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| 1 | Impact of microbubble enhanced, pulsed, focused ultrasound on tumor circulation of subcutaneous VX2 cancer显示文摘 | Li Peijing Zhu Mei Xu Yali Zhao Yang Gao Shunji Liu Zheng Gao Yun-hua | 2014 | Chinese Medical Journal2014，，14： | 6 |
| 2 | Magnetic properties of perpendicularly orientated L1_0 FePt nanoparticles显示文摘L10 FePt films were deposited on MgO (001) substrates heated to 700°C by magnetron sputtering.Assisted by the misfit of lattice between film and substrate,strong (001) texture was formed.The film at nominal thickness t N=5 nm was composed of nanoparticles with a size of~70 nm,and showed a high coercivity of~105 kOe at 4.2 K.At t N=~50 nm,as the film changed from discontinuous to continuous,the coercivity dropped about one order of magnitude.Micromagnetic simulation implies that the magnetization reversal is a vortex-like nuclear type.The ideal coercivity of a separated single-domain L10 FePt nanoparticle with a size of 70 nm×70 nm×5 nm is~121 kOe.This tells us that the experimental coercivity has nearly reached the limit of ideal single crystalline nanoparticles. | MO XiaoJing XIANG Hui LI GuoQing CHEN Peng XIONG ZuHong WANG JunZhong ISHIO ShunJi SMTO Hitoshi SHIMA ToshiYuki TAKANASHI KoKi | 2010 | Chinese Science Bulletin2010，55，8： | 3 |
| 3 | The characteristics of recycling gas drilling technology显示文摘Recycling gas drilling is a new drilling technology. This paper can be divided into three parts, with the purpose of introducing and analyzing the characteristics of this new technology. First, the major equipment characteristic of this technology was introduced. Secondly, compared with conventional gas drilling, Angel's model was used to analyze the wellbore flow characteristics. Due to the closed loop and the effect of back pressure caused by the equipment, the gas flow rate decreases dramatically during drilling. Apart from this, it is also found that the kinetic energy at the casing shoe is always smaller than that at the top of the collar. The proposing of the drilling limit concept points out the basic difference between the two gas drilling technologies. Lastly, according to the results of the theoretical analysis, gas supplement operations for the wellbore must be conducted. Thus, two gas supplement schemes are presented in this paper, to provide some guidance for field operations. | Yang Shunji Liu Gonghui Li Jun | 2012 | Petroleum Science2012，9，1： | 3 |
| 4 | Grain in- terface modification and magnetic properties of Nd-Fe-B sin- tered magnets 显示文摘 | Deshan Li Shunji Suzuki Takashi Kawasaki | 2008 | Japanese Journal of Applied Physics2008，47，10： | 1 |
| 5 | Genetically engineered bacterial-like particles induced specific cellular and humoral immunity as effective tick-borne encephalitis virus vaccine显示文摘Tick-borne encephalitis(TBE)is a natural focal disease with fatal encephalitis induced by tick-borne encephalitis virus(TBEV),seriously threatening human and public health.Protection of TBE depends on vaccination with inactivated vaccine,which requires high cost and multiple immunizations.Here,we construct genetically engineered bacterial-like particles(BLPs)as an effective TBEV vaccine with simplified immunizations and improved immune efficacy.The TBEV BLPs involve the combination of the gram-positive enhancer matrix from Lactococcus lactis,and TBEV envelope(E)protein expressed by genetically engineered recombinant baculovirus.The prepared TBEV BLPs can effectively stimulate the activation of dendritic cells to present the TBEV E proteins to T and B cells,leading to strong and durable cellular and humoral immune responses in mice.Surprisingly,the serum levels of specific IgG antibodies in mice remain about 10^(6)at 6 months after the secondary immunization.Overall,the TBEV BLPs can be used as a potent vaccine candidate,laying the foundation for developing novel TBEV genetically engineered vaccines. | Mengyao Zhang Hongli Jin Yuanyuan Li Cuicui Jiao Pei Huang Yujie Bai Zhiyuan Gong Haili Zhang Shunjie Liu Hualei Wang | 2023 | Aggregate2023，4，3： | 1 |
| 6 | Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway显示文摘Excessive exposure to UVB induces skin diseases.Silibinin,a flavonolignan used for treating liver diseases,is found to be effective against UVB-caused skin epidermal and dermal cell damage.In this study we investigated the molecular mechanisms underlying.Human nonmalignant immortalized keratinocyte HaCaT cells and neonatal human foreskin fibroblasts HFFs were exposed to UVB irradiation.We showed that pre-treatment with silibinin dose-dependently decreased UVB-induced apoptosis of HaCaT cells.Furthermore,we showed that silibinin treatment inhibited nuclear translocation of YAP after UVB irradiation.Molecular docking analysis and DARTS assay confirmed the direct interaction of silibinin with YAP.Silencing YAP by siRNA had no influence on the survival of HaCaT cells,whereas inhibiting classical YAP-TEAD signaling pathway by siRNA targeting TEAD1 or its pharmaceutical inhibitor verteporfin further augmented UVB-induced apoptosis,suggesting that YAP-TEAD pathway was prosurvival,which did not participate in the protective effect of silibinin.We then explored the pro-apoptotic YAP-p73 pathway.p73 was upregulated in UVB-irradiated cells,but reduced by silibinin cotreatment.The mRNA and protein levels of p73 target genes(PML,p21 and Bax)were all increased by UVB but decreased by silibinin co-treatment.Inhibiting p73 by using siRNA reduced UVB-induced apoptosis,suggesting that downregulation of p73 was responsible for the cytoprotective effect of silibinin.In HFFs,the upregulated YAP-p73 pathway by UVB irradiation was also suppressed by silibinin.Collectively,YAP-p73 pathway is a major cause of the death of UVB-exposed epidermal HaCaT cells and dermal HFFs.Silibinin directly inhibits YAP-p73 pathway,exerting the protective action on UVB-irradiated skin cells. | Wei-wei Liu Fang Wang Can Li Xiao-yu Song Wuxiyar Otkur Yu-ying Zhu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima | 2022 | Acta Pharmacologica Sinica2022，43，8： | 1 |
| 7 | prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish显示文摘Prpf4(pre-mRNA processing factor 4),a key component of spliceosome,plays critical roles in pre-mRNA splicing and its mutations result in retinitis pigmentosa due to photoreceptor defects.In this study,we characterized a zebrafishharboring a Tol2 transposon-based gene trap cassette in the third intron of the prpf4 gene.Cells in the brain and spinal cord gradually undergo p53-dependent apoptosis after 28 hpf insuggesting that a widespread function of prpf4 in neural cell survival.In addition,prpf4 is essential for survival of posterior lateral line primordial(pLLP)cells.prpf4 deficiency perturbs Fgf,and chemokine signaling pathways and impairs pLLP migration.RNA-Seq analysis suggests that prpf4 deficiency may impair spliceosome assembly,leading to compensatory upregulation of core spliceosomal genes and alteration of pre-mRNA splicing.Taken together,our studies uncover an essential role of prpf4 in pre-m RNA splicing,cell survival and pLLP migration. | Yixia Wang Yanchao Han Pengfei Xu Shihui Ding Guangyuan Li Hongbin Jin Yaping Meng Anming Meng Shunji Jia | 2018 | Journal of Genetics and Genomics2018，45，8： | 1 |
| 8 | Analysis and Development Proposals of Aronia mealnocarpa Planting Industry in Heilongjiang Province显示文摘Aornial mealnocarpa Elliot is a rare tree species that combined edible,medicinal,ornamental and ecological values. This article analyzes the economic value,domestic research and development status and development trend of A. mealnocarpa. Heilongjiang Province has been hurried to introduce A. mealnocarpa,lack of understanding of the characteristics of the tree species,resulting in serious cold damage and great economic losses. For these issues,proposals are put forward to promote the development of A. mealnocarpa planting industry. | Shunjie ZHANG Jinguang ZHAO Chenyang XIE Ming TAN Hui LI | 2018 | Asian Agricultural Research2018，10，8： | 1 |
| 9 | Determination of Total Flavonoids in Acanthopanax senticosus(Rupr. et Maxim.) Harms by Enzymolysis and Its Technological Optimization显示文摘In order to optimize the ultrasonic extraction technique for the total flavonoid of leaf yellows plus, the contents of 21 leaf yellows plus total flavonoid from four regions in Heilongjiang Province were comparatively analyzed. The ultrasonic extraction technology was optimized by Box-Behnken response surface method, and the total flavonoid content of 21 kinds of Acanthopanax senticosus(Rupr. et Maxim.) Harms from different producing areas were analyzed by cluster analysis. The optimal process conditions were determined as ultrasonic time 30 min, solid-liquid ratio 1 : 12 and ultrasonic power 250 W, and the average yield of the total flavonoid was 1.453 mg·g^ (-1). By optimizing the ultrasonic-assisted extraction method, the total flavonoid content from different producing areas was compared in the experiment, which provided certain data support for the optimization of the extraction process in the future and laid a certain theoretical foundation for the quality analysis of Chinese medicinal materials. | Li Xinzhi Wang Yudan Wang Meiliang Liu Tianyang Gao Ruihua Qiu Youwen Zhang Shunjie | 2024 | Journal of Northeast Agricultural University(English Edition)2024，31，1： | 0 |
| 10 | In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy显示文摘The copper(Ⅱ)diethyldithiocarbamate(Cu(DDC)2)complex exhibited excellent inhibition to cancer cells.The usual administration is intravenous injection for disulfram and oral for copper.A new strategy was reported to improve the administration efficiency of the Cu(DDC)2 drug.Poly(lactide-co-glycolide)(PLGA)nanoparticles were used to trap disulfram and copper gluconate separately,the two types of drug loaded nanoparticles were injected in mesothelioma-bearing nude mice via intraperitoneal injection.The in vivo formation of Cu(DDC)2 complex was induced by disulfiram and Cu^2+ released from PLGA nanoparticles.This stra tegy avoided many obstacles in the use of Cu(DDC)2 complex as chemothe rapeutic and exhibited excellent anticancer activity to mesothelioma. | Yixin Zhang Shunjie Ding Junhua Li Xinyu Peng Jing Li Jing Chang Wenxia Gao Bin He | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 11 | Temporospatial inhibition of Erk signaling is required for lymphatic valve formation显示文摘Intraluminal lymphatic valves(LVs)and lymphovenous valves(LVs)are critical to ensure the unidirectional flow of lymphatic fluid.Morphological abnormalities in these valves always cause lymph or blood reflux,and result in lymphedema. | Yaping Meng Tong Lv Junfeng Zhang Weimin Shen Lifang Li Yaqi Li Xin Liu Xing Lei Xuguang Lin Hanfang Xu Anming Meng Shunji Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 12 | Cyclic(Amino)(Aryl)Nitrenium Cations with Lewis Acidity Controlled by Remote Substituents显示文摘N-Heterocyclic nitrogen Lewis acids are important in synthetic chemistry.Stable cyclic(amino)(aryl)nitrenium cations,cyc-1^(+)-cyc-3^(+),were synthesized by chemical oxidation of aryl azo compounds with different substituents,H and I,at the para positions of the phenyl group.The excited triplet states of cyc-1^(+)-cyc-3^(+) abstract H-atoms step by step to generate radical intermediates cyc-1H^(*+-)cyc-3H^(*+)traced by EPR spectroscopy and products cyc-1H^(2+)-cyc-3H^(2+) characterized by single crystal X-ray diffraction.The Lewis acidity of species cyc-1^(+)-cyc-3^(+) are remote substituent-dependent.Cyc-2^(+)-cyc-3^(+) have much higher acidity than those previously reported congeners based on energies of LUMOs.The electrophilicity enables them to form Lewis adducts with neutral Lewis base Me_(3)P,and to gain one-electron to produce neutral radicals cyc-1^(*)-cyc-3^(*). | Wenqing Wang Xin Zheng Leran Zhang Shunjie Li Yue Zhao Xinping Wang | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 13 | Organic near-infrared photodetectors with photoconductivityenhanced performance显示文摘Organic near-infrared(NIR)photodetectors with essential applications in medical diagnostics,night vision,remote sensing,and optical communications have attracted intensive research interest.Compared with most conventional inorganic counterparts,organic semiconductors usually have higher absorption coefficients,and their thin active layer could be sufficient to absorb most incident light for effective photogeneration.However,due to the relatively poor charge mobility of organic materials,it remains challenging to inhibit the photogenerated exciton recombination and effectively extract carriers to their respective electrodes.Herein,this challenge was addressed by increasing matrix conductivities of a ternary active layer(D–A–D structure NIR absorber[2TT-oC6B]:poly(N,N′-bis-4-butylphenyl-N,N′-bisphenyl)benzidin[PolyTPD]:[6,6]-phenyl-C61-butyric acid methyl ester[PCBM]=1:1:1)upon in situ incident light illumination,significantly accelerating charge transport through percolated interpenetrating paths.The greatly enhanced photoconductivity under illumination is intrinsically related to the unique donor–acceptor molecular structures of PolyTPD and 2TT-oC6B,whereas stable intermolecular interaction has been verified by systematic molecular dynamics simulation.In addition,an ultrafast charge transfer time of 0.56 ps from the NIR aggregation-induced luminogens of 2TT-oC6B absorber to PolyTPD and PCBM measured by femtosecond transient absorption spectroscopy is beneficial for effective exciton dissociation.The solution-processed organic NIR photodetector exhibits a fast response time of 83μs and a linear dynamic range value of 111 dB under illumination of 830 nm.Therefore,our work has opened up a pioneering window to enhance photoconductivity through in situ photoirradiation and benefit NIR photodetectors as well as other optoelectronic devices. | Siwei Zhang Zhenlong Li Jingzhou Li Bingzhe Wang Fang Chen Xubiao Li Shunjie Liu Jacky W.Y.Lam Guichuan Xing Jiangyu Li Zheng Zhao Feiyu Kang Guodan Wei Ben Zhong Tang | 2023 | Aggregate2023，4，5： | 0 |
| 14 | The second polar body contributes to the fate asymmetry in the mouse embryo显示文摘The polar bodies(PBs)are extruded microcells during oocyte meiosis and generally regarded as inessentials for embryonic development.Therefore,PBs have been widely used as important materials for pre-implantation genetic diagnosis in human.Here we report that the second PB(PB2)in the mouse zygote may play roles in cell-fate specification and post-implantation development.A subset of mRNAs encoding pluripotency-related factors are enriched in PB2.Nascent proteins may be synthesized in PB2 after fertilization and transport from PB2 to the zygote before the two-cell stage.The PB2-attached blastomere(pbB)at the two-cell stage,compared to the other blastomere(npbB),likely contributes more descendants to the inner cell mass(ICM)lineage in the blastocyst.Removal of PB2 from the zygote or transient blockage of material exchange between PB2 and the zygote by nocodazole treatment appears to cause a loss of the ICM fate bias of pbB.PB2 removal or nocodazole treatment also results in abnormal post-implantation development.Injection of PB2 lysate into pbB of PB2-removed two-cell-stage embryos may reset the cell-fate preference and rescue post-implantation development.Our data collectively suggest that PB2 would demarcate the earliest cell-fate asymmetry of the mouse zygote and be required for post-implantation development. | Hongbin Jin Yang Han Huasong Wang J.Xiao He Li Weimin Shen Lin Zhang Luxi Chen Shunji Jia Ping Yuan Hui Chen Anming Meng | 2022 | National Science Review2022，9，7： | 0 |
| 15 | Effect of Phosphor Addition on Intergranular Exchange Coupling of Co-Pt Thin Films显示文摘In this paper, ternary Co-Pt-P thin films were prepared by magnetron sputtering with platinum and home-made Co-P chips pasted on the cobalt target. The structure and magnetic properties were investigated by X-ray diffraction (XRD) and vibrating sample magnetometer (VSM), respectively. With increasing phosphor content, the coercivities of Co-12 at.% Pt-P films increase from 1034 to 1525 Oe owing to the exchange decoupling among magnetic grains. The decrease of inter-granular exchange coupling was confirmed by delta-M curve measurement and magnetic force microscopy (MFM). Transmission electronic microscopy (TEM) with nano- beam composition analysis shows that phosphor segregated at cobalt-based grain boundaries is responsible for the exchange decoupling. It is thus suggested that the phosphor addition is e?ective to tune the exchange coupling of magnetic grains, particularly for perpendicular recording media. | Bo Yang Gaowu Qin Wenli Pei Song Li Yuping Ren Shunji Ishio | 2011 | Journal of Materials Science & Technology2011，27，5： | 0 |
| 16 | Fgf8^(P2A-3×GFP/+):A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells显示文摘The cochlear auditory epithelium contains two types of sound receptors,inner hair cells(IHCs)and outer hair cells(OHCs).Mouse models for labelling juvenile and adult IHCs or OHCs exist;however,labelling for embryonic and perinatal IHCs or OHCs are lacking.Here,we generated a new knock-in Fgf8^(P2A-3×GFP/+)(Fgf8^(GFP)/+)strain,in which the expression of a series of three GFP fragments is controlled by endogenous Fgf8 cis-regulatory elements.After confirming that GFP expression accurately reflects the expression of Fgf8,we successfully obtained both embryonic and neonatal IHCs with high purity,highlighting the power of Fgf8^(GFP)/+.Furthermore,our fate-mapping analysis revealed,unexpectedly,that IHCs are also derived from inner ear progenitors expressing Insm1,which is currently regarded as an OHC marker.Thus,besides serving as a highly favorable tool for sorting early IHCs,Fgf8^(GFP)/+will facilitate the isolation of pure early OHCs by excluding IHCs from the entire hair cell pool. | Yi Pan Shuting Li Shunji He Guangqin Wang Chao Li Zhiyong Liu Mingliang Xiang | 2023 | Neuroscience Bulletin2023，39，12： | 0 |
| 17 | A time-coded multi-concentration microfluidic chemical waveform generator for high-throughput probing suspension single-cell signaling显示文摘The cellular response to the complex extracellular microenvironment is highly dynamic in time and type of extracellular matrix.Accurately reconstructing this process and analyzing the changes in receptor conformation on the cell membrane surface and intracellular or intercellular signaling has been a major challenge in analytical chemistry and biophysical methodology.In this paper,a time-coded multiconcentration microfluidic chemical waveform generator was developed for the dynamic signaling probing with single-cell array of high temporal resolution,high throughput,and multi-concentration combination stimulation.Based on innovative microchannel structure,sophisticated external control methods and multiplexing technology,the system not only allowed for temporally sequential permutations of the four concentrations of stimuli(time code),but also generated pulsed and continuous waveforms at different frequencies in a highly controllable manner.Furthermore,the single-cell trap array was set up to efficiently capture cells in suspension,dramatically increasing throughput and reducing experiment preparation time.The maximum frequency of the platform was 1 Hz,and one cell could be stimulated at multiple frequencies.To show the ability of the system to investigate rapid biochemical events in high throughput,pulse stimulation and continuous stimulation of different frequencies and different time codes,combined with four concentrations of histamine(HA),were generated for probing G protein-coupled receptor(GPCR)signaling in He La cells.Then,statistical analysis was performed for the mean peak height and mean peak area of the cellular response.We believe that the time-coded multi-concentration microfluidic chemical waveform generator will provide a novel strategy for analytical chemistry,biophysics,cell signaling,and individualized medicine applications. | Yiran Guo Peng Chen Zhaolong Gao Yiwei Li Shunji Li Xiaojun Feng Bi-Feng Liu | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 18 | BER Performance of Frequency Domain Differential Demodulation OFDM in Flat Fading Channel显示文摘A closed form expression for the bit error rate (BER) performance of frequency domaindifferential demodulation(FDDD) for orthogonal frequency division multiplexing system in flat fadingchannel is derived.The performance is evaluated by computer simulation and compared with the timedomain differential demodulation(TDDD).The results indicate that the performance of FDDD is betterthan that of TDDD,and the lower band of BER in the former is lower than that of the latter. | SONG Lijun TANG Youxi LI Shaoqian HUANG Shunji(National Key Laboratory of Communication,UESTC Chengdu 610054 China) | 2003 | Journal of Electronic Science and Technology of China2003，1，1： | 0 |
| 19 | Comparative study of the adsorption performance of NH_(2)-functionalized metal organic frameworks with activated carbon composites for the treatment of phenolic wastewaters显示文摘To better understand the role of the-NH_(2)group in adsorption process of phenolic wastewaters,NH_(2)-functionalized MIL-53(Al)composites with activated carbon(NH_(2)-M(Al)@(B)AC)were prepared.The results showed that the-NH_(2)group could increase the mesopore volume for composites,which promotes mass transfer and full utilization of active sites,because hierarchical mesopore structure makes the adsorbent easier to enter the internal adsorption sites.Furthermore,the introduction of the-NH_(2)group can improve the adsorption capacity,decrease the activation energy,and enhance the interaction between the adsorbent and p-nitrophenol,demonstrating that the-NH_(2)group plays a crucial role in the adsorption of p-nitrophenol.The density functional theory calculation results show that the H-bond interaction between the-NH_(2)group in the adsorbent and the-NO_(2)in the p-nitrophenol(adsorption energy of -35.5 kJ·mol^(-1)),and base-acid interaction between the primary-NH_(2)group in the adsorbent and the acidic-OH group in the p-nitrophenol(adsorption energy of -27.3 kJ·mol^(-1))are predominant mechanisms for adsorption in terms of the NH_(2)-functionalized adsorbent.Both NH_(2)-functionalized M(Al)@AC and M(Al)@BAC composites exhibited higher p-nitrophenol adsorption capacity than corresponding nonfunctionalized composites.Among the composites,the NH_(2)-M(Al)@BAC had the highest p-nitrophenol adsorption capacity of 474 mg·g^(-1). | Bolong Jiang Shunjie Shi Yanyan Cui Jiayou Li Nan Jiang Yanguang Chen | 2023 | Chinese Journal of Chemical Engineering2023，63，11： | 0 |
| 20 | Influence of gelator structures on formation and stability of supramolecular hydrogels显示文摘超分子的水疗院胶化(定义为 G1 ) 从 1,2,4,5 苯 tetracarboxylic 酸(BTCA ) 形成了, 2-amino-3-hydroxypyridine 比另一水疗院胶化的拥有了更高的 Tgel (定义为 G2 ) 从 BTCA 和 3-hydroxypyridine 形成了。由 1H NMR,红外和 XRD 基于他们的 xerogels 的分析, G1 的更高的稳定性被归因于剩菜提高的更强壮的氢绑定的形成惊讶 2-amino-3-hydroxypyridine 的氨基的组。 | Shunji Kono Yu Jiang Wang Li Ming Tang | 2007 | Chinese Chemical Letters2007，18，12： | 0 |
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