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| 1 | Microglial migration mediated by ATP-induced ATP release from lysosomes显示文摘Microglia 是在中央神经系统充当活跃有免疫力的防卫的主要形式的高度能动的房间。由免除损坏房间的因素吸引了, microglia 向损坏或感染的地点被招募,在他们涉及退化、再生的回答和房间碎片的 phagocytotic 清理的地方。从损坏神经纸巾的 ATP 版本被建议了调停向损害的地点的 microglial 过程的快速的延期。然而, microglia 的远程的迁居的机制尚待被澄清。这里,我们发现在 microglia 的 lysosomes 响应各种各样的刺激包含丰富的 ATP 和展览 Ca 2+-dependent exocytosis。由建立一在 vitro 趋化性试金有效,我们证明从 microglia 的 释放endogenously 的 ATP 由 ATPγ 的本地 microinjection 被触发; S 为 microglia 的远程的趋化性是批评的,显著地在与导致 lysosome osmodialysis 的一个代理人或在房间对待的 microglia 被禁止的回答源于在 Rab 27a (灰老鼠)缺乏的老鼠,为能分泌的 lysosomes 的 trafficking 和 exocytosis 要求的小 GTPase 。这些结果建议 microglia 由通过 lysosomal exocytosis 自己释放 ATP 对细胞外的 ATP 作出回应,从而提供积极反馈机制为吸引远 microglia 移居向并且在损害的地点积累产生一个远程的细胞外的信号。 | Ying Dou Hang-jun wu Hui-quan Li Song Qin Yin-er Wang Jing Li Hui-fang LOU Zhong Chew Xiao-ming Li Qing-ming Luo Shumin Duan | 2012 | Cell Research2012，22，6： | 10 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus显示文摘Trans-neuronal viral tracing is becoming one of the most important methods for mapping neuronal circuit connections,but an anterograde trans-synaptic tracer compatible with functional assays is still lacking.Adeno-associated virus(AAV)is replication-defective,and its production of offspring needs the help of adenovirus(AV)[1]or herpesvirus co-infection[2].The replication deficiency,non-pathogenicity,easy manipulability。 | Fei Zhao Hai-Fei Jiang Wen-Bo Zeng Yousheng Shu Min-Hua Luo Shumin Duan | 2017 | Neuroscience Bulletin2017，33，3： | 4 |
| 4 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 5 | Modulation instability of femtosecond pulses in dispersion decreasing fibers显示文摘 | Zhang Shumin Luo Aiping | 2001 | Optics Communications2001，199，56： | 1 |
| 6 | Additively manufactured heterogeneously porous metallic bone with biostructural functions and bone-like mechanical properties显示文摘A compatible artificialbone impla nt requires large pores for enhanced nutrients transports,small pores to allow cell seeding and bone-like mechanical properties to avoid stress shielding.Herein,we report novel improved gyroid lattices with millimetre-scaled gyroid wall spacings and micrometre-scaled additional pores on the walls.Designs are successfully fabricated by electron beam melting using Ti-6 Al-4 V to high part qualities while exhibiting bone-like mechanical properties with a range of Young's modulus of 8-15 GPa and strength of 150-250 MPa.The improved design also eliminates brittle failure by allowing the structure to deform more stably. | Pan Wang Xinwei Li Shumin Luo Mui Ling Sharon Nai Jun Ding Jun Wei | 2021 | Journal of Materials Science & Technology2021，，3： | 1 |
| 7 | Nonaqueous capillary electrophoresis with laserinduced fluorescence detection:A case study of comparison with aqueous media显示文摘 | Weiping Wang Shumin Wang Yang Hui Zhi Luo Zhide Hu | 2008 | Analytica Chimica Acta2008，611，： | 1 |
| 8 | Au Nanoparticles Loaded on Hollow TiO2 Microspheres with (001) Exposed Facets: a Strategy for Promoting Photocatalytic Performance显示文摘 | WANG Shumin YAN Xiaoxia ZHU Yan DENG Dongmei HE Haibo LUO Liqiang | 2018 | Chemical Research in Chinese Universities2018，34，5： | 1 |
| 9 | Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells显示文摘 | JinJin Yin YanQin Luo HouLiang Deng ShuMin Qin WaiJiao Tang Lu Zeng BenJie Zhou | 2014 | Journal of Ethnopharmacology2014，，1： | 1 |
| 10 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 11 | FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight显示文摘Fat mass and obesity-associated (FTO) protein is a ferrous ion (Fe^2+)/2-oxoglutarate (2-OG)-dependent demethylase preferentially catalyzing m^6A sites in RNA. The FTO gene is highly expressed in the hypothalamus with fluctuation in response to various nutritional conditions, which is believed to be involved in the control of whole body metabolism. However, the underlying mechanism in response to different nutritional cues remains poorly understood. Here we show that ketogenic diet-derived ketone body β-hydroxybutyrate (BHB) transiently increases FTO expression in both mouse hypothalamus and cultured cells. Interestingly, the FTO protein represses Fto promoter activity, which can be offset by BHB. We then demonstrate that FTO binds to its own gene promoter, and Fe^2+, but not 2-OG, impedes this binding and increases FTO expression. The BHB-induced occupancy of the promoter by FTO influences the assembly of the basal transcriptional machinery. Importantly, a loss-of-function FTO mutant (I367F), which induces a lean phenotype in FTO^I367F mice, exhibits augmented binding and elevated potency to repress the promoter. Furthermore, FTO fails to bind to its own promoter that promotes FTO expression in the hypothalamus of high-fat diet-induced obese and 48-h fasting mice, suggesting a disruption of the stable expression of this gene. Taken together, this study uncovers a new function of FTO as a Fe^(2+)-sensitive transcriptional repressor dictating its own gene switch to form an auto-regulatory loop that may link with the hypothalamic control of body weight. | Shu-Jing Liu Hui-Ling Tang Qian He Ping Lu Tao Fu Xu-Ling Xu Tao Su Mei-Mei Gao Shumin Duan Yan Luo Yue-Sheng Long | 2019 | Journal of Molecular Cell Biology2019，11，2： | 0 |
| 12 | cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors显示文摘cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net. | Fan Wang Wenjie Sun Lei Chang Kefang Sun Leying Hou Linna Qian Chaoyin Jin Jiandong Chen Jiali Pu Panmeng Ye Shuang Qiu Jianhong Luo Shumin Duan Baorong Zhang Zhihua Gao Xiaojun Hu | 2021 | Neuroscience Bulletin2021，37，10： | 0 |
| 13 | Adult tiger beetles Cicindela gemmata modify their foraging strategy in different hunting contexts显示文摘Predator–prey interaction has long been an interesting item in the research of animal behaviors.Given that live prey can damage their predators,predators must trade foraging efficiency for safety while hunting,but the extent of this trade-off is not yet clear.Tiger beetles display diversity in their diets and hunting strategies,and hence,they become an ideal system to address how self-security affects foraging efficiency.We addressed this question in captive adult tiger beetles Cicindela gemmata.By offering several types of arthropod and plant foods,we confirmed that C.gemmata is carnivorous.We found that C.gemmata hunt by either ambushing or chasing their prey,and that they switch between strategies based on differences in the number of prey,the prey status and encounter rate,and the number of predators.Ambushing success increased with the number of prey but decreased with prey encounter rate.Chasing success decreased as prey body size and encounter rate increased.Foraging Cicindela gemmata often gave up an attack when it was nonfatal.This active giving up of hunting may be a consequence of a trade-off between foraging efficiency and self-security.Therefore,it is an adaptive response to the risk of injury when hunting for larger live prey. | Shumin Wang Panshuai Fei Zifeng Wu Zeyi Luo Yichen Wu Ningning Sun Yujie Wang Shumei Zi Lifang Gao Bo Du | 2023 | Insect Science2023，30，6： | 0 |
| 14 | High-performance supercapacitors based on Ni_(2)P@CNT nanocomposites prepared using an ultrafast microwave approach显示文摘We present a one-step route for the preparation of nickel phosphide/carbon nanotube(Ni_(2)P@CNT)nanocomposites for supercapacitor applications using a facile,ultrafast(90 s)microwave-based approach.Ni2P nanoparticles could grow uniformly on the surface of CNTs under the optimized reaction conditions,namely,a feeding ratio of 30:50:25 for CNT,Ni(NO_(3))_(2)-6H_(2)O,and red phosphorus and a microwave power of 1000 W for 90 s.Our study demonstrated that the single-step microwave synthesis process for creating metal phosphide nanoparticles was faster and simpler than all the other existing methods.Electrochemical results showed that the specific capacitance of the optimal Ni2P@CNT-nanocomposite electrode displayed a high specific capacitance of 854 F•g^(-1) at 1 A•g^(-1) and a superior capacitance retention of 84% after 5000 cycles at 10 Ag^(-1).Finally,an asymmetric supercapacitor was assembled using the nanocomposite with activated carbon as one electrode(Ni_(2)P@CNT//AC),which showed a remarkable energy density of 33.5 W•h•kg^(-1) and a power density of 387.5 W·kg^(-1).This work will pave the way for the microwave synthesis of other transition metal phosphide materials for use in energy storage systems. | Yunrui Tian Haishun Du Shatila Sarwar Wenjie Dong Yayun Zheng Shumin Wang Qingping Guo Jujie Luo Xinyu Zhang | 2021 | Frontiers of Chemical Science and Engineering2021，15，4： | 0 |
| 15 | The effect of Bi composition on the electrical properties of InP1-xBix显示文摘Ⅲ-ⅤSemiconductors containing a small amount of Bi,known as dilute bismides,have attracted great interest in recent years,due to the large band-gap reduction and other unique properties[1,2].Previous studies have been primarily focused on the growth and optical properties of the GaAs-based bismuthides[3],while the properties of other dilute bismides are less well understood.Berding et al.[4]theoretically predicted that InPBi is expected to be | GuanNan Wei Xing Dai Qi Feng WenGang Luo YiYang Li Kai Wang LiYao Zhang WenWu Pan ShuMin Wang ShenYuan Yang KaiYou Wang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 0 |
| 16 | Erratum to: The effect of Bi composition on the electrical properties of InP1-xBix [Sci. China-Phys. Mech. Astron. 60, 047022 (2017)]显示文摘 | GuanNan Wei Xing Dai Qi Feng WenGang Luo YiYang Li Kai Wang LiYao Zhang WenWu Pan ShuMin Wang ShenYuan Yang KaiYou Wang | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，5： | 0 |
| 17 | 颞叶癫痫继发性全身性大发作与下托脑区特异性地存在异常去极化信号通路相关显示文摘文章简介癫痫是一种常见的中枢神经系统疾病,以脑内同步化放电引起的反复且突发性的发作为特征。经典学说认为癫痫发作是由于脑内兴奋—抑制失衡理论引起,因此临床上常用增强脑内抑制性功能的药物治疗癫痫。 | Yi Wang Cenglin Xu Zhenghao Xu Caihong Ji Jiao Liang Ying Wang Bin Chen Xiaohua Wu Feng Gao Shuang Wang Yi Guo Xiaoming Li Jianhong Luo Shumin Duan 陈忠 | 2018 | 科学新闻2018，0，4： | 0 |
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