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| 1 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 2 | Biogeographic distribution patterns of algal community in different urban lakes in China: Insights into the dynamics and co-existence显示文摘Urban lake ecosystems are significant for social development,but currently we know little about the geographical distribution of algal community in urban lakes at a large-scale.In this study,we investigated the algal community structure in different areas of urban lakes in China and evaluated the influence of water quality parameters and geographical location on the algal community.The results showed that obvious differences in water quality and algal communities were observed among urban lakes in different geographical areas.Chlorophyta was the dominant phylum,followed by cyanobacteria in all areas.The network analysis indicated that algal community composition in urban lakes of the western and southern area showed more variations than the eastern and northern areas,respectively.Redundancy analysis and structural equation model revealed that nutrients and p H were dominant environmental factors that affected the algal community,and they showed higher influence than that of iron,manganese and COD Mn concentration.Importantly,algal community and density exhibited longitude and latitude relationship.In general,these results provided an ecological insight into large-scale geographical distributions of algal community in urban lakes,thereby having potential applications for management of the lakes. | Haihan Zhang Rongrong Zong Huiyan He Kaiwen Liu Miaomiao Yan Yutian Miao Ben Ma Xin Huang | 2021 | Journal of Environmental Sciences2021，33，2： | 9 |
| 3 | Applications of aptamers for chemistry analysis, medicine and food security显示文摘Since aptamer and its in vitro selection process called SELEX were independently described by Ellington and Gold in 1990, extensive research has been undertaken and numerous isolated aptamers for various targets have been applied. Aptamers can bind to a wide range of targets that include small organic molecules, inorganic compounds, haptens and even whole cells with high binding affinity and specificity. Aptamers for a wide range of targets have been selected currently. In addition, aptamers are thermo stable and can also be regenerated easily within a few minutes denaturation, which makes them easy to store or handle. These advantages make aptamers extremely suitable for applications based on molecular recognition as analytical, diagnostic and therapeutic tools. In this review, the recent applications of aptamers for chemistry analysis, medicine and food security, along with the future trend will be discussed. | Rongrong Huang Zhijiang Xi Nongyue He | 2015 | Science China Chemistry2015，58，7： | 7 |
| 4 | Damage on lining concrete in highway tunnels under combined sulfate and chloride attack显示文摘 | Rongrong YIN Chenchen ZHANG Qing WU Baocheng LI He XIE | 2018 | Frontiers of Structural and Civil Engineering2018，12，3： | 7 |
| 5 | Current signal amplification strategies in aptamer-based electrochemical biosensor:A review显示文摘Due to their high specificity and affinity towards various targets,along with other unique advantages such as stability and low cost,aptamers are widely applied in analytical techniques.A typical aptamerbased electrochemical biosensor is composed of a aptamer as the biological recognition element and transducer converting the biologic interaction into electrical signals for the quantitative measurement of targets.Improvement of the sensitivity of a biosensor is significantly important in order to achieve the detection of biomolecules with low abundance,and different amplification strategies have been explored.The strategies either employ nanomaterials such as gold nanoparticles to con struct electrodes which can transfer the biological reactions more efficiently,or attempt to obtain enhanced signal through multi-labeled carriers or utilize enzyme mimics to catalyze redox cycling.This review discusses recent advances in signal amplification methods and their applications.Critical assessment of each method is also considered. | Lei He Rongrong Huang Pengfeng Xiao Yuan Liu Lian Jin Hongna Liu Song Li Yan Deng Zhu Chen Zhiyang Li Nongyue He | 2021 | Chinese Chemical Letters2021，32，5： | 3 |
| 6 | Current status,trends,and predictions in the burden of gallbladder and biliary tract cancer in China from 1990 to 2019显示文摘Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC. | Shimin Chen Ke Han Yang Song Shaohua Liu Xuehang Li Shengshu Wang Haowei Li Rongrong Li Jianhua Wang Yao He Miao Liu | 2022 | Chinese Medical Journal2022，，14： | 2 |
| 7 | The aptamers generated from HepG2 cells显示文摘Liver cancer, as the second cause of cancer death all around the world, resulted in a series of chronic liver diseases. More than 80%of the patients cannot receive effective treatment because of their advanced disease or poor liver function. It is time to improve early clinical diagnosis and find optimal therapeutic treatments. As the tumor cells behave differently from the cell-surface molecules, it is necessary to find a highly specific probe. The aptamers, known as 'chemical antibodies', can bind to their target molecules with high affinity and high specificity. The apatmers were obtained by Cell-SELEX, which was aimed at finding the aptamers against whole living cells. In the article, after 19 selections, the ssDNA pool was cloned and sequenced. After that, six aptamers were obtained, named apt_A to apt_F. By incubating the aptamers with different cells, except apt_E, the other aptamers showed high specificity. As for apt_E, which showed high affinity to several cancer cells, was a potential probe for the common protein presented by several different cancer cells. The equilibrium dissociation constants(Kd) were evaluated by measuring the flow cytometry signal that characterized the binding ability of aptamers to the target cells at a series of concentrations ranging from 46.3(4.5) nM to 199.4(44.2) nM, which exposed the high binding affinities of these aptamers. The research in the confocal fluorescence images further confirmed the specificity of these aptamers and the fact that the aptamers were combined with the targets on the cell-surface. | Rongrong Huang Zhongsi Chen Mei Liu Yan Deng Song Li Nongyue He | 2017 | Science China Chemistry2017，60，6： | 2 |
| 8 | Spinal cord injury:molecular mechanisms and therapeutic interventions显示文摘Spinal cord injury(SCI)remains a severe condition with an extremely high disability rate.The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system.In the past few decades,researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling. | Xiao Hu Wei Xu Yilong Ren Zhaojie Wang Xiaolie He Runzhi Huang Bei Ma Jingwei Zhao Rongrong Zhu Liming Cheng | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 9 | Microstructure,magnetic domain and dynamic loss of surface-textured Fe-based nanocrystalline alloy显示文摘Heterogeneous coarse surface crystallites induced in the industrial Fe-rich nanocrystalline alloy is an obstacle for high-frequency and high-power commercial applications.Herein,the phase,crystal orientation,nanostructure and magnetic domain evolution of the surface-crystallized Fe-rich alloy were systematically investigated.Microstructure and inverse pole figures analysis confirms that the DOordered dendriticcrystallites bear<001>-oriented fiber texture before and after annealing at the free surface,while ultrafine nanocrystals are randomly oriented in the interior and wheel surface after annealing.As compared to zero magnetic-field-annealing,the transverse magnetic-field-annealing induces weakly oriented fiber texture and relatively uniform dendritic-crystallites at the surface,and uniform anisotropy in the interior and surface,which promotes smooth wall motion at the surface and magnetization rotation in the interior.This synergetic effect reduces the excess loss and leads reduction in dynamic loss at 1.0 T and10 kHz by 36%. | Aina He Jiawei Li Mingkun Wang Anding Wang Yao Xiao Yaqiang Dong Hai Guo Rongrong Jiang Weixing Xia Lihong Dong Haidou Wang Jianya Ge | 2022 | Journal of Materials Science & Technology2022，，25： | 1 |
| 10 | Specific responses of monoamine neurotransmitters to various acute stressors显示文摘This study determined the composition of histamine,serotonin and dopamine using high performance liquid chromatography and electrochemical detection,and compared the changes in monoamine levels in plasma,the cortex and midbrain of mice exposed to acute stressors,such as blood-drawing stimulation or restraint.Results demonstrated that plasma histamine levels were markedly increased when mice were exposed to blood-drawing stimulation and restraint stress.However,serotonin levels decreased in plasma of mice treated with restraint stress,and dopamine levels in plasma had no significant response to the two acute stressors.The three monoamines (histamine,serotonin and dopamine) increased at different degrees in restraint mice,but not in brain regions of blood-drawing stressed mice.Results indicated that histaminergic,serotonergic or dopaminergic systems have their own specific response to different acute stressors. | Rongrong He Guanyu Lin Yifang Li Keiich Abe Xinsheng Yao Hiroshi Kurihara | 2011 | Neural Regeneration Research2011，6，14： | 1 |
| 11 | PdRu/C catalysts for ethanol oxidation in anion-exchange membrane direct ethanol fuel cells显示文摘 | Liang Ma Hui He Andrew Hsu Rongrong Chen | 2013 | Journal of Power Sources2013，，： | 1 |
| 12 | Tripodalsporormielones A-C,unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems显示文摘A chemical investigation on Sporormiella sp.led to the isolation and structural elucidation of tripodalsporormielones Ae C(1-3),a new class of polyketide possessing unprecedented cage-like skeletons with polyvdent bridged and fused ring systems.These polyketides with cage-like skeletons were characterized as a high non-protonated carbon-containing system,which resulted in few HMBC correlations observed and made the accurate structures hard to be obtained by NMR.Especially,some signals of non-protonated sp;carbons are weak and even unobservable in compound 1.In order to establish the structure of 1,the calculated NMR with DP4 evaluation was applied to determine the structure from the plausible structure candidates obtained from the detailed NMR analysis.Based on NMR experiments and calculated NMR,the structures of isolated compounds were established and confirmed by X-ray technology.Through chiral isolation,the optically pure enantiomers of 1 and 3 were obtained,and their absolute configurations were determined based on ECD quantum chemical calculation.Based on the isolated compounds and our previous work,1-3 would be derived from 3-methylorcinaldehyde,and their plausible biosynthetic mechanism was proposed.Furthermore,1 exhibited obvious short-term memory improvement activity on an Alzheimer’s disease fly model. | Guodong Chen Bingxin Zhao Meijuan Huang Jia Tang Yanbing Li Liangdong Guo Rongrong He Dan Hu Xinsheng Yao Hao Gao | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 13 | Chlorogenic acid protects MSCs against oxidative stress by altering FOXO family genes and activating intrinsic pathway显示文摘 | Shiyong Li Hetao Bian Zhe Liu Ye Wang Jianghua Dai Wenfeng He Xingen Liao Rongrong Liu Jun Luo | 2011 | European Journal of Pharmacology2011，，2： | 1 |
| 14 | Mineral element concentrations in grains of Chinese wheat cultivars显示文摘 | Yong Zhang Qichao Song Jun Yan Jianwei Tang Rongrong Zhao Yueqiang Zhang Zhonghu He Chunqin Zou Ivan Ortiz-Monasterio | 2010 | Euphytica2010，，3： | 1 |
| 15 | Extracellular vesicles based electrochemical biosensors for detection of cancer cells:A review显示文摘Extracellular vesicles(EVs)derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis,and are stable and abundant.Electrochemical methods for the detection of EVs are prefe rred over co nventional methods such as Western blotting and enzyme-linked immunosorbent assay for their high sensitivity and real-time detection.This article summaries studies proposing the electrochemical methods utilizing immunological and molecular methodologies for detecting EVs derived biomacromolecules such as miRNAs and transme mbrane protein for cancer diagnosis.Moreover,the electrochemical detection methods are compared and future prospects for the development of electrochemical methods for EVs detection are concluded. | Hui Xie Kaili Di Rongrong Huang Adeel Khan Yanyan Xia Hongpan Xu Chang Liu Tingting Tan Xinyu Tian Han Shen Nongyue He Zhiyang Li | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 16 | Influence of immunosuppressive drugs on natural killer cells in therapeutic drug exposure in liver transplantation显示文摘Background:Natural killer(NK)cells are enriched in the liver and are the main regulators in liver transplantation regarding rejection or tolerance,viral infection,or tumor recurrence.Immunosuppression consists of a triple drug standard regimen comprising tacrolimus(TAC)and corticosteroids(CS)with either mycophenolate mofetil(MMF)or sirolimus(SIR)/everolimus(EVE).The aim of this study was to evaluate the impact of trough levels of these regimens under clinical conditions and exposure on human NK-cell activity and function in order to better understand the antiviral and anti-tumor effects of mammalian target of rapamycin inhibitor(mTORI).Methods:Peripheral blood mononuclear cells(PBMCs)were collected from liver transplant recipients and healthy controls.Number and phenotypes of NK cells in vivo were analyzed by flow cytometry.In this study we simulated the immunosuppressive microenvironment in vitro.PBMCs were cultured at the clinically effective plasma concentration of drugs for 3 d to detect the effect of immunosuppressants on NK cells.Drug type and concentration:single drug[EVE,5 ng/mL;SIR,5 ng/mL;TAC,5 ng/mL;cyclosporine A(CSA),125 ng/mL;MMF,15μg/mL;CS,0.5μg/mL]and combined immunosuppressants(Group 1:TAC,5 ng/mL+MMF,15μg/mL+CS,0.5μg/mL;Group 2:TAC,5 ng/mL+SIR,5 ng/mL+CS,0.5μg/mL;Group 3:TAC,5 ng/mL+EVE,5 ng/mL+CS,0.5μg/mL).In addition,NK cells were sorted from PBMCs and treated under the above conditions to detect NK cell killing function and RNA transcription characteristics.Results:CS significantly impaired the cytolytic activity of NK cells,followed by MMF and SIR/EVE.CS and TAC/CSA significantly decreased the secretion of IFN-γand CD107a.NK cell function in liver transplant recipients was most pronouncedly inhibited by a triple immunosuppressive regimen,with CS playing the most prominent role compared with the other drugs.The MMF-containing regimen demonstrated a significant increase in the expression of suppressive genes,especially of the Siglec7/9 family.The SIR group had stronger NK cell activity compared with that of the MMF group,although liver transplantation patients have lower NK cell activity and function.Conclusions:Despite an overall comparable immunosuppressive efficiency in terms of prevention of acute rejection,a mTORIs-including regimen might be considered as having less impact on NK cell function. | Rongrong Qin Jiwei Qin Xuefeng Li Zhijun Xu Peiqi He Xiaodong Yuan Cheng Sun Björn Nashan | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 17 | Identifying nasopharyngeal carcinoma patients with metachronous metastasis sensitive to local treatment:a real-world study显示文摘It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and individualize treatments for patients with metastatic NPC.Data were collated from 240 NPC patients diagnosed with metachronous metastasis between 2006 and 2020 who received palliative chemotherapy with or without local treatment.Multivariable Cox regression was implemented to construct a nomogram which had a concordance index of 0.764 when predicting 1-,3-,and 5-year overall survival(OS).We then classified patients according to risk,creating low-and high-risk groups using the nomogram.Differences in OS between the two groups were significant(P<0.001).In the low-risk group,the OS for patients who received local treatment was longer than those without(P=0.009).This novel nomogram shows good performance in classifying patients according to risk and may also be a promising tool for determining who responds best to local treatment.Further validation using external center data is warranted. | Fanyu Peng Yizhi Ge Rongrong Wang Dingdong Hu Xiang Cao Yujie Zhang Dan Zong Xia He | 2022 | The Journal of Biomedical Research2022，36，4： | 0 |
| 18 | Simulations and Projections of Winter Sea Ice in the Barents Sea by CMIP6 Climate Models显示文摘Dramatic changes in the sea ice characteristics in the Barents Sea have potential consequences for the weather and climate systems of mid-latitude continents,Arctic ecosystems,and fisheries,as well as Arctic maritime navigation.Simulations and projections of winter sea ice in the Barents Sea based on the latest 41 climate models from the Coupled Model Intercomparison Project Phase 6(CMIP6)are investigated in this study.Results show that most CMIP6 models overestimate winter sea ice in the Barents Sea and underestimate its decreasing trend.The discrepancy is mainly attributed to the simulation bias towards an overly weak ocean heat transport through the Barents Sea Opening and the underestimation of its increasing trend.The methods of observation-based model selection and emergent constraint were used to project future winter sea ice changes in the Barents Sea.Projections indicate that sea ice in the Barents Sea will continue to decline in a warming climate and that a winter ice-free Barents Sea will occur for the first time during 2042-2089 under the Shared Socioeconomic Pathway 585(SSP5-8.5).Even in the observation-based selected models,the sensitivity of winter sea ice in the Barents Sea to global warming is weaker than observed,indicating that a winter ice-free Barents Sea might occur earlier than projected by the CMIP6 simulations. | Rongrong PAN Qi SHU Zhenya SONG Shizhu WANG Yan HE Fangli QIAO | 2023 | Advances in Atmospheric Sciences2023，40，12： | 0 |
| 19 | Artful union of a zirconium-porphyrin MOF/GO composite for fabricating an aptamer-based electrochemical sensor with superb detecting performance显示文摘More and more attentions have been focused on design and synthesis of novel metal-organic framework/graphene oxide(MOF/GO)composites with unique performance.Zirconium-porphyrin MOF(PCN-222)is in-situ synthesis with the existence of GO with-COOH group to artfully fabricate a PCN-222/GO composite.This composite can be employed as functional material to modify the working electrode.Thanks to excellent electrical conductivity of GO,abundant mesoporous channels and numerous Zr(Ⅳ)metal sites of PCN-222,this composite can immobilize a large amount of aptamer through strongπ-πstacking interaction and high affinity between phosphate group of aptamer and Zr(Ⅳ)site of PCN-222 simultaneously.Hence,an ultra-sensitive electrochemical aptasensor based on PCN-222/GO composite can quantificationally detect trace chloramphenicol with limit of detection of 7.04 pg/m L(21.79 pmol/L)from 0.01 ng/m L to 50 ng/m L by electrochemical impedance spectroscopy even in real samples.Meanwhile,this fabricated aptasensor reveals good repeatability,outstanding selectivity and preferable long-term storage.This research provides a useful approach to construct MOF/GO composites for fabricating electrochemical aptasensors in the electrochemical detection field. | Hong-Kai Li Hai-Lin Ye Xiao-Xue Zhao Xiao-Long Sun Qian-Qian Zhu Zhang-Ye Han Rongrong Yuan Hongming He | 2021 | Chinese Chemical Letters2021，32，9： | 0 |
| 20 | An intriguing electrochemical impedance aptasensor based on a porous organic framework supported silver nanoparticles for ultrasensitively detecting theophylline显示文摘Porous organic frameworks(POFs)are excellently stable porous materials,which can be employed as host platforms to support metal nanoparticles as functional composites for various applications.Herein,a novel POF is successfully prepared via Friedel-Crafts reaction.Silver nanoparticles(AgNPs)are embedded in the prepared POF to generate an Ag@POF composite,which not only possesses high surface area,outstanding physicochemical stability and outstretchedπ-conjugation skeleton,but also exhibits preferable electrochemical stability and conductivity.This composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical aptasensor.Electrochemical impedance spectroscopy(EIS)is a commonly used technology to analyze the electrochemical signal variation.The Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing EIS.For instance theophylline as a research mode,the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness,high selectivity,remarkable stability,good repeatability and simple operability even in various real samples.Notably,this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/m L(1.06 pmol/L)in a wide concentration range of 5.0×10^(-4)–5.0 ng/m L(2.78×10^(-3)–27.8 nmol/L). | Zhang-Ye Han Hong-Kai Li Qian-Qian Zhu Rongrong Yuan Hongming He | 2021 | Chinese Chemical Letters2021，32，9： | 0 |
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