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| 1 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 2 | Under the surface:Pressure-induced planetary-scale waves,volcanic lightning,and gaseous clouds caused by the submarine eruption of Hunga Tonga-Hunga Ha'apai volcano显示文摘We present a narrative of the eruptive events culminating in the cataclysmic January 15, 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and lightning data available within the first few weeks after the eruption occurred. The first hour of eruptive activity produced fast-propagating tsunami waves, long-period seismic waves, loud audible sound waves, infrasonic waves, exceptionally intense volcanic lightning and an unsteady volcanic plume that transiently reached-at 58km-the Earth’s mesosphere. Energetic seismic signals were recorded worldwide and the globally stacked seismogram showed episodic seismic events within the most intense periods of phreatoplinian activity, and they correlated well with the infrasound pressure waveform recorded in Fiji. Gravity wave signals were strong enough to be observed over the entire planet in just the first few hours, with some circling the Earth multiple times subsequently. These large-amplitude, long-wavelength atmospheric disturbances come from the Earth’s atmosphere being forced by the magmatic mixture of tephra, melt and gasses emitted by the unsteady but quasicontinuous eruption from 0402±1–1800 UTC on January 15, 2022. Atmospheric forcing lasted much longer than rupturing from large earthquakes recorded on modern instruments, producing a type of shock wave that originated from the interaction between compressed air and ambient(wavy) sea surface. This scenario differs from conventional ideas of earthquake slip, landslides, or caldera collapse-generated tsunami waves because of the enormous(~1000x) volumetric change due to the supercritical nature of volatiles associated with the hot,volatile-rich phreatoplinian plume. The time series of plume altitude can be translated to volumetric discharge and mass flow rate. For an eruption duration of ~12 h, the eruptive volume and mass are estimated at 1.9 km^(3) and~2 900 Tg, respectively, corresponding to a VEI of 5–6 for this event. The high frequency and intensity of lightning was enhanced by the production of fine ash due to magma-seawater interaction with concomitant high charge per unit mass and the high pre-eruptive concentration of dissolved volatiles. Analysis of lightning flash frequencies provides a rapid metric for plume activity and eruption magnitude. Many aspects of this eruption await further investigation by multidisciplinary teams. It represents a unique opportunity for fundamental research regarding the complex, non-linear behavior of high energetic volcanic eruptions and attendant phenomena, with critical implications for hazard mitigation, volcano forecasting, and first-response efforts in future disasters. | David A.Yuen Melissa A.Scruggs Frank J.Spera Yingcai Zheng Hao Hu Stephen R.McNutt Glenn Thompson Kyle Mandli Barry R.Keller Songqiao Shawn Wei Zhigang Peng Zili Zhou Francesco Mulargia Yuichiro Tanioka | 2022 | Earthquake Research Advances2022，2，3： | 7 |
| 3 | Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience显示文摘To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters. | Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang Jacques Goldstein Kai Harenski | 2021 | Chinese Medical Journal2021，，18： | 6 |
| 4 | Effects of high-frequency oscillatory ventilation and conventional mechanical ventilation on oxygen metabolism and tissue perfusion in sheep models of acute respiratory distress syndrome显示文摘 | Liu Songqiao Huang Yingzi Wang Maohua Chen Qiuhua Liu Ling Xie Jianfeng Tan Li Guo Fengmei Yang Congshan Pan Chun Yang Yi Qiu Haibo | 2014 | Chinese Medical Journal2014，，18： | 6 |
| 5 | Partial retrieval of CAD models based on the gradient flows in Lie group显示文摘 | Songqiao Tao Zhengdong Huang Bingquan Zuo Yangping Peng Weirui Kang | 2011 | Pattern Recognition2011，，4： | 1 |
| 6 | A resource aware software partitioning algorithm based on mobility constraints in pervasive grid environments 显示文摘 | Han Songqiao Zhmlg Shensheug Cao Jian | 2008 | Future Generation Computer Systems2008，24，6： | 1 |
| 7 | A new methodology of QoS evaluation and service selection for ubiquitous computing显示文摘 | ZHANG Yong ZHANG Shengsheng HAN Songqiao | 2006 | Lecture Notes in Computer Science2006，4138，： | 1 |
| 8 | The cost of becoming anonymous: on the participant payload in Crowds显示文摘 | Hongfei Sui Jianxin Wang Jianer Chen Songqiao Chen | 2004 | Information Processing Letters2004，，： | 1 |
| 9 | GENERAL STRUCTURE OF OBPES SHELL SYSTEM显示文摘GENERALSTRUCTUREOFOBPESSHELLSYSTEM①LiSongren,LuoShouzhang,ChenSongqiaoDepartmentofMineralEnginering,CentralSouthUniversityofT... | Li, Songren Luo, Shouzhang Chen, Songqiao | 1997 | 中国有色金属学会会刊:英文版1997，7，2： | 1 |
| 10 | Locally Subcube-Connected Hypercube Networks:Theoretical Analysis and Experimental Results显示文摘 | Chen Jianer Wang Guojun Chen Songqiao | 2002 | IEEE Trans on Computers2002，51，5： | 1 |
| 11 | An algorithm research for distributed association rules mining with item constraints based on frequent pattern tree显示文摘 | Li Hong Du Jianfeng Chen Songqiao | 2005 | Computer Engineering And Applications2005，41，7： | 1 |
| 12 | A simple linear time approximation algorithm for multiprocessor job scheduling on four processors显示文摘 | Huang Jingui Chen Jianer Chen Songqiao | 2007 | Journal of Combinatorial Optimization2007，13，1： | 1 |
| 13 | Evolution of the Lop Desert and the Lop Nor显示文摘 | Zhao Songqiao Xia Xuncheng | 1984 | Geographical Journal1984，150，3： | 1 |
| 14 | Anycast service model and its QoS routing algorithm显示文摘 | CHEN Jianer Chen Songqiao Wang Jianxin | 2001 | Joumal of Central South University of Technology2001，8，2： | 1 |
| 15 | Locally Subcubeconnected Hypercube Networks: Theoretical Analysis and Experimental Results显示文摘 | Chen Jianer Wang Guojun Chen Songqiao | 2002 | IEEE Transactions on Computers2002，51，5： | 1 |
| 16 | A STUDY ON FORMAL MODEL INTEGRATION显示文摘Model integration is an important section of the model management research area. The paper puts forward a formalization representation of model, and presents some concepts, such as the compound model re- lation, the composite model and so on. Additionally, the existence of model integration is also analyzed in de- tail and several sufficient conditions are proved. | Wang Jiayang Chen Songqiao Luo An | 2006 | Journal of Electronics(China)2006，23，5： | 0 |
| 17 | A SIMPLE CHARACTERIZATION OF THE BOOLEAN HIERARCHY显示文摘We give a new characterization of the Boolean hierarchy. Our characterization is simple and intuitive, which is based on a single algebraic operator,the symmetric difference, which is commutative and associative. | Cai Liming Chen Jianer Chen Songqiao (Department of Computer Science, Central South University of Technology,Changsha, 410083,China) | 1995 | Journal of Central South University1995，7，1： | 0 |
| 18 | Empirical likelihood-based evaluations of Value at Risk models显示文摘Value at Risk (VaR) is a basic and very useful tool in measuring market risks. Numerous VaR models have been proposed in literature. Therefore, it is of great interest to evaluate the efficiency of these models, and to select the most appropriate one. In this paper, we shall propose to use the empirical likelihood approach to evaluate these models. Simulation results and real life examples show that the empirical likelihood method is more powerful and more robust than some of the asymptotic method available in literature. | WEI ZhengHong WEN SongQiao ZHU LiXing | 2009 | Science China Mathematics2009，52，9： | 0 |
| 19 | THE STUDY AND APPLICATION OFF显示文摘THESTUDYANDAPPLICATIONOFFLOTATIONTECHNOLOGYDESIGNSOFTWAREWangYuhuaZhouLongtingChenSongqiaoChenJin(DepartmentofMineralEngineer... | Wang Yuhua Zhou Longting Chen Songqiao Chen Jin(Department of Mineral Engineering, Central South University ofTechnology, Changsha 410083, China) | 1996 | Journal of Central South University1996，8，2： | 0 |
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