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| 1 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 2 | Accelerated flow softening and dynamic transformation of Ti-6Al-4V alloy in two-phase region during hot deformation via coarsening αgrain显示文摘The flow softening is an important phenomenon during hot deformation of metallic materials.In the present work,a more evident flow softening of Ti-6 Al-4 V alloy when deformed in two-phase region was observed in coarser a grain sample,which was attributed to an accelerated dynamic transformation from harder α phase into β phases.Notably,full β microstructure was observed in coarse grain samples at strain of 1.2,while retained a phase was observed in fine a grain specimens.In the views of thermodynamics and crystallographic analysis,the in-depth mechanisms of dynamic transformation were further investigated. | Xiankun Ji Baoqi Guo Fulin Jiang Hong Yu Dingfa Fu Jie Teng Hui Zhang John J.Jonas | 2020 | Journal of Materials Science & Technology2020，36，1： | 5 |
| 3 | Effect of Konjac Food on Blood Glucose Level in Patients with Diabetes显示文摘Seventy-two type II diabetic subjects were given Konjac food for 65 days. The data analyzed by multiple F test indicate that the fasting blood glucose (FBG) and the 2-h postprandial blood glucose (PBG) on the 30th and the 65th days after the food was ingested were significantly reduced (P = 0.001, P < 0.001, respectively), as was the glycosylated hemoglobin level at the end of the trial (P < 0.05). The final FBG and PBG of the subjects with initial FBG-O >200 mg% decreased on the average by 51.8 and 84.6 mg%. respectively; those with FBG-0 150-200 mg% decreased by 24.1 and 68.7 mg%; and those with FBG-O < 150 mg% decreased by 4.8 and 21.4 mg%. No significant changes in blood lipid indexes were observed, except that the triglycer-ide values of subjects with hypertriglyceridemia (>200 mg%) significantly decreased by 118.7 mg%. It was concluded that Konjac food is very useful in the prevention and treatment of hyperglycemia. (C)1990 Academic Press. Inc. | HUANG CHENG-YU,~*ZHANG MAO-YU,~*PENG SHU-SHENG,~*HONG JUN-RONG,~*WANG XU,~*JIANG HUIJUN,~*ZHANG FULIN,~*BAI YUNXIANG,~*LIANG JINZHONG,Yu YERONG,LUO ZHAOTIAN,ZHANG XIANGXUN,AND ZHOU ZANCHENG~*School of Public Health, West China University of Medical Sciences (WCUMS). Chengdu, China Department of Endocrinology, First University Hospital of WCUMS, Chengdu, China and Staff Hospital of 107 Post Office Box, Chengdu, China | 1990 | Biomedical and Environmental Sciences1990，3，2： | 2 |
| 4 | Ribonuclease H-like gene SMALL GRAIN2 regulates grain size in rice through brassinosteroid signaling pathway显示文摘Grain size is a key agronomic trait that determines the yield in plants.Regulation of grain size by brassinosteroids(BRs)in rice has been widely reported.However,the relationship between the BR signaling pathway and grain size still requires further study.Here,we isolated a rice mutant,named small grain2(sg2),which displayed smaller grain and a semi-dwarf phenotype.The decreased grain size was caused by repressed cell expansion in spikelet hulls of the sg2 mutant.Using map-based cloning combined with a Mut Map approach,we cloned SG2,which encodes a plant-specific protein with a ribonuclease H-like domain.SG2 is a positive regulator downstream of GLYCOGEN SYNTHASE KINASE2(GSK2)in response to BR signaling,and its mutation causes insensitivity to exogenous BR treatment.Genetical and biochemical analysis showed that GSK2 interacts with and phosphorylates SG2.We further found that BRs enhance the accumulation of SG2 in the nucleus,and subcellular distribution of SG2 is regulated by GSK2 kinase activity.In addition,Oryza sativa OVATE family protein 19(OsOFP19),a negative regulator of grain shape,interacts with SG2 and plays an antagonistic role with SG2 in controlling gene expression and grain size.Our results indicated that SG2 is a new component of GSK2-related BR signaling response and regulates grain size by interacting with Os OFP19. | Yunshuai Huang Hui Dong Changling Mou Ping Wang Qixian Hao Min Zhang Hongmin Wu Fulin Zhang Tengfei Ma Rong Miao Kai Fu Yaping Chen Ziyan Zhu Cheng Chen Qikai Tong Zhuoran Wang Shirong Zhou Xi Liu Shijia Liu Yunlu Tian Ling Jiang Jianmin Wan | 2022 | Journal of Integrative Plant Biology2022，64，10： | 1 |
| 5 | A comparison of optical performance between evacuated collector tubes with flat end semicylindric absorbers显示文摘 | He Zinian Ge Hongehuan Jiang Fulin Li Wei | 1997 | Solar Energy1997，60，2： | 1 |
| 6 | Revealing the grain size dependent hot workability and deformation mechanisms in a Mg-Zn-Y alloy显示文摘Despite the industrial significance of grain size for enhancing mechanical properties and formability,the in-depth deformation mechanisms at elevated temperature are still unclear.To investigate the functions of grain size on hot workability and deformation mechanisms,three groups of Mg-1.2Zn-0.2Y alloy specimens with different grain sizes were hot compressed and then studied by combining constitutive model,processing map and microstructural observations.The results showed that the enhanced hot workability accompanying low deformation activation energy and small instability regime was obtained with refined grain size.During hot deformation,the decreased grain size in Mg1.2Zn-0.2Y alloy mainly improved the plastic deformation homogeneity,especially for the weakened local straining around grain boundaries.As a result,the dynamic recrystallization nucleation and texture development at lower strain level were influenced by the initial grain size.At higher strain magnitude,the growth and coarsening of dynamic recrystallized grains would further release strain localization and improve hot workability,while the texture was less impacted.Further,unlike the primary basal slip and deformation twinning in the specimen with coarse grain at low temperature,non-basal slips of dislocations were initiated with less deformation twins in the specimens with refined grain size. | Ruiqing Lu Zhiming Xu Fulin Jiang Shiwei Xu Dingfa Fu Hui Zhang Jie Teng | 2023 | Journal of Magnesium and Alloys2023，11，4： | 1 |
| 7 | Acomparison of optical performance between evacuated collector tubes with flat end semicylindric absorbers显示文摘 | He Zinian GeHongchuan Jiang Fulin etal | 1997 | Solar Energy1997，60，2： | 1 |
| 8 | Speed of disentanglement in multiqubit systems under depolarizing channel 显示文摘 | ZHANG Fulin JIANG Yue LIANG Mailin | 2013 | Annals of Physics2013，，： | 1 |
| 9 | Comparative hot deformation characters of Al–Mn–Mg–RE alloy and Al–Mn–Mg–RE–Ti alloy显示文摘 | Fulin Jiang Hui Zhang Xiankun Ji Xianna Meng Luoxing Li | 2014 | Materials Science & Engineering A2014，，： | 1 |
| 10 | Unravelling the precipitation evolutions of AZ80 magnesium alloy during non-isothermal and isothermal processes显示文摘The precipitation evolutions of Mg-Al-Zn alloys play essential roles in their mechanical properties,corrosion performance,formability,plastic deformation mechanisms and texture development.In the present work,the precipitation evolutions of AZ80 magnesium alloy during both non-isothermal and isothermal processes were unraveled by utilizing in situ electrical resistivity monitoring,hardness testing,differential scanning calorimetry and microstructural characterization.The results showed that discontinuous precipitation(DP)and continuous precipitation(CP)occurred competitively during non-isothermal and isothermal processes.The precipitation of dominantβ-Mg17 Al12 phase during non-isothermal processes was highly dependent on the thermal history.During isothermal processes,the precipitation behavior of AZ80 magnesium alloy could be considered as the functions of holding temperature and time.At lower temperatures,massive DP and CP were gradually formed to equally strengthen the alloy.At higher temperatures,the Ostwald coarsening was characterized in the later stages and indicated to slightly soften the alloy.Isothermal time-temperature-precipitation curves and quantitative precipitate evolution were estimated to unravel precipitation characteristics and their strengthening functions. | Longqing Tang Guowei Bo Fulin Jiang Shiwei Xu Jie Teng Dingfa Fu Hui Zhang | 2021 | Journal of Materials Science & Technology2021，，16： | 1 |
| 11 | Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008显示文摘 | Yipeng Sun Juan Pu Zhanlei Jiang Tao Guan Yingju Xia Qi Xu Linqing Liu Bo Ma Fulin Tian E.G. Brown Jinhua Liu | 2010 | Veterinary Microbiology2010，，3： | 1 |
| 12 | The kinetics of dy- namic and static softening during multistage hot deformation of 7150 aluminum alloy 显示文摘 | Jiang Fulin Zhang Hui Li Luoxing | 2012 | Materials Science and Engineering A2012，552，： | 1 |
| 13 | A comparison of optical performance between evacuated collector tubes with flat and semicylindric absorbers显示文摘 | He Zinian Ge Hongchuan Jiang Fulin | 1997 | Solar Energy1997，60，2： | 1 |
| 14 | Revealing the decomposition mechanisms of dislocations and metastableα’phase and their effects on mechanical properties in a Ti-6Al-4V alloy显示文摘The metastableα’phase and dislocation characteristics(e.g.,density and constituents)are of vital importance for the mechanical responses of(α+β)titanium alloys.In this work,to reveal the in-depth decomposition mechanisms of dislocations and metastableα’and their influences on mechanical properties in a Ti-6Al-4V(α+β)alloy,the thermal stability of different microstructures tailored by various cooling approaches were investigated utilizing scanning electron microscope,electron backscattered diffraction,transmission electron microscope and X-ray diffraction line profile analysis.The results showed that the initial characteristics ofα’andαlaths and dislocation density were influenced by the cooling methods remarkably.The thermal stability of Ti-6Al-4V alloy increased with decreasing cooling rate.The improvement in thermal stability can be ascribed by the decrement in dislocations,partitioning of the alloying elements and grain orientations variation of theα’lath andαphase.It is also found that the plastic strain accommodation ofβ→α’transformation was dominated by dislocations.During stabilization annealing treatments,the,and dislocations simultaneously decomposed.The decomposition of dislocations and metastableα’phase during various stabilization annealing and the particular twins and stacking faults microstructures formed during quenching have a great influence on the properties of the studied Ti-6Al-4V alloy. | Jinlong Su Xiankun Ji Jin Liu Jie Teng Fulin Jiang Dingfa Fu Hui Zhang | 2022 | Journal of Materials Science & Technology2022，，12： | 0 |
| 15 | Unraveling precipitation evolution and strengthening function of the Al-Zn-Mg-Cu alloys with various Zn contents:Multiple experiments and integrated internal-state-variable modeling显示文摘Zn content is one of the most concerned factors in the development of next generation ultra-strength Al-Zn-Mg-Cu alloys owing to its essential role in precipitation strengthening.In the present work,the underlying functions of Zn content in precipitation evolution and strengthening function of Al-Zn-Mg-Cu alloys were systematically investigated by combining multiple experiments and an integrated internalstate-variable model.The experimental results indicated that the increased Zn content in Al-Zn-Mg-Cu alloys would promote the development of precipitates and enhance aging hardening.The diffusion flux of soluble Zn and the coordination of Mg atom controlled the crystallographic microstructures evolution during precipitates nucleation,growth and transition processes.By integrating precipitation development with electrical resistivity and hardness evolutions,an improved internal-state-variable physical model was then developed for the aging responses of Al-Zn-Mg-Cu alloys.The unified model considered the intrinsic characteristics of precipitates such as crystallographic orientation,morphology,component,and distribution.The specific improvements were to balance the combined functions of Zn element and Mg element and consider the plate-like morphology and directed growth as indicated by experiments.This model was also adaptive to heat-treatment variables and chemical compositions,and owned the notable advantages to simultaneously rationalize the observed microstructural characteristics,mechanical and electrical properties following artificial aging of Al-Zn-Mg-Cu alloys.In addition,a preliminary model framework between electrical resistivity and hardness for Al-Zn-Mg-Cu alloys was established. | Jie Tang Mingcai Liu Guowei Bo Fulin Jiang Chunhui Luo Jie Teng Dingfa Fu Hui Zhang | 2022 | Journal of Materials Science & Technology2022，，21： | 0 |
| 16 | Microstructure, mechanical properties and deformation characteristics of Al-Mg-Si alloys processed by a continuous expansion extrusion approach显示文摘In the present work,a double-pass continuous expansion extrusion forming(CEEF) process was proposed for an Al-Mg-Si alloy,in which the diameter of rods was gradually expanded.The microstructural evolution,mechanical properties and deformation characteristics were investigated by utilizing microstructural observations,mechanical testing and a finite element method coupled with a cellular automata model.The results showed that the strength and ductility of the double-pass CEEF processed Al-Mg-Si alloys were improved synchronously,especially in artificially aged alloys.The grain size of the processed Al-Mg-Si alloy rods was refined remarkably by continuous dynamic recrystallization(CDRX)and geometric dynamic recrystallization(GDRX),and the homogeneity of microstructure was gradually improved with increasing number of processing passes.The artificially aged alloy processed with double-pass CEEF and water quenching contained fine(sub)grains and high-density dislocations,which resulted in more needle-shaped β' precipitates and a larger precipitate aspect ratio than the as-received and air-cooled CEEF alloys owing to the different precipitation kinetics.The severe cumulate strain and microshear bands were found to accelerate CDRX and GDRX for grain refinement between adjacent positions of the parabolic metal flow due to the special temperature characteristics and la rge shear straining during the CEEF process. | Ruiqing Lu Shuwei Zheng Jie Teng Jiamin Hu Dingfa Fu Jianchun Chen Guodong Zhao Fulin Jiang Hui Zhang | 2021 | Journal of Materials Science & Technology2021，，21： | 0 |
| 17 | A simulation method on target strength and circular SAS imaging of Xrudder UUV including multiple acoustic scattering显示文摘Target strength(TS)and circular synthetic aperture sonar(CSAS)images provide essential information for active acoustic detection and recognition of non-cooperative unmanned undersea vehicles(UUVs),which pose a significant threat to underwater preset facilities.To access them,we propose an iterative physical acoustics(IPA)-based method to simulate the multiple acoustic scattered fields on rigid surfaces in high-frequency cases.It uses the Helmholtz integral equation with an appropriate Green's function in terms of the Neumann series,and then incorporates the ideas of triangulation and iteration into a numerical implementation.Then two approximate analytic formulae with precise physical meanings are derived to predict the TS and CSAS images of concave targets,respectively.There are no restrictions on the surface's curvature and the order of multiple scattering.The method is validated against the finite element method(FEM)for acoustic scattering from a sphere segment and against an experiment involving an X-rudder UUV's stern.On this basis,we simulate and analyze the TS and CSAS images of an X-rudder UUV.In addition,the influence of the angle of adjacent rudders on the multiple scattering characteristics is discussed.Results show that this method can potentially predict accurate UUV features,especially the multiple scattered features. | Wenhuan Wang Bin Wang Jun Fan Fulin Zhou Kaiqi Zhao Zhou Jiang | 2023 | Defence Technology(防务技术)2023，23，5： | 0 |
| 18 | Hypersonic shock wave and turbulent boundary layer interaction in a sharp cone/flare model显示文摘A direct numerical simulation of hypersonic Shock wave and Turbulent Boundary Layer Interaction(STBLI)at Mach 6.0 on a sharp 7.half-angle circular cone/flare configuration at zero angle of attack is performed.The flare angle is 34.and the momentum thickness Reynolds number based on the incoming turbulent boundary layer on the sharp circular cone is Re θ=2506.It is found that the mean flow is separated and the separation bubble occurring near the corner exhibits unsteadiness.The Reynolds analogy factor changes dramatically across the interaction,and varies between 1.06 and 1.27 in the downstream region,while the QP85 scaling factor has a nearly constant value of 0.5 across the interaction.The evolution of the reattached boundary layer is characterized in terms of the mean profiles,the Reynolds stress components,the anisotropy tensor and the turbulence kinetic energy.It is argued that the recovery is incomplete and the near-wall asymptotic behavior does not occur for the hypersonic interaction.In addition,mean skin friction decomposition in an axisymmetric turbulent boundary layer is carried out for the first time.Downstream of the interaction,the contributions of transverse curvature and body divergence are negligible,whereas the positive contribution associated with the turbulence kinetic energy production and the negative spatial-growth contribution are dominant.Based on scale decomposition,the positive contribution is further divided into terms with different spanwise length scales.The negative contribution is analyzed by comparing the convective term,the streamwise-heterogeneity term and the pressure gradient term. | Fulin TONG Junyi DUAN Jiang LAI Dong SUN Xianxu YUAN | 2023 | Chinese Journal of Aeronautics2023，36，3： | 0 |
| 19 | Microstructure, mechanical properties and deformation mechanisms of an Al-Mg alloy processed by the cyclical continuous expanded extrusion and drawing approach显示文摘Al-Mg alloys are an important class of non-heat treatable alloys in which Mg solute and grain size play essential role in their mechanical properties and plastic deformation behaviors.In this work,a cyclical continuous expanded extrusion and drawing(CCEED)process was proposed and implemented on an Al-3Mg alloy to introduce large plastic deformation.The results showed that the continuous expanded extrusion mainly improved the ductility,while the cold drawing enhanced the strength of the alloy.With the increased processing CCEED passes,the multi-pass cross shear deformation mechanism progressively improved the homogeneity of the hardness distributions and refined grain size.Continuous dynamic recrystallization played an important role in the grain refinement of the processed Al-3Mg alloy rods.Besides,the microstructural evolution was basically influenced by the special thermomechanical deformation conditions during the CCEED process. | Ruiqing Lu Long Zhang Shuwei Zheng Dingfa Fu Jie Teng Jianchun Chen Guodong Zhao Fulin Jiang Hui Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 0 |
| 20 | 急性髓系白血病致癌性RNA去甲基酶FTO的小分子靶向干预研究显示文摘文章简介RNA甲基化是高等生物mRNA上最普遍的修饰,参与RNA稳定性、定位、运输、剪切等调控,在基因表达调控中发挥重要作用。2011年FTO被鉴定为m^6A修饰去甲基化酶,开辟了'表观转录'研究新方向。2017年报导急性髓系白血病(AML)高表达FTO导致下游某些mRNA上甲基化丰度降低,引起蛋白水平变化,促进AML形成。然而由于缺乏高质量的小分子工具,FTO是否可以成为抗肿瘤药物的作用靶标有待于深入确证。 | 黄悦 Rui Su Yue Sheng Lei Dong Ze Dong Hongjiao Xu Tengfeng Ni Zijie Scott Zhang Tao Zhang Chenying Li Li Han Zhenyun Zhu Fulin Lian Jiangbo Wei Qiangqiang Deng Yungui Wang Mark Wunderlich Zhiwei Gao Guoyu Pan Dafang Zhong Hu Zhou Naixia Zhang Jianhua Gan Hualiang Jiang James C.Mulloy Zhijian Qian Jianjun Chen 杨财广 | 2020 | 科学新闻2020，，2： | 0 |
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