|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Review of Electronic Speckle Pattern Interferometry(ESPI) for Three Dimensional Displacement Measurement显示文摘Three dimensional(3D)displacements,which can be translated further into 3D strain,are key parameters for design,manufacturing and quality control.Using different optical setups,phase-shift methods,and algorithms,several different 3D electronic speckle pattern interferometry(ESPI)systems for displacement and strain measurements have been achieved and commercialized.This paper provides a review of the recent developments in ESPI systems for 3D displacement and strain measurement.After an overview of the fundamentals of ESPI theory,temporal phase-shift,and spatial phase-shift techniques,3D deformation measurements by the temporal phase-shift ESPI system,which is suited well for static measurement,and by the spatial phase-shift ESPI system,which is particularly useful for dynamic measurement,are discussed.For each method,the basic theory,a brief derivation and different optical layouts are presented.The state of art application,potential and limitation of the ESPI systems are shown and demonstrated. | YANG Lianxiang XIE Xin ZHU Lianqing WU Sijin WANG Yonghong | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 20 |
| 2 | An important role of the hepcidin-ferroportin signaling in affecting tumor growth and metastasis显示文摘 | Wenli Guo Shuping Zhang Yue Chen Daoqiang Zhang Lin Yuan Haibo Cong Sijin Liu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 14 |
| 3 | LncRNA PU.1 AS regulates arsenic-induced lipid metabolism through EZH2/Sirt6/SREBP-1c pathway显示文摘Arsenic (As) is an omnipresent metalloid toxicant,which has elicited serious environmental pollution and health risky problems.Previous studies have uncovered that the As exposure could also cause markedly reduction of serum triglycerides in mice.However,the regulation mechanisms are still largely unknown.The present study is aimed to elucidate the molecular mechanisms of lncRNAs in As-induced lipid metabolic disequilibrium.We demonstrated that lncRNA PU.1 AS was significantly induced in the liver of As-feed mice companied with lower serum triglycerides contents;further in vitro experiment confirmed that PU.1 AS regulated liver cells lipid accumulation by nile red fluorescence staining.Intensive mechanistic investigations illustrated that PU.1 AS could interact with EZH2 protein to regulate its downstream target gene expression,and Asinduced PU.1 AS attenuated EZH2-supppressed Sirt6 expression,thereafter leading to a decreased SREBP-1c protein expression,as well as the diminished synthesis of triglycerides in hepatocytes.In conclusion,this study provided a new lncRNA-related regulatory signaling pathway participating in As-induced abnormal lipid metabolism. | Zheng Dong Changying Li Chunyang Yin Ming Xu Sijin Liu Ming Gao | 2019 | Journal of Environmental Sciences2019，31，11： | 8 |
| 4 | Research on the ecological risk of heavy metals in the soil around a Pb–Zn mine in the Huize County, China显示文摘The soil pollution by heavy metals was characterized in the mine tailings and surrounding soils of an old Pb–Zn mine in Huize County. Three hundred and ninety-six samples of agricultural and non-agricultural soil were analyzed for the total metal concentration by acid digestion and sixty-eight selected soil samples were used to determine the chemical fractionation of heavy metals with the modified BCR sequential extraction method. The pollution index of the heavy metals indices for As, Cd, Cr, Cu,Hg, Pb and Zn of non-agricultural soil and agricultural soils in the study area indicated the spreading of heavy metal pollution. Sequential extraction showed that most of Cd existed in an exchangeable form(31.2 %). The available content of Pb, Cu and Zn was mainly distributed in acid extractable fractions and Fe/Mn oxide fractions(27.9, 30 and 27.2 %), and Hg, As and Cr were mainly associated with residual fractions(90.4, 72.9 and 76.8 %). The risks of heavy metals were also evaluated by the risk assessment code(RAC) and potential ecological risk index, respectively. The results of RAC showed a medium and high risk of Cd(45.6 and 54.4 %), medium risk of Zn(100 %), low and medium risk of Cu(41.2 and 58.8 %), largely no risk of Hg(97.1 %), and mainly low risk of As and Pb(92.6and 91.8 %). The range of the potential ecological risk of soil was 58.2–1839.3, revealing a considerably high ecological risk in the study area, most likely related to acid mine drainage and the mining complexes located in the area. The results can be used during the ecological risk screening stage, in conjunction with the total concentrations and metal fractionation values, to better estimate ecological risk. | Sijin Lu Yanguo Teng Yeyao Wang Jing Wu Jinsheng Wang | 2015 | Chinese Journal Of Geochemistry2015，34，4： | 8 |
| 5 | The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide's biocompatibility显示文摘Graphene oxide(GO)displays promising properties for biomedical applications including drug delivery and cancer therapeutics.However,GO exposure also raises safety concerns such as potential side effects on health.Here,the biological effects of GO suspended in phosphate buffered saline(PBS)with or without 1% nonionic surfactant Tween 80 were investigated.Based on the ex vivo experiments,Tween 80 significantly affected the interaction between GO and peripheral blood from mice.GO suspension in PBS tended to provoke the aggregation of diluted blood cells,which could be prevented by the addition of Tween 80.After intravenous administration,GO suspension with or without 1% Tween 80 was quickly eliminated by the mononuclear phagocyte system.Nevertheless,GO suspension without Tween 80 showed greater accumulation in lungs than that containing 1% Tween 80.In contrast,less GO was found in livers for GO suspension compared to Tween 80 assisted GO suspension.Organs including hearts,livers,lungs,spleens,kidneys,brains,and testes did not reveal histological alterations.The indexes of peripheral blood showed no change upon GO exposure.Our results together demonstrated that Tween 80 could greatly alter GO's biological performance and determine the pattern of its biodistribution in mice. | Guangbo Qu Xiaoyan Wang Qian Liu Rui Liu Nuoya Yin Juan Ma Liqun Chen Jiuyang He Sijin Liu Guibin Jiang | 2013 | Journal of Environmental Sciences2013，25，5： | 7 |
| 6 | Antimicrobial activity of silver loaded MnO_2 nanomaterials with different crystal phases against Escherichia coli显示文摘Silver-loaded MnO_2 nanomaterials(Ag/MnO_2),including Ag/α-MnO_2,Ag/β-MnO_2,Ag/γ-MnO_2and Ag/δ-MnO_2 nanorods,were prepared with hydrothermal and impregnation methods.The bactericidal activities of four types of Ag/MnO_2 nanomaterials against Escherichia coli were investigated and an inactivation mechanism involving Ag^+ and reactive oxygen species(ROS)was also proposed.The bactericidal activities of Ag/MnO_2 depended on the MnO_2 crystal phase.Among these nanomaterials,Ag/β^-MnO_2 showed the highest bactericidal activity.There was a 6-log decrease in E.coli survival number after treatment with Ag/β^-MnO_2 for120 min.The results of 5,5-dimethyl-l-pyrroline-N-oxide spin-trapping measurements by electron spin resonance indicate OH and O_2^- formation with addition of Ag/β-MnO_2,Ag/γ-MnO_2 or Ag/δ-MnO_2.The strongest peak of OH appeared for Ag/β-MnO_2,while no OH or ·O_2^-signal was found over Ag/α-MnO_2.Through analysis of electron spin resonance(ESR) and Ag+elution results,it could be deduced that the toxicity of Ag^+ eluted from Ag/MnO_2 nanomaterials and ROS played the main roles during the bactericidal process.Silver showed the highest dispersion on the surface of β-MnO_2,which promoted ROS formation and the increase of bactericidal activity.Experimental results also indicated that Ag/MnO_2 induced the production of intracellular ROS and disruption of the cell wall and cell membrane. | Lian Wang Hong He Changbin Zhang Li Sun Sijin Liu Shaoxin Wang | 2016 | Journal of Environmental Sciences2016，28，3： | 6 |
| 7 | Superatomic Aub clusters ligated by different N-heterocyclic carbenes and their ligand-dependent catalysis, photoluminescence, and proton sensitivity显示文摘We report herein a class of superatomic AU13 clusters stabilized by different N-heterocyclic carbenes(NHCs).The clusters show diverse metal surface structures,properties and functions as exemplified by:(1)the first anionic AU13 cluster[Au1g(NHC-1)sBr6],which has bulky NHC-1 ligands that lead to a rather open metal surface contributing to its high catalytic activity;(2)the tricationic cluster[Au13(NHC-2)sBr2]+which has bidentate,benzyl-rich NHC-2 ligands that make it ultra-stable and highly-luminescent,suitable for bio-imaging;and(3)by bearing two pyridyl groups on NHC-3,the dicationic cluster[Au:a(NHC-3)gClg]f+exhibits reversible and stable visible absorption and solubility responses to protonation/deprotonation cycles,making it a potential pH sensor(NHC-1=1,3-disopropylbenzimidazolin-ylidene;NHC-2=1,3-bis(1-benzyl-1H-benzimidazol-1-ium-yl)propane;NHC-3=1,3-bis(icolyI)benzimidazolin-ylidene).The study nicely demonstrates the importance of ligands in designing metal nanoclusters with desired functionalities. | Hui Shen Sijin Xiang Zhen Xu Chen Liu Xihua Li Cunfa Sun Shuichao Lin Boon K.Teo Nanfeng Zheng | 2020 | Nano Research2020，13，7： | 6 |
| 8 | Multi-perspective digital image correlation method using a single color camera显示文摘A novel 3 D digital image correlation(DIC) system based on a single three charge-couple device(3 CCD) color camera is proposed in this paper. Images from three different perspectives are captured by a 3 CCD camera using a reflective-based pseudo-vision system. These images are then separated by the different CCD channels, and the correlation algorithm for the multi-camera DIC system is adopted to evaluate the images. Compared to the conventional multi-camera DIC system, the proposed system is much more compact. In addition, the proposed system has no loss of spatial resolution, compares to the traditional single camera DIC system. The complex surface measurement ability and the measurement accuracy is significantly improved through the use of the multi-camera DIC algorithm. The principle of the proposed system is described in detail as well as the experimental setup. A series of validation tests are performed, and the results are verified with the commercial 3 D-DIC system. | WANG YongHong DAN XiZuo LI JunRui WU SiJin YANG LianXiang | 2018 | Science China(Technological Sciences)2018，61，1： | 5 |
| 9 | Primary cilia in hard tissue development and diseases显示文摘Bone and teeth are hard tissues.Hard tissue diseases have a serious effect on human survival and quality of life.Primary cilia are protrusions on the surfaces of cells.As antennas,they are distributed on the membrane surfaces of almost all mammalian cell types and participate in the development of organs and the maintenance of homeostasis.Mutations in cilium-related genes result in a variety of developmental and even lethal diseases.Patients with multiple ciliary gene mutations present overt changes in the skeletal system,suggesting that primary cilia are involved in hard tissue development and reconstruction.Furthermore,primary cilia act as sensors of external stimuli and regulate bone homeostasis.Specifically,substances are trafficked through primary cilia by intraflagellar transport,which affects key signaling pathways during hard tissue development.In this review,we summarize the roles of primary cilia in long bone development and remodeling from two perspectives:primary cilia signaling and sensory mechanisms.In addition,the cilium-related diseases of hard tissue and the manifestations of mutant cilia in the skeleton and teeth are described.We believe that all the findings will help with the intervention and treatment of related hard tissue genetic diseases. | Sijin Li Han Zhang Yao Sun | 2021 | Frontiers of Medicine2021，15，5： | 4 |
| 10 | Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century显示文摘Air pollution is a severe threat to public health globally,afecting everyone in developed and developing countries alike.Among diferent air pollutants,particulate mater(PM),particularly combustion-produced ine PM(PM2.5) has been shown to play a major role in inducing various adverse health efects.Strong associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality,cardiopulmonary diseases,asthma and allergic sensitization,and lung cancer.he mechanisms of PM-induced toxicological efects are related to their size,chemical composition,lung clearance and retention,cellular oxidative stress responses and pro-inlammatory efects locally and systemically.Particles in the ultraine range(<100 nm),although they have the highest number counts,surface area and organic chemical content,are oten overlooked due to insuicient monitoring and risk assessment.Yet,ample studies have demonstrated that ambient ultraine particles have higher toxic potential compared with PM2.5.In addition,the rapid development of nanotechnology,bringing ever-increasing production of nanomaterials,has raised concerns about the potential human exposure and health impacts.All these add to the complexity of PM-induced health efects that largely remains to be determined,and mechanistic understanding on the toxicological efects of ambient ultraine particles and nanomaterials will be the focus of studies in the near future. | Tian Xia Yifang Zhu Lina Mu Zuo-Feng Zhang Sijin Liu | 2016 | National Science Review2016，3，4： | 3 |
| 11 | Facile synthesis of zinc-based organic framework for aqueous Hg (Ⅱ) removal: Adsorption performance and mechanism显示文摘Mercury(Hg)ions can lead to a serious impact on the environment;therefore,it was necessary to find an effective method for absorbing these toxic Hg ions.Here,the adsorbent(Zn-AHMT)was synthesized from zinc nitrate and 4-amino 3-hydrazine-5 mercapto-1,2,4-triazole(AHMT)by one-step method and,characterized the microstruc-ture and absorption performance by fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Brunauer-Emmett Teller(BET),Thermal Gravimetric Analyzer(TGA)and X-ray photoelectron spectroscopy(XPS).Through a plethora of measurements,we found that the maximum adsorption capacity was 802.8 mg/g when the optimal pH of Zn-AHMT was 3.0.The isothermal and kinetic experiments confirm that the reaction process of Zn-AHMT was chemisorption,while the adsorption process conforms to the Hill model and pseudo second order kinetic model.Thermodynamic experiments showed that the adsorption process was spontaneous and exothermic.Selective experiments were performed in the simulated wastewater containing Mn,Mg,Cr,Al,Co,Ni,Hg ions.Our results showed that the Zn-AHMT has a stronger affinity for Hg ions.The removal rate of Zn-AHMT remained above 98%,indicating that the Zn-AHMT had a good stability validated by three adsorption-desorption repeatable tests.According to the XPS results,the adsorption reaction of Zn-AHMT was mainly attributed to the chelation and ion exchange.This was further explained by both density functional theory(DFT)calculation and frontier molecular orbital theory.We therefore propose the adsorption mechanism of Zn-AHMT.The adsorption reaction facilitates via the synergistic action of S and N atoms.Moreover,the bonding between the adsorbent and the N atom has been proved to be more stable.Our study demonstrated that Zn-AHMT had a promising application prospect in mercury removal. | Biao Zeng Wei Wang Sijin He Guo Lin Wenjia Du Jun Chang Zhao Ding | 2021 | Nano Materials Science2021，3，4： | 3 |
| 12 | An expression profile of human α-lactalbumin in the milk of transgenic mouse显示文摘Five female transgenic mice were produced by microinjection using a construct made up of a 7.3-kb-5′ flanking region and a 2.0-kb coding region of human a-lactalbumin, as well as a 227-bp 3′-flanking region from bovine growth hormone gene. A founder female ex-pressed human a-lactalbumin as much as 0.3 g per liter of its milk, approximately a 3-fold in-crease in the total a-lactalbumin concentration of the transgenic mouse milk. Compared with the normal mice, the expression profile of the ha-Lac transgene in the transgenics is different during the lactation, showing low level in the first 3 days and becoming increased from day 4, then gradually reaching and stabilizing at the highest level from day 13. In addition, the milk yielding volume in the transgenics tended to be higher than in normal mice, suggesting higher concen-trations of a-lactalbumin might boost more milk output. | LIU Siguo WEI Yingyun HU Guofa GAO Hong LIU Sijin LAO Weide | 2004 | Science China(Life Sciences)2004，47，3： | 3 |
| 13 | Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants:A critical review显示文摘Environmental pollution has become one of the greatest problems in the world, and the concerns about environmental pollutants released by human activities from agriculture and industrial production have been continuously increasing. Although intense efforts have been made to understand the health effects of environmental pollutants, most studies have only focused on direct toxic effects and failed to simultaneously evaluate the long-term adaptive, compensatory and secondary impacts on health. Burgeoning evidence suggests that environmental pollutants may directly or indirectly give rise to disordered element homeostasis, such as for iron. It is crucially important to maintain concerted cellular and systemic iron metabolism. Otherwise, disordered iron metabolism would lead to cytotoxicity and increased risk for various diseases, including cancers. Thus, study on the effects of environmental pollutants upon iron homeostasis is urgently needed. In this review, we recapitulate the available findings on the direct or indirect impacts of environmental pollutants, including persistent organic pollutants(POPs), heavy metals and pesticides, on iron homeostasis and associated adverse health problems. In view of the unanswered questions, more efforts are warranted to investigate the disruptive effects of environmental pollutants on iron homeostasis and consequent toxicities. | Wenli Guo Jie Zhang Wenjun Li Ming Xu Sijin Liu | 2015 | Journal of Environmental Sciences2015，27，8： | 3 |
| 14 | Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition,cytotoxicity,inflammation and lung fibrosis显示文摘Environmental exposure and health risk upon engineered nanomaterials are increasingly concerned. The family of mesoporous carbon nanomaterials(MCNs) is a rising star in nanotechnology for multidisciplinary research with versatile applications in electronics,energy and gas storage, and biomedicine. Meanwhile, there is mounting concern on their environmental health risks due to the growing production and usage of MCNs. The lung is the primary site for particle invasion under environmental exposure to nanomaterials. Here, we studied the comprehensive toxicological profile of MCNs in the lung under the scenario of moderate environmental exposure. It was found that at a low concentration of 10 μg/mL MCNs induced biophysical inhibition of natural pulmonary surfactant. Moreover, MCNs at similar concentrations reduced viability of J774 A.1 macrophages and lung epithelial A549 cells.Incubating with nature pulmonary surfactant effectively reduced the cytotoxicity of MCNs.Regarding the pro-inflammatory responses, MCNs activated macrophages in vitro, and stimulated lung inflammation in mice after inhalation exposure, associated with lung fibrosis.Moreover, we found that the size of MCNs played a significant role in regulating cytotoxicity and pro-inflammatory potential of this nanomaterial. In general, larger MCNs induced more pronounced cytotoxic and pro-inflammatory effects than their smaller counterparts. Our results provided valuable information on the toxicological profile and environmental health risks of MCNs, and suggested that fine-tuning the size of MCNs could be a practical precautionary design strategy to increase safety and biocompatibility of this nanomaterial. | Yunan Chen Yi Yang Bolong Xu Shunhao Wang Bin Li Juan Ma Jie Gao Yi Y.Zuo Sijin Liu | 2017 | Journal of Environmental Sciences2017，29，12： | 3 |
| 15 | Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles显示文摘As well-known persistent organic pollutants(POPs), organofluorine pollutants such as perfluorooctane sulfonate(PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles,trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles(PTFEPMMA NPs) were synthesized with various fluorine contents(PTFE-PMMA-1 NPs 12.0 wt.%,PTFE-PMMA-2 NPs 6.1 wt.% and PTFE-PMMA-3 NPs 5.0 wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine(F) contents and Fcontaining side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose(50 μg/m L) for 24 hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species(ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials(ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications. | Xue Wang Wenge Cheng Qiuyuan Yang Hongyun Niu Qian Liu Yun Liu Ming Gao Ming Xu An Xu Sijin Liu Xiaoyu Huang Yuguo Du | 2018 | Journal of Environmental Sciences2018，30，7： | 2 |
| 16 | Paraffin section observation of flower bud differentiation of Chimonanthus praecox in Kunming and comparison of the differentiation processes in different regions,China显示文摘Chimonanthus praecox is an important ornamental plant and cut flower material in China.It blooms in the freezing winter and its flower emits charming fragrance.However,in different region the flowering time is variable.In order to understand the flowering mechanism of Ch.praecox in the winter,we studied the flower bud differentiation in Spring City-Kunming using paraffin sectioning method in the present study.Meanwhile we compared the differentiation process difference from different regions.It was found that the temperature is the key factor for its flower bud differentiation and blossom of Ch.praecox.In the process of bud differentiation,the temperature 20℃was the optimum for inducing changes from vegetative axillary buds to reproductive buds and subsequent morphological differentiation in Ch.praecox.Furthermore in the first three differentiation periods—tepal primordial stage,staminal primordial stage and pistil primordial stage,Kunming took the shortest time to finish the process due to very rapid temperature rise to 20℃,whereas,in Zhengzhou the time for these differentiations was the longest,which may be caused by the slow temperature rise.After May,the high temperature stress forced the flower buds into the first long dormant period in all regions except Kunming.In Kunming,the average temperature was only 20–25℃,so the flower bud continued to differentiate.In all regions,Kunming is the first to complete whole flower bud differentiation even on the early August,and started the second dormancy very early but very long.In the other regions,the plants went through a shorter dormancy and the low temperature broke the dormancy rapidly.Contrarily the plants of Kunming spent a longer period for the low temperature.Thus,the low temperature less than 10℃is a key factor to breaking the second dormancy.Surely the regular effects of temperature on flower bud differentiation and blossom is very helpful for florescence regulation of Ch.praecox. | Sijin Li Nan Yang Longqing Chen | 2022 | Horticultural Plant Journal2022，8，2： | 2 |
| 17 | A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability显示文摘Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor progression.As a key glycolytic enzyme,hexokinase 2(HK2)plays an instrumental role in aerobic glycolysis and tumor progression.However,whether HK2 directly contribute to CSC stemness maintenance in small cell lung cancer(SCLC)is largely unclear.In this study,we aimed to investgate whether HK2 independent of its glycolytic activity is directly involved in stemness maintenance of CSC in SCLC.Methods:Immunoblotting analyses were conducted to determine the expression of HK2 in SCLC CSCs and their differentiated counterparts.CSC-like properties and tumorigenesis of SCLC cells with or without HK2 depletion or overexpression were examined by sphere formation assay and xenograft mouse model.Immunoprecipitation and mass spectrometry analyses were performed to identify the binding proteins of CD133.The expression levels of CD133-associated and CSC-relevant proteins were evaluated by immunoblotting,immunoprecipitation,immunofluorescence,and immunohistochemistry assay.RNA expression levels of Nanog,POU5F1,Lin28,HK2,Prominin-1 were analyzed through quantitative reverse transcription PCR.Polyubiquitination of CD133 was examined by in vitro or in vivo ubiquitination assay.CD133+cells were sorted by flow cytometry using an anti-CD133 antibody.Results:We demonstrated that HK2 expression was much higher in CSCs of SCLC than in their differentiated counterparts.HK2 depletion inhibited CSC stemness and promoted CSC differentiation.Mechanistically,nonmitochondrial HK2 directly interacted with CD133 and enhanced CD133 expression without affecting CD133 mRNA levels.The interaction of HK2 and CD133 promoted the binding of the deubiquitinase ubiquitin-specific protease 11(USP11)to CD133,thereby inhibiting CD133 polyubiquitylation and degradation.HK2-mediated upregulation of CD133 expression enhanced the expression of cell renewal regulators,SCLC cell stemness,and tumor growth in mice.In addition,HK2 expression was positively correlated with CD133 expression in human SCLC specimens,and their expression levels were associated with poor prognosis of SCLC patients.Conclusions:These results revealed a critical non-metabolic function of HK2 in promotion of cancer cell stemness.Our findings provided new insights into the multifaceted roles of HK2 in tumor development. | Juhong Wang Fei Shao Yannan Yang Wei Wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu | 2022 | Cancer Communications2022，42，10： | 2 |
| 18 | Application of bacteria-plant association in bio-degradation of diesel oil pollutants in soil显示文摘The bacteria and plants were associated to remove diesel oil pollutants from soil.Three efficiently degrading bacteria(named strains Q10,Q14 and Q18,respectively) were isolated.Two plants(alfalfa and Indian mustard) were selected to form the association.Biodegradation of diesel oil pollutants in soil was accelerated by bacteria-plants association.The main results are summarized as follows.The plants-bacteria association was more effective in biodegradation of diesel oil pollutants in soil than in respective experiments carried out with plants or bacteria alone.Strain Q18-Indian mustard association resulted in the maximum diesel oil reduction(69.18%).The activities of catalase and polyphenol oxidase in soil were enhanced and microbial populations in soil,especially in rhizosphere,were also stimulated in the treatment of bacteria-plant association.Overall,the soil conditions might be improved by alfalfa or Indian mustard to benefit the growth of bacteria,which resulted in degradation of diesel oil pollutants more effective by the bacteria-plant association.The bacteria-plants association may be a better approach to the removal of diesel oil pollutants from soil. | Lu, Sijin Teng, Yanguo Sun, Zongjian Wang, Jinsheng | 2011 | Chinese Journal Of Geochemistry2011，30，2： | 2 |
| 19 | Endogenous Fe^(2+)-activated ROS nanoamplifier for esterase-responsive and photoacoustic imaging-monitored therapeutic improvement显示文摘Chemodynamic therapy(CDT)is well acknowledged as potent reactive oxygen species(ROS)-mediated anticancer strategy.Especially,the study about labile iron pool(LIP)as endogenous ferrous catalyzer has paved the way for future CDT development.However,limited H_(2)O_(2) expression,mild acidity,reduced glutathione(GSH)ablation of ROS,etc.,all require employing alternate peroxo-complex to achieve enhanced CDT effect.As a non-Fenton-type substrate,artesunate(ART)has been utilized as a source of free radicals through decomposition of endoperoxide bridges catalyzed by ferrous ions,nonetheless,the non-tumor-specific delivery,inferior pharmacokinetics,and hydrophobic nature minimize the efficacy of ART in physiological systems.Herein,we devise a PPA nanoamplifier by conjugating ART with PEG-functionalized Pd@Pt nanoplates(PP NPs)to form ester linkage,ensuring specific intratumoral esterase-responsive ART release.Significantly,the PPA nanoamplifier combines the in situ decomposition of ARTs endoperoxide bridges by Fe^(2+) to superoxide anions(O_(2)^(·-))and peroxidase(POD)-like enzymatic catalysis of endogenous H_(2)O_(2) by PP to hydroxyl radicals(*OH),thus achieving amplified ROS-mediated tumor therapy.Besides,PPA displays GSH destruction potential,thereby protecting ROS from the cleavage by GSH oxidation.In addition,the strong absorption of PPA in near-infrared(NIR)region also endows PPA with photoacoustic property to realize imaging-guided CDT.In short,by taking advantages of the high enrichment and esterase-responsive drug release at tumor sites,PPA amplified ROS signals via dual pathways,killing tumor cells in vitro are inhibiting tumor growth in vivo,thereby realizing high-efficiency non-Fenton CDT.We believe our novel anti-tumor strategy based on PPA will broaden the future of ROS-mediated tumor-targeted therapy. | Sijin Xiang Zhongxiong Fan Ziehen Ye Tianbao Zhu Dao Shi Shefang Ye Zhenqing Hou Xiaolan Chen | 2022 | Nano Research2022，15，2： | 2 |
| 20 | Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics显示文摘Gold nanoparticles(AuNPs) have been attractive for nanomedicine because of their pronounced optical properties.Here,we customerized the methods to synthesize two types of gold nanostars,Au nanostars-1 and Au nanostars-2,which have different spire lengths and optical properties,and also spherical AuNPs.Compared to nanospheres,gold nanostars were less toxic to a variety of cells,including macrophages.Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres,and but reveled less liver retention than nanospheres.Due to their strong absorption in the near-infrared(NIR),Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm,and elicited a robust photothermal therapy(PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells.Meanwhile,Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy(SERS) in 4T1 cells.Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy. | Jie Gao Maria Sanchez-Purra Hao Huang ShunhaoWang Yunan Chen Xuefeng Yu Qian Luo Kimberly Hamad-Schifferli Sijin Liu | 2017 | Science China Chemistry2017，60，9： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员