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| 1 | Effects of Honghua preserved amniotic membrane on scar healing in experimental glaucoma surgery显示文摘AIM:To investigate the efficacy and safety of Honghua preserved amniotic membrane(AM)for preventing scar formation of the filtering bleb in a rabbit model of glaucoma trabeculectomy surgery.METHODS:Totally 36 rabbits(36 eyes)were randomly divided into 3 groups:the experimental group(ocular trabeculectomy in combination with Honghua preserved AM transplantation),the control group(ocular trabeculectomy surgery in combination with AM implantation),and the blank group(single trabeculectomy).Clinical observations[including intraocular pressure(IOP),filtering blebs and complications],MassonTrichrome staining,real-time quantitative reverse transcription-polymerase chain reaction(real-time PCR),Western blot were performed on different time points(D1,D7,D14,D21 and D56)after the surgery.RESULTS:After operated for 14d,there were statistically significant differences in the filtering blebs compared to the situation before operation(P<0.05),whereas no statistically difference on that among three groups(P>0.05).After 21d,the IOP of experimental group was lowest(P<0.05).There was significant difference between control group and blank group(P<0.05).On postoperative D14,the mean number of fibroblasts in the experimental group was significantlylower(40.6±10.2)compared to those in the control group(54.4±10.8)and blank group(68.2±11.6)(P<0.05,respectively).The mean numbers of the macrophage in the experimental and control groups were respcitively significantly lower versus the blank group(P<0.05,P<0.05,respectively).Compared to that in blank group,the level of transforming growth factor-β(TGF-β1)expression in sclera and conjunctival areas was reduced in the experimental and control groups on protein and mRNA level(P<0.05),but not significant difference between these two groups(P>0.05).CONCLUSION:The trabeculectory surgery with Honghua preserved AM can control IOP,sustain the functional filtration bleb,inhibit the proliferation of fibroblasts and open the filtrating pathway on the rabbit glaucoma models. | Yi Shao Yao Yu Qiu-Ping Liu Jing-Ming Li Fei Dong Xin Huang Chong-Gang Pei Ping Tu Hen-Hui Li Gui-Ping Gao | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 16 |
| 2 | MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘 | Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen | 2015 | Chinese Medical Journal2015，，7： | 15 |
| 3 | Nonintubated uniportal video-assisted thoracoscopic surgery for primary spontaneous pneumothorax显示文摘Objective:The objective of the current study was to evaluate the feasibility and safety of nonintubated uniportal video-assisted thoracoscopic surgery(VATS) for the management of primary spontaneous pneumothorax(PSP).Methods:From November 2011 to June 2013,32 consecutive patients with PSP were treated by nonintubated uniportal thoracoscopic bullectomy using epidural anaesthesia and sedation without endotracheal intubation.An incision 2 cm in length was made at the 6^(th) intercostal space in the median axillary line.The pleural space was entered by blunt dissection for placement of a soft incision protector.Instruments were then inserted through the incision protector to perform thoracoscopic bullectomy.Data were collected within a minimum follow-up period of 10 months.Results:The average time of surgery was 49.0 min(range,33-65 min).No complications were recorded.The postoperative feeding time was 6 h.The mean postoperative chest tube drainage and hospital stay were19.3 h and 41.6 h,respectively.The postoperative pain was mild for 30 patients(93.75%) and moderate for two patients(6.25%).No recurrences of pneumothorax were observed at follow-up.Conclusions:The initial results indicated that nonintubated uniportal video-assisted thoracoscopic operations are not only technically feasible,but may also be a safe and less invasive alternative for select patients in the management of PSP.This is the first report to include the use of a nonintubated uniportal technique in VATS for such a large number of PSP cases.Further work and development of instruments are needed to define the applications and advantages of this technique. | Shuben Li Fei Cui Jun Liu Xin Xu Wenlong Shao Weiqiang Yin Hanzhang Chen Jianxing He | 2015 | Chinese Journal of Cancer Research2015，27，2： | 15 |
| 4 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 5 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
| 6 | Evaluation of ecological sensitivity in Karamay, Xinjiang, China显示文摘Karamay 城市是一个典型采矿城市,依靠油矿探索和开发。在 60 年建设和开发以后, Karamay 在中国成为了第一个大油矿和国家石油和石油化学的工业的一个重要的底。基于空间分析,和地理信息系统( GIS )格子计算和覆盖技术,虽然考虑油矿开发的效果并且在中国的 Xinjiang Uygur 自治区域瞄准了 Karamay 城市的生态的问题,我们在 Karamay 的全面生态的敏感的空间特征上进行了研究。自然环境进化的生态的问题包括土壤侵蚀,陆地 desertification,土壤 salinization,和生物多样性减小。从在这个区域的人的活动的最重要的骚乱因素是油矿利用。这研究执行单个因素的分析生态的问题敏感和综合生态的敏感。研究的结果如下:(1 ) 土壤侵蚀是相对敏感的,特别在 Karamay 区域, Dushanzi 区域, Urho 区域的北方和 Baijiantan 区域的西方,它主要是垂直落下斜坡的结果。(2 ) 陆地 desertification 的主要类型被高、中等的等级敏感代表,并且高、极其高敏感的区域在 Karamay 和 Baijiantan 区域的交叉是分布式的。这由于在这些区域超过降雨的蒸发,并且土壤主要由沙组成并且是很少由植被盖住。(3 ) 土壤 salinizatiion 敏感等级主要中等、高、极其高。高度敏感的区域主要在 Karamay 区域的 Baijiantan 区域,北方和东方和 Urho 区域的东方的东南被散布。主要原因是超过降雨和极端人的活动的蒸发。(4 ) 生物多样性敏感的主要类型是光和中等等级。高度敏感的区域位于 Karamay 区域的东方和南方, Baiyang 河盆的北方和沼泽地区域的部分。(5 ) 油地发展区域是高度生态地敏感,它位于 Urho 区域, Baijiantan 区域的西方的油矿, Karamay dis trict 的西北的油矿和 Dushanzi 的中央油矿的北油矿区域。(6 ) 综合生态的敏感的主要类型高、中等。高、极其高度敏感的区域位于 Baijiantan 区域的 Karamay 区域,和西南的中央、北的部分。评估结果将为计划的未来和发展提供指导,生态的环境的保护和在 Karamay 的和谐社会、经济、生态的开发的实现城市。 | PAN Feng TIAN Changyan SHAO Feng ZHOU Wei CHEN Fei | 2012 | Journal of Geographical Sciences2012，22，2： | 9 |
| 7 | Primary site and regional lymph nodeinvolvement are independent prognosticfactors for early?stage extranodal nasal?typenatural killer/T cell lymphoma显示文摘Background:Nasal-type extranodal natural killer/T-cell lymphoma(ENKTCL) originates primarily in the nasal cavity or extra-nasal sites within the upper aerodigestive tract.However,it is unclear whether the primary site can serve as an independent prognostic factor or whether the varying clinical outcomes observed with different primary sites can be attributed merely to their propensities of regional lymph node involvement.The aim of this study was to investigate the prognostic implications of the primary site and regional lymph node involvement in patients with early-stage nasal-type ENKTCL.Methods:To develop a nomogram,we reviewed the clinical data of 215 consecutively diagnosed patients with early-stage nasal-type ENKTCL who were treated in Sun Yat-sen University Cancer Center with chemotherapy and radiotherapy between 2000 and 2011.The predictive accuracy and discriminative ability of the nomogram were determined using a concordance index(C-index) and calibration curve.Results:The 5-year overall survival(OS) and progression-free survival(PFS) rates of patients with nasal ENKTCL were higher than those of patients with extra-nasal ENKTCL(OS:68.2%vs.46.0%,P = 0.030;PFS:53.4%vs.26.6%,P = 0.010).The 5-year OS and PFS rates of patients with Ann Arbor stage IE ENKTCL were higher than those of patients with Ann Arbor stage HE ENKTCL(OS:66.3%vs.59.2%,P = 0.003;PFS:51.4%vs.40.3%,P = 0.009).Multivariate analysis showed that age >60 years,ECOG performance status score >2,elevated lactate dehydrogenase(LDH) level,extranasal primary site,and regional lymph node involvement were significantly associated with lower 5-year OS rate;age >60 years,elevated LDH level,extra-nasal primary site,and regional lymph node involvement were significantly associated with lower 5-year PFS rate.The nomogram included the primary site and regional lymph node involvement based on multivariate analysis.The calibration curve showed good agreement between the predicted and actual 5-year OS and PFS rates,and the C-indexes of the nomogram for the OS and PFS rates were 0.697 and 0.634,respectively.Conclusions:The primary site and regional lymph node involvement are independent prognostic factors for earlystage ENKTCL treated with chemotherapy followed by definitive radiotherapy. | Shao‑Qing Niu Yong Yang Yi‑Yang Li Ge Wen Liang Wang Zhi‑Ming Li Han‑Yu Wang Lu‑Lu Zhang Yun‑Fei Xia Yu‑Jing Zhang | 2016 | Chinese Journal of Cancer2016，35，5： | 8 |
| 8 | An all-optical modulator based on a stereo graphene–microfiber structure显示文摘An in-line,all-optical fiber modulator based on a stereo graphene–microfiber structure(GMF)utilizing the lab-on-rod technique was demonstrated in this study.Owing to its unique spring-like geometry,an ultra-long GMF interaction can be achieved,and a modulation depth of,7.5 dB(,2.5 dB)and a modulation efficiency of,0.2 dB mW^(-1)(,0.07 dB mW^(-1))were demonstrated for two polarization states.The modulation depth and modulation efficiency are more than one order of magnitude larger than those of other graphene–microfiber hybrid all-optical modulators,although at the cost of a higher insertion loss.By further optimizing the transferring and cleaning process,the upper limit of the modulation depth is mainly determined by the loss from the intrinsic absorption,which depends on the light–graphene interaction.Then,the modulator can quickly switch between the on-state and the off-state with a theoretically maximized modulation depth of tens of decibels.This modulator is compatible with the current fiber-optic communication systems and may be applied in the near future to meet the impending need for ultrafast optical signal processing. | Jin-Hui Chen Bi-Cai Zheng Guang-Hao Shao Shi-Jun Ge Fei Xu Yan-Qing Lu | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 9 | Whole Genome Analysis Reveals New Insights into Macrolide Resistance in Mycoplasma pneumoniae显示文摘Objective Mutations in 23 S rRNA gene are known to be associated with macrolide resistance in Mycoplasma pneumoniae(M. pneumoniae). However, these mutations alone do not fully explain the high resistance rates in Asia. The aim of this study was to investigate other possible mutations involved in macrolide resistance in M. pneumoniae. Methods The whole genomes of 10 clinical isolates of M. pneumoniae with macrolide resistance were sequenced by Illumina Hi Seq2000 platform. The role of the macrolide-specific efflux transporter was assessed by efflux-pump inhibition assays with reserpine and carbonyl cyanide m-chlorophenyl-hydrazone(CCCP). Results A total of 56 single nucleotide polymorphisms(SNPs) were identified in 10 clinical isolates in comparison to the reference strains M129 and FH. Strikingly, 4 of 30 SNPs causing non-synonymous mutations were clustered in macrolide-specific efflux system gene mac B encoding macrolide-specific efflux pump protein of the ATP-binding cassette transporter family. In assays of the minimal inhibitory concentrations(MIC) of macrolide antibiotics in the presence of the efflux pump inhibitors caused a significant decrease of MICs, even under detectable levels in some strains. Conclusion Our study suggests that macrolide efflux pump may contribute to macrolide resistance in M. pneumoniae in addition to the common point mutations in 23 S r RNA gene. | LI Shao Li SUN Hong Mei ZHU Bao Li LIU Fei ZHAO Han Qing | 2017 | Biomedical and Environmental Sciences2017，30，5： | 7 |
| 10 | Gene Expression Profiling in Apoptotic K562 Cells Treated by Homoharringtonine显示文摘基因薄片技术被用来在 homoharringtonine 导致的 apoptotic K562 房间决定基因表达侧面。mRNAs 被发现显著地被换掉的 44 的表达式在与能够同时检测 14,218 不同人的 mRNA 种类的一块基因芯片屏蔽以后被识别。这些基因, 17 是起来调整的, 27 是下面调整的。他们中的大多数被发现与 apoptosis, oncogenes,或肿瘤抑制有关。有改变的基因表达的几基因,例如人的转变生长因素贝它可诱导的早蛋白质基因( TIEG ),在调整蛋白质上面的 维生素 D3 1 基因( VDUP1 ), RNA 有约束力的主题蛋白质 4 基因( RBM4 )和 v-myc myelocytomatosis 病毒的癌基因相当或相同的事物( C-MYC ),被RNA 印迹分析证实。根据在这些 apoptotic 房间的动态基因表达模式,激活的转变生长因素贝它和肿瘤坏死因素发信号小径在导致 homoharringtonine 的 apoptosis 起一个重要作用。TIEG 显著地在 apoptosis 正式就职以后被改变,它应该为 apoptosis 信号传播是批评的。 | Wei JINX Jiong WU Zhigang ZHUANG Junjie Li Fei FEI Genhong DI Ying CHEN Ming YAO Zhimin SHAO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 11 | Accumulation characteristic of protein bodies in different regions of wheat endosperm under drought stress显示文摘The structural characteristics of protein body accumulation in different endosperm regions of hard wheat cultivar(XM33) and soft wheat cultivar(NM13) under drought stress were investigated. Drought stress treatment was implemented from plant regreening to the caryopsis mature stage. Microscope images of endosperm cells were obtained using resin semithin slice technology to observe the distribution and relative area of protein body(PB). Compared with NM13, relative PB area of XM33 was significantly higher in sub-aleurone endosperm region. The amount of accumulation, including the size and relative area of PB, in two wheat cultivars was higher in sub-aleurone region than that in central region at 18 days post anthesis(DPA). Drought stress significantly enhanced the sizes and relative areas of PBs in the dorsal and abdominal endosperms in two wheat cultivars. Particularly for dorsal endosperm, drought stress enhanced the relative PB area at 18 DPA and NM13(5.0% vs. 6.73%) showed less enhancement than XM33(5.49% vs. 8.96%). However, NM13(9.58% vs. 12.02%) showed greater enhancement than XM33(10.25% vs. 11.7%) at 28 DPA. The protein content in the dorsal and abdominal endosperms of the two wheat cultivars decreased at 12 DPA and then increased until 38 DPA. Drought stress significantly increased the protein contents in the two main regions. From 12 to 38 DPA, the amount of PB accumulation and the protein content were higher in XM33 than those in NM13. The results revealed that PB distribution varied in different endosperm tissues and that the amount of PB accumulation was remarkably augmented by drought stress. | CHEN Xin-yu LI Bo SHAO Shan-shan WANG Lei-lei ZHU Xiao-wei YANG yang WANG Wen-jun YU Xu-run XIONG Fei | 2016 | Journal of Integrative Agriculture2016，15，12： | 6 |
| 12 | An efficient synthesis of 3-(guaiazulene-1-yl)succinimides by addition of guaiazulene to maleimides显示文摘A facile,efficient synthesis of 3-(guaiazulen-1-yl)succinimides was developed by Michael-type addition of guaiazulene to maleimides in the presence of p-toluenesulfonic acid under mild reaction conditions. | Dao Lin Wang Shao Fei Li Wei Li Yuan Feng Li Li Nan Lin | 2011 | Chinese Chemical Letters2011，22，7： | 6 |
| 13 | Preparation of ultrafine chitosan particles by reverse microemulsion显示文摘Ultrafine chitosan particles were prepared by reverse microemulsion consisting of water, Triton X-100, octanol and cyclohexane. Two methods of preparing ultrafine chitosan particles were adopted and compared using TEM and IR, and possible mechanisms for the formation of ultrafine chitosan particles were proposed. Experimental results show that the method which combined ionic gelation and cross-linking gave uniformly sized chitosan nanoparticles with an average diameter of 92 nm, while the cross-linking without ionic gelation produced spindly chitosan particles with an average length of 943 nm and width of 188 nm. | Guogen Liu Lei Shao Fei Ge Jianfeng Chen | 2007 | China Particuology2007，5，6： | 5 |
| 14 | Direct synthesis of L10-FePt nanopartides from single-source bimetallic complex and their electrocatalytic applications in oxygen reduction and hydrogen evolution reactions显示文摘L10-FePt nan oparticles(NPs)with high chemical ordering represent effective electrocatalysts to reduce the cost and enhance theircatalytic performanee in fuel cells.A molecular strategy of preparing highly ordered FePt NPs was used by direct pyrolysis of a Fe,Pt-containing bimetallic complex.The resultant L10-FePt NPs had very high crystallinity as reflected by the obvious diffractionpatterns,clear lattice fringes and characteristic X-ray diffraction peaks,etc.Besides,the strong ferromagnetism with room temperaturecoercivity of 27 kOe further confirmed the face-centered tetrag on al(fet)phase in good agreement with the ordered nano structures.TheFePt NPs can be used as electrocatalysts to catalyze oxygen reduction reaction(ORR)in an O2·saturated 0.1 M HClO4 solution andhydrogen evolution reaction(HER)in the 0.5 M H2SO4 electrolyte with much better performance than commercial Pt/C,and showedquite high stability after 10,000 cycles.The strategy utilizing orga no metallic precursors to prepare metal alloy NPs was dem on strated tobe a reliable approach for improving the catalytic efficiency in fuel cells. | Zhengong Meng Fei Xiao Zhuoxun Wei Xuyun Guo Ye Zhu Yurong Liu Guijun Li Zhen-Qiang Yu Minhua Shao Wai-Yeung Wong | 2019 | Nano Research2019，12，12： | 5 |
| 15 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 16 | Pushing periodic-disorder-induced phase matching into the deep-ultraviolet spectral region:theory and demonstration显示文摘Nonlinear frequency conversion is a ubiquitous technique that is used to obtain broad-range lasers and supercontinuum coherent sources.The phase-matching condition(momentum conservation relation)is the key criterion but a challenging bottleneck in highly efficient conversion.Birefringent phase matching(BPM)and quasiphase matching(QPM)are two feasible routes but are strongly limited in natural anisotropic crystals or ferroelectric crystals.Therefore,it is in urgent demand for a general technique that can compensate for the phase mismatching in universal nonlinear materials and in broad wavelength ranges.Here,an additional periodic phase(APP)from order/disorder alignment is proposed to meet the phase-matching condition in arbitrary nonlinear crystals and demonstrated from the visible region to the deep-ultraviolet region(e.g.,LiNbO_(3) and quartz).Remarkably,pioneering 177.3-nm coherent output is first obtained in commercial quartz crystal with an unprecedented conversion efficiency above 1‰.This study not only opens a new roadmap to resuscitate those long-neglected nonlinear optical crystals for wavelength extension,but also may revolutionize next-generation nonlinear photonics and their further applications. | Mingchuan Shao Fei Liang Haohai Yu Huaijin Zhang | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 17 | A grid-based clustering algorithm for wild bird distribution显示文摘 | Yuwei WANG Yuanchun ZHOU Ying LIU Ze LUO Danhuai GUO Jing SHAO Fei TAN Liang WU Jianhui LI Baoping YAN | 2013 | Frontiers of Computer Science2013，7，4： | 4 |
| 18 | Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China显示文摘Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula(PIF) presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins(BoNTs) and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis(PFGE) revealed that the two strains of C. botulinum isolated from the two samples produced indistinguishable pulsotypes. These findings confirmed this case of type B infant botulism associated with the ingestion of PIF contaminated by type B C. botulinum spores. | DONG Yin Ping WANG Wei JIANG Tao XU Jin HAN Chun Hui YAN Shao Fei Séamus Fanning LI Ying MA Xiao Chen ZHANG Di ZHAO Yao ZENG Biao LI Feng Qin | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
| 19 | Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:a TCGA pan-cancer analysis显示文摘Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the clini-cal significance of PGK1 expression and function in cancer progression is unclear.Here,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism regulation.Methods:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas datasets.Using specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer types.Results:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,respectively.In breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor prognosis.Positively correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal cancers.PGK1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach cancer.Conclusions:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of cancer.PGK1 and PDHK1 phosphorylation may be potential prognostic biomarkers. | Fei Shao Xueying Yang Wei Wang Juhong Wang Wei Guo Xiaoli Feng Susheng Shi Qi Xue Shugeng Gao Yibo Gao Zhimin Lu Jie He | 2019 | Cancer Communications2019，39，1： | 4 |
| 20 | The Distribution and Concentration Monitoring of Benzene Industries—Six PLADs,China,2020显示文摘Summary What is already known about this topic?Benzene is classified as a Class I human carcinogen by the International Agency for Research on Cancer.Long-term exposure to benzene increases the risk of chronic benzene poisoning and leukemia.However,benzene is still widely used in the manufacturing industry.What is added by this report? | Xue Wang Jin Zhou Lei Han Xiurong Cheng Hua Shao Qiang Jia Peiyu Xu Jing Liu Jie Ren Jin Li Fei Li Baoli Zhu Meibian Zhang Caihong Xing | 2021 | China CDC weekly2021，3，43： | 4 |
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