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| 1 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 2 | Kallistatin,a new and reliable biomarker for the diagnosis of liver cirrhosis显示文摘Kallistatin,which protects organs and cells against inflammation,fibrosis and oxidative stress,is mainly synthesized and secreted in liver.However,its relationship to human liver disease remains unclear.The purpose of this study was to explore the relationship between serum kallistatin and clinical evidence of both cirrhosis and hepatocellular carcinoma(HCC),and to determine if serum kallistatin levels could be used as a diagnostic indicator of hepatic health status,especially human liver cirrhosis(LC).Our cohort consisted of 115 patients with clinically proven liver fibrosis(LF),LC,or HCC by liver biopsies,and 31 healthy controls(CON).Serum kallistatin levels were quantified by ELISA.Results of the present study demonstrated that irrespective of the underlying etiology,serum kallistatin levels were significantly lower in the LF/LC group when compared with the CON group.A decrease in serum kallistatin levels appeared to reflect the extent of cirrhosis,with the lowest levels associated with higher grades of cirrhosis.Patients with LC had a noticeable correlation between serum kallistatin levels and other serum biochemical indicators.The area under the curve(AUC) for LC,viral liver cirrhosis(VLC)and alcoholic liver cirrhosis(ALC) was 0.845,0.757 and 0.931,respectively.In conclusion,our findingsdemonstrated that kallistatin,a plasma protein produced by the liver,can be a useful and reliable diagnostic indicator of hepatic health status,especially for LC. | Zhiyun Cheng Yinghui Lv Suqiu Pang Ruyu Bai Mingxi Wang Shuyu Lin Tianwen Xu Duncan Spalding Nagy Habib Ruian Xu | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 7 |
| 3 | Numerical simulation of a buried hot crude oil pipeline during shutdown显示文摘In this paper a mathematical model is built for a buried hot crude oil pipeline during shutdown,and an unstructured grid and polar coordinate grid are respectively applied to generating grids for the soil region and the three layers in the pipe(wax layer,pipe wall,and corrosion-inhibiting coating) . The governing equations are discretized using the fi nite volume method. The variations in temperatures of static oil and soil were investigated during pipeline shutdown in both summer and winter,in which some important parameters of the soil and crude oils of a Northeast pipeline are employed. | Xu Cheng Yu Bo Zhang Zhengwei Zhang Jinjun Wei Jinjia Sun Shuyu | 2010 | Petroleum Science2010，7，1： | 6 |
| 4 | A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL显示文摘Bone regeneration originates from proliferation and differentiation of osteoprogenitors via either endochondral or intramembranous ossifcation;and the regeneration capacities decline with age and estrogen loss.Maillary sinus floor lifting(MSFL)is a commonly used surgical procedure for guiding bone regeneration in mailla.Radiographic analysis of 1210 clinical cases of maxilla bone regeneration after MSFL revealed that the intrasinus osteogenic eficacy was independent of age and gender,however;and this might be related to the Schneiderian membrane that lines the sinus cavity.In view of the particularity of this biological process,our present study aimed to elucidate the underlying mechanism of MSFL-induced bone regeneration.We frst established a murine model to simulate the clinical MSFL.By single cell RNA-sequencing and flow cytometry-based bulk RNA-sequencing,we identifed a novel Krt14^(+)Ctsk^(+)subset of cells that display both epithelial and mesenchymal properties and the transcriptomic feature of osteoprogenitors.Dual recombinases-mediated lineage tracing and oss-offunction analyses showed that these Krt14^(+)Ctsk^(+)progenitors contribute to both MSFL-induced osteogenesis and physiological bone homeostasis by differentiating into Krt14 Ctsk^(+)descendants which show robust osteogenic capacity.In addition,we detected a similar population of Kt14^(+)Ctsk^(+)cells in human samples of Schneiderian membrane,which show a highly similar osteogenic potential and transcriptomic feature to the corresponding cells in mice.The identifcation of this Krt14^(+)Ctsk^(+)population,featured by osteoprogenitor charateristics and dual epithelial-mesenchymal properties,provides new insight into the understanding of bone regeneration and may open more possibilities for clinical applications. | Yuteng Weng Haicheng Wang Di Wu Shuyu Xu Xiaofan Chen Jie Huang Yanhuizhi Feng Lin Li Zuolin Wang | 2022 | Cell Research2022，32，9： | 5 |
| 5 | Production and measurement of Bose-Einstein condensate of ^(87)Rb atomic gas显示文摘The research platform for Bose-Einstein condensate in 87 Rb atomic gas,which is composed of a double MOT configuration and a QUIC trap,was reported.The properties of the condensate were measured both in time-of-flight and in tight confinement by the absorption imaging method.The measurements agreed with the criterions of Bose-Einstein condensation phase transition.About 2×10 5 atoms were pure condensed. | XU Zhen ,ZHOU ShuYu,ZHOU ShanYu&WANG YuZhu Key Laboratory for Quantum Optics,Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，1： | 3 |
| 6 | Oryza sativa mediator subunit OsMED25 interacts with OsBZR1 to regulate brassinosteroid signaling and plant architecture in rice显示文摘Brassinosteroids(BRs)are plant-specific steroid hormones which regulate plant growth,development,and adaptation.Transcriptional regulation plays key roles in plant hormone signaling.A mediator can serve as a bridge between gene-specific transcription factors and the RNA polymerase machinery,functioning as an essential component in regulating the transcriptional process.However,whether a mediator is involved in BR signaling is unknown.Here,we discovered that Oryza sativa mediator subunit 25(Os MED25)is an important regulator of rice BR signaling.Phenotypic analyses showed that the Os MED25-RNAi and osmed25 mutant presented erect leaves,as observed in BR-deficient mutants.In addition,the Os MED25-RNAi and osmed25 mutant exhibited decreased BR sensitivity.Genetic analysis indicated that Os MED25-RNAi could suppress the enhanced BR signaling phenotype of Osbzr1-D.Further biochemical analysis showed that Os MED25 interacts with Os BZR1 in vivo,and Os MED25 is enriched on the promoter of Os BZR1 target genes.RNA sequencing analysis indicated that Os MED25 affects the expression of approximately 45%of Os BZR1-regulated genes and mainly functions as a corepressor of Os BZR1.Together,these findings revealed that Os MED25 regulates rice BR signaling by interacting with Os BZR1 and modulating the expression of Os BZR1 target genes,thus expanding our understanding of the roles of mediators in plant hormone signaling. | Yuekun Ren Xiaojie Tian Shuyu Li Enyang Mei Mingliang He Jiaqi Tang Min Xu Xiufeng Li Zhenyu Wang Chuanyou Li Qingyun Bu | 2020 | Journal of Integrative Plant Biology2020，62，6： | 3 |
| 7 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 8 | An Ecologically Oriented Operation Strategy for a Multi-Reservoir System: A Case Study of the Middle and Lower Han River Basin, China显示文摘水库群的建设和调度改变了河流的自然流态,对河流生态系统造成了不利影响。本文提出了一种面向生态的水库群调度策略,将河流内不同生态功能所需的生态流量整合到水库群联合调度中,以实现生态流量需求和人类用水需求之间的均衡。该策略耦合了常规优化调度方案和一系列实时生态调度方案。在人类用水需求与生态流量需求冲突较小的时段,水库群调度在保障河流最小流量的前提下采用常规优化调度方案,最大限度地提高人类用水效益。在水库引发的水文改变对河流关键生态功能产生严重影响的时期,水库群调度采用实时生态调度方案,调整下泄流量,从而满足河流生态流量需求。该策略被应用于位于中国汉江中下游流域的一个大型水库群中。模拟调度结果表明,实时生态调度方案保证了河流关键生态功能的生态流量需求,其对人类用水效益的不利影响可通过常规优化调度方案得到部分补偿。本文提出的面向生态的水库群调度策略丰富了考虑生态流量需求的水库群联合调度的理论应用。 | Hao Wang Xiaohui Lei Denghua Yan Xu Wang Shuyue Wu Zhengjie Yin Wenhua Wan | 2018 | Engineering2018，4，5： | 3 |
| 9 | Recent developments and progress of inorganic photo-stimulated phosphors显示文摘Photo-stimulated luminescence(PSL) is the process in which trapped charges are released by photons and produce luminescence through recombination. The variegated optical characteristics of photostimulated phosphors(PSPs) have drawn increasing attention and a large body of work encompassing mechanism and application of PSPs has been addressed. The optical data storage capacity resulting from abundant defect states enables PSPs to be applied to information storage. Moreover, PSPs provide potential application for anti-counterfeiting, as color changes due to the tunneling process. Recently, near infrared(NIR) light PSPs have been developed, exhibiting enormous potential for in vivo bio-imaging, as the stable and high noise-signal ratio characteristic of PSL. In this review, we devote to introducing the development and process of PSPs, and the challenge and future advance have also been demonstrated. | Xiaotong Fan Zhichao Liu Xiuxia Yang Wenbo Chen Wei Zeng Shuyu Tian Xue Yu Jianbei Qiu Xuhui Xu | 2019 | Journal of Rare Earths2019，37，7： | 2 |
| 10 | Parameter estimation of GTD model and RCS extrapolation based on a modified 3D-ESPRIT algorithm显示文摘The noise robustness and parameter estimation performance of the classical three-dimensional estimating signal parameter via rotational invariance techniques(3D-ESPRIT)algorithm are poor when the parameters of the geometric theory of the diffraction(GTD)model are estimated at low signal-to-noise ratio(SNR).To solve this problem,a modified 3D-ESPRIT algorithm is proposed.The modified algorithm improves the parameter estimation accuracy by proposing a novel spatial smoothing technique.Firstly,we make cross-correlation of the auto-correlation matrices;then by averaging the cross-correlation matrices of the forward and backward spatial smoothing,we can obtain a novel equivalent spatial smoothing matrix.The formula of the modified algorithm is derived and the performance of this improved method is also analyzed.Then we compare root-meansquare-errors(RMSEs)of different parameters and the locating accuracy obtained by different algorithms.Furthermore,radar cross section(RCS)of radar targets is extrapolated.Simulation results verify the effectiveness and superiority of the modified 3DESPRIT algorithm. | ZHENG Shuyu ZHANG Xiaokuan ZHAO Weichen ZHOU Jianxiong ZONG Binfeng XU Jiahua | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 2 |
| 11 | Analysis of the sandwich ul trasonic transducer with two sets of piezoelectric ele ments显示文摘 | Lin Shuyu Xu Chunlong | 2008 | Smart Materials and Structures2008，17，： | 1 |
| 12 | Association between Serum Lipids, Blood Pressure, and Simple Anthropometric Measures in an Adult Chinese Population显示文摘 | Chengli Xu Xiaolin Yang Shuyu Zu | 2009 | Archives of Medical Research2009，39，： | 1 |
| 13 | Association betweenerum Lipids, Blood Pressure, and Simple Anthropometric Measures in an Adult Chinese Population 显示文摘 | Chengli Xu Xiaolin Yang Shuyu Zu | 2008 | Archives of Medical Research2008，39，6： | 1 |
| 14 | Association between Serum Lipids, Blood Pressure, and Simple Anthropometric Measures in an Adult Chinese Population 显示文摘 | Cbengli Xu Xiaolin Yang Shuyu Zu etc | 2009 | Archives of Medical Research2009，39，： | 1 |
| 15 | Division and identification of vertical reservoir units in Archaeozoic metamorphic buried hill of Bozhong Sag,Bohai Bay Basin,East China显示文摘Based on the data associated with cores,sidewall cores,casting thin sections,reservoir physical properties,conventional logging and imaging logging,the classification schemes of vertical reservoir units are proposed for the two types of Archaeozoic buried hills(exposed and covered ones)in the Bozhong Sag,Bohai Bay Basin.The geological characteristics and storage spaces of these reservoir units are described,and their identification markers in conventional and imaging log curves are established.The Archaeozoic metamorphic buried hills can be vertically classified into two primary reservoir units:weathering crust and inner buried hill.The weathering crust contains four secondary units,i.e.,the clay zone,weathered glutenite zone,leached zone,disaggregation zone;and the interiors contain two secondary units,i.e.,interior fracture zone and tight zone.In particular,the inner fracture zone was further divided into cataclasite belts and dense-fracture belts.It is proposed that the favorable reservoirs of exposed Archaeozoic metamorphic buried hills are mainly developed in four parts including weathered glutenite zone,leached zone,disintegration zone superposed with the cataclasite belt and the cataclasite belt of inner fracture zone,and are controlled by both weathering and tectonic actions.Favorable reservoirs in covered Archaeozoic metamorphic buried hills are mainly developed in the weathering crust superposed with the cataclasite belts and the cataclasite belts of inner fracture zone,and are mainly controlled by tectonic actions. | YI Jian LI Huiyong SHAN Xuanlong HAO Guoli YANG Haifeng WANG Qingbin XU Peng REN Shuyue | 2022 | Petroleum Exploration and Development2022，49，6： | 1 |
| 16 | Association between serum lipids, blood pressure, and simple anthropo- metric measures in an adult Chinese Population 显示文摘 | Chengli Xu Xiaolin Yang Shuyu Zu | 2008 | Arch Med Res2008，39，： | 1 |
| 17 | Association between se-rum lipids,blood pressure,and simple anthropometric measures inan adult Chinese Population显示文摘 | Xu Chengli Yang Xiaolin Zu Shuyu | 2008 | Arch Med Res2008，39，6： | 1 |
| 18 | Tgf-β1 induces autophagy and promotes apoptosis in renal tubular epithelialcells显示文摘 | Yanfang Xu Shuyu Yang Jiyi Huang Shiwei Ruan Zhang Zheng Jiumao Lin | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 19 | Salvianolic Acid B In- hibited PPAR'y Expression and Attenuated Weight Gain in Mice with High - Fat Diet - Induced Obesity显示文摘 | Peijian Wang Shuyu Xu Wenzhang Li | 2014 | Cell Physiol Biochem2014，34，： | 1 |
| 20 | Symmetry-aware recursive image similarity exploration for materials microscopy显示文摘In pursuit of scientific discovery,vast collections of unstructured structural and functional images are acquired;however,only an infinitesimally small fraction of this data is rigorously analyzed,with an even smaller fraction ever being published.One method to accelerate scientific discovery is to extract more insight from costly scientific experiments already conducted.Unfortunately,data from scientific experiments tend only to be accessible by the originator who knows the experiments and directives.Moreover,there are no robust methods to search unstructured databases of images to deduce correlations and insight.Here,we develop a machine learning approach to create image similarity projections to search unstructured image databases.To improve these projections,we develop and train a model to include symmetry-aware features.As an exemplar,we use a set of 25,133 piezoresponse force microscopy images collected on diverse materials systems over five years.We demonstrate how this tool can be used for interactive recursive image searching and exploration,highlighting structural similarities at various length scales.This tool justifies continued investment in federated scientific databases with standardized metadata schemas where the combination of filtering and recursive interactive searching can uncover synthesis-structure-property relations.We provide a customizable open-source package(https://github.com/m3-learning/Recursive_Symmetry_Aware_Materials_Microstructure_Explorer)of this interactive tool for researchers to use with their data. | Tri N.M.Nguyen Yichen Guo Shuyu Qin Kylie S.Frew Ruijuan Xu Joshua C.Agar | 2021 | npj Computational Materials2021，，1： | 0 |
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