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| 1 | Hydrocarbon generation characteristics and exploration prospects of Proterozoic source rocks in China显示文摘A large number of primary oil and gas reservoirs have been discovered in Proterozoic strata all over the globe.Proterozoic sequences are widely distributed in China, and the discovery of large Sinian-aged gas reservoirs in the Sichuan Basin and Mesoproterozoic liquid oil seepages in North China shows that attention should be paid to the exploration potential of Proterozoic strata. In this paper, the main controlling factors of Proterozoic source rocks are discussed. Principally, active atmospheric circulation and astronomical cycles may have driven intense upwelling and runoff to provide nutrients; oxygenated oceanic surface waters could have provided suitable environments for the organisms to thrive; volcanic activity and terrestrial weathering caused by continental break-up would have injected large amounts of nutrients into the ocean, leading to persistent blooms of marine organisms; and extensive anoxic deep waters may have created ideal conditions for the preservation of organic matter. Additionally, the appearance of eukaryotes resulted in diversified hydrocarbon parent material, which effectively improved the generation potential for oil and gas. Through the comparison of Formations across different cratons, seven sets of Proterozoic organic-rich source rocks have been recognized in China, which mainly developed during interglacial periods and are also comparable worldwide. The Hongshuizhuang and Xiamaling Formations in North China have already been identified previously as Mesoproterozoic source rocks. The early Proterozoic Changchengian System is highly promising as a potential source rock in the Ordos Basin. In the Upper Yangtze area, the Neoproterozoic Datangpo and Doushantuo Formations are extensively distributed, and represent the major source rocks for Sinian gas reservoirs in the Sichuan Basin. Moreover, the Nanhuan System may contain abundant shales with high organic matter contents in the Tarim Basin, although this possibility still needs to be verified. Indeed, all three cratons may contain source rocks of Proterozoic strata; thus, these strata represent major exploration targets worthy of great attention. | Wenzhi ZHAO Xiaomei WANG Suyun HU Shuichang ZHANG Huajian WANG Shuwei GUAN Yuntao YE Rong REN Tongshan WANG | 2019 | Science China Earth Sciences2019，62，6： | 9 |
| 2 | Large-scale evaluation of pea(Pisum sativum L.)germplasm for cold tolerance in the field during winter in Qingdao显示文摘As a cool-season crop, pea(Pisum sativum L.) can tolerate frost at the vegetative stage but experiences yield loss when freezing stress occurs at the reproductive stage. Cold-tolerance improvement of pea varieties is important for stable yield and expansion of the winter pea planting area. Under natural low-temperature conditions during winter in Qingdao,Shandong, China, we evaluated the cold tolerance of 3672 pea germplasm accessions in the field and categorized them as displaying high resistance(214), moderate resistance(835), or susceptibility(2623). The highly and moderately resistant genotypes were validated in the following year. We found that genotypes from the winter production region showed higher cold tolerance than genotypes from the spring production region. The accessions identified as having high levels of cold tolerance are recommended as potential genetic resources in cold-tolerance breeding of pea. | Xiaoyan Zhang Shuwei Wan Junjie Hao Jinguo Hu Tao Yang Xuxiao Zong | 2016 | The Crop Journal2016，4，5： | 2 |
| 3 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 4 | Influence of tribofilm on superlubricity of highly-hydrogenated amorphous carbon films in inert gaseous environments显示文摘In this study,we mainly focus on the structural morphology and inter-atomic bonding state of tribofilms resulting from a highly-hydrogenated amorphous carbon(a-C:H) film in order to ascertain the underlying mechanisms for its superlubric behavior(i.e.,less than 0.01 friction coefficient).Specifically,we achieved superlubricity(i.e.,friction coefficients of down to 0.003) with this film in dry nitrogen and argon atmospheres especially when the tribo-pair is made of an a-C:H coated Si disk sliding against an a-C:H coated steel ball,while the a-C:H coated disk against uncoated ball does not provide superlubricity.We also found that the state of superlubricity is more stable in argon than in nitrogen and the formation of a smooth and uniformly-thick carbonaceous tribofilm appears to be one of the key factors for the realization of such superlubricity.Besides,the interfacial morphology of sliding test pairs and the atomic-scale bond structure of the carbon-based tribofilms also play an important role in the observed superlubric behavior of a-C:H films.Using Raman spectroscopy and high resolution transmission electron microscopy,we have compared the structural differences of the tribofilms produced on bare and a-C:H coated steel balls.For the a-C:H coated ball as mating material which provided superlow friction in argon,structural morphology of the tribofilm was similar or comparable to that of the original a-C:H coating;while for the bare steel ball,the sp^2-bonded C fraction in the tribofilm increased and a fingerprint-like nanocrystalline structure was detected by high resolution transmission electron microscopy(HRTEM).We also calculated the shear stresses for different tribofilms,and established a relationship between the magnitude of the shear stresses and the extent of sp^3-sp^2 phase transformation. | LIU ShuWei ZHANG ChenHui OSMAN Eryilmaz CHEN XinChun MA TianBao HU YanZhong LUO JianBin ALI Erdemir | 2016 | Science China(Technological Sciences)2016，59，12： | 2 |
| 5 | Growth of SiC as Binder to Adhere Diamond Particle and Tribological Properties of Diamond Particles Coated SiC显示文摘The purpose of this work was to grow SiC as binder to adhere diamond particles to graphite substrate by low pressure chemical vapor deposition(LPCVD) at 1100 °C and 100 Pa using methyltrichlorosilane(MTS: CH3 SiCl3) as precursor. The composite coatings on graphite substrates were analyzed by various techniques. Results show that a dense SiC coating with a cloud-cluster shape was formed both on the diamond particles and the substrate after deposition. The thermal stress(290.6 MPa) strengthened the interfacial bonding between the diamond particle and the SiC coating, which is advantageous for the purpose of adhering diamond particles to graphite substrate. The applied load of sliding wear test was found to affect not only the friction coefficient, but also the wear surface morphology. With increasing loads, the asperity penetration was high and the friction coefficient decreased. | Shengjie Yu Zhaofeng Chen Yang Wang Shuwei Hu Ruiying Luo Sheng Cui | 2015 | Journal of Materials Science & Technology2015，31，11： | 1 |
| 6 | β-delayed proton decay of89Ru显示文摘 | Zhankui Li Shuwei Xu Yong Yu Yuanxiang Xie Chunfang Wang Jianping Xing Qiangyan Pan Qingyuan Hu Shihong Li Hongyan Chen Tianmei Zhang | 2000 | Science in China Series A: Mathematics2000，，12： | 1 |
| 7 | Single-Molecule Sequencing Assists Genome Assembly Improvement and Structural Variation Inference显示文摘 | Yan, Jun Lv, Shuwei Hu, Min Gao, Zhaoxu He, Hang Ma, Qingwei Deng, Xing Wang Zhu, Zuofeng Wang, Xiangfeng | 2016 | Molecular Plant2016，9，7： | 1 |
| 8 | 进一步落实七项措施促进上海港国际集装箱转运的发展显示文摘In an effort to speed up the construction of shanghai international shipping center,shanghai port has introduced seven measures to promote the transshipment of international containers via shanghai port.now these measures have been put into practice step by step while there is still much work to do. | by Hu Shuwei ( Shanghai Maritine University Shanghai 200135) | 1998 | 集装箱化1998，，3： | 0 |
| 9 | Internal friction peak associated with dislocations in Mg-0.6%Zr alloy显示文摘The internal friction(IF) of Mg-0.6%Zr alloy is measured in the present study and two IF peaks of(P 1(97 C,1 Hz) and P 2(230 C,1Hz) ) are found,respectively.It is shown that the novel P 1 peak is frequency independent and the peak temperature increased with the increase of strain amplitude or heating rate.P 1 peak could be repressed by the reheating-up measurements and represented by heat treatment.The mechanism of P 1 peak is clarified by optical microscope(OM) and transmission electron microscope(TEM) observation,and considered to be caused by the creation and expansion of dislocations during plastic deformation.The P 2 peak is a thermally activated relaxation IF peak,and activation energy is 1.46 eV,which is caused by the relaxation of the grain boundaries in Mg-0.6%Zr alloy. | Shuwei LIU Xiaofeng HU Haichang JIANG Xiuyan LI Lijian RONG | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，5： | 0 |
| 10 | Microstructure, mechanical properties and deformation characteristics of Al-Mg-Si alloys processed by a continuous expansion extrusion approach显示文摘In the present work,a double-pass continuous expansion extrusion forming(CEEF) process was proposed for an Al-Mg-Si alloy,in which the diameter of rods was gradually expanded.The microstructural evolution,mechanical properties and deformation characteristics were investigated by utilizing microstructural observations,mechanical testing and a finite element method coupled with a cellular automata model.The results showed that the strength and ductility of the double-pass CEEF processed Al-Mg-Si alloys were improved synchronously,especially in artificially aged alloys.The grain size of the processed Al-Mg-Si alloy rods was refined remarkably by continuous dynamic recrystallization(CDRX)and geometric dynamic recrystallization(GDRX),and the homogeneity of microstructure was gradually improved with increasing number of processing passes.The artificially aged alloy processed with double-pass CEEF and water quenching contained fine(sub)grains and high-density dislocations,which resulted in more needle-shaped β' precipitates and a larger precipitate aspect ratio than the as-received and air-cooled CEEF alloys owing to the different precipitation kinetics.The severe cumulate strain and microshear bands were found to accelerate CDRX and GDRX for grain refinement between adjacent positions of the parabolic metal flow due to the special temperature characteristics and la rge shear straining during the CEEF process. | Ruiqing Lu Shuwei Zheng Jie Teng Jiamin Hu Dingfa Fu Jianchun Chen Guodong Zhao Fulin Jiang Hui Zhang | 2021 | Journal of Materials Science & Technology2021，，21： | 0 |
| 11 | A randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients显示文摘Background:The calcineurin inhibitor(CNI)-based immune maintenance regimen that is commonly used after renal transplantation has greatly improved early graft survival after transplantation;however,the long-term prognosis of grafts has not been significantly improved.The nephrotoxicity of CNI drugs is one of the main risk factors for the poor long-term prognosis of grafts.Sirolimus(SRL)has been employed as an immunosuppressant in clinical practice for over 20 years and has been found to have no nephrotoxic effects on grafts.Presently,the regimen and timing of SRL application after renal transplantation vary,and clinical data are scarce.Multicenter prospective randomized controlled studies are particularly rare.This study aims to investigate the effects of early conversion to a low-dose CNI combined with SRL on the long-term prognosis of renal transplantation.Methods:Patients who receive four weeks of a standard regimen with CNI+mycophenolic acid(MPA)+glucocorticoid after renal transplantation in multiple transplant centers across China will be included in this study.At week 5,after the operation,patients in the experimental group will receive an additional administration of SRL,a reduction in the CNI drug doses,withdrawal of MPA medication,and maintenance of glucocorticoids.In addition,patients in the control group will receive the maintained standard of care.The patients’vital signs,routine blood tests,routine urine tests,blood biochemistry,serum creatinine,BK virus(BKV)/cytomegalovirus(CMV),and trough concentrations of CNI drugs and SRL at the baseline and weeks 12,24,36,48,72,and 104 after conversion will be recorded.Patient survival,graft survival,and estimated glomerular filtration rate will be calculated,and concomitant medications and adverse events will also be recorded.Conclusion:The study data will be utilized to evaluate the efficacy and safety of early conversion to low-dose CNIs combined with SRL in renal transplant patients. | Xiang Zheng Weijie Zhang Hua Zhou Ronghua Cao Zhangfei Shou Shuwei Zhang Ying Cheng Xuchun Chen Chenguang Ding Zuofu Tang Ning Li Shaohua Shi Qiang Zhou Qiuyuan Chen Gang Chen Zheng Chen Peijun Zhou Xiaopeng Hu Xiaodong Zhang Ning Na Wei Wang | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 12 | Striatum shape development of the human fetal brain in early second trimester显示文摘The striatum is the largest structure of the basal ganglia,receiving synaptic input from multiple regions including the neocortex,thalamus,external globus pallidus,and midbrain.One of its major roles is to integrate sensorimotor,associative and limbic information.The development and evolution of basal ganglia is one of the most fundamental and important questions in neuroscience.Here,we segmented the fetal striatum using 7.0T MR images from 46 specimens from 14 to 22 gestational weeks and revealed the developmental course of the fetal striatum using volume and shape analyses.The absolute volume of caudate nucleus(CN)was linearly expanded and moderate hemisphere effect was observed in the absolute volume of CN.While the relative volume had a nonlinear relationship with GW,and there was no obvious difference between hemispheres.Both absolute and relative volumes of the putamen showed linear expansion,and there was no obvious difference between hemispheres. | Tian Mimi Xu Feifei Zhang Zhonghe Hu Minqi Liu Shuwei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | MRI-based morphological analysis of the adult brainstem during aging显示文摘The brainstem is a critical structure that possesses numerous neural nuclei,regulates vital autonomic functions,and closely related to many neurological disorders.The morphological changes of brainstem can reflect the condition of nuclei and might be early biomarkers of neurological disorders.We used strict brainstem segmentation criteria to manually segment 1.5T MRI of 187 normal adults aged from 19 to 70.There are obvious atrophy of volume of midbrain and medulla oblongata during aging process,and the pons was hardly changed. | Hu Minqi Liu Shuwei Tang Yuchun | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 14 | Activating transcription factor 3,glucolipid metabolism,and metabolic diseases显示文摘Lipids and glucose exert many essential physiological functions,such as providing raw materials or energy for cellular biosynthesis,regulating cell signal transduction,and maintaining a constant body temperature.Dysregulation of lipid and glucose metabolism can lead to glucolipid metabolic disorders linked to various metabolic diseases,such as obesity,diabetes,and cardiovascular disease.Therefore,intervention in glucolipid metabolism is a key therapeutic strategy for the treatment of metabolic diseases.Activating transcription factor 3(ATF3)is a transcription factor that acts as a hub of the cellular adaptive-response network and plays a pivotal role in the regulation of inflammation,apoptosis,DNA repair,and oncogenesis.Emerging evidence has illustrated the vital roles of ATF3 in glucolipid metabolism.ATF3 inhibits intestinal lipid absorption,enhances hepatic triglyceride hydrolysis and fatty acid oxidation,promotes macrophage reverse cholesterol transport,and attenuates the progression of western diet-induced nonalcoholic fatty liver disease and atherosclerosis.In addition to its role in lipid metabolism,ATF3 has also been identified as an important regulator of glucose metabolism.Here,we summarize the recent advances in the understanding of ATF3,mainly focusing on its role in glucose and lipid metabolism and potential therapeutic implications. | Shuwei Hu Xiaojie Zhao Rui Li Chencheng Hu Huijuan Wu Jing Li Yanqiao Zhang Yanyong Xu | 2022 | Journal of Molecular Cell Biology2022，14，10： | 0 |
| 15 | Urgent Need of Continuing Medical Education:The Key for Patient Awareness of Labor Epidural Analgesia-A Survey of Chinese Perinatal Care Providers显示文摘Objective:This survey was designed to understand the misconceptions about labor epidurals.Methods:This voluntary and anonymous online survey on wenjuan.com was conducted from September 1st,2015 to January 1st,2016 via mainly WeChat groups dedicated to perinatal healthcare providers in China.The questionnaire included items inquiring the knowledge and opinions about labor epidural analgesia related to maternal complications,baby safety,and effect on laboring.Incomplete surveys were excluded from the data analysis.The data was presented as percentages and a Chi-square test or Fisher's exact test,as appreciate,was used to quantitatively compare the results.Results:A total of 1412 respondents completed surveys with 42.9%(606/1412)of them being anesthesiologists,35.1%(495/1412)being obstetricians,11.8%(167/1412)being midwives,3.7%(52/1412)being labor and delivery nurses,and 6.5%(92/1412)being hospital administrators and unspecified.The study revealed a lack of knowledge in labor pain control.Although 82.4%(1164/1412)of respondents were familiar with labor epidural analgesia,8.9%(126/1412)did not know how it works,and 1.1%(15/1412)never heard it in a multiple-choice question.The three main groups(anesthesiologists,obstetricians,and midwives/labor and delivery nurses)were chosen for comparisons.Opinions among these three groups concerning five questions in the three main concerns were evaluated using a statistical significance of P<0.05.Conclusion:The results in our survey indicated an urgent need of continuing medical education to multidisciplinary specialties to improve evidence-based medical practices as these misconceptions have existed for over 10 years in the medical professionals.Lack of public awareness fueled by misconceptions related to labor epidural analgesia may be associated with a lack of professional knowledge.Correct knowledge in professionals needs to be disseminated to the public in order to dispel possible misconceptions and rumors about labor epidural analgesia.This would not only enhance patient understanding of their care but also improve maternal,fetal,and neonatal outcomes. | Peishan Zhao Ling-Qun Hu Chunyuan Liu Huiling Li Anna Huang Shuwei Yang Zhenyu Cai | 2021 | Maternal-Fetal Medicine2021，3，3： | 0 |
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