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| 1 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 2 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 3 | Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response显示文摘The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosollc DNA derived from microbial pathogens or mls-located cellular DNA.Upon DNA binding,cGAS utilizes GTP and ATP as substrates to synthesize cGAMP,leading to MITA-mediated innate immune response.In this study,we identified the phosphatase PPP6C as a negative regulator of cGASmediated innate immune response.PPP6C is constitutively associated with cGAS in un-stimulated cells.DNA virus infection causes rapid disassociation of PPP6C from cGAS,resulting in phosphorylation of human cGAS S435 or mouse cGAS S420 in its catalytic pocket.Mutation of this eerine residue of cGAS impairs its ability to synthesize cGAMP upon DNA virus infection.In vitro experiments indicate that S420-phosphorylated mcGAS has higher affinity to GTP and enzymatic activity.PPP6Cdeficiency promotes innate immune response to DNA virus in various cells.Our findings suggest that PPP6Cmediated dephosphorylation of a catalytic pocket serine residue of cGAS impairs its substrate binding activity and innate immune response,which provides a mechanism for keeping the DNA sensor cGAS inactive in the absence of infection to avoid autoimmune response. | Mi Li Hong-Bing Shu | 2020 | Protein & Cell2020，11，8： | 7 |
| 4 | Bioactive Study on Mixtures of Epimedin C and Icariin Monomers with Invariant Molarity to Zebrafish Osteoporosis Model显示文摘Objective To evaluate the anti-osteoporosis effect of the mixtures of epimedin C and icariin monomers with invariant molarity on zebrafish osteoporosis model. Methods The zebrafishes, fertilized 4 d ago, were exposed in 11 groups of nutrient solutions with prednisolone(25 μmol/L) as well as epimedin C and icariin(15 μmol/L) of various contents. The ratio of epimedin C and icariin in the 11 groups were as follows: A(10:0), B(9:1), C(8:2), D(7:3), E(6:4), F(5:5), G(4:6), H(3:7), I(2:8), J(1:9), and K(0:10). Meanwhile, a negative control group with prednisolone(25 μmol/L) was prepare as S. The selected zebrafish fetus was put into the 24-hole culture plate, and ensure every 5 zebrafishes in 1 hole and 2 holes as a group. They were placed in incubator at 28.5 o C, and the daily changes of fluid were investigated until they were put to death on day 8and then fixed. After dyeing with alizarin red, the segmental venter of zebrafish skulls was observed and quantitative analysis of dyed area was conducted. Results Compared with the negative control group S, the integrated optical density(IOD) values of cranial dyed area in all groups increased significantly(P < 0.05); Compared with group S, the IOD value of cranial dyed area in mixtures of epimedium monomers increased significantly(P < 0.05). The mixtures of epimedium monomers were all effective in facilitating zebrafish cranial mineralization and preventing prednisolone from inducing osteoporosis. According to mixtures of A-K groups, zebrafish cranial mineralization gradually decreased with gradually reduced content of epimedin C, with significant difference among groups(P < 0.05). Conclusion The higher the content of epimedin C in mixtures with invariant molarity is, the more active the anti-osteoporosis effect of epimedin C to zebrafish osteoporosis model is. | Mi Huang Jing Feng Ping Xia Zai-xuan Zhong Shun-ping He Yu-qin Shu Jiang-yan He Ying Wang | 2017 | Chinese Herbal Medicines2017，9，1： | 5 |
| 5 | Pharmacokinetics of H002, a novel S1PR_1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry显示文摘A rapid and sensitive liquid chromatography–tandem mass spectrometry(LC–MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated metabolite H002-M, in rat blood. H001, an analogue of H002, was used as the internal standard.Blood samples were prepared by simple protein precipitation. The analytes and internal standard were separated on a Zorbax SB-C18 column with a gradient mobile phase consisting of methanol and water containing 0.1% formic acid at a flow rate of 0.2 mL /min with an operating temperature of 20 1C. The detection was performed on a triple quadrupole tandem mass spectrometer with positive electrospray ionization in multiple-reaction monitoring mode.Linear detection responses were obtained from 0.2–100 ng/mL for H002 and H002-M, while 0.5–100 ng/mL for H002-P. The intra- and inter-day precision(RSD%) was within 11.76%, with the accuracy(RE%) ranging from –9.84% to 9.12%. The analytes were shown to be stable during sample storage, preparation and analytic procedures.The method was applied to determine the pharmacokinetics of H002 in rats, and a preliminary study showed that the pharmacokinetics of H002 correlated with its biological effect on peripheral blood lymphocytes. | Jiaqi Mi Manman Zhao Shu Yang Shuang Yang Jing Jin Xiaojian Wang Qiong Xiao Jinping Hu Yan Li | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 5 |
| 6 | Characteristics of Nitric-Oxide Emissions from Traditional Flame and MILD Combustion Operating in a Laboratory-Scale Furnace显示文摘This study investigated the formation and emission characteristics of nitric oxide(NO) from flameless MILD(moderate or intensive low-oxygen dilution) combustion(MILDC) versus traditional visible-flame combustion(TC) in a 30-k W furnace. Both combustion processes were experimentally operated successively in the same furnace, burning natural gas at a fixed rate of 19 k W and the equivalence ratio of 0.86. Numerical simulations of TC and MILDC were carried out to explain their distinction in the measured furnace temperature and exhaust NO emissions. Present measurements of the NO emission(XNO) versus a varying furnace wall temperature(Tw) have revealed, at the first time, that the relationship of XNO ~ Tw was exponential in both TC and MILDC. By analyzing the simulated results, the average temperature over the reaction zone was identified to be the common characteristic temperature for scaling NO emissions of both cases. Moreover, relative to TC, MILDC had a fairly uniform temperature distribution and low peak temperature, thus reducing the NO emission by over 90%. The thermal-NO formation was found to contribute more than 70%-80% to the total XNO from TC while the N2O-intermediate route dominated the NO emission from MILDC. | SHU Ziyun WANG Feifei DAI Chong SI Jicang WANG Bo MI Jianchun | 2020 | Journal of Thermal Science2020，29，4： | 2 |
| 7 | Synthesis of monodispersed Fe3O4@C core/shell nanoparticles显示文摘We report a facile method to synthesize dispersed Fe_3O_4@C nanoparticles(NPs). Fe_3O_4 NPs were firstly prepared via the high temperature diol thermal decomposition method. Fe_3O_4@C NPs were fabricated using glucose as a carbon source by hydrothermal process. The obtained products were characterized by X-ray diffraction(XRD), transmission electron microscopy(TEM), vibrating sample magnetometer(VSM) and Raman spectra. The results indicate that the original shapes and magnetic property of Fe_3O_4 NPs can be well preserved. The magnetic particles are well dispersed in the carbon matrix. This strategy would provide an efficient approach for existing applications in Li-ion batteries and drug delivery. Meanwhile, it offers the raw materials to assemble future functional nanometer and micrometer superstructures. | Rui Liu Shu Mi Yuanyuan Li Cong Chen Yong Xie Qiang Chen Ziyu Chen | 2016 | Science China Chemistry2016，59，4： | 2 |
| 8 | Photodynamic Elects of 5 - Aminolevulinic Acid and Its Hexylester on Several Cell Lines 显示文摘 | Wu Shu Min Ren Qing Guang Zhou Mi Ou | 2003 | Acta Biochimicaer Biophysica Siniea2003，，7： | 1 |
| 9 | Apatinib (YN968D1) enhances the efficacy of conventional chemotherapeutical drugs in side population cells and ABCB1-overexpressing leukemia cells显示文摘 | Xiu-zhen Tong Fang Wang Shu Liang Xu Zhang Jie-hua He Xing-Gui Chen Yong-ju Liang Yan-jun Mi Kenneth Kin Wah To Li-wu Fu | 2011 | Biochemical Pharmacology2011，，5： | 1 |
| 10 | Study on the preparation of by Mg-Li-Zn alloys electrochemical codeposition from LiCl-KCl-MgCl2-ZnCl2 melts显示文摘 | Yong De Yan Mi Lin Zhang Yun Xue Wei Han Dian Xue Cao Shu Quan Wei | | 0，，12： | 1 |
| 11 | Reciprocal repression between TUSC 7 and mi R ‐23b in gastric cancer显示文摘 | Peng Qi Mi‐die Xu Xiao‐Han Shen Shu‐Juan Ni Dan Huang Cong Tan Wei‐Wei Weng Wei‐Qi Sheng Xiao‐Yan Zhou Xiang Du | 2015 | Cancer2015，，6： | 1 |
| 12 | Chintin/PLGA Blend Microspheres as a Biodegradable Drug Delivery Sys- tem:a New Deli-Very System for Protein显示文摘 | MI F L SHU S S LIN Y M | 2003 | Bioma- terials2003，，11： | 1 |
| 13 | Sucrose metabolism in cotton ( Gossypium hirsutum L.) fibre under low temperature during fibre development显示文摘 | Hongmei Shu Zhiguo Zhou Naiyin Xu Youhua Wang Mi Zheng | 2009 | European Journal of Agronomy2009，，2： | 1 |
| 14 | Prepara- tion and characterization on mechanical and antibacterial properties of chitsoan/cellulose blends, 显示文摘 | Yu-Bey Wu Shu Huei Yu Fwu-Long Mi | 2004 | Carhohydr Polym2004，57，4： | 1 |
| 15 | Brucine,an alkaloid from seeds of Strychnos nux-vomica Limn,represses hepatocellular carcinoma cell migration and metastasis:the role of hypoxia inducible factor 1 pathway显示文摘 | Shu G Mi X Cai J | 2013 | Toxicol Lett2013，222，2： | 1 |
| 16 | 中国大鲵隐存种及其灭绝危机显示文摘文章简介由于栖息地破坏及人为过度捕捉,中国大鲵的野生资源锐减。由于缺乏显著的外部性状差异,中国大鲵长期以来被认为是一个物种。不同地方的种群是否存在显著的分化?目前基于'一个物种'的保护策略是否得当. | 颜芳 Jingcai Lü Baolin Zhang Zhiyong Yuan Haipeng Zhao Song Huang Gang Wei Xue Mi Dahu Zou Wei Xu Shu Chen Jie Wang Feng Xie Minyao Wu Hanbin Xiao Zhiqiang Liang Jieqiong Jin Shifang Wu CunShuan Xu Benjamin Tapley Samuel T.Turvey Theodore J.Papenfuss Andrew A.Cunningham Robert W.Murphy 张亚平 车静 | 2019 | 科学新闻2019，0，2： | 1 |
| 17 | 转染瘦素人胎盘源间充质干细胞对经X射线辐照后人脐静脉内皮细胞的成血管潜能和周围炎症的影响显示文摘目的:放创复合伤是一种以血管损伤和促炎细胞因子缺乏为特征的难愈性创伤。瘦素(leptin)的直接应用在血管生成和炎症中起着重要作用。本研究构建了一种可持续稳定的leptin表达系统——leptin修饰的人胎盘来源间充质干细胞(HPMSCs/leptin),并探究其对经X射线辐照后的人脐静脉内皮细胞(HUVECs)的成血管潜能及周围炎症的影响和潜在机制。创新点:可持续稳定的leptin表达系统(HPMSCs/leptin)促进受X射线辐照后HUVECs的成血管潜能及外周炎症反应,有助于解决放创复合伤伤口愈合过程中血管损伤和促炎因子缺乏的问题。方法:利用慢病毒载体将leptin基因转染HPMSCs获得HPMSCs/leptin。采用X射线单次照射HUVECs,剂量为20 Gy。细胞迁移侵袭实验技术(Transwell)检测照射后HUVECs的迁移情况。在Transwell体系的基础上,建立HPMSCs与受辐照HUVECs共培养体系。CCK-8比色法测定细胞增殖。酶联免疫吸附法(ELISA)检测促炎细胞因子(粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-1α(IL-1α)、IL-6和IL-8)的分泌。实时荧光定量聚合酶链式反应(RT-qPCR)检测促血管生成因子(VEGF和bFGF)mRNA的表达。蛋白免疫印迹法(westernblot)检测核因子κB(NF-κB)和JAK/STAT信号通路的相关分子表达。结论:可持续稳定的leptin表达系统(HPMSCs/leptin)具有更好的细胞增殖、迁移和成血管潜能。HPMSCs/leptin单独培养和HPMSCs/leptin与受辐照HUVECs共培养体系中,促炎细胞因子的分泌增加与NF-κB和JAK/STAT信号通路的相互作用有关。HPMSCs/leptin可能促进X射线照射后HUVECs的成血管潜能和外周炎症反应。 | Shu CHEN Qian WANG Bing HAN Jia WU Ding-kun LIU Jun-dong ZOU Mi WANG Zhi-hui LIU | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，4： | 1 |
| 18 | A high-speed imaging and modeling study of dendrite fragmentation caused by ultrasonic cavitation 显示文摘 | SHU D SUN B MI J GRANT P S | 2012 | Metallurgical and Materials Transactions A2012，43，： | 1 |
| 19 | Photodynamic Effects of 5-AminolevulinicAcid and Its Hexylester on Several Cell Lines 显示文摘 | Wu Shu Min Ren Qing Guang Zhou Mi Ou | 2003 | Acta Biochimica er Biophysica Sinica2003，，7： | 1 |
| 20 | Intra-host Ebola viral adaption during human infection显示文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions. | William JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu | 2019 | Biosafety and Health2019，1，1： | 1 |
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