-soluble drug from chitosanesodium alginate matrix tablets显示文摘The objective of this study is to investigate the feasibility of using chitosanesodium alginate(CSeSA)based matrix tablets for extended-release of highly water-soluble drugs by changing formulation variables.Using trimetazidine hydrochloride(TH)as a water-soluble model drug,influence of dissolution medium,the amount of CSeSA,the CS:SA ratio,the type of SA,the type and amount of diluents,on in vitro drug release from CSeSA based matrix tablets were studied.Drug release kinetics and release mechanisms were elucidated.In vitro release experiments were conducted in simulated gastric fluid(SGF)followed by simulated intestinal fluid(SIF).Drug release rate decreased with the increase of CSeSA amount.CS:SA ratio had only slight effect on drug release and no influence of SA type on drug release was found.On the other hand,a large amount of water-soluble diluents could modify drug release profiles.It was found that drug release kinetics showed the best fit to Higuchi equation with Fickian diffusion as the main release mechanism.In conclusion,this study demonstrated that it is possible to design extended-release tablets of watersoluble drugs using CSeSA as the matrix by optimizing formulation components,and provide better understanding about drug release from CSeSA matrix tablets. | Liang Li Jinfeng Li Shanshan Si Linlin Wang Chenjun Shi Yujiao Sun Zhenglin Liang Shirui Mao | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，4： | 2 |
| 5 | Chitosan-based formulations for delivery of DNA and siRNA显示文摘 | Shirui Mao Wei Sun Thomas Kissel | 2009 | Advanced Drug Delivery Reviews2009，，1： | 1 |
| 6 | Chitosan-based formulations for delivery of DNA and siRNA显示文摘 | Mao ShiRui Sun Wei Kissel T | 2010 | Adv Drug Deliv Rev2010，62，1： | 1 |
| 7 | Immunological and metabolic characteristics of the Omicron variants infection显示文摘The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global pandemics.Here,we systemically examined immunological and metabolic characteristics of Omicron variants infection.We found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype SARS-CoV-2.Omicron could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta variant.Through mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with Delta.These epitopes could induce robust CD8+T cell responses.Moreover,we found booster vaccination increased the cross-memory CD8+T cell responses against Omicron.Metabolic regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T cells.Consistently,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of Omicron.CD147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar pneumonia.Taken together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron. | Jiejie Geng Xu Yang Kun Wang Ke Wang Ruo Chen Zhi-Nan Chen Chuan Qin Guizhen Wu Youchun Wang Ke Xu Peng Du Jiangning Liu Shirui Chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin Qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu Hongzhou Lu Ping Zhu Huijie Bian Liang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 8 | 原肠运动中期细胞谱系与细胞命运的空间转录组特征显示文摘哺乳动物的早期胚胎发育,特别是着床后原肠运动过程中,多能性干细胞通过多个层次的细胞命运决定,形成了胚胎器官发生、形态建成的整个发育蓝图,是生命体最重要的分子事件之一。 | Guangdun Peng Shengbao Suo Jun Chen Weiyang Chen Chang Liu Fang Yu Ran Wang Shirui Chen Na Sun Guizhong Cui Lu Song Patrick P.L.Tam 韩敬东 景乃禾 | 2017 | 科学新闻2017，0，4： | 0 |
| 9 | Computational approach to the design of hyaluronic acid copolymer based doxorubicin micelles显示文摘Compatibility between drug and carrier is essential for improving drug loading in particulate drug delivery system.In the last few decades,computational approach for the design of drug delivery system has drawn great attention[1].In this study,solubility parameter was used as a guidance to design a stable micellar system.First of all,using doxorubicin(DOX)as a model drug,the compatibility between DOX and three hyaluronic acid copolymers were predicted using molecular dynamics by calculating the Flory–Huggins interaction parameter(χFH)and mixing energy(Emix)of DOX with three fatty glycerides;glycerol monooleate(GMO),glycerol monolaurate(GML)and glycerol monocaprylin(GMC),and hyaluronic acid(HA)respectively.Rank order was then determined based on theχFH and Emix values. | Yujiao Sun Shirui Mao | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
| 10 | Nutrition in Alzheimer's disease:a review of an underappreciated pathophysiological mechanism显示文摘Alzheimer's disease(AD)is the leading cause of dementia in older individuals and is an escalating challenge to global public health.Pharmacy therapy of AD is one of the well-funded areas;however,little progress has been made due to the complex pathogenesis.Recent evidence has demonstrated that modifying risk factors and lifestyle may prevent or delay the incidence of AD by 40%,which suggests that the management should pivot from single pharmacotherapy toward a multipronged approach because AD is a complex and multifaceted disease.Recently,the gut-microbiota-brain axis has gained tremendous traction in the pathogenesis of AD through bidirectional communication with multiple neural,immune,and metabolic pathways,providing new insights into novel therapeutic strategies.Dietary nutrition is an important and profound environmental factor that influences the composition and function of the microbiota.The Nutrition for Dementia Prevention Working Group recently found that dietary nutrition can affect cognition in AD-related dementia directly or indirectly through complex interactions of behavioral,genetic,systemic,and brain factors.Thus,considering the multiple etiologies of AD,nutrition represents a multidimensional factor that has a profound effect on AD onset and development.However,mechanistically,the effect of nutrition on AD is uncertain;therefore,optimal strategies or the timing of nutritional intervention to prevent or treat AD has not been established.Thus,this review summarizes the current state of knowledge concerning nutritional disorders,AD patient and caregiver burden,and the roles of nutrition in the pathophysiology of AD.We aim to emphasize knowledge gaps to provide direction for future research and to establish optimal nutrition-based intervention strategies for AD. | Jiwei Jiang Hanping Shi Shirui Jiang Anxin Wang Xinying Zou Yanli Wang Wenyi Li Yuan Zhang Mengfan Sun Qiwei Ren Jun Xu | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 11 | Current strategies for improving limitations of proteolysis targeting chimeras显示文摘Proteolysis targeting chimeras(PROTACs)are bifunctional degrader molecules via hijacking the ubiquitinproteasome system(UPS)to specifically eliminate targeted proteins.PROTACs have gained momentum as a new modality of attractive technologies in the drug discovery landscape,since it allows to degrade disease-related proteins effectively.Although some PROTACs drugs reached the clinical research,they are still facing some bottlenecks and challenges that should not be neglected,such as poor oral bioavailability and potential toxic side effects.To overcome these limitations,herein,we provide an overview of recent strategies for improving the durability of PROTACs by enhancing cell permeability and reducing toxic side effects.Meanwhile,the impact of these strategies on improving oral bioavailability as well as their advantages and drawbacks will also be discussed.This review will give a useful reference toolbox for PROTACs design and further promote its clinical application. | Chunlan Pu Shirui Wang Lei Liu Zhonghui Feng Hongjia Zhang Qianyuan Gong Yueshan Sun Yuanbiao Guo Rui Li | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 12 | Genome-wide meta-analysis identifies ten new psoriasis susceptibility loci in the Chinese population显示文摘Psoriasis is caused by many factors and is characterized by excessive proliferation of the epidermis and erythema with silver scales on the surface of the skin and concomitant with a variety of diseases(Griffiths et al., 2021). Despite the unclear aetiology,increasing evidence has demonstrated that genetic factors play key roles in the pathogenesis of psoriasis. | Weiwei Chen Wenjun Wang Liang Yong Qi Zhen Yafen Yu Huiyao Ge Yiwen Mao Lu Cao Ruixue Zhang Xia Hu Zhuo Li Yirui Wang Wencheng Fan Qiongqiong Xu Hui Zhang Shirui Chen Jing Wu Liangdan Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 13 | Data-independent acquisition mass spectrometry quantitative proteomic analysis reveals that skin aging-related proteins differ between men and women显示文摘The skin is the largest organ of the human body,and its aging is visible to the naked eye.The aging rate of men and women is slightly different.This study compared the protein expression of skin samples on the curved forearms of 11 healthy women and 9 healthy men.Quantitative proteomics analysis found that the expression of epidermal proteins in men and women of the same age group was different.Compared with female skin,in male skin,20 proteins were upregulated,and 7 proteins were downregulated.These data suggest that men and women have differences in the speed of skin aging.For the first time in this experiment,a non-invasive mass spectrometer was used to detect 27 different-related epidermal proteins between men and women.Compared with women,among the 20 epidermal proteins upregulated in men,their functions can be classified into antioxidants,epidermal lipid metabolism,signal transduction,membrane transport,and cell biological processes;the 7 downregulated proteins are involved in a variety of biological processes and inflammatory reactions.Our experiments have discovered epidermal proteins related to the differences between men and women,enriching the library of epidermal differential proteins between men and women and enriching the mechanism of skin aging between men and women from the perspective of epidermal differential proteins. | HUI ZHANG SHIRUI CHEN MENGTING LIU YAOCHI WANG CONG XIN JING MA XIAODONG ZHENG YUANDI HUANG BO ZHANG XUEJUN ZHANG LIANGDAN SUN SEN YANG | 2021 | BIOCELL2021，45，5： | 0 |
| 14 | Lower Limb Muscle Forces in Table Tennis Footwork during Topspin Forehand Stroke Based on the OpenSim Musculoskeletal Model:A Pilot Study显示文摘Introduction:Footwork is one of the training contents that table tennis players and coaches focus on.This study aimed to gain a thorough understanding of the muscle activity of the table tennis footwork and creating a musculoskeletal model to investigate the muscle forces,joint kinematic,and joint kinetic characteristics of the footwork during topspin forehand stroke.Methods:Six male table tennis athletes(height:171.98±4.97 cm;weight:68.77±7.86 kg;experience:10.67±1.86 years;age:22.50±1.64 years)performed chasse step and one-step footwork to return the ball from the coach by topspin forehand stroke.The kinematics,kinetics,and muscle activity of the lower limb were recorded by the motion capture,force platform,and Electromyography(EMG)system.Statistical parametric mapping(SPM)analysis was used to investigate any difference between the chasse step and one-step footwork during the stroke.Results and Conclusion:The muscle force of the biceps femoris long head(p<0.001),lateral gastrocnemius(p<0.001),vastus lateralis(p<0.001),vastus medial(p<0.001),rectus femoris(p<0.001),and tibia anterior(p<0.001)of the chasse step were significantly greater than the one-step footwork during the early stroke phase(stance).At the end of the stroke phase(push-off),the muscle force of the biceps femoris long head(p<0.001),medial gastrocnemius(p<0.001),lateral gastrocnemius(p<0.001),rectus femoris(p<0.001),and tibias anterior(p<0.001)in the chasse step footwork was significantly greater than the one-step footwork.The muscle force of the ankle plantar flexor and valgus muscle groups in the one-step was significantly greater than in the chasse step.Besides,the moment and angle of hip flexion(p=0.001)and axial rotation(p=0.009)were significantly greater for the chasse step than the one-step footwork,as well as the ankle plantarflexion angle(p<0.001)and moment(p<0.001)of the one-step footwork were significantly higher than the chasse step footwork.The results of this study can be applied to movement control and injury prevention in table tennis footwork. | Yuqi He Shirui Shao Gusztáv Fekete Xiaoyi Yang Xuanzhen Cen Yang Song Dong Sun Yaodong Gu | 2022 | Molecular & Cellular Biomechanics2022，19，4： | 0 |
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