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| 1 | Petrogenesis of Mesozoic granitoids and volcanic rocks in South China: A response to tectonic evolution显示文摘 | Xinmin Zhou Tao Sun Weizhou Shen Liangshu Shu Yaoling Niu | 2006 | Episodes2006，29，1： | 645 |
| 2 | Lithology, kinematics and geochronology related to Late Mesozoic basin-mountain evolution in the Nanxiong-Zhuguang area, South China显示文摘The Nanxiong red-bed basin and its adjacent Zhuguang granite form a distinctive basin-mountain landform in the Nanling region, South China. Research results suggest that the Zhuguang granite is a polyphase composite pluton developed on the metamorphic basement of the paleo-Tethys-paleo-Asian tectonic regime and possesses geometrical and kinematic features of hot-doming extensional tectonics at the middle-upper crustal level, which is considered as a magmatic complex that resulted from the collision-orogeny during the Indosinian Period, the subduction-consuming during the Early Yanshanian Period and the intra-continental basaltic underplating and deep-seated geodynamics during the Late Yanshanian Period. The Nanxiong basin is a Late Cretaceous-Paleogene asymmetric faulted basin that is characterized by a fault boundary on the northern side and an uncomformable boundary on the southern side, its deposit center was migrated gradually from south to north. Structural kinematic results on the ba-sin-mountain coupled zone demonstrate that the ductile and the brittle rheological layers show a quite coincident sense of shear, implying that it is a continuous process from the ductile exten-sional deformation followed by locally sinistral strike-slip shear at a middle-crustal level to the brittle tensional deformation at a upper-crustal level during formation of granitic doming exten-sional tectonics. The Zhuguang granite and the Nanxiong faulted basin constructed a semi-graben tectonic system. Lithological and geochemical results suggest that the Late Triassic to Jurassic granitic bodies in the Zhuguang have some similar features: high SiO2, Al2O3, K2O contents, alkalinity index > 2.8, ANKC value > 1.1, LREE-enriched pattern with high REE con-tents, marked negative Eu anomalies, enrichment in Rb and Th, depletion in Ba and Nb, showing a K-rich and Al-rich calc-alkaline affinity, which suggest a continuous magmatic evolution from Late Triassic to Jurassic. Formation of Nanxiong basin and evolution of basin-mountain system were controlled both by the Zhuguang granitic-doming and the regional extensional tectonics. Development of the olivine basalt in the basin suggests that tension action was very strong dur-ing lava eruption. The magma-type zircon grains of basalt from the Nanxiong basin yielded the SHRIMP age of 96?Ma, providing reliable geochronological constraint on the tectono-thermal event and basin-mountain evolution in the Nanling region, South China. | SHU Liangshu1, DENG Ping1,2, WANG Bin1, TAN Zhengzhong2, YU Xinqi1 & SUN Yan1 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Research Institute No.290, CNNC, Shaoguan 512026, China | 2004 | Science China Earth Sciences2004，47，8： | 41 |
| 3 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 4 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 5 | Maize-soybean strip intercropping: Achieved a balance between high productivity and sustainability显示文摘Intercropping is one of the most vital practice to improve land utilization rate in China that has limited arable land resource. However, the traditional intercropping systems have many disadvantages including illogical field lay-out of crops, low economic value, and labor deficiency, which cannot balance the crop production and agricultural sustainability. In view of this, we developed a novel soybean strip intercropping model using maize as the partner, the regular maize-soybean strip intercropping mainly popularized in northern China and maize-soybean relay-strip intercropping principally extended in southwestern China. Compared to the traditional maize-soybean intercropping systems, the main innovation of field lay-out style in our present intercropping systems is that the distance of two adjacent maize rows are shrunk as a narrow strip, and a strip called wide strip between two adjacent narrow strips is expanded reserving for the growth of two or three rows of soybean plants. The distance between outer rows of maize and soybean strips are expanded enough for light use efficiency improvement and tractors working in the soybean strips. Importantly, optimal cultivar screening and increase of plant density achieved a high yield of both the two crops in the intercropping systems and increased land equivalent ratio as high as 2.2. Annually alternative rotation of the adjacent maize-and soybean-strips increased the grain yield of next seasonal maize, improved the absorption of nitrogen, phosphorus, and potasium of maize, while prevented the continuous cropping obstacles. Extra soybean production was obtained without affecting maize yield in our strip intercropping systems, which balanced the high crop production and agricultural sustainability. | DU Jun-bo HAN Tian-fu GAI Jun-yi YONG Tai-wen SUN Xin WANG Xiao-chun YANG Feng LIU Jiang SHU Kai LIU Wei-guo YANG Wen-yu | 2018 | Journal of Integrative Agriculture2018，17，4： | 34 |
| 6 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 7 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 8 | EMP chemical ages of monazites from Central Zone of the eastern Kunlun Orogen:Records of multi-tectonometamorphic events显示文摘Two generations of monazite were identified in one mica schist sample from the central zone of the eastern Kunlun Orogen at the northern margin of the Qinghai-Tibet Plateau. The first generation was found in the cores of garnet porphyroblasts with relatively high Y2O3 contents (averaging 1.012±0.088 wt%). The second generation occurs either as inclusions in the rims of garnet porphyroblasts,matrix kyanite,plagioclase and quartz,or as separate crystals associated with matrix biotite and muscovite mostly having a relatively low Y2O3 content (averaging 0.479±0.100 wt%). Electron microprobe (EMP) Th-U-Pbtotal chemical dating for two grains of the first generation monazite yields average ages of 455 ± 18 Ma and 420 ± 20 Ma,respectively; six grains of the second generation gave an average age of 246.1 ± 3.8 Ma. These ages suggest that the core and rim of the garnet porphyroblasts and their associated assemblages record two events of significant tectonometamorphism. The formation of the Ordovician monazite is related to the tectonometamorphic event responsible for continuous amalgamation of the Gondwanaland in the Late Pan-African period or for consumption of the Proto-Tethys,whereas the development of the Triassic monazite is related to the tectonometamorphic event for consumption of the Paleo-Tethys. | CHEN NengSong SUN Min WANG QingYan ZHAO GuoChun CHEN Qiang SHU GuiMing | 2007 | Chinese Science Bulletin2007，52，16： | 28 |
| 9 | High-resolution remote sensing mapping of global land water显示文摘Land water, one of the important components of land cover, is the indispensable and important basic information for climate change studies, ecological environment assessment, macro-control analysis, etc. This article describes the overall study on land water in the program of global land cover remote sensing mapping. Through collection and processing of Landsat TM/ETM+, China's HJ-1 satellite image, etc., the program achieves an effective overlay of global multi-spectral image of 30 m resolution for two base years, namely, 2000 and 2010, with the image rectification accuracy meeting the requirements of 1:200000 mapping and the error in registration of images for the two periods being controlled within 1 pixel. The indexes were designed and selected reasonably based on spectral features and geometric shapes of water on the scale of 30 m resolution, the water information was extracted in an elaborate way by combining a simple and easy operation through pixel-based classification method with a comprehensive utilization of various rules and knowledge through the object-oriented classification method, and finally the classification results were further optimized and improved by the human-computer interaction, thus realizing high-resolution remote sensing mapping of global water. The completed global land water data results, including Global Land 30-water 2000 and Global Land 30-water 2010, are the classification results featuring the highest resolution on a global scale, and the overall accuracy of self-assessment is 96%. These data are the important basic data for developing relevant studies, such as analyzing spatial distribution pattern of global land water, revealing regional difference, studying space-time fluctuation law, and diagnosing health of ecological environment. | LIAO AnPing CHEN LiJun CHEN Jun HE ChaoYing CAO Xin CHEN Jin PENG Shu SUN FangDi GONG Peng | 2014 | Science China Earth Sciences2014，57，10： | 22 |
| 10 | Grenvillian orogeny in the Southern Cathaysia Block:Constraints from U-Pb ages and Lu-Hf isotopes in zircon from metamorphic basement显示文摘Metamorphic basement rocks in the Cathaysia Block are composed mainly of meta-sediments with different ages. New zircon U-Pb geochronological results from the meta-sedimentary rocks exposed in the Zengcheng and Hezi areas, southern Cathaysia Block, show that they consist dominantly of early Neoproterozoic (1.0―0.9 Ga) materials with minor Paleo- to Mesoproterozoic and late Neoproterozoic (0.8―0.6 Ga) components, suggesting that the detritus mostly come from a Grenvillian orogen. The youngest detrital zircon ages place a constraint on the deposition time of these sediments in Late Neoproterozoic. Zircon Hf isotopic compositions indicate that the Grenvillian zircons were derived from the reworking of Mesoproterozoic arc magmatic rocks and Paleoproterozoic continental crust, implying an arc-continent collisional setting. Single-peak age spectra and the presence of abundant euhedral Grenvillian zircons suggest that the sedimentary provenance is not far away from the sample location. Thus, the Grenvillian orogen probably preexisted along the southern margin of the Cathaysia Block, or very close to the south. Similarity in the ages of Grenvillian orogeny and the influence of the assembly of Gondwana in South China with India and East Antarctic are discussed, with suggestion that South China was more likely linked with the India-East Antarctica continents in Early Neoproterozoic rather than between western Laurentia and eastern Australia. | WANG LiJuan YU JinHai S.Y. O'REILLY W.L. GRIFFIN SUN Tao WEI ZhenYang JIANG ShaoYong SHU LiangShu | 2008 | Chinese Science Bulletin2008，53，19： | 21 |
| 11 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 12 | Survival of transplanted neurotrophin-3 expressing human neural stem cells and motor function in a rat model of spinal cord injury显示文摘<正>BACKGROUND:Many methods have been attempted to repair nerves following spinal cord injury, including peripheral nerve transplantation,Schwann cell transplantation,olfactory ensheathing cell transplantation,and embryonic neural tissue transplantation.However,there is a need for improved outcomes. OBJECTIVE:To investigate the repair feasibility for rat spinal cord injury using human neural stem cells(hNSCs) genetically modified by lentivirus to express neurotrophin-3. DESIGN,TIME AND SETTING:In vitro cell biological experiment and in vivo randomized,controlled, genetic engineering experiment were performed at the Third Military Medical University of Chinese PLA and First People's Hospital of Yibin,China from March 2006 to December 2007. MATERIALS:A total of 64 adult,female,Wistar rats were used for the in vivo study.Of them,48 rats were used to establish models of spinal cord hemisection,and were subsequently equally and randomly assigned to model,genetically modified hNSC,and normal hNSC groups.The remaining 16 rats served as normal controls. METHODS:hNSCs were in vitro genetically modified by lentivirus to secrete both green fluorescence protein and neurotrophin-3.Neurotrophin-3 expression was measured by Western blot. Genetically modified hNSC or normal hNSC suspension(5×10~5) was injected into the rat spinal cord following T_(10) spinal cord hemisection.A total of 5μL Dulbecco's-modified Eagle's medium was infused into the rat spinal cord in the model group.Transgene expression and survival of transplanted hNSCs were determined by immunohistochemistry.Motor function was evaluated using the Basso,Beattie,and Bresnahan(BBB) scale. MAIN OUTCOME MEASURES:The following parameters were measured:expression of neurotrophin-3 produced by genetically modified hNSCs,transgene expression and survival of hNSCs in rats,motor function in rats. RESULTS:hNSCs were successfully genetically modified by lentivirus to stably express neurotrophin-3.The transplanted hNSCs primarily gathered at,or around,the injection site two weeks following transplantation,and gradually migrated towards the surrounding tissue. Transplanted hNSCs were observed 7.0-8.0 mm away from the injection site.In addition,hNSCs were observed 10 weeks after transplantation.At week 4,BBB locomotor scores were significantly greater in the genetically modified hNSC and normal hNSC groups,compared with the model group (P<0.05),and scores were significantly greater in the genetically modified hNSC group compared with the normal hNSC group(P<0.05). CONCLUSION:hNSCs were genetically modified with lentivirus to stably secrete neurotrophin-3. hNSCs improved motor function recovery in rats following spinal cord injury. | Peiqiang Cai Guangyun Sun Peishu Cai Martin Oudega Rui Xiao Xuewen Wang Wei Li Yunbing Shu Cheng Cai Haihao Yang Xuebing Shan Wuhua Luo | 2009 | Neural Regeneration Research2009，4，7： | 18 |
| 13 | The minimum heat consumption for heat-driven binary separation processes with linear phenomenological heat transfer law显示文摘The optimal performance of heat-driven binary separation processes with linear phenomenological heat transfer law(q∝△(T-1)) is analyzed by taking the processes as heat engines which work between high-and low-temperature reservoirs and produce enthalpy and energy flows out of the system,and the temperatures of the heat reservoirs are assumed to be time-and space-variables.A numerical method is employed to solve convex optimization problem and Lagrangian function is employed to solve the average optimal control problem.The dimensionless entropy production rate coefficient and dimensionless enthalpy flow rate coefficient are adopted to indicate the major influence factors on the performance of the separation process,such as the properties of different materials and various separation requirements for the separation process.The dimensionless minimum average entropy production rate and dimensionless minimum average heat consumption of the heat-driven binary separation processes are obtained.The obtained results are compared with those obtained with the Newtonian heat transfer law(q∝△(T)). | SHU LiWei CHEN LinGen SUN FengRui | 2009 | Science China Chemistry2009，52，8： | 17 |
| 14 | Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China,2017显示文摘Background:After the scale-up of antiretroviral therapy(ART)for HIV infected people,increasing numbers of patients have pretreatment drug resistance(PDR).In this study,the prevalence of PDR was evaluated in adults initiating antiretroviral therapy in China.Methods:Blood samples were obtained from 1943 patients who initiated antiretroviral therapy(ART)in 2017 from 13 provinces or cities in China.Pol sequences were used to analyze drug resistance and construct transmission networks.Logistic regression model was used to estimate the potential factors associated with PDR.Results:In total,1711 eligible patients(76.0%male;87.8%aged≥25 years)were included,of which 117(6.8%)had PDR.The highest rates of PDR were 12.2%in Liangshan Prefecture of Sichuan and 9.3 and 8.9%in Dehong and Lincang Prefecture of Yunnan.A multivariate logistic regression analysis revealed that PDR was significantly higher among intravenous drug users(adjusted Odds Ratio(aOR)=2.64,95%CI:1.57–4.44)and individuals from Liangshan,Dehong,and Lincang(aOR=2.04,95%CI:1.26–3.30).In total,754 sequences were used to generate 164 transmission networks.Five transmission networks had two or three sequences containing the same mutations,two networks contained subjects from Liangshan,and one network contained subjects from Dehong.Conclusions:Overall,the PDR prevalence was moderate,with a particularly high prevalence in areas with severe HIV epidemics.These results indicate the importance of continuous PDR monitoring in patients initiating antiretroviral therapy. | Rui-Hua Kang Shu-Jia Liang Yan-Ling Ma Shu Liang Lin Xiao Xin-Hui Zhang Hong-Yan Lu Xiao-Qin Xu Shui-Bin Luo Xiao-Guang Sun Lin Chen Jian-Mei He Guo-Hui Wu Ling-Jie Liao Hui Xing Yi-Ming Shao Yu-Hua Ruan | 2020 | Infectious Diseases of Poverty2020，9，3： | 17 |
| 15 | Nickel accumulation and its effects on the survival rate of Spodoptera litura Fabricius under continuous nickel stress显示文摘The artificial diets mixed with various concentrations of nickel were offered to the larvae of the phytophagous insect Spodoptera litura Fabricius for 3 generations. Nickel accumulations in the 6th instar larvae, pupae and newly emerged adults of the corresponding generations of S. litura were investigated by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), and the effects of nickel accumulations on the survival rate of S. litura were also evaluated by individual rearing. The results showed that nickel accumulated in the 6th instar larvae, pupae and adults of S. litura, and the accu- mulated nickel in all the tested developmental stages within a generation increased with the increase of the nickel doses in the treated diets and showed significant dose-dependent relationship with the nickel doses in the artificial diets. The results also indicated that the nickel accumulations in the 6th instar larvae, pupae, and newly emerged adults from the 3rd generation were higher than those from the 2nd generation, which were also higher than those from the 1st generation. Nickel concentrations in pupae and adults were significantly lower than those in larvae, which indicated that the excessive nickel might be excreted during metamorphosis. Furthermore, larval survival rate, pupation rate and eclosion rate of S. litura in the tested three generations all decreased with the increase of the nickel doses in the treated diets. | SUN HongXia SHU YingHua TANG WenCheng WANG Qi ZHOU Qiang ZHANG GuRen | 2007 | Chinese Science Bulletin2007，52，14： | 16 |
| 16 | OsGRF4 controls grain shape, panicle length and seed shattering in rice显示文摘Traits such as grain shape, panicle length and seed shattering, play important roles in grain yield and harvest. In this study, the cloning and functional analysis of PANICLE TRAITS 2(PT2), a novel gene from the Indica rice Chuandali(CDL), is reported. PT2 is synonymous with Growth-Regulating Factor 4(OsGRF4), which encodes a growth-regulating factor that positively regulates grain shape and panicle length and negatively regulates seed shattering. Higher expression of OsGRF4 is correlated with larger grain, longer panicle and lower seed shattering. A unique OsGRF4 mutation, which occurs at the Osmi RNA396 target site of OsGRF4, seems to be associated with high levels of OsGRF4 expression, and results in phenotypic difference. Further research showed that OsGRF4 regulated two cytokinin dehydrogenase precursor genes(CKX5 and CKX1) resulting in increased cytokinin levels,which might affect the panicle traits. High storage capacity and moderate seed shattering of OsGRF4 may be useful in high-yield breeding and mechanized harvesting of rice. Our Resefindings provide additional insight into the molecular basis of panicle growth. | Pingyong Sun Wuhan Zhang Yihua Wang Qiang He Fu Shu Hai Liu Jie Wang Jianmin Wang Longping Yuan Huafeng Deng | 2016 | Journal of Integrative Plant Biology2016，58，10： | 16 |
| 17 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 18 | Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis显示文摘 | Shu DONG Fei-fei CAI Qi-long CHEN Ya-nan SONG Yang SUN Bin WEI Xiao-yan LI Yi-yang HU Ping LIU Shi-bing SU | 2018 | Acta Pharmacologica Sinica2018，39，6： | 15 |
| 19 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 20 | A new triterpene glycoside from sea cucumber Holothuria leucospilota显示文摘A new triterpene glycoside, leucospilotaside A, along with a known saponin, isolated from sea cucumber Holothuria leucospilota, and its structure was elucidated as 3β-O-[4-O-sodiumsulfate-β-D-quinovopyranosyl-(1→2)-β-D-xylopyranosyl]-holosta-22-ketone-9-en-17α,25α-diol (1) by extensive spectroscopic analysis and chemical methods. Leucospilotaside A (1) has a ketone carbonyl group (22) in the aglycon side chain. | Hua Han Yang Hua Yi Ling Li Xiao Hua Wang Bao Shu Liu Peng Sun Min Xiang Pan | 2007 | Chinese Chemical Letters2007，18，2： | 13 |
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