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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Assessing the health risk of heavy metals in vegetables to the general population in Beijing,China显示文摘A systematic survey of As, Cd, Cr, Cu, Ni, Pb and Zn concentrations in vegetables from 416 samples (involving 100 varieties) in Beijing was carried out for assessing the potential health risk to local inhabitants. The results indicated that the metal concentrations in vegetables ranged from < 0.001 to 0.479 μg/g fresh weight (fw) (As), < 0.001 to 0.101 μg/g fw (Cd), < 0.001 to 1.04 μg/g fw (Cr), 0.024 to 8.25 μg/g fw (Cu), 0.001 to 1.689 μg/g fw (Ni), < 0.001 to 0.655 μg/g fw (Pb) and 0.01 to 25.6 μg/g fw (Zn), with average concentrations of 0.013, 0.010, 0.023, 0.51, 0.053, 0.046 and 2.55 μg/g fw, respectively. The results showed that the concentrations of As, Cr, Cu, Cd, Pb and Ni in vegetables from open-fields were all significantly higher than those grown in greenhouses. In addition, in local-produced vegetables, all HMs except Zn were significantly higher than those in provincial vegetables. The estimated daily intake (EDI) of As, Cd, Cr, Cu, Ni, Pb and Zn from vegetables was 0.080, 0.062, 0.142, 3.14, 0.327, 0.283 and 15.7 μg/(kg body weight (bw)·d) for adults, respectively. Arsenic was the major risk contributor for inhabitants since the target hazard quotient based on the weighted average concentration (THQw) of arsenic amounted to 44.3% of the total THQ (TTHQ) value according to average vegetable consumption. The TTHQ was lower than 1 for all age groups, indicating that it was still safe for the general population of Beijing to consume vegetables. | SONG Bo LEI Mei CHEN Tongbin ZHENG Yuanming XIE Yunfeng LI Xiaoyan GAO Ding | 2009 | Journal of Environmental Sciences2009，21，12： | 45 |
| 3 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 4 | Regulation of Stamen Development by Coordinated Actions of Jasmonate, Auxin, and Gibberellin in Arabidopsis显示文摘合适的雄蕊开发是必要的让植物完成他们的生命周期。在雄蕊开发的缺点将引起 malesterility。研究努力的一个广阔数组被使理解雄蕊发展过程和规章的 mechanismsover 过去的十年。包括 jasmonate,植物生长素,赤霉素, brassinosteroid,和细胞激动素,植物激素在雄蕊开发的规定起必要作用,这到目前为止被报导。这评论将简短在 Arabidopsis.Key 词由 jasmonate,植物生长素,和赤霉素为雄蕊开发的协调规定总结 molecularbasis: | Susheng Song Tiancong Qi Huang Huang Daoxin Xie | 2013 | Molecular Plant2013，6，4： | 29 |
| 5 | Application and Prospect of Mixed Reality Technology in Medical Field显示文摘Mixed reality(MR)technology is a new digital holographic image technology,which appears in the field of graphics after virtual reality(VR)and augmented reality(AR)technology,a new interdisciplinary frontier.As a new generation of technology,MR has attracted great attention of clinicians in recent years.The emergence of MR will bring about revolutionary changes in medical education training,medical research,medical communication,and clinical treatment.At present,MR technology has become the popular frontline information technology for medical applications.With the popularization of digital technology in the medical field,the development prospects of MR are inestimable.The purpose of this review article is to introduce the application of MR technology in the medical field and prospect its trend in the future. | Hong-zhi HU Xiao-bo FENG Zeng-wu SHAO Mao XIE Song XU Xing-huo WU Zhe-wei YE | 2019 | Current Medical Science2019，39，1： | 29 |
| 6 | PVT v2:Improved baselines with Pyramid Vision Transformer显示文摘Transformers have recently lead to encouraging progress in computer vision.In this work,we present new baselines by improving the original Pyramid Vision Transformer(PVT v1)by adding three designs:(i)a linear complexity attention layer,(ii)an overlapping patch embedding,and(iii)a convolutional feed-forward network.With these modifications,PVT v2 reduces the computational complexity of PVT v1 to linearity and provides significant improvements on fundamental vision tasks such as classification,detection,and segmentation.In particular,PVT v2 achieves comparable or better performance than recent work such as the Swin transformer.We hope this work will facilitate state-ofthe-art transformer research in computer vision.Code is available at https://github.com/whai362/PVT. | Wenhai Wang Enze Xie Xiang Li Deng-Ping Fan Kaitao Song Ding Liang Tong Lu Ping Luo Ling Shao | 2022 | Computational Visual Media2022，8，3： | 30 |
| 7 | Emissions of SO_2, NO and N_2O in a circulating fluidized bed combustor during co-firing coal and biomass显示文摘这份报纸论述排出物 ofSO2 的试验性的调查,没有并且在传播的凳子规模的 N2O 使流体化为燃烧室的热能力是的煤燃烧和 co-firingcoal 和 biomass.The 的 bedcombustor 30 kW.The 安装是过量空气的 electricallyheatedduring startup.The 影响,空气阶段的度,在 SO2 的排出物上喂 thefuels 的位置的生物资源份额 andthe ,没有并且 N2O 是 studied.The 结果 showedthat | XIE Jian-jun YANG Xue-min ZHANG Lei DING Tong-li SONG Wen-li LIN Wei-gang | 2007 | Journal of Environmental Sciences2007，19，1： | 26 |
| 8 | Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent显示文摘铁在 Parkinson 的疾病(PD ) 起一个关键作用。substantia nigra (SN ) 的增加的铁内容在 PD 病人,和二价的金属 transporter 被发现了(DMT1 ) 1 被显示了在两个导致 MPTP 的 PD 模型和 PD 病人的 SN 起来调整。然而,位于 DMT1 起来规定下面的机制大部分是未知的。在现在的学习,我们观察到那在 6-hydroxydopamine ( 6-OHDA )的 SN 导致了 PD 老鼠,有铁的 DMT1 应答的元素(怒火, DMT1+IRE ),然而并非没有怒火( DMT1?IRE )的 DMT1 ,是起来调整的,建议那增加的 DMT1+IRE 表情可能在 PD 老鼠说明 nigral 铁累积。这可能性进一步被估计在一在里面 vitro 学习使用 6-OHDA-treated 和 DMT1+IRE-over-expressing MES23.5 房间。在 6-OHDA-treated MES23.5 房间,增加了铁规章的蛋白质(IRP ) 1 并且 IRP2 表示被观察,当 IRP 的 silencing 戏剧性地减少了时 6-OHDA-induced DMT1+IRE 起来规定。有 N-acetyl-L-cysteine 的预告的处理充分由 6-OHDA-induced 的抑制压制了 IRP 起来规定氧化应力。增加的 DMT1+IRE 表示由 MES23.5 房间导致了增加的铁流入。我们的数据提供 DMT1+IRE 起来规定能说明细胞内部的氧化应力和那增加了的 6-OHDA-induced 开始的 IRE/IRP-dependent 6-OHDA-induced 铁累积的直接证据细胞内部的铁的层次导致加重的氧化应力。这研究的结果提供在 PD 的处理支持抗氧化剂的使用的新奇证据,旨在禁止由 DMT1 表示的规定的铁累积。 | Hong Jiang Ning Song Huamin Xu Shuzhen Zhang Jun Wang Junxia Xie | 2010 | Cell Research2010，20，3： | 25 |
| 9 | Deep Learning and Its Applications in Biomedicine显示文摘Advances in biological and medical technologies have been providing us explosive volumes of biological and physiological data,such as medical images,electroencephalography,genomic and protein sequences.Learning from these data facilitates the understanding of human health and disease.Developed from arti?cial neural networks,deep learning-based algorithms show great promise in extracting features and learning patterns from complex data.The aim of this paper is to provide an overview of deep learning techniques and some of the state-of-the-art applications in the biomedical?eld.We?rst introduce the development of arti?cial neural network and deep learning.We then describe two main components of deep learning,i.e.,deep learning architectures and model optimization.Subsequently,some examples are demonstrated for deep learningapplications,including medical image classi?cation,genomic sequence analysis,as well as protein structure classi?cation and prediction.Finally,we offer our perspectives for the future directions in the?eld of deep learning. | Chensi Cao Feng Liu Hai Tan Deshou Song Wenjie Shu Weizhong Li Yiming Zhou Xiaochen Bo Zhi Xie | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 22 |
| 10 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 11 | Ratios of T-helper 2 Cells to T-helper 1 Cells and Cytokine Levels in Patients with Hepatitis B显示文摘 | Ming-Hui Li Dan Zhang Lu Zhang Xiao-Jing Qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Hong-Xiao Hao Wen-Hao Hua Shu-Jing Song Gang Wan Shun-Ai Liu Yao Xie | 2017 | Chinese Medical Journal2017，，15： | 21 |
| 12 | Identification of QTLs Related to Bolting in Brassica rapa ssp. pekinensis (syn. Brassica campestris ssp. pekinensis)显示文摘A genetic linkage map of Brassica rapa ssp. pekinensis was constructed with 186 AFLP (amplified fragment length polymorphism) markers by using a doubled-haploid (DH) population with 183 individuals. The individuals were derived from F1 which was developed by crossing a bolting resistant DH line Y-177-12 and an easy bolting DH line Y195-93a. AFLPs were generated by the use of restriction enzymes EcoR Ⅰ and Mse Ⅰ. The segregation of each marker and linkage was analyzed by using JoinMap version 3.0. Mapped markers were aligned in ten linkage groups which covered 887.8 cM with an average marker interval of 4.47 cM. Markers showing skewed segregation ratio were clustered in six LGs. Quantitative trait loci (QTL) were mapped for bolting resistance by using MAPQTL 4.0 package. Four QTLs explaining from 7.0 to 9.4% of the total variation were detected, all of them increase bolting resistance. These mapped QTLs could be used to develop a marker assisted selection programme for bolting resistance breeding. | ZHANG Xiao-wei WU Jian ZHAO Jian-jun SONG Xiao-fei LI Ying ZHANG Yan-guo XU Dong-hui SUN Ri-fei YUAN Yu-xiang XIE Cong-hua WANG Xiao-wu | 2006 | Agricultural Sciences in China2006，5，4： | 20 |
| 13 | Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats显示文摘AIM:To explore the effect of sophocarpine on experimental liver fibrosis and the potential mechanism involved.METHODS:Sophocarpine was injected intraperitoneally in two distinct rat hepatic fibrosis models induced either by dimethylnitrosamine or bile duct ligation.Masson’s trichrome staining,Sirius red staining and hepatic hydroxyproline level were used for collagen determination.Primary hepatic stellate cells(HSCs)were isolated and treated with different concentrations of sophocarpine.Real-time reverse transcription-polymerase chain reaction was used to detect the mRNA levels of fibrotic markers and cytokines.The expression of pathway proteins was measured by Western blot.The Cell Counting Kit-8 test was used to detect the proliferation rate of activated HSCs treated with a gradient concentration of sophocarpine.RESULTS:Sophocarpine decreased serum levels of aminotransferases and total bilirubin in rats under chronic insult.Moreover,administration of sophocarpine suppressed extracellular matrix deposition and prevented the development of hepatic fibrosis.Furthermore,sophocarpine inhibited the expression ofα-smooth muscle actin(SMA),interleukin(IL)-6,transforming growth factor-β1(TGF-β1),Toll-like receptor 4(TLR4),and extracellular-related kinase(ERK)in rats.Sophocarpine also down-regulated the mRNA expression ofα-SMA,collagenⅠ,collagenⅢ,TGF-β1,IL-6,tumor necrosis factor-αand monocyte chemoattractant protein-1,and decreased protein levels of TLR4,p-ERK,p-JNK,p-P38 and p-IKK in vitro after Lipopolysaccharide induction.In addition,sophocarpine inhibited the proliferation of HSCs accompanied by a decrease in the expression of Cyclin D1.The protein level of proliferating cell nuclear antigen was decreased in activated HSCs following a gradient concentration of sophocarpine.CONCLUSION:Sophocarpine can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway.Sophocarpine may be a potential chemotherapeutic agent for chronic liver diseases. | Hui Qian Jian Shi Ting-Ting Fan Jiao Lv Si-Wen Chen Chun-Yan Song Zhi-Wu Zheng Wei-Fen Xie Yue-Xiang Chen | 2014 | World Journal of Gastroenterology2014，20，7： | 19 |
| 14 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 15 | Inhibitory effects of tanshinone Ⅱ-A on invasion and metastasis of human colon carcinoma cells显示文摘 | Yun-feng SHAN Xian SHEN Yuan-kang XIE Ji-cai CHEN Hong-qi SHI Zheng-ping YU Qi-tong SONG Men-tao ZHOU Qi-yu ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，11： | 18 |
| 16 | Kinetics of Hepatitis B Surface Antigen Level in Chronic Hepatitis B Patients who Achieved Hepatitis B Surface Antigen Loss during Pegylated Interferon Alpha-2a Treatment显示文摘 | Ming-Hui Li Lu Zhang Xiao-Jing Qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping HU Zhen-Zhen Li Wen-Hao Hua Shu-Jing Song Yao Xie | 2017 | Chinese Medical Journal2017，，5： | 18 |
| 17 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 18 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 19 | Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected Late Presenters显示文摘 | Fu-Ping Guo Yi-Jia Li Zhi-Feng Qiu Wei Lv Yang Han Jing Xie Yan-Ling Li Xiao-Jing Song Shan-Shan Du Vikram Mehraj Tai-Sheng Li Jean-Pierre Routy | 2016 | Chinese Medical Journal2016，，22： | 16 |
| 20 | Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals显示文摘瞄准:在脂肝上评估 osthole 的效果,并且调查可能的机制。方法:有 hyperlipidemic 脂肝的一个鹑模型和有含酒精的脂肝的老鼠模型被分别地喂多脂饮食和白酒建立。这些实验动物然后分别地为 6 wk 与 osthole 5-20 mg/kg 被对待。然后,在浆液的类脂化合物和肝的织物,和肝的重量的系数被测量。结果:胆固醇(TC ) ,甘油三酸酯(TG ) ,更低的密度脂蛋白胆固醇(LDL-C ) ,肝的重量的系数,和肝的织物 TC 和 TG 满足的有浆液的层次总计的 osthole 的术后疗法显著地被减少。在肝的超级氧化物歧化酶(草皮) 的活动被改进。在导致白酒的脂肝老鼠,在肝的 malondialdehyde (MDA ) 的水平被减少。在高导致脂肪的脂肝鹑,在肝的谷胱甘肽过氧化物酶(GSH-PX ) 显著地被改进。肝标本的组织学的评估证明 osthole 戏剧性地减少了类脂化合物累积。结论:这些结果建议 osthole 在酒精和高导致脂肪的脂肝上有治疗学的效果。机制可能与它的反氧化被联系。 | Fang Song Mei-Lin Xie Lu-Jia Zhu Ke-Ping Zhang Jie Xue Zhen-Lun Gu | 2006 | World Journal of Gastroenterology2006，12，27： | 15 |
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