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| 1 | Analysis of Pathological data of renal biopsy at one single center in China from 1987 to 2012显示文摘 | Zhang Xueguang Liu Shuwen Tang Li Wu Jie Chen Pu Yin Zhong Li Minxia Xie Yuansheng Cai Guangyan Wei Ribao Qiu Qiang Wang Yuanda Shi Suozhu Chen Xiangmei | 2014 | Chinese Medical Journal2014，，9： | 30 |
| 2 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 3 | Brown and beige fat: the metabolic function, induction, and therapeutic potential显示文摘脂肪质的织物是为精力动态平衡的一个重要机关。白脂肪质的织物存储在 triglycerides 形式的精力,而棕色的 adipocytes 和最近识别的米黄色的 adipocytes 被专攻由在血处理葡萄糖和清楚的 triglycerides 的生热作用或贡献浪费体力。在棕色的脂肪质的织物活动和身体质量之间的反的关联对身体脂肪累积建议它的保护的角色。因此,棕色或米黄色的脂肪质的织物的招募和激活为增加精力开销成为特别地呼吁的目标。Angiogenesis 和同情的神经信号是为褐和米黄色的脂肪质的织物开发,以及为他们的新陈代谢的函数的基本决定因素。包括 BMP 的秘书因素能导致发展,褐的激活或米黄色的脂肪质的织物,它似乎为治疗学的开发有希望。 | Shuwen Qian Haiyan Huang Qiqun Tang | 2015 | Frontiers of Medicine2015，9，2： | 5 |
| 4 | Spatio-temporal Pattern and Spatial Heterogeneity of Ecotones Based oh Land Use Types of Southeastern Da Hinggan Mountains in China显示文摘Ecotones have received great attention due to its critical function in energy flux, species harbor, global carbon sequestration, and land-atmosphere interaction. This study investigated land use pattern and spatial heterogeneity of the ecotones among agricultural land, forest land, and grassland of the southeastern Da Hinggan Mountains in the northeastern China. The change of these delineated ecotones under different slopes and aridity conditions was analyzed by two landscape indices, edge density(ED) and core area percentage of landscape(CPL), to explore the inter-linkage between spatial structure of ecotones and socioeconomic development and land management. Specifically, the ecotones such as agriculture-forest(AF) ecotone, forest-grassland(FG) ecotone, and agriculture-forestgrassland(AFG) ecotone moved from the arid southeast to the humid northwest. The flat area with small slope is more edge-fragmented than the steep area since the ED decreases as the slope increases. The AF ecotone mostly found in the humid region is moving to more humid areas while the agriculture-grassland(AG) ecotone mostly found in the dry region is moving towards the drier region. | YU Lingxue ZHANG Shuwen LIU Tingxiang TANG Junmei BU Kun YANG Jiuchun | 2015 | Chinese Geographical Science2015，25，2： | 4 |
| 5 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 6 | Comparison and Analysis of Agricultural and Forest Land Changes in Typical Agricultural Regions of Northern Mid-latitudes显示文摘The northeastern China, the United States, and the western Europe are important agricultural regions both on the global and regional scales. The western Europe has a longer history of agricultural land development than the eastern United States. These two regions have changed from the deforestation and reclamation phase in the past to the current land abandonment and reforestation phase. Compared with the two regions, large-scale land exploitation has only been practiced in the northeastern China during the last century. After a short high-intensity deforestation and reclamation period, agricultural and forest lands are basically in a dynamic steady state. By comparing domestic and international agro-forestry development and considering the ecological environment and socio-economic benefits that can be derived from agro-forestry, this paper suggests that large area of reforestation would be inevitable in future though persistent and large agricultural demand in coming decades even more. And local reforestation at slope farmland with ecological vulnerability should be imperative at present to avoid severer damage. At the same time, from the perspective of Land Change Science, the results demonstrate that the research on land use change in the agro-forestry ecotone is typical and critical, particularly those dealing with the analysis of spatial and temporal characteristics and the simulation of climate, hydrology, and other environmental effects. | LIU Tingxiang ZHANG Shuwen TANG Junmei LI Tianqi | 2013 | Chinese Geographical Science2013，23，2： | 3 |
| 7 | A MODIS Time Series Data Based Algorithm for Mapping Forest Fire Burned Area显示文摘Burned area mapping is an essential step in the forest fire research to investigate the relationship between forest fire and climate change and the effect of forest fire on carbon budgets. This study proposed an algorithm to map forest fire burned area using the Moderate-Resolution Imaging Spectroradiameter (MODIS) time series data in Heilongjiang Province, China. The algorithm is divided into two steps: Firstly, the′core′pixels were extracted to represent the most possible burned pixels based on the comparison of the temporal change of Global Environmental Monitoring Index (GEMI), Burned Area Index (BAI) and MODIS active fire products between pre- and post-fires. Secondly, a 15-km distance was set to extract the entire burned areas near the′core′pixels as more relaxed conditions were used to identify the fire pixels for reducing the omission error as much as possible. The algorithm comprehensively considered the thermal characteristics and the spectral change between pre-and post-fires, which are represented by the MODIS fire products and the spectral index, respectively. Tahe, Mohe and Huma counties of Heilongjiang Province, China were chosen as the study area for burned area mapping and a time series of burned maps were produced from 2000 to 2011. The results show that the algorithm | YANG Wei ZHANG Shuwen TANG Junmei BU Kun YANG Jiuchun CHANG Liping | 2013 | Chinese Geographical Science2013，23，3： | 3 |
| 8 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 9 | Autophagosome activity in macrophage for atherosclerotic plaques in ApoE^-/-mice enhanced by Tiaozhi Tongmai Granules显示文摘Objective:Atherosclerosis is the fundamental pathophysiologic component of cardiovascular disease,and Tiaozhi Tongmai Granules show great efficiency in the treatment of the disease.However,the mechanism of Tiaozhi Tongmai Granules is still unclear.In this study,we have combined experiments with network pharmacology to explore the antiatherosclerosis mechanism of Tiaozhi Tongmai Granules.Method:120 male ApoE/mice were randomly divided into three groups:the model group,Chinese herb group and Atorvastatin group.The model group,Atorvastatin group and Chinese herb group were fed with a high-fat diet,a high-fat diet plus atorvastatin(5.1 mg/kg/d)and a high-fat diet plus Tiaozhi Tongmai Granules(16.5 g/kg/d)for 16 weeks,respectively.Atherogenesis was identified by H&E staining.The colocalization of neutral lipid stain BODIPY and microtubule-associated protein 1 light chain 3(LC3)and the colocalization of BODIPY and lysosomal-associated membrane protein 1(LAMP1)within ApoE/mice aortic plaques were tested using fluorescence confocal microscopy and the Pearson’s coefficients were calculated.To further explore the anti-atherosclerosis mechanism of Tiaozhi Tongmai Granules,the network pharmacology was used to construct the herb-compound-target network.Results:The size of the aortic lipid plaque in the Chinese herb group and Atorvastatin group were smaller compared with the model group on the 16th week.Compared with the model group on the 16th week,the BODIPY and LC3 colocalization rate,the BODIPY and LAMP1 colocalization rate of the Chinese herb group and Atorvastatin group all presented significant increase in the aortic plaque(P<.001),showing that Tiaozhi Tongmai Granules could enhance autophagosome activity in the macrophage.In the herb-compound-target network,17 active compounds and 27 targets were obtained through literature searching and using LHRI&DAVID Bioinformatics.It was found that 23 targets were correlated with the macrophage.Some of them participated in macrophage inflammatory response,and the other targets could promote/inhibit phagocytosis of the macrophage.It was hypothesized that the active compounds of Tiaozhi Tongmai Granules were acting on these targets and having y the biological effects.Conclusions:In the progression stage of atherosclerosis,Tiaozhi Tongmai Granules can still make the macrophage have higher autophagosome activity,and play a role of anti-atherogenesis. | Chenglong Zheng Qing Sun Lu Zhang Shuwen Guo Min Zheng Yan Tang Jiangong Wu Jiani Wu Wenchen Liu Zhaoduo Su Xi Chen | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 2 |
| 10 | Psychological Capital as a Moderator Between Emotional Labor, Burn- out, and Job Satisfaction Among School Teachers in China 显示文摘 | Francis Cheung Catherine So-kum Tang Shuwen Tang | 2011 | International Journal of Stress Management2011，18，4： | 1 |
| 11 | Psychological Capital as a Moderator between Emotional Labor, Burnout, and Job Satisfaction among School Teachers in China 显示文摘 | Francis Cheung Catherine So-Kum Tang & Shuwen Tang | 2011 | International Journal of Stress Management2011，10，3： | 1 |
| 12 | Application of Image Processing for Pulsed-heating Infrared Thermography Quantitative Testing显示文摘 | Tang Huijun Ding Tieying Xue Shuwen Zong Mingcheng | 2001 | Journal of Northern Jiaotong University2001，23，2： | 1 |
| 13 | 海马Rac1蛋白的激活调节新物体识别记忆的遗忘过程显示文摘在神经生物学的研究当中,遗忘过程普遍被认为属于被动过程即记忆不能够形成和维持,因而大部分的研究集中在记忆形成和维持的分子机制上,而忽略了遗忘本身的分子机制,即记忆形成过程中生物体通过激活自身的分子信号途径介导主动遗忘过程。 | Yunlong Liu Shuwen Du Li Lv Bo Lei Wei Shi Yikai Tang Lianzhang Wang 钟毅 | 2017 | 科学新闻2017，19，4： | 1 |
| 14 | 5-19 Research Progress in Group of RIB Physics in 2015显示文摘The progress of research going on in Group of Rare Isotope Beam Physics (RIB), Experimental Physics Research Center, in 2015 is in the following two aspects. Construction of the plastic scintillator detector array (PSD) for the DArk Matter Particle Explorer (DAMPE) project.DAMPE is part of the “Strategic Priority Research Program” of the Chinese Academy of Science for space science, and it is a large space telescope aimed for the evidence of dark matter existence through the measurements of their decay products. | Sun Zhiyu Zhang Xueheng Yu Yuhong Yue Ke Wang Shitao Tang Shuwen Chen Jinda Fang Fang | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | 5-21 A Large Area Plastic Scintillation Detector with 4-corner-readout显示文摘Large area plastic scintillation detectors are applied widely in modern physics labs due to the development of the time-of-flight technique. They are usually constructed with a module array design, such as the TOF Wall. The performance of such detectors is excellent, but the number of electronics channels is quite large, and the operation and calibration are too complicated. As a result, a large area plastic scintillation detector with only 4 readout signals from the corners is constructed and developed as a simple TOF Wall at ETF in IMP. | Tang Shuwen Yu Yuhong Zhou Yong Sun Zhiyu Zhang Xueheng Wang Shitao Yue Ke Liu Longxiang Fang Fang Yan Duo Sun Yu Wang Zhaomin | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 17 | Diagnostic and classification value of immune-related lncRNAs in dilated cardiomyopathy显示文摘Background:Various physiological mechanisms are linked to dilated cardiomyopathy(DCM)development,including oxidative stress,immune irregularities,inflammation,fibrosis,and genetic changes.However,precise molecular drivers of DCM,especially regarding abnormal immune responses,remain unclear.This study investigates immune-related long non-coding RNAs(lncRNAs)in DCM’s diagnostic and therapeutic potential.Methods:GSE141910,GSE135055,and GSE165303 datasets were acquired from the GEO database.LASSO,SVM-RFE,and random forest algorithms identified DCM-associated immune-related lncRNAs.Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic(ROC)curves.Multivariate linear regression explored lncRNA correlations with ejection fraction.Single-sample gene set enrichment analysis(ssGSEA)gauged immune cell infiltration/functions.Functional enrichment analyses were performed using Gene set variation analysis(GSVA),gene ontology(GO),and the Kyoto Encyclopedia of Genes and Genomes(KEGG).Consensus clustering categorized DCM cases.Results:Ten immune-related lncRNAs emerged:C10orf71-AS1,FHAD1-AS1,SCIRT,FNDC1-AS1,MELTFAS1,LOC101928834,GDNF-AS1,DCXR-DT,C3orf36,and LOC107985323.These lncRNAs,tied to immunomodulation,showed promising DCM diagnostic accuracy.Adjusted for confounders,they independently correlated with ejection fraction.Using lncRNA expression,DCM patients were grouped into subtypes.Subtype C1 displayed a higher level of immune cell infiltration and immune checkpoint expression compared to subtype C2,emphasizing the variations in the immune microenvironment.Conclusion:This study identifies ten immune-related lncRNAs for further exploration in DCM diagnosis and subtyping.Based on expression patterns,we propose two potential DCM subtypes.Notably,findings are preliminary and hypothesis-generating,demanding validation and further investigation.This research provides insights into DCM diagnosis and classification. | CONGCHEN BAI QIHANG KONG HAO TANG SHUWEN ZHANG JUNTENG ZHOU XIAOJING LIU | 2023 | BIOCELL2023，47，11： | 0 |
| 18 | 2-27 Research Progress in Group of RIB Physics in 2014显示文摘The progress of research going on in Group of Rare Isotope Beam Physics (RIB), Experimental Physics ResearchCenter, in 2014 is in the following three aspects.1. Detector construction for the Dark Matter Particle Explorer (DAMPE) project. DAMPE is a large spacetelescope aimed at the evidence of dark matter existence through the measurements of their decay products. It isa part of the 'Strategic Priority Research Program' of the Chinese Academy of Sciences for space science, and willbe launched in 2015. In this project, the RIB group is involved in the design and construction of the plastic scintillatorFig. 1 (color online) Accumulative adsorp-tion capacity of uranium from brine.detector array (PSD), which is a key component of theload with an active area of 0.8 m 0.8 m. | Sun Zhiyu Zhang Xueheng Yu Yuhong Yue Ke Wang Shitao Tang Shuwen Chen Jinda Fang Fang | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 19 | 2-28 Knockout Reactions from 14O at Around 300 MeV/u显示文摘Knockout reactions at intermediate and high energies have been proved to be a powerful tool for probing thesingle-particle structure of rare isotopes[1]. The spectroscopic factors and orbital angular momenta of the removednucleons can be deduced by comparison of the experimental cross sections and longitudinal-momentum distributionsto those calculated in the Glauber reaction theory. Recently, study shows that for strongly bound valence nucleonknockout, the experimental cross sections are much smaller than reaction theory predictions[2]. | Wang Shitao Sun Zhiyu Zhang Xueheng Yu Yuhong Yue Ke Tang Shuwen Fang Fang Yan Duo Zhou Yong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 20 | cyy-287,a novel pyrimidine-2,4-diamine derivative,inhibits tumor growth of EGFR-driven non-small cell lung cancer via the ERK pathway显示文摘In recent decades,EGFR-targeted tyrosine kinase inhibitors(TKIs)have been proven to be an effective therapy for EGFR-mutant non-small cell lung cancer(NSCLC).However,resistance to EGFR-TKIs limits their clinical application.In the present study,we investigate the antitumor effect and underlying mechanism of a novel pyrimidine-2,4-diamine derivative,cyy-287,in NSCLC.We find that cyy-287 has a high affinity for lung tissue and inhibits the proliferation of NSCLC cells.Interestingly,the significant suppression of migration and induction of apoptosis by cyy-287 are only observed in EGFR-driven but not in EGFR-wild-type(wt)cells.According to the RNA sequencing and KEGG enrichment analysis results,cyy-287 markedly inhibits the MAPK pathway in EGFR-driven PC9 cells,and western blot analysis results further indicate that cyy-287 selectively blocks the ERK pathway in EGFR-driven cells.Meanwhile,apoptosis induced by cyy-287 could be partially reversed by ERK pathway inhibition.Further experiment indicates that cyy-287 inhibits the EGFR pathway in both EGFR-driven and EGFR-overexpressing cells.Interestingly,it only induces apoptosis in EGFR-driven cells,not in EGFR-overexpressing cells.The growth of EGFR-driven cells is suppressed by cyy-287 in vivo,with fewer side effects.Our results suggest that cyy-287 may be a potential therapeutic drug with promising antitumor effects against NSCLC. | Qianwen Zhang Huijing Huang Shuwen Zheng Yelin Tang Xiaodan Zhang Qianqian Zhu Zefeng Ni Xiaohui Zheng Kun Wang Lehao Huang Yunjie Zhao Zhiguo Liu Jianchang Qian | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
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